| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Koenig, M A Mayfield, R J Coppings, S M McCann, L Krulic. Role of central nervous system neurotransmitters in mediating the effects of morphine on growth hormone- and prolactin-secretion in the rat. Brain research. vol 197. issue 2. 1980-11-24. PMID:6105900. |
depletion of brain serotonin stores with p-chlorophenylalanine (300 mg/kg) or 5,7-dihydroxytryptamine or administration of serotonin receptor blocker, cyproheptadine (2.5 mg/kg), did not diminish the gh respnse to mor but it inhibited, or in the case of 5,7-dht treatment abolished the activation of prl secretion. |
1980-11-24 |
2023-08-12 |
rat |
| K Fuxe, S O Ogren, L F Agnati, K Andersson, H Hall, C Köhler, B Fredhol. Central monoamine synapses as sites of action for ergot drugs. Advances in biochemical psychopharmacology. vol 23. 1980-09-23. PMID:6104914. |
some ergot drugs also had affinity for 5-ht receptor binding sites, possibly reflecting a 5-ht agonistic action in some areas, as shown in behavioral studies. |
1980-09-23 |
2023-08-12 |
rat |
| R Samanin, T Mennini, A Ferraris, C Bendotti, F Borsin. Hyper- and hyposensitivity of central serotonin receptors:[3H]serotonin binding and functional studies in the rat. Brain research. vol 189. issue 2. 1980-07-12. PMID:7189434. |
the data show that central 5-ht receptor numbers and sensitivity may change after repeated treatments with drugs acting on brain serotonin. |
1980-07-12 |
2023-08-12 |
rat |
| E Chung Hwang, M H Van Woer. Comparative effects of substituted phenylethylamines on brain serotonergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6965983. |
a series of substituted phenylethylamines were examined for their relative potencies to 1) release and inhibit accumulation of labeled serotonin in brain synaptosomes, 2) compete with serotonin receptor binding and 3) induce the "serotonin syndrome" in mice. |
1980-06-27 |
2023-08-12 |
mouse |
| E Chung Hwang, M H Van Woer. Comparative effects of substituted phenylethylamines on brain serotonergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6965983. |
in general, the relative potencies of the phenylethylamine derivatives to produce the serotonin syndrome did not correlates well with their effects on synaptosomal uptake or release of serotonin or serotonin receptor binding. |
1980-06-27 |
2023-08-12 |
mouse |
| J R Fozard, A T Mobarok Ali, G Newgros. Blockade of serotonin receptors on autonomic neurones by (-)-cocaine and some related compounds. European journal of pharmacology. vol 59. issue 3-4. 1980-04-26. PMID:527645. |
selective blockade of 5-ht neuronal responses is a property shared by several structural analogues of (--)-cocaine and (+)-pseudococaine; nor-(--)-cocaine proved the most potent of these, being active at a concentration of 2 x 10(-8) m. these data indicate that (--)-cocaine and several of its derivatives inhibit 5-ht stimulation of both adrenergic and cholinergic autonomic neurones through competition with the agonist at serotonin receptor sties. |
1980-04-26 |
2023-08-11 |
rabbit |
| N Weiner, C Martin, W Wesemann, P Riedere. Effects of post-mortem storage on synaptic 5-HT binding and uptake in mammalian brain. Journal of neural transmission. vol 46. issue 3. 1980-04-17. PMID:528997. |
freezing at --80 degrees c of whole brain or of isolated membranes did not affect 5-ht receptor interaction.--the capacity of specific 5-ht binding to membranes isolated from human post-mortem brain was comparable to that found with synaptic membranes from rat brain. |
1980-04-17 |
2023-08-11 |
human |
| L Pawłowski, J Ruczyńska, E Wojtasi. An evidence for the central serotoninergic activity of viloxazine. Polish journal of pharmacology and pharmacy. vol 31. issue 4. 1980-03-17. PMID:523336. |
this effect of viloxazine was inhibited by serotonin receptor blockers, cyproheptadine, danitracen and metergoline, and by serotonin uptake blocking agents imipramine and clomipramine. |
1980-03-17 |
2023-08-11 |
rat |
| S O Ogren, K Fuxe, L F Agnati, J A Gustafsson, G Jonsson, A C Hol. Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs. Journal of neural transmission. vol 46. issue 2. 1980-02-15. PMID:574536. |
a number of antidepressant drugs such as amitriptyline, nortriptyline, mianserine, doxepine, nomifensine and dibenzepine appear to possess marked 5-ht receptor blocking activity at some type of 5-ht receptors in brain. |
1980-02-15 |
2023-08-11 |
mouse |
| S O Ogren, K Fuxe, L F Agnati, J A Gustafsson, G Jonsson, A C Hol. Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs. Journal of neural transmission. vol 46. issue 2. 1980-02-15. PMID:574536. |
new antidepressant drugs such as zimelidine, which specifically inhibit 5-ht reuptake and do not block 5-ht receptor sites, may after chronic treatment also reduce the functional activity of 5-ht systems by producing adaptive changes in postsynaptic 5-ht mechanisms. |
