| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D W Dalton, W Feniuk, P P Humphre. An investigation into the mechanisms of the cardiovascular effects of 5-hydroxytryptamine in conscious normotensive and DOCA-salt hypertensive rats. Journal of autonomic pharmacology. vol 6. issue 3. 1986-12-16. PMID:3771594. |
the actions of intravenously administered 5-hydroxytryptamine (5-ht) have been analysed in conscious doca-salt hypertensive rats using selective 5-ht receptor agonists and antagonists to determine the receptor mechanisms involved and to compare them with those in conscious normotensive rats. |
1986-12-16 |
2023-08-11 |
rat |
| T Knauss, H E Abbou. Effect of serotonin on prostaglandin synthesis in rat cultured mesangial cells. The American journal of physiology. vol 251. issue 5 Pt 2. 1986-12-15. PMID:3022603. |
this effect was structurally specific for the 5-ht receptor since indole-containing precursors and metabolites of 5-ht as well as the aminergic compounds, adenosine, and dopamine were without effect. |
1986-12-15 |
2023-08-11 |
rat |
| S Yamawaki, K Yanagawa, I Hotta, Y Uchitom. [Effect of long-term lithium treatment on serotonin syndrome in rats]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 6. issue 2. 1986-11-24. PMID:3096011. |
intraperitoneal injection of the 5-ht receptor agonist 5-meodmt elicited 5-ht syndrome in a dose-dependent manner. |
1986-11-24 |
2023-08-11 |
rat |
| T J Feuerstein, G Herttin. Serotonin (5-HT) enhances hippocampal noradrenaline (NA) release: evidence for facilitatory 5-HT receptors within the CNS. Naunyn-Schmiedeberg's archives of pharmacology. vol 333. issue 3. 1986-10-30. PMID:3762733. |
the stimulation induced tritium overflow was increased by the 5-ht receptor agonists, 5-ht, 2-methyl-5-ht and 5-carboxamidotryptamine in a concentration dependent manner; a tyramine-like displacement of na by the 5-ht agonists was prevented by (+)oxaprotilin. |
1986-10-30 |
2023-08-11 |
rabbit |
| S L Dickinson, G Curzo. 5-Hydroxytryptamine-mediated behaviour in male and female rats. Neuropharmacology. vol 25. issue 7. 1986-10-21. PMID:3748324. |
preliminary experiments showed that females had largely similar responses to the releaser of 5-ht, p-chloroamphetamine (pca) and the 5-ht receptor agonist 5-methoxy-n,n-dimethyltryptamine (5-meodmt) at different stages of the oestrus cycle. |
1986-10-21 |
2023-08-11 |
rat |
| F G Graeff, M L Brandão, E A Audi, M T Schüt. Modulation of the brain aversive system by GABAergic and serotonergic mechanisms. Behavioural brain research. vol 21. issue 1. 1986-10-02. PMID:3017372. |
similar experiments with drugs influencing serotonergic neurotransmission evidenced that intra-cg microinjection of serotonin (5-ht) or of the direct 5-ht receptor agonist 5-methoxy-n,n-dimethyltryptamine increased the aversive threshold. |
1986-10-02 |
2023-08-11 |
rat |
| S Garattini, T Mennini, C Bendotti, R Invernizzi, R Samani. Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system. Appetite. vol 7 Suppl. 1986-09-18. PMID:2427023. |
development of serotonin receptor hyposensitivity and, in some instances, decreased serotonin levels may lead to tolerance to the anorectic activity of drugs enhancing serotonin transmission, the degree of this depending critically on the type of effect on serotonin mechanisms and intensity and duration of serotonin receptor activation. |
1986-09-18 |
2023-08-11 |
Not clear |
| M D Hall, H Gozlan, M B Emerit, S el Mestikawy, L Pichat, M Hamo. Differentiation of pre- and post-synaptic high affinity serotonin receptor binding sites using physico-chemical parameters and modifying agents. Neurochemical research. vol 11. issue 6. 1986-09-17. PMID:3016581. |
the two 3h-labeled agonists [3h]8-hydroxy-2-(di-n-propylamino) tetralin ([3h]8-oh-dpat) and [3h]serotonin ([3h]5-ht) have been used to examine the effects of physico-chemical parameters and modulatory agents on the high affinity 5-ht receptor binding sites in various regions of the rat central nervous system. |
1986-09-17 |
2023-08-11 |
rat |
| K Iverfeldt, L L Peterson, E Brodin, S O Ogren, T Bartfa. Serotonin type-2 receptor mediated regulation of substance P release in the ventral spinal cord and the effects of chronic antidepressant treatment. Naunyn-Schmiedeberg's archives of pharmacology. vol 333. issue 1. 1986-09-16. PMID:2426604. |
thus the 5-ht receptor which regulates the release of sp appears to belong to the type-2 5-ht receptors. |
1986-09-16 |
2023-08-11 |
rat |
| M Göthert, P Kollecker, N Rohm, H R Zerkowsk. Inhibitory presynaptic 5-hydroxytryptamine (5-HT) receptors on the sympathetic nerves of the human saphenous vein. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 4. 1986-09-16. PMID:2942782. |
the inhibitory effect of 5-ht on the impulse-evoked 3h overflow was abolished by the nonselective 5-ht receptor antagonist metitepin, but was not attenuated by propranolol. |
1986-09-16 |
2023-08-11 |
