| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Fillion, M P Fillion, J C Roussell. [Increase in binding affinity of the 5-HT receptor and decrease in 5-HT sensitive adenylate cyclase activity following prolonged exposure to 5-HT (author's transl)]. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:7288651. |
[increase in binding affinity of the 5-ht receptor and decrease in 5-ht sensitive adenylate cyclase activity following prolonged exposure to 5-ht (author's transl)]. |
1981-12-22 |
2023-08-12 |
Not clear |
| L Noreika, G Pastor, J Liebma. Delayed emergence of antidepressant efficacy following withdrawal in olfactory bulbectomized rats. Pharmacology, biochemistry, and behavior. vol 15. issue 3. 1981-12-22. PMID:7291242. |
the olfactory bulbectomy syndrome may reflect functional serotonin deficiency, which would be ameliorated through antidepressant-induced alterations in serotonin receptor sensitivity. |
1981-12-22 |
2023-08-12 |
rat |
| M O Carruba, G B Picotti, M Calogero, J Negreanu, P Mantegazz. Hyperthermic responses to direct and indirect 5-HT agonists in rabbits following induction of 5-HT receptor supersensitivity by pharmacological manipulations which either reduce or leave unmodified brain 5-HT stores. Pharmacological research communications. vol 13. issue 8. 1981-12-15. PMID:6457307. |
hyperthermic responses to direct and indirect 5-ht agonists in rabbits following induction of 5-ht receptor supersensitivity by pharmacological manipulations which either reduce or leave unmodified brain 5-ht stores. |
1981-12-15 |
2023-08-12 |
Not clear |
| H Nagayama, J N Hingtgen, M H Apriso. Postsynaptic action by four antidepressive drugs in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 15. issue 1. 1981-12-15. PMID:6974869. |
since acute pretreatment with comparable clinical doses of the antidepressive drugs, mianserin, amitriptyline, imipramine, or iprindole, resulted in blockade of the 5-htp induced depression by 70, 50, 40, and 20% respectively, these drugs can act as antagonists of 5-ht at the postsynaptic serotonin receptor. |
1981-12-15 |
2023-08-12 |
rat |
| C Singleton, C A Marsde. Circadian variation in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine and p-chloroamphetamine in the mouse. Psychopharmacology. vol 74. issue 2. 1981-10-29. PMID:6168003. |
mice maintained on a 12-h light-dark cycle showed a maximum response to the direct 5-ht receptor agonist 5-meodmt (5 mg/kg iv) towards the end of the dark period, when the 5-ht level was at its lowest. |
1981-10-29 |
2023-08-12 |
mouse |
| C Singleton, C A Marsde. Circadian variation in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine and p-chloroamphetamine in the mouse. Psychopharmacology. vol 74. issue 2. 1981-10-29. PMID:6168003. |
it is concluded that 5-ht receptor response shows a circadian rhythm related to both pre-synaptic availability of 5-ht and post-synaptic receptor sensitivity. |
1981-10-29 |
2023-08-12 |
mouse |
| A R Green, J E Hall, A R Ree. A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists. British journal of pharmacology. vol 73. issue 3. 1981-09-25. PMID:6166345. |
in contrast, cypropheptadine, cinanserin and mianserin had no effects on the behaviour.3 similar findings were obtained when the behaviours were elicited by administration of tranylcypromine (10 mg/kg) followed by the putative 5-ht receptor agonist, 5-methoxy-n,n-dimethyltryptamine (5-meodmt) (2 mg/kg).4 when the behaviours were elicited by the putative 5-ht receptor agonist, quipazine (50 mg/kg), all the drugs effectively inhibited head weaving and forepaw treading.5 when the dose of cypropheptadine was doubled to 20 mg/kg an inhibition of the tranylcypromine/l-tryptophan induced behaviours was seen.6 methiothepin produced a marked inhibition of apomorphine-induced locomotor activity whilst all the others enhanced this response, suggesting that only methiothepin inhibits the 5-ht behaviours by dopamine antagonism and that the increased reactivity seen following tranylcypromine/l-tryptophan after pretreatment with methysergide or methergoline might be due to enhanced dopamine function.7 pretreatment with p-chlorophenylalanine resulted in enhanced behavioural responses to both 5-meodmt and quipazine.8 both methergoline and methiothepin decreased