| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J S Meyer, N S Buckholtz, W O Bogga. Serotonergic stimulation of pituitary-adrenal activity in the mouse. Neuroendocrinology. vol 26. issue 5. 1978-10-18. PMID:150549. |
corticosterone (cs) responses to 5-htp were uninfluenced by pretreatment with a tryptophan hydroxylase inhibitor, p-chlorophenylalanine (pcpa), but were significantly potentiated by a serotonin (5-ht) reuptake inhibitor (lilly 110140), attenuated by two 5-ht receptor blockers, cyproheptadine and methergoline, and almost completely abolished by 2 extracerebral aromatic l-amino acid decarboxylase inhibitors, mk 486 and a low dose of ro 4-4602. |
1978-10-18 |
2023-08-11 |
mouse |
| T O De Roij, J Frens, F Woutersen-Van-Nijnanten, M Vianen-Meijerin. Comparison of the thermoregulatory responses to intracerebroventricularly injected dopamine, noradrenaline and 5-hydroxytryptamine in the goat. European journal of pharmacology. vol 49. issue 4. 1978-09-25. PMID:668811. |
the thermoregulatory responses to dopamine (da), noradrenaline (na) and 5-hydroxytryptamine (5-ht), injected into the third cerebral ventricle of goats at 20 degrees c ambient temperature (ta) or during cold exposure, were compared before and after pretreatment with the da receptor blocker haloperidol or the 5-ht receptor blocker methysergide. |
1978-09-25 |
2023-08-11 |
Not clear |
| E Friedman, G A Lambert, E Buchweit. 2,5-Dimethoxy-4-methylamphetamine (DOM)- a central component of its cardiovascular effects in rats; involvement of serotonin. European journal of pharmacology. vol 49. issue 2. 1978-08-14. PMID:26578. |
tachyphylaxis may be the result of irreversible binding of dom to 5-ht receptors or to 5-ht receptor densensitization. |
1978-08-14 |
2023-08-11 |
rat |
| S Bourgoin, F Artaud, J Bockaert, F Héry, J Glowinski, M Hamo. Paradoxical decrease of brain 5-HT turnover by metergoline, a central 5-HT receptor blocker. Naunyn-Schmiedeberg's archives of pharmacology. vol 302. issue 3. 1978-08-14. PMID:662027. |
paradoxical decrease of brain 5-ht turnover by metergoline, a central 5-ht receptor blocker. |
1978-08-14 |
2023-08-11 |
rat |
| K Golembiowska-Nikitin, G Wiszniowska, J Marcha. The effect of serotonin receptor blocking agents--cyproheptadine and danitracen--on serotonin turnover in the rat brain. Polish journal of pharmacology and pharmacy. vol 29. issue 5. 1978-02-18. PMID:145590. |
the effect of serotonin receptor blocking agents--cyproheptadine and danitracen--on serotonin turnover in the rat brain. |
1978-02-18 |
2023-08-11 |
rat |
| H Y Meltzer, R G Fessler, M Simonovic, J Doherty, V S Fan. Lysergic acid diethylamide: evidence for stimulation of pituitary dopamine receptors. Psychopharmacology. vol 54. issue 1. 1977-11-30. PMID:143671. |
lsd was more potent than methysergide, a serotonin receptor blocker, in lowering plasma prl levels and more potent than apomorphine, a known direct acting dopamine agonist, in blocking the increase in plasma prl produced by quipazine, a 5-ht agonist. |
1977-11-30 |
2023-08-11 |
rat |
| J B Malick, E Doren, A Barnet. Quipazine-induced head-twitch in mice. Pharmacology, biochemistry, and behavior. vol 6. issue 3. 1977-06-22. PMID:140381. |
the present studies suggest that quipazine influences serotonin receptors in the brain to produce head-twitch by two mechanisms of action: (1) by direct serotonin receptor activation, and (2) indirectly by causing a release of endogenous serotonin. |
1977-06-22 |
2023-08-11 |
mouse |
| A R Gree. Repeated chlorpromazine administration increases a behavioural response of rats to 5-hydroxytryptamine receptor stimulation. British journal of pharmacology. vol 59. issue 2. 1977-04-15. PMID:264797. |
it is suggested therefore that the enhanced behavioural response to 5-ht receptor stimulation following repeated chlorpromazine administration may be because this drug blocks 5-ht receptors. |
1977-04-15 |
2023-08-11 |
rat |
| G F Oksenkry. [Effect of D-, M- and T-antagonists of serotonin on its absorption by human thrombocytes]. Biulleten' eksperimental'noi biologii i meditsiny. vol 82. issue 9. 1977-01-25. PMID:990460. |
it is supposed that "serotonin" centre of the membrane carrier participating in the process of transmembrane serotonin transport was not identical to any definite type of serotonin receptor. |
1977-01-25 |
2023-08-11 |
human |
| G S Allen, C J Gross, L M Henderson, S N Cho. Cerebral arterial spasm. Part 4: in vitro effects of temperature, serotonin analogues, large nonphysiological concentrations of serotonin, and extracellular calcium and magnesium on serotonin-induced contractions of the canine basilar artery. Journal of neurosurgery. vol 44. issue 5. 1976-07-06. PMID:1262918. |
cumulative log-dose response curves for analogues of serotonin demonstrated a high degree of specificity for the serotonin receptor and large nonphysiological concentrations of serotonin caused relaxation of the contracted artery. |