human |
| E A Mueller, D L Murphy, T Sunderlan. Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: evidence for a serotonin receptor mediated mechanism of action in humans. Psychopharmacology. vol 89. issue 3. 1986-08-21. PMID:3014595. |
further studies of the putative serotonin agonist, m-chlorophenylpiperazine: evidence for a serotonin receptor mediated mechanism of action in humans. |
1986-08-21 |
2023-08-11 |
human |
| E A Mueller, D L Murphy, T Sunderlan. Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: evidence for a serotonin receptor mediated mechanism of action in humans. Psychopharmacology. vol 89. issue 3. 1986-08-21. PMID:3014595. |
to further evaluate the effects and mechanism of action of the putative serotonin agonist m-chlorophenylpiperazine (m-cpp) in humans, changes in plasma prolactin, cortisol, growth hormone, acth and body temperature were studied in a group of 10 healthy volunteers following oral administration of m-cpp (0.75 mg/kg), before and after pretreatment with the serotonin receptor antagonist metergoline (mtg). |
1986-08-21 |
2023-08-11 |
human |
| M L Vitale, M de las Nieves Parisi, S R Chiocchio, J H Tramezzan. Serotonin stimulates gonadotrophin release by acting directly on the median eminence. Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia. vol 35. issue 4. 1986-07-24. PMID:2940808. |
pretreatment with the 5-ht receptor blocker cyproheptadine (1 um) completely inhibited the stimulatory effect of 5-ht. |
1986-07-24 |
2023-08-11 |
rat |
| K Kuniyoshi, T Kushiro, N Kajiwar. [The role of the sympathetic nervous system and adrenals in hemodynamic changes after intracerebroventricular administration of 5-hydroxytryptamine in rats]. Nihon Naibunpi Gakkai zasshi. vol 62. issue 3. 1986-07-24. PMID:3086142. |
administration of 5-ht in rats elicited consistent pressor response with concomitant increase in plasma norepinephrine and that the pressor response was abolished by systemic pretreatment of phenoxybenzamine or by serotonin receptor antagonist, methysergide. |
1986-07-24 |
2023-08-11 |
rat |
| E M Sternberg, J Trial, C W Parke. Effect of serotonin on murine macrophages: suppression of Ia expression by serotonin and its reversal by 5-HT2 serotonergic receptor antagonists. Journal of immunology (Baltimore, Md. : 1950). vol 137. issue 1. 1986-07-18. PMID:2423604. |
these data provide functional evidence that 5-ht suppression of ifn-gamma-induced ia expression is mediated through a 5-ht receptor with some characteristics of the 5-ht2 type. |
1986-07-18 |
2023-08-11 |
mouse |
| S J Gunning, A J Bradbury, B Costall, R J Naylo. Evidence that 5-hydroxytryptamine may exert both facilitatory and inhibitory control of electrical field stimulation-evoked contractions in longitudinal muscle taken from the body of guinea-pig stomach. The Journal of pharmacy and pharmacology. vol 38. issue 3. 1986-06-06. PMID:2871152. |
therefore, the actions of 5-ht agonists and antagonists to modify contractions in stomach strips will reflect the balance between 5-ht inhibitory and facilitatory influences, and the specificity of action of the compounds for the two 5-ht receptor systems. |
1986-06-06 |
2023-08-11 |
human |
| N K Hollenber. Serotonin and the peripheral circulation. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 4. issue 1. 1986-06-06. PMID:3457902. |
serotonin influences large arteries in vivo to induce constriction through an action on the 5-ht2 serotonin receptor. |
1986-06-06 |
2023-08-11 |
rabbit |
| N K Hollenber. Serotonin and the peripheral circulation. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 4. issue 1. 1986-06-06. PMID:3457902. |
several studies now show, at least for the limb blood supply, that collateral arteries after major artery occlusion are extremely sensitive to serotonin acting on the 5-ht2 serotonin receptor. |
1986-06-06 |
2023-08-11 |
rabbit |
| M Göthert, E Schlicker, P Kollecke. Receptor-mediated effects of serotonin and 5-methoxytryptamine on noradrenaline release in the rat vena cava and in the heart of the pithed rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 2. 1986-05-30. PMID:2939353. |
in segments of the rat inferior vena cava preincubated with 3h-noradrenaline, it was examined whether presynaptic serotonin (5-ht) receptors exist on the postganglionic sympathetic nerves of the circulatory system; for this purpose the effects of 5-ht receptor agonists and antagonists on the electrically evoked 3h overflow were studied. |
1986-05-30 |
2023-08-11 |
rat |
| P Kaulen, G Brüning, H Rommelspacher, H G Baumgarte. Characterization and quantitative autoradiography of [3H]tryptamine binding sites in rat brain. Brain research. vol 366. issue 1-2. 1986-05-30. PMID:3697697. |
serotonin (5-ht, ic50 = 2600 nm) as well as the 5-ht receptor antagonists methysergide and metergoline displace [3h]tryptamine at much higher concentrations from brain slices. |
1986-05-30 |
2023-08-11 |
rat |