| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J S Carp, W Z Ryme. Enhancement by serotonin of tonic vibration and stretch reflexes in the decerebrate cat. Experimental brain research. vol 62. issue 1. 1986-05-22. PMID:3007191. |
the prolonged motor output that continues after cessation of high frequency longitudinal tendon vibration was strongly enhanced by the serotonin reuptake blocker fluoxetine and the serotonin precursor 5-hydroxytryptophan, and was decreased by the serotonin receptor antagonist methysergide. |
1986-05-22 |
2023-08-11 |
cat |
| P E Ganey, K H Sprugel, K B Hadley, R A Rot. Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin. The Journal of pharmacology and experimental therapeutics. vol 237. issue 1. 1986-05-15. PMID:2937908. |
to investigate the role of 5-ht, the effects of two 5-ht receptor antagonists were examined in mctp-treated rats. |
1986-05-15 |
2023-08-11 |
rat |
| P E Ganey, K H Sprugel, K B Hadley, R A Rot. Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin. The Journal of pharmacology and experimental therapeutics. vol 237. issue 1. 1986-05-15. PMID:2937908. |
these results indicate that cotreatment with either of these two 5-ht receptor antagonists does not alter the lung injury or right ventricular hypertrophic response to mctp and suggest that 5-ht is not necessary for mctp-induced toxicity. |
1986-05-15 |
2023-08-11 |
rat |
| R W Fulle. Pharmacologic modification of serotonergic function: drugs for the study and treatment of psychiatric and other disorders. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:3514585. |
the development of direct serotonin agonists, selective inhibitors of serotonin uptake, serotonin receptor antagonists, and other drugs affecting serotonergic function has aided the study of physiologic functions of brain serotonin neurons in laboratory animals and the recognition and classification of serotonin receptor subtypes. |
1986-05-14 |
2023-08-11 |
Not clear |
| D L Murphy, E A Mueller, N A Garrick, C S Aulak. Use of serotonergic agents in the clinical assessment of central serotonin function. The Journal of clinical psychiatry. vol 47 Suppl. 1986-05-14. PMID:3514586. |
these agents are also being used to assess postulated changes in serotonin metabolism and serotonin receptor adaptation during longer term treatment with antidepressant drugs, lithium, and other psychoactive agents. |
1986-05-14 |
2023-08-11 |
Not clear |
| G G Holz, S A Shefner, E G Anderso. Serotonin decreases the duration of action potentials recorded from tetraethylammonium-treated bullfrog dorsal root ganglion cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 3. 1986-05-08. PMID:3485707. |
the 5-ht receptor antagonists methysergide and metergoline did not block the response to 5-ht. |
1986-05-08 |
2023-08-11 |
Not clear |
| N H Majeed, W Lasoń, B Przewłocka, R Przewłock. Serotonergic regulation of the brain and gut beta-endorphin and dynorphin content in the rat. Polish journal of pharmacology and pharmacy. vol 37. issue 6. 1986-05-06. PMID:2870487. |
administration of the serotonin receptor agonist m-chlorophenylpiperazine (m-cpp, 2.5-5 mg/kg ip) or the serotonin releasing agent fenfluramine (20-40 mg/kg ip) induced a significant increase in the hypothalamic ir-be content and a decrease in its anterior pituitary level. |
1986-05-06 |
2023-08-11 |
rat |
| S O Ogre. Serotonin receptor involvement in the avoidance learning deficit caused by p-chloroamphetamine-induced serotonin release. Acta physiologica Scandinavica. vol 126. issue 3. 1986-04-30. PMID:2870606. |
serotonin receptor involvement in the avoidance learning deficit caused by p-chloroamphetamine-induced serotonin release. |
1986-04-30 |
2023-08-11 |
rat |
| R W Fuller, N R Mason, H D Snoddy, K W Perr. 1-(1-Naphthyl)piperazine, a central serotonin agonist. Research communications in chemical pathology and pharmacology. vol 51. issue 1. 1986-04-22. PMID:2419952. |
reduced serotonin turnover and elevated serum corticosterone concentrations are interpreted as evidence of central serotonin receptor activation by compounds of this structural class. |
1986-04-22 |
2023-08-11 |
rat |
| G Engel, M Göthert, D Hoyer, E Schlicker, K Hillenbran. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:2936965. |
in rat brain cortex slices preincubated with [3h]5-ht, the potencies of 17 5-ht receptor agonists to inhibit the electrically evoked 3h overflow and the affinities of 13 antagonists (including several beta-adrenoceptor blocking agents) to antagonize competitively the inhibitory effect of unlabelled 5-ht on evoked 3h overflow were determined. |
1986-04-22 |
2023-08-11 |
rat |
| M R Pranzatelli, S R Snodgras. Antimyoclonic properties of S2 serotonin receptor antagonists in the rat. Neuropharmacology. vol 25. issue 1. 1986-04-11. PMID:2936977. |
