| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B V Clineschmidt, D R Reiss, D J Pettibone, J L Robinso. Characterization of 5-hydroxytryptamine receptors in rat stomach fundus. The Journal of pharmacology and experimental therapeutics. vol 235. issue 3. 1986-02-12. PMID:2934542. |
with respect to having a high affinity for 5-ht, the 5-ht receptor mediating contraction of fundic smooth muscle resembles the 5-ht1 recognition site (as defined in brain tissue by radioligand binding), but identity remains unproven. |
1986-02-12 |
2023-08-11 |
rat |
| T Archer, B Tandberg, L Rènyi, S B Ros. Antagonism of 5-methoxy-N,N-dimethyltryptamine-induced changes in postdecapitation convulsions in rats by repeated treatment with drugs enhancing 5-hydroxytryptamine neurotransmission. The Journal of pharmacy and pharmacology. vol 37. issue 9. 1986-01-29. PMID:2867187. |
these findings indicate down-regulation of the 5-hydroxytryptamine receptors which mediate the action of 5-meodmt on the pdcs and offer a simple model system for studying 5-ht receptor sensitivity changes at the spinal level. |
1986-01-29 |
2023-08-11 |
rat |
| P J Cowen, D P Geaney, M Schächter, A R Green, J M Elliot. Desipramine treatment in normal subjects. Effects on neuroendocrine responses to tryptophan and on platelet serotonin (5-HT)-related receptors. Archives of general psychiatry. vol 43. issue 1. 1986-01-24. PMID:3942474. |
our findings further indicate that desipramine may alter both 5-ht uptake and 5-ht receptor sensitivity, and suggest that the platelet lsd receptor may in certain conditions provide a useful model of 5-ht receptors in the brain. |
1986-01-24 |
2023-08-11 |
human |
| S Ahlenius, C O Criborn, C Henriksso. Central 5-HT and the respiratory response to acoustic stimulation in awake rats: effects of PCPA, 5-HTP and 8-OH-DPAT. Journal of neural transmission. vol 63. issue 3-4. 1986-01-10. PMID:2933488. |
thus, in the present experiment, using a simple sensory-motor response, 8-oh-dpat behaves as a 5-ht antagonist and the results provide further support for mixed 5-ht receptor agonist/antagonist properties of this compound. |
1986-01-10 |
2023-08-11 |
rat |
| W Feniuk, P P Humphrey, M J Perren, A D Watt. A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists. British journal of pharmacology. vol 86. issue 3. 1986-01-09. PMID:2933110. |
using recently available selective agonists and antagonists we have examined further our postulate (apperley et al., 1980) that 5-hydroxytryptamine (5-ht) mediates contraction of dog saphenous vein via a different 5-ht receptor type from that in the rabbit aorta. |
1986-01-09 |
2023-08-11 |
dog |
| A Nishi, A Karasawa, S Yoshikawa, R Ishitan. [3H]5-hydroxytryptamine binding to reconstituted fraction with sulphatides, phosphatidylserine and phosphatidylinositol. Japanese journal of pharmacology. vol 38. issue 4. 1986-01-06. PMID:4068380. |
as a first step toward the examination of the involvement of sulphatides, phosphatidylserine and phosphatidylinositol in 5-ht receptor mechanisms, we performed [3h]5-ht binding experiments on the various reconstituted fractions with these acidic lipids. |
1986-01-06 |
2023-08-11 |
Not clear |
| Y Shenker, M D Gross, R J Greki. Peripheral serotonin2 receptor blockade does not inhibit 5-hydroxytryptophan-induced aldosterone stimulation. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:2932460. |
to assess the effects of serotonin receptor blockade on 5-hydroxytryptophan (5htp)-induced aldosterone secretion, we studied six normal men using the serotonin antagonists ketanserin and methysergide. |
1985-12-13 |
2023-08-11 |
human |
| J F Marwood, G S Stoke. Bucindolol has serotonin and alpha-adrenoceptor blocking properties. Journal of cardiovascular pharmacology. vol 7 Suppl 7. 1985-10-17. PMID:2412063. |
these results are consistent with our proposal that 5-ht receptors and alpha-adrenoceptors overlap on the cell surface, sharing common binding sites, such that alpha-adrenoceptor blockade causes interference with the full expression of 5-ht receptor stimulation. |
1985-10-17 |
2023-08-11 |
rat |
| H Kilbinger, I Pfeuffer-Friederic. Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus. British journal of pharmacology. vol 85. issue 2. 1985-10-17. PMID:3161573. |
the results suggest that the excitatory 5-ht receptor ('m'-receptor) differs in its pharmacological properties from other neuronal 5-ht receptors. |
1985-10-17 |
2023-08-11 |
Not clear |
| F G Graeff, A W Zuardi, J S Giglio, E C Lima Filho, I G Karnio. Effect of metergoline on human anxiety. Psychopharmacology. vol 86. issue 3. 1985-10-01. PMID:3929304. |
since met is a 5-ht receptor antagonist, active on the central nervous system, an inhibitory role of 5-ht on subjective anxiety might be suggested. |
1985-10-01 |
2023-08-11 |
human |
