| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D N Middlemiss, M E Bremer, S M Smit. A pharmacological analysis of the 5-HT receptor mediating inhibition of 5-HT release in the guinea-pig frontal cortex. European journal of pharmacology. vol 157. issue 1. 1989-05-05. PMID:3234493. |
it is concluded that the 5-ht receptor modulating 5-ht release in the guinea-pig frontal cortex does not correspond to any of the 5-ht1-subtype recognition sites or to 5-ht2 or 5-ht3 receptors. |
1989-05-05 |
2023-08-11 |
Not clear |
| K Fink, E Schlicker, R Betz, M Göther. Identification of presynaptic 5-HT1 autoreceptors in pig brain cortex synaptosomes and slices. Naunyn-Schmiedeberg's archives of pharmacology. vol 338. issue 1. 1989-05-02. PMID:3237252. |
pig brain cortex synaptosomes and slices preincubated with 3h-5-hydroxytryptamine (3h-5-ht) were superfused with physiological salt solution containing citalopram (an inhibitor of 5-ht uptake), and the effects of indolethylamines and 5-ht receptor antagonists on the potassium- or electrically evoked 3h overflow were determined. |
1989-05-02 |
2023-08-11 |
Not clear |
| G Reiser, B Hamprech. Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line. Brain research. vol 479. issue 1. 1989-04-28. PMID:2466536. |
various other neurotransmitters and peptides had no effect on the response of the hybrid cells to substance p. the serotonin receptor interacting with the substance p receptor may be classified as a 5-ht3-receptor since methysergide, cimetidine, and ketanserin were ineffective, but two inhibitors specific for 5-ht3-receptors, ics 205-930 (3 alpha-tropanyl-1h-indole-3-carboxylic acid ester) and mdl 72222 (1 alpha h,3 alpha,5 alpha h-tropan-3-yl-3,5-dichlorobenzoate), blocked the effect of serotonin at nanomolar concentrations. |
1989-04-28 |
2023-08-11 |
Not clear |
| P Schoeffter, C Waeber, J M Palacios, D Hoye. The 5-hydroxytryptamine 5-HT1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:3216894. |
3) the following 5-ht receptor agonists inhibited adenylate cyclase activity (in decreasing order of potency): 5-carboxamidotryptamine greater than 5-ht greater than 5-methoxytryptamine greater than 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h indole (ru 24969) greater than or equal to n,n-dipropyl-5-carboxamidotryptamine greater than 8-hydroxy-2(di-n-propylamino)-tetralin (8-oh-dpat) greater than buspirone greater than ipsapirone; the latter two compounds apparently behaved as partial agonists. |
1989-03-02 |
2023-08-11 |
Not clear |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
in summary, dorsal raphe 5-ht neurons appear highly responsive to 5-ht1a, but not to 5-ht1b compounds; these findings are discussed with regard to the 5-ht receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons. |
1989-02-21 |
2023-08-11 |
rat |
| S G Britt, S L Gonias, J M Sanders, S R Vandenber. Agonist and antagonist activities of arylpiperazines at human platelet serotonin2 receptors. The Journal of pharmacology and experimental therapeutics. vol 247. issue 3. 1989-01-31. PMID:3204525. |
this study demonstrates that the arylpiperazines, which are variably selective for the multiple brain 5-ht receptors, are all antagonists on the platelet 5-ht receptor. |
1989-01-31 |
2023-08-11 |
human |
| M E el Halawani, O M Youngren, J L Silsby, R E Phillip. Involvement of serotonin in prolactin release induced by electrical stimulation of the hypothalamus of the turkey (Meleagris gallopavo). General and comparative endocrinology. vol 72. issue 2. 1989-01-25. PMID:3197951. |
the possibility that serotonin (5-ht) plays a role in electrical stimulation-induced prl release was investigated after administration of methysergide, a 5-ht receptor blocker (20 mg/kg), and stimulation in either the vmn or the infundibular nuclear complex-median eminence (inf-me) region. |
1989-01-25 |
2023-08-11 |
Not clear |
| E L Rodríguez Echandía, A S González, M R Fóscolo, S T Broitma. Excitatory and inhibitory behavioral responses to the pharmacological stimulation of serotonergic function in dorsalis raphe lesioned rats. Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia. vol 38. issue 1. 1989-01-25. PMID:3264446. |
this model was used in the present work to analyze the role of 5-ht receptor subtypes in the mechanism controlling the excitatory and inhibitory behavioral responses to the pharmacological stimulation of 5-ht systems. |
1989-01-25 |
2023-08-11 |
rat |
| A Dumuis, R Bouhelal, M Sebben, R Cory, J Bockaer. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Molecular pharmacology. vol 34. issue 6. 1989-01-23. PMID:2849052. |
on this 5-ht receptor, 5-ht (ec50 = 109 +/- 17 nm) and 5-methoxytryptamine (5-meot) were equipotent agonists. |
1989-01-23 |
2023-08-11 |
mouse |
