| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Brown, J Amedro, G Williams, D Smit. A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:2965026. |
the 5-ht receptor agonists serotonin (1-100 nm), lysergic acid diethylamide (10 nm-1 microm) and the 5-ht1b receptor agonists 1-(m-trifluoromethylphenyl)piperazine (100 nm-1 microm) and 1-(m-chlorophenyl) piperazine (100 nm-3 microm) concentration dependently decreased [3h]5-ht release, while 8-hydroxy-2-(di-n-propylamino)tetralin, a selective 5-ht1a receptor agonist, was inactive. |
1988-05-06 |
2023-08-11 |
rat |
| G J Marek, L S Seide. Effects of selective 5-hydroxytryptamine-2 and nonselective 5-hydroxytryptamine antagonists on the differential-reinforcement-of-low-rate 72-second schedule. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:2894458. |
the effects of antidepressant drugs, administered with and without a 5-hydroxytryptamine (5-ht) antagonist that is not selective for 5-ht receptor subtypes, were assessed in rats responding under a differential-reinforcement-of-low-rate 72-second (drl 72-s) schedule of reinforcement. |
1988-04-12 |
2023-08-11 |
rat |
| R Gardette, M Krupa, F Crepe. Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices. Neuroscience. vol 23. issue 2. 1988-03-28. PMID:2893990. |
the serotonin-induced increase in the cell firing rate appeared to be methysergide-resistant whereas the serotonin-induced decrease in the responses elicited by excitatory amino acids was depressed by this antagonist, which could indicate that these differential effects of serotonin are mediated via different mechanisms and/or serotonin receptor subtypes. |
1988-03-28 |
2023-08-11 |
rat |
| M A Taranger, A M Galzin, S Z Lange. Methiothepin enhances the potassium-evoked release of [3H]-noradrenaline in rat pineal gland. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 4. 1988-03-24. PMID:2963232. |
however, 5-ht and the 5-ht receptor agonists, lsd and 5-methoxytryptamine, were inactive at modulating the k+-evoked release of [3h]-noradrenaline in pineal glands from normal and pcpa-treated rats. |
1988-03-24 |
2023-08-11 |
rat |
| G R Martin, P Leff, D Cambridge, V J Barret. Comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 4. 1988-03-24. PMID:3431594. |
at low concentrations of 5-ht (0.001-0.1 mumol/l) vascular relaxation was mediated indirectly by the endothelial 5-ht receptor previously described by leff et al. |
1988-03-24 |
2023-08-11 |
rabbit |
| J O Willoughby, M F Menadue, H J Liebel. Activation of 5-HT 1 serotonin receptors in the medial basal hypothalamus stimulates prolactin secretion in the unanaesthetized rat. Neuroendocrinology. vol 47. issue 1. 1988-03-15. PMID:3340274. |
prolactin secretion was also evoked by serotonin injections in the preoptic/anterior hypothalamic area, but the response was not blocked by serotonin receptor antagonists. |
1988-03-15 |
2023-08-11 |
rat |
| S J Estey, T E Mansou. Nature of serotonin-activated adenylate cyclase during development of Schistosoma mansoni. Molecular and biochemical parasitology. vol 26. issue 1-2. 1988-03-14. PMID:3431567. |
forskolin and serotonin act synergistically to activate cyclase, and the degree of potentiation is the same (four-fold) at all stages of development, indicating that the coupling between the serotonin receptor and the catalytic component of cyclase is fully developed in the schistosomulum. |
1988-03-14 |
2023-08-11 |
Not clear |
| D S Charney, W K Goodman, L H Price, S W Woods, S A Rasmussen, G R Heninge. Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Archives of general psychiatry. vol 45. issue 2. 1988-02-24. PMID:3337615. |
to evaluate the role of serotonin (5-ht) function in obsessive-compulsive disorder (ocd), behavioral and biochemical responses to the 5-ht receptor agonist m-chlorophenylpiperazine (mcpp) and the 5-ht precursor tryptophan were examined in healthy subjects and patients with ocd. |
1988-02-24 |
2023-08-11 |
human |
| M L Cohen, K D Kurz, R W Fulle. Effect of meta-chlorophenylpiperazine (mCPP), a central serotonin agonist and vascular serotonin receptor antagonist, on blood pressure in SHR. Clinical and experimental hypertension. Part A, Theory and practice. vol 9. issue 10. 1988-01-21. PMID:3677442. |
effect of meta-chlorophenylpiperazine (mcpp), a central serotonin agonist and vascular serotonin receptor antagonist, on blood pressure in shr. |
1988-01-21 |
2023-08-11 |
rat |
| E Schlicker, K Fink, K Classen, M Göther. Facilitation of serotonin (5-HT) release in the rat brain cortex by cAMP and probable inhibition of adenylate cyclase in 5-HT nerve terminals by presynaptic alpha 2-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 3. 1988-01-11. PMID:2825046. |
