| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J O Willoughby, M F Menadue, H Liebel. Activation of serotonin receptors in the medial basal hypothalamus stimulates growth hormone secretion in the unanesthetized rat. Brain research. vol 404. issue 1-2. 1987-05-26. PMID:3567575. |
the effects of serotonin on gh were blocked by the non-selective serotonin receptor blocker, metergoline 2.5 mg/kg, but not by the serotonin type 2 receptor blocker, ketanserine 0.2 mg/kg. |
1987-05-26 |
2023-08-11 |
rat |
| C Eva, M Fabrazzo, E Cost. Changes of cholinergic, noradrenergic and serotonergic synaptic transmission indices elicited by ethylcholine aziridinium ion (AF64A) infused intraventricularly. The Journal of pharmacology and experimental therapeutics. vol 241. issue 1. 1987-05-22. PMID:2437288. |
in contrast the decrease of hippocampal 5-ht concentration elicited by af64a fails to change the 5-ht receptor indices that were measured. |
1987-05-22 |
2023-08-11 |
rat |
| R N Cory, B Rouot, G Guillon, F Sladeczek, M N Balestre, J Bockaer. The 5-hydroxytryptamine (5-HT2) receptor stimulates inositol phosphate formation in intact and broken WRK1 cells: determination of occupancy-response relationships for 5-HT agonists. The Journal of pharmacology and experimental therapeutics. vol 241. issue 1. 1987-05-22. PMID:2952788. |
the selective blockade of the 5-ht response by nanomolar concentrations of 5-ht2 selective antagonists but not by drugs acting at other 5-ht receptor subtypes suggest that the receptor in wrk1 cells is of the 5-ht2 type. |
1987-05-22 |
2023-08-11 |
rat |
| U J Povlsen, U Noring, A L Laursen, S Korsgaard, J Gerlac. Effects of serotonergic and anticholinergic drugs in haloperidol-induced dystonia in Cebus monkeys. Clinical neuropharmacology. vol 9. issue 1. 1987-05-21. PMID:3470140. |
acute dystonia induced by subcutaneous injections of haloperidol was slightly reduced by the 5-ht antagonist methysergide (4.0 mg/kg), while mianserin, ketanserin, and ritanserin (r 55 667; a new selective and potent 5-ht receptor blocker) had no effect. |
1987-05-21 |
2023-08-11 |
monkey |
| R A Cohen, K M Zitna. Adenosine diphosphate potentiates the inhibition of norepinephrine-induced relaxation by 5-hydroxytryptamine in canine coronary arteries. European journal of pharmacology. vol 133. issue 3. 1987-05-20. PMID:3493910. |
the decreases in sensitivity to norepinephrine caused by 5-hydroxytryptamine and adenosine diphosphate were prevented by the serotonin receptor antagonist, methiothepin. |
1987-05-20 |
2023-08-11 |
Not clear |
| J Yamada, Y Sugimoto, K Horisak. The behavioural effects of intravenously administered tryptamine in mice. Neuropharmacology. vol 26. issue 1. 1987-05-07. PMID:3561719. |
these results indicate that the 5-ht syndrome induced by intravenous administration of tryptamine is due to the direct effect of tryptamine on the 5-ht receptor. |
1987-05-07 |
2023-08-11 |
mouse |
| M D Tricklebank, J Neill, E J Kidd, J R Fozar. Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. European journal of pharmacology. vol 133. issue 1. 1987-05-01. PMID:2881789. |
the 8-oh-dpat cue was found to be highly selective; neither the 5-ht receptor agonists, quipazine, lsd, mk 212 and ru 24969, the 5-ht releasing agent, p-chloroamphetamine, nor the alpha 2-adrenoceptor agonist, clonidine, were able to substitute for 8-oh-dpat in tests of generalization. |
1987-05-01 |
2023-08-11 |
rat |
| A Verheyen, E Vlaminckx, F Lauwers, M Borgers, L Wouter. Radioactive colloidal gold as a tool to quantify extravasation of macromolecules in the rat cremaster muscle. International journal of microcirculation, clinical and experimental. vol 5. issue 4. 1987-04-27. PMID:2881904. |
the increased permeability elicited by serotonin was inhibited in a dose-dependent way by serotonin receptor antagonists (potency: methysergide greater than or equal to ketanserin = ritanserin greater than cinanserin), suggesting the presence of functional s2-serotonergic receptors on postcapillary venular endothelial cells. |
1987-04-27 |
2023-08-11 |
rat |
| G Maura, E Roccatagliata, M Raiter. Serotonin autoreceptor in rat hippocampus: pharmacological characterization as a subtype of the 5-HT1 receptor. Naunyn-Schmiedeberg's archives of pharmacology. vol 334. issue 4. 1987-04-20. PMID:3821924. |
the 5-hydroxytryptamine (5-ht) autoreceptors mediating inhibition of [3h]5-ht release in rat hippocampus have been characterized pharmacologically in terms of 5-ht receptor subtype by using superfused synaptosomes depolarized with 15 mm kcl. |
1987-04-20 |
2023-08-11 |
rat |
| S Benkirane, S Arbilla, S Z Lange. Newly synthesized noradrenaline mediates the alpha 2-adrenoceptor inhibition of [3H]5-hydroxytryptamine release induced by beta-phenylethylamine in rat hippocampal slices. European journal of pharmacology. vol 131. issue 2-3. 1987-04-07. PMID:3028829. |