| T Torda, J Culman, E Cechová, K Murga. 3-H-ketanserin (serotonin type 2) binding in the rat frontal cortex: effect of immobilization stress. Endocrinologia experimentalis. vol 22. issue 2. 1988-09-30. PMID:3261685. |
it was concluded that the enhanced number of cortical 5-ht2 receptor binding sites may result from accelerated serotonin turnover induced by stress, but the results did not indicate any direct association between the serotonin turnover and 5-ht receptor function in the rat frontal cortex. |
1988-09-30 |
2023-08-11 |
rat |
| L E Mello, Z A Bortolotto, E A Cavalheir. Brain indoleamines in alloxan- and streptozotocin-induced diabetic rats. Journal of neurochemistry. vol 51. issue 3. 1988-09-26. PMID:2970524. |
blockade of wet-dog shakes by 5-ht receptor antagonists strengthens the proposal that this behavior is a good index of central 5-ht activity. |
1988-09-26 |
2023-08-11 |
rat |
| M R Pranzatell. Effect of chronic treatment with 5-hydroxytryptophan on cortical serotonin receptors in the rat. Clinical neuropharmacology. vol 11. issue 3. 1988-09-21. PMID:3261199. |
however, the chronic effects of 5-htp on central 5-ht receptors and the activity of 5-htp at 5-ht receptor subtypes have not been previously reported. |
1988-09-21 |
2023-08-11 |
rat |
| D E Nichols, D H Lloyd, M P Johnson, A J Hoffma. Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. Journal of medicinal chemistry. vol 31. issue 7. 1988-08-05. PMID:3385733. |
synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-ht1b receptors. |
1988-08-05 |
2023-08-11 |
rat |
| T D Brewerton, D L Murphy, E A Mueller, D C Jimerso. Induction of migrainelike headaches by the serotonin agonist m-chlorophenylpiperazine. Clinical pharmacology and therapeutics. vol 43. issue 6. 1988-07-22. PMID:3378382. |
in a study of serotonin (5-ht) function in patients with eating disorders and healthy control subjects, severe headaches with features of common migraine occurred unexpectedly in 28 of 52 subjects (54%) 8 to 12 hours after receiving a single oral dose of the 5-ht receptor agonist m-chlorophenylpiperazine (m-cpp), 0.5 mg/kg. |
1988-07-22 |
2023-08-11 |
human |
| A H Bom, D J Duncker, P R Saxena, P D Verdou. 5-Hydroxytryptamine-induced tachycardia in the pig: possible involvement of a new type of 5-hydroxytryptamine receptor. British journal of pharmacology. vol 93. issue 3. 1988-07-14. PMID:3370393. |
it was concluded that the tachycardia induced by 5-ht in the pig does not involve the receptors for some common neurotransmitter substances but may be mediated by a new 5-ht receptor type that is clearly different from '5-ht1-like', 5-ht2 or 5-ht3 receptors. |
1988-07-14 |
2023-08-11 |
rat |
| D I Wallis, N J Du. Fast and slow depolarizing responses of guinea-pig coeliac ganglion cells to 5-hydroxytryptamine. Journal of the autonomic nervous system. vol 21. issue 2-3. 1988-06-27. PMID:3450693. |
it is concluded that guinea-pig coeliac ganglion cells display either a rapid depolarization, a slow depolarization or a biphasic response to 5-ht, that the fast depolarization appears to be mediated by a conductance increase to na and k, while a different mechanism appears to underlie the slow depolarization, and that the two responses are mediated by different kinds of 5-ht receptor. |
1988-06-27 |
2023-08-11 |
Not clear |
| M T Lowy, H Y Meltze. Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist. Biological psychiatry. vol 23. issue 8. 1988-06-13. PMID:3365458. |
mk-212 may stimulate the secretion of cortisol and prolactin in humans via a serotonin (5-ht2) receptor mechanism and may be a valuable tool with which to study 5-ht receptor sensitivity in humans. |
1988-06-13 |
2023-08-11 |
human |
| K Herrick-Davis, M Titele. Detection and characterization of the serotonin 5-HT 1D receptor in rat and human brain. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:3361315. |
this putative novel 5-ht receptor has a similar pharmacology to the "5-ht 1d" site detected in bovine brain by heuring and peroutka. |
1988-06-02 |
2023-08-11 |
human |
| M R Pranzatell. The comparative pharmacology of the behavioral syndromes induced by TRH and by 5-HT in the rat. General pharmacology. vol 19. issue 2. 1988-05-12. PMID:2895033. |
the relationship of the behavioral syndromes induced by the co-transmitters thyrotropin releasing hormone (trh) and serotonin (5-ht) has not been previously studied with drugs selective for 5-ht receptor subtypes. |
1988-05-12 |
2023-08-11 |
rat |
| L Brown, J Amedro, G Williams, D Smit. A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:2965026. |
the pharmacological characteristics of the presynaptic 5-ht receptor associated with the modulation of 5-ht release were investigated in a preparation of rat spinal cord synaptosomes (nerve terminals) superfused with a tris-buffered krebs solution containing fluoxetine (1 microm). |
1988-05-06 |
2023-08-11 |
rat |