forskolin plus ah 21-132 did not alter the inhibitory effect of serotonin (examined in the presence of 6-nitroquipazine) and the facilitatory effect of metitepin (a serotonin receptor antagonist) on evoked 3h overflow, but considerably decreased the inhibitory effect of clonidine or b-ht 920 (2-amino-6-allyl-5,6,7,8-tetrahydro-4h-thiazolo-[5,4-d]-azepine). |
1988-01-11 |
2023-08-11 |
rat |
| M Göthert, E Schlicke. Classification of serotonin receptors. Journal of cardiovascular pharmacology. vol 10 Suppl 3. 1988-01-07. PMID:2446065. |
the identity of a given 5-ht binding site with a 5-ht receptor was suggested by correlating the agonists' and antagonists' affinities for the binding site with their potencies to produce certain effects. |
1988-01-07 |
2023-08-11 |
Not clear |
| M E Apfelbau. Effect of serotonin on the basal and gonadotrophin-releasing hormone-induced release of luteinizing hormone from rat pituitary glands in vitro. Life sciences. vol 41. issue 17. 1987-11-23. PMID:3312904. |
methysergide, a serotonin receptor blocking agent, partially antagonized the inhibitory effect of 5-ht on lh release, either basal or gnrh-stimulated. |
1987-11-23 |
2023-08-11 |
rat |
| R B McCall, B N Patel, L T Harri. Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity. The Journal of pharmacology and experimental therapeutics. vol 242. issue 3. 1987-11-05. PMID:2958619. |
the role of 5-ht receptor subtypes in mediating the 5-ht excitation of sympathetic neurons is discussed. |
1987-11-05 |
2023-08-11 |
Not clear |
| T Nabeshima, K Ishikawa, K Yamaguchi, H Furukawa, T Kameyam. Phencyclidine-induced head-weaving observed in mice after ritanserin treatment. European journal of pharmacology. vol 139. issue 2. 1987-10-29. PMID:2888667. |
these results indicate that pcp induces head-weaving by interacting with a 5-ht receptor (possibly of the 5-ht1 subtype) indirectly after 5-ht release and induces head-twitch by interacting with 5-ht2 receptors directly. |
1987-10-29 |
2023-08-11 |
mouse |
| G J Sange. Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: potential clinical importance of BRL 24924. British journal of pharmacology. vol 91. issue 1. 1987-08-05. PMID:3594084. |
the mechanism by which brl 24924 can increase gut ach release is not certain, but most likely involves activation of an enteric 5-ht receptor which differs from those 5-ht m-receptors antagonized by ics 205-930 or by higher concentrations of brl 24924 in other test systems. |
1987-08-05 |
2023-08-11 |
rat |
| D S Charney, S W Woods, W K Goodman, G R Heninge. Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology. vol 92. issue 1. 1987-08-04. PMID:3110824. |
to assess the role of serotonin function in the development of panic anxiety, the behavioral and biochemical responses to the serotonin receptor agonist, m-chlorophenylpiperazine (mcpp) was examined in healthy subjects and agoraphobic and panic disorder patients. |
1987-08-04 |
2023-08-11 |
human |
| J G Bernstei. Induction of obesity by psychotropic drugs. Annals of the New York Academy of Sciences. vol 499. 1987-07-30. PMID:2886102. |
numerous studies indicate that a wide variety of compounds, including the serotonin precursor, tryptophan, the serotonin receptor stimulant, fenfluramine, and the serotonin reuptake inhibitor, fluoxetine, are all capable of decreasing carbohydrate hunger, reducing consumption of carbohydrate-rich foods, and inhibiting weight gain in humans and animals. |
1987-07-30 |
2023-08-11 |
Not clear |
| J G Bernstei. Induction of obesity by psychotropic drugs. Annals of the New York Academy of Sciences. vol 499. 1987-07-30. PMID:2886102. |
because many antidepressants, including trazodone and amitriptyline, the neuroleptic, chlorpromazine, and the mood stabilizer, lithium, may all, under some circumstances, inhibit serotonin reuptake mechanisms and may simultaneously block serotonin receptor sites, their effects on appetite and weight gain may represent a balance between serotonergic and antiserotonin activities. |
1987-07-30 |
2023-08-11 |
Not clear |
| A Cheung, T R Hall, S Harve. Serotoninergic regulation of corticosterone secretion in domestic fowl. The Journal of endocrinology. vol 113. issue 2. 1987-07-20. PMID:3585229. |
administration of the serotonin receptor agonist 2-(1-piperazinyl)quinoline maleate (quipazine), an inhibitor of serotonin metabolism, n-methyl-n-2-propynylbenzylamine hcl (pargyline), as well as serotonin itself, all increased plasma concentrations of corticosterone. |
1987-07-20 |
2023-08-11 |
Not clear |
| M A Hashim, D Biege. Excitatory action of 5-HT on deglutitive substrates in the rat solitary complex. Brain research bulletin. vol 18. issue 3. 1987-07-16. PMID:2884023. |
non-selective deglutitive inhibition after high doses of 5-ht could, therefore, result from neuronal desensitization secondary to excessive stimulation or activation of a different type of 5-ht receptor. |
1987-07-16 |
2023-08-11 |
rat |