the inhibition of tyrosine hydroxylase activity by alpha-mpt does not modify the inhibition of the evoked release of [3h]5ht by the alpha 2-adrenoceptor agonist, 6-fluoronoradrenaline, or the serotonin receptor agonist, 5-methoxytryptamine. |
1987-04-07 |
2023-08-11 |
rat |
| P Ribeiro, R A Web. Characterization of a serotonin transporter and an adenylate cyclase-linked serotonin receptor in the cestode Hymenolepis diminuta. Life sciences. vol 40. issue 8. 1987-03-26. PMID:3027490. |
characterization of a serotonin transporter and an adenylate cyclase-linked serotonin receptor in the cestode hymenolepis diminuta. |
1987-03-26 |
2023-08-11 |
Not clear |
| M A Blackshear, L L Martin, E Sanders-Bus. Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists. Neuropharmacology. vol 25. issue 11. 1987-02-11. PMID:3796800. |
similar adaptive changes in 5-ht2 sites after administration of mianserin, a presumed 5-ht antagonist, and after tfpp, a presumed 5-ht agonist, suggests that adaptive mechanisms in the serotonergic system are different from those in other aminergic systems or that the drugs used to characterize 5-ht receptor systems need to be re-evaluated. |
1987-02-11 |
2023-08-11 |
rat |
| L Rény. Long lasting supersensitivity to 5-HT mediated behaviour following monoamine depletion in the rat brain. Acta pharmacologica et toxicologica. vol 59. issue 4. 1987-02-10. PMID:2948371. |
these results underline the usefulness of the 5-ht mediated behavioural models for studies of changes in 5-ht receptor activity. |
1987-02-10 |
2023-08-11 |
rat |
| F G Graeff, M L Brandão, E A Audi, M T Schüt. Modulation of the brain aversive system by GABAergic and serotonergic mechanisms. Behavioural brain research. vol 22. issue 2. 1987-02-10. PMID:3024664. |
similar experiments with drugs influencing serotonergic neurotransmission evidenced that intra-cg microinjection of serotonin (5-ht) or of the direct 5-ht receptor agonist 5-methoxy-n,n-dimethyltryptamine increased the aversive threshold. |
1987-02-10 |
2023-08-11 |
rat |
| G M Mawe, T A Branchek, M D Gersho. Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 24. 1987-02-06. PMID:3467338. |
the other class of 5-ht receptor, which we propose to call 5-ht2p, appears not to have a high affinity for [3h]5-ht. |
1987-02-06 |
2023-08-11 |
Not clear |
| W Cole, Y D Lapierr. The use of tryptophan in normal-weight bulimia. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 31. issue 8. 1987-02-03. PMID:3791132. |
hypothalamic serotonin receptor sites have been postulated to explain the inhibitory effect of serotonin on feeding behavior. |
1987-02-03 |
2023-08-11 |
Not clear |
| H Moritoki, H Fukuda, J Kanaya, Y Ishid. Ketanserin potentiates the prejunctional inhibitory effect of 5-hydroxytryptamine on rat vas deferens. The Journal of pharmacy and pharmacology. vol 38. issue 10. 1987-01-23. PMID:2878993. |
these results suggest that the 5-ht receptor that mediates prejunctional inhibition is not of the 5-ht2 type, and that ketanserin acts by suppressing the 5-ht-induced stimulatory effect, which is possibly mediated by a postjunctional 5-ht2 receptor, thus unmasking the inhibitory effect of 5-ht. |
1987-01-23 |
2023-08-11 |
rat |
| G A Gudelsky, J I Koenig, H Jackman, H Y Meltze. Suppression of the hypo- and hyperthermic responses to 5-HT agonists following the repeated administration of monoamine oxidase inhibitors. Psychopharmacology. vol 90. issue 3. 1987-01-16. PMID:2947256. |
in view of the concept that the hypo- and hyperthermic responses to 5-ht agonists are mediated by 5-ht1a and 5-ht2 receptor subtypes, respectively, it is concluded that the responsiveness of these 5-ht receptor subtypes involved in thermoregulatory responses is decreased following chronic treatment of rats with monoamine oxidase inhibitors. |
1987-01-16 |
2023-08-11 |
rat |
| P W Glue, P J Cowen, D J Nutt, T Kolakowska, D G Grahame-Smit. The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors. Psychopharmacology. vol 90. issue 3. 1987-01-16. PMID:3097730. |
lithium had no effect on platelet 5-ht content, platelet imipramine binding and platelet 5-ht receptor binding. |
1987-01-16 |
2023-08-11 |
human |
| M E Hamilton, R M Zacharko, H Anisma. Influence of p-chloroamphetamine and methysergide on the escape deficits provoked by inescapable shock. Psychopharmacology. vol 90. issue 2. 1986-12-22. PMID:3097700. |
consistent with the view that the behavioral interference was related to reductions of serotonin (5-ht), treatment with the 5-ht receptor blocker methysergide mimicked the effects of inescapable shock in that it increased escape latencies. |
1986-12-22 |
2023-08-11 |
Not clear |