1980-02-15 |
2023-08-11 |
mouse |
| J H Jacoby, R F Thomas, J J Poulakos, A Siege. Studies on tryptophan accumulation in brain during methiothepin-induced enhancement of 5-hydroxyindole synthesis. Naunyn-Schmiedeberg's archives of pharmacology. vol 307. issue 2. 1979-11-29. PMID:481614. |
the elevation of brain tryptophan, 5-hydroxytryptophan and 5-hydroxyindoles (serotonin + 5-hydroxyindole acetic acid) that results from a tryptophan load is potentiated by prior administration of methiothepin, a serotonin receptor antagonist. |
1979-11-29 |
2023-08-11 |
rat |
| C L Williams, J S Rosenblatt, W G Hal. Inhibition of suckling in weaning-age rats: a possible serotonergic mechanism. Journal of comparative and physiological psychology. vol 93. issue 3. 1979-11-21. PMID:479391. |
it was found that (a) methysergide, a serotonin (5-ht) receptor blocker, reinstated suckling behavior in pups 15 days of age and older but had no effect on the suckling of 10-day old pups, (b) quipazine, a 5-ht receptor agonist, inhibited suckling of pups 10 days of age and older, (c) methysergide pretreatment blocked the quipazine inhibition of suckling, and (d) metergoline, another 5-ht blocker, also stimulated suckling, and fenfluramine, a 5-ht releaser, blocked suckling in deprived pups. |
1979-11-21 |
2023-08-11 |
rat |
| P Steigrad, I Tobler, P G Waser, A A Borbél. Effect of p-chlorophenylalanine on cerebral serotonin binding, serotonin concentration and motor activity in the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 305. issue 2. 1979-03-24. PMID:153478. |
it is concluded that the initial pcpa-induced decrease in kd was due to a reduced competition for binding sites by the endogenous 5-ht, whereas the increase of bmax after a prolonged 5-ht depletion may reflect a 5-ht receptor supersensitivity. |
1979-03-24 |
2023-08-11 |
rat |
| E Müller-Schweinitze. Studies on the 5-HT receptor in vascular smooth muscle. Research and clinical studies in headache. vol 6. 1979-02-23. PMID:725257. |
bc-105 was nearly equipotent in antagonizing responses to 5-ht, e and dhe suggesting that both ergot alkaloids act as noncompetitive dualists at the 5-ht receptor. |
1979-02-23 |
2023-08-11 |
cattle |
| J E Blundel. Is there a role for serotonin (5-hydroxytryptamine) in feeding? International journal of obesity. vol 1. issue 1. 1979-01-26. PMID:361584. |
in general, treatments and procedures believed to lead to an increased availability of 5-ht in the synaptic cleft or which directly activate 5-ht receptors reduce food consumption, while procedures which either directly or indirectly decrease 5-ht receptor activation bring about the opposite effect. |
1979-01-26 |
2023-08-11 |
Not clear |
| J F Deakin, A R Gree. The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708990. |
3 none of the putative 5-ht receptor antagonists affected brain 5-ht turnover as assessed by rate of accumulation of 5-ht following monoamine oxidase inhibition with tranylcypromine. |
1979-01-26 |
2023-08-11 |
rat |
| J F Deakin, A R Gree. The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708990. |
the behavioural response to the putative 5-ht receptor agonist, 5-methoxy n,n-dimethyltryptamine (2 mg/kg), was potentiated in these animals suggesting that 5-ht receptors become supersensitive on denervation, and that some components of the behavioural syndrome are mediated by spinal cord 5-ht receptors. |
1979-01-26 |
2023-08-11 |
rat |
| L Edvinsson, J E Hardeb. Demonstration of 5-hydroxytryptamine receptors through inhibition by methergoline in cat pial arteries in vitro. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708997. |
1 in an attempt to characterize further the nature of the 5-hydroxytryptamine (5-ht)-induced contraction of intracranial vessels, cat's middle cerebral artery was exposed to this amine and the specific 5-ht receptor antagonist, methergoline, under standardized conditions in vitro. |
1979-01-26 |
2023-08-11 |
cat |
| G Jonsson, T Pollare, H Hallman, C Sach. Developmental plasticity of central serotonin neurons after 5,7-dihydroxytryptamine treatment. Annals of the New York Academy of Sciences. vol 305. 1978-12-27. PMID:280250. |
studies of the postsynaptic 5-ht receptor in vitro with [3h]-5-ht and [3h]lsd binding indicate that this receptor develops independently of presynaptic 5-ht nerve terminals. |
1978-12-27 |
2023-08-11 |
rat |
| M O Carruba, G Nisticò, G Gargiul. Effect of central nervous system-acting drugs after selective destruction by neurotoxins of 5-hydroxytryptamine fibers in the brain. Annals of the New York Academy of Sciences. vol 305. 1978-12-27. PMID:309299. |
since identical behavioral, electrocortical, and body temperature effects have been observed after 5-ht or 5,6-dht infusion into the third ventricle of fowl, it may be concluded that 5,6-dht behaves also as a central 5-ht receptor agonist. |
1978-12-27 |
2023-08-11 |
Not clear |