| K Gradin, A Pettersson, T Hedner, B Persso. Acute administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat. Journal of neural transmission. vol 62. issue 3-4. 1985-09-27. PMID:3161997. |
the cardiovascular effects of 8-oh-dpat were not prevented by pretreatment with methergoline, methiothepin, pirenperone or cianserine or by 5-ht depletion by means of p-chlorophenylalanine, which suggests that the putative 5-ht receptor that is responsible for the hypotension and bradycardia to 8-oh-dpat is not of a presynaptic type and does not have the pharmacological characteristics of a general 5-ht1 receptor. |
1985-09-27 |
2023-08-11 |
rat |
| P C Moser, P H Redfer. Circadian variation in behavioural responses to central 5-HT receptor stimulation in the mouse. Psychopharmacology. vol 86. issue 1-2. 1985-09-25. PMID:3927360. |
it is suggested that the demonstration of a circadian rhythm in the head-twitch response and the failure to show any comparable rhythm in the 5-ht syndrome provides further evidence that these behaviours are mediated by different 5-ht receptor subtypes. |
1985-09-25 |
2023-08-11 |
mouse |
| H J Liu, M T Li. Cholecystokinin-induced hypothermia: possible involvement of serotoninergic mechanisms in the rat hypothalamus. Pharmacology. vol 31. issue 2. 1985-09-23. PMID:4023045. |
the thermal effects of rats which were pretreated with 5,7-dihydroxytryptamine to deplete hypothalamic 5-hydroxytryptamine (5-ht) or with a 5-ht receptor blocker to intrahypothalamic administration of cholecystokinin (cck) were compared with those of control rats. |
1985-09-23 |
2023-08-11 |
rat |
| D N Middlemis. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. The Journal of pharmacy and pharmacology. vol 37. issue 6. 1985-09-16. PMID:2862270. |
the putative central 5-ht receptor agonist, 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)-1h-indole succinate (ru 24969), was found to be a potent inhibitor of the continuous k+ evoked efflux of [3h]5-ht from superfused rat frontal cortex slices (pd2 7.45). |
1985-09-16 |
2023-08-11 |
rat |
| P Willne. Antidepressants and serotonergic neurotransmission: an integrative review. Psychopharmacology. vol 85. issue 4. 1985-09-12. PMID:2410942. |
acute antidepressant treatment has variable effects: transmission may be enhanced, unchanged or reduced, depending mainly upon the relative contributions of 5-ht uptake blockade and 5-ht receptor antagonism. |
1985-09-12 |
2023-08-11 |
Not clear |
| S O Ogren, K Fuxe, L Agnat. The importance of brain serotonergic receptor mechanisms for the action of antidepressant drugs. Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3927330. |
the present studies have shown that chronic antidepressant treatment with different types of antidepressant drugs results in adaptive changes in postsynaptic 5-ht receptor mechanisms which appear to result in 5-ht sub- or supersensitivity development depending upon the 5-ht nerve terminal system analyzed. |
1985-09-03 |
2023-08-11 |
Not clear |
| M D Gershon, M Takaki, H Tamir, T Branche. The enteric neural receptor for 5-hydroxytryptamine. Experientia. vol 41. issue 7. 1985-08-22. PMID:3874089. |
antagonists active at receptors for other neurotransmitters than 5-ht, at either of the two known types of cns 5-ht receptor, and at 5-ht uptake sites on serotonergic neurons failed to inhibit binding of 3h-5-ht. |
1985-08-22 |
2023-08-11 |
Not clear |
| M D Gershon, M Takaki, H Tamir, T Branche. The enteric neural receptor for 5-hydroxytryptamine. Experientia. vol 41. issue 7. 1985-08-22. PMID:3874089. |
the structural requirements of analogues for binding to the enteric 5-ht receptor matched the known pharmacology of m or neural 5-ht receptors. |
1985-08-22 |
2023-08-11 |
Not clear |
| A K Saxena, A K Saksena, M S Agnihotri, S Vrat, K K Tangri, K P Bhargav. Cardiovascular responses elicited by microinjection of monoamines into mesencephalic nucleus dorsalis raphe in cats. Naunyn-Schmiedeberg's archives of pharmacology. vol 329. issue 2. 1985-08-13. PMID:2861570. |
microinjection of monoamines, noradrenaline, phenylephrine and 5-hydroxytryptamine (5-ht) into nucleus dorsalis raphe elicited hypertension and tachycardia which could be blocked by local pretreatment with piperoxan (an alpha-adrenoceptor blocker) and methysergide (a 5-ht receptor blocker) respectively. |
1985-08-13 |
2023-08-11 |
Not clear |
| S O Ogren, O G Berg. Evidence for selective serotonergic receptor involvement in p-chloroamphetamine-induced antinociception. Naunyn-Schmiedeberg's archives of pharmacology. vol 329. issue 2. 1985-08-13. PMID:4010792. |
the analgesia was attenuated by administration of the 5-ht antagonists methiothepin (0.125-0.5 mg/kg) and danitracen (0.25-2.5 mg/kg) but not by a series of other 5-ht receptor antagonists or antagonists acting on noradrenergic, dopaminergic, gabaergic, histaminergic or muscarinic receptors. |
1985-08-13 |
2023-08-11 |
rat |