the capacity of the putative s2 serotonin receptor antagonists, pirenperone, pipamperone, ketanserin and cinanserin, to block the myoclonic syndrome produced by 30 mg/kg of l-5-hydroxytryptophan (5-htp) [after lesioning 5-hydroxytryptamine (serotonin, 5-ht)-containing neurons with 5,7-dihydroxytryptamine (dht)] or 15 mg/kg of fenfluramine (ff) or p-chloroamphetamine (pca) was tested in adult male sprague-dawley rats. |
1986-04-11 |
2023-08-11 |
human |
| G M Goodwin, R J De Souza, A R Gree. The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). A model of presynaptic 5-HT1 function. Neuropharmacology. vol 24. issue 12. 1986-04-07. PMID:2869435. |
since the response was almost abolished by a lesion induced by 5,7-dht and was antagonised by quipazine, which is known to antagonise presynaptic 5-ht function in vitro, it is suggested that the hypothermic response is due to 8-oh-dpat acting as an agonist at a presynaptic 5-ht receptor, which also appears to be sensitive to butyrophenones (the antagonism elicited by haloperidol but not by flupenthixol). |
1986-04-07 |
2023-08-11 |
mouse |
| C Post, B G Minor, M Davies, T Arche. Analgesia induced by 5-hydroxytryptamine receptor agonists is blocked or reversed by noradrenaline-depletion in rats. Brain research. vol 363. issue 1. 1986-03-28. PMID:3484988. |
the antinociceptive effect of acute administration of 5-ht receptor agonists and agents releasing 5-ht from neuronal terminals was studied in rats by using the hot-plate, tail-flick and shock-titration tests. |
1986-03-28 |
2023-08-11 |
rat |
| G Luscombe, P Jenner, C D Marsde. 5-HT-mediated myoclonus in the guinea pig as a model of brainstem 5-HT and tryptamine receptor action. Advances in neurology. vol 43. 1986-03-07. PMID:2418649. |
further evidence for the involvement of a brainstem 5-ht receptor subpopulation in the initiation of myoclonus is shown by the differential ability of 5-ht antagonists to inhibit 5-htp-induced myoclonus and of 5-ht reuptake blockers to potentiate threshold myoclonus. |
1986-03-07 |
2023-08-11 |
human |
| H R Wagner, A Reches, E Yablonskaya, S Fah. Clonazepam-induced up-regulation of serotonin1 and serotonin2 binding sites in rat frontal cortex. Advances in neurology. vol 43. 1986-03-07. PMID:2418653. |
these data suggest that serotonin receptor changes seen after chronic clonazepam may occur as a compensatory response to decreases in the presynaptic release of serotonin. |
1986-03-07 |
2023-08-11 |
rat |
| G Battaglia, A B Norman, P L Newton, I Crees. In vitro and in vivo irreversible blockade of cortical S2 serotonin receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline: a technique for investigating S2 serotonin receptor recovery. Journal of neurochemistry. vol 46. issue 2. 1986-02-19. PMID:2934516. |
in vitro and in vivo irreversible blockade of cortical s2 serotonin receptors by n-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline: a technique for investigating s2 serotonin receptor recovery. |
1986-02-19 |
2023-08-11 |
rat |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
thus, the similarity in affinities of these phenylpiperazine derivatives for serotonin receptors mediating contraction in the rat fundus along with their different affinities for 5ht1a and 5ht1b binding sites argues against the possibility that the serotonin receptor in the rat fundus is of the 5ht1a or 5ht1b subtype of serotonin receptor. |
1986-02-18 |
2023-08-11 |
rat |
| R W Fuller, H D Snodd. Flumezapine and zotepine: 5-hydroxytryptamine antagonism not involved in the lack of synergism of these antipsychotic drugs with amfonelic acid in rats. The Journal of pharmacy and pharmacology. vol 37. issue 10. 1986-02-13. PMID:2867152. |
since flumezapine, zotepine and clozapine antagonize 5-hydroxytryptamine (5-ht) receptors with potency similar to their potency in antagonizing dopamine receptors, the possibility that 5-ht receptor blockade prevented their synergism with amfonelic acid was considered. |
1986-02-13 |
2023-08-11 |
rat |
| B V Clineschmidt, D R Reiss, D J Pettibone, J L Robinso. Characterization of 5-hydroxytryptamine receptors in rat stomach fundus. The Journal of pharmacology and experimental therapeutics. vol 235. issue 3. 1986-02-12. PMID:2934542. |
potent 5-ht2 receptor antagonists (pirenpirone and ketanserin) antagonized only weakly or were without effect against 5-ht, indicating that the fundic 5-ht receptor is not of the 5-ht2 subtype. |
1986-02-12 |
2023-08-11 |
rat |
| B V Clineschmidt, D R Reiss, D J Pettibone, J L Robinso. Characterization of 5-hydroxytryptamine receptors in rat stomach fundus. The Journal of pharmacology and experimental therapeutics. vol 235. issue 3. 1986-02-12. PMID:2934542. |
because the fundic receptor has high affinity for 5-ht (as does the 5-ht1 binding site in brain tissue), the possible correspondence of the fundic 5-ht receptor with the 5-ht1 recognition site in rat brain cortex was considered. |
1986-02-12 |
2023-08-11 |
rat |