1976-07-06 |
2023-08-11 |
Not clear |
| J P Evans, D G Grahame-Smith, A R Green, A F Tordof. Electroconvulsive shock increases the behavioural responses of rats to brain 5-hydroxytryptamine accumulation and central nervous system stimulant drugs. British journal of pharmacology. vol 56. issue 2. 1976-06-02. PMID:3248. |
4 the hyperactivity following administration of the 5-ht agonist 5-methoxy n,n-dimethyltryptamine was enhanced by repeated (10 day) ecs, suggesting altered post-synaptic responses to 5-ht receptor stimulation. |
1976-06-02 |
2023-08-11 |
rat |
| K Fuxe, L F Agnati, U Ungersted. The effect of mepiprazole on central monoamine neurons. Evidence for increased 5-hydroxytryptamine and dopamine receptor activity. European journal of pharmacology. vol 35. issue 1. 1976-06-02. PMID:943291. |
the extensor hindlimb reflex, which is dependent on 5-ht receptor activity, was only increased with higher doses (2.5-10 mg/kg), suggesting that the spinal 5-ht nerve terminals are less sensitive to the releasing action of pap. |
1976-06-02 |
2023-08-11 |
rat |
| A Seiger, L Olson, L O Farneb. Brain tissue transplanted to the anterior chamber of the eye. 4. Drug-modulated transmitter release in central monoamine nerve terminals lacking normal postsynaptic receptors. Cell and tissue research. vol 165. issue 2. 1976-04-10. PMID:174817. |
the 5-ht receptor stimulating agent ergocornine tended to reduce the stimulation-induced release of 3h-5-ht from central 5-ht fibers on the iris. |
1976-04-10 |
2023-08-11 |
rat |
| W B Mendelson, L S Jacobs, J D Reichman, E Othmer, P E Cryer, B Trivedi, W H Daughada. Suppression of sleep-related prolactin secretion and enhancement of sleep-related growth hormone secretion. The Journal of clinical investigation. vol 56. issue 3. 1975-12-04. PMID:1159082. |
it seems likely from these data that the role of serotonin in the control of prolactin secretion is relatively more important, since serotonin receptor blockade dramatically reduced sleep-related prolactin secretion. |
1975-12-04 |
2023-08-11 |
Not clear |
| R A O'Brien, M Boublik, S Specto. Immunopharmacological studies using 5-hydroxytryptamine antibody. The Journal of pharmacology and experimental therapeutics. vol 194. issue 1. 1975-10-30. PMID:1151746. |
the antibody was capable of effectively competing with 5-ht receptor sites for free molecules of 5-ht. |
1975-10-30 |
2023-08-11 |
Not clear |
| H Corrodi, L O Farnebo, K Fuxe, B Hamberge. Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation. European journal of pharmacology. vol 30. issue 2. 1975-07-28. PMID:1173234. |
it was found that ergocornine increased the 5-ht receptor activity independent of presynaptic 5-ht stores and that it didnot have any effects on uptake, retention and spontaneous overflow of 3-h-5-ht in vitro but reduced the fiedl stimulation-induced release of 3-h-5-ht in vitro. |
1975-07-28 |
2023-08-11 |
rat |
| H Corrodi, L O Farnebo, K Fuxe, B Hamberge. Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation. European journal of pharmacology. vol 30. issue 2. 1975-07-28. PMID:1173234. |
mpme, on the other hand, seems to increase 5-ht receptor release of 5-ht stores, mainly from extragranular sites. |
1975-07-28 |
2023-08-11 |
rat |
| H Corrodi, L O Farnebo, K Fuxe, B Hamberge. Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation. European journal of pharmacology. vol 30. issue 2. 1975-07-28. PMID:1173234. |
it is suggested that mpme is a releaser of extragranular 5-ht stores leading to increased 5-ht receptor activity and reduction of 5-ht turnover in the same way as indicated for ergocornine. |
1975-07-28 |
2023-08-11 |
rat |
| P B Bradley, I Brigg. Further studies on the mode of action of psychotomimetic drugs: antagonism of the excitatory actions of 5-hydroxytryptamine by methylated derivatives of tryptamine. British journal of pharmacology. vol 50. issue 3. 1974-11-08. PMID:4277490. |
it therefore seems that the 5-ht mimicking actions are unlikely to be due to release of 5-ht, but are due to direct actions on 5-ht receptors.6 the evidence presented supports the hypothesis that lsd-like psychotomimetics act by an antagonism of 5-ht in the lower brain stem, and is not compatible with the suggestion that the psychotomimetic action of these drugs is related to 5-ht receptor stimulation. |
1974-11-08 |
2023-08-11 |
rat |
| D A Coo. Blockade by phenoxybenzamine of the contractor response produced by agonists in the isolated ileum of the guinea-pig. British journal of pharmacology. vol 43. issue 1. 1972-03-30. PMID:4400182. |
in the case of the contraction induced by 5-ht, phenoxybenzamine probably interferes with the 5-ht receptor responsible for neuronal release of acetycholine. |
1972-03-30 |
2023-08-11 |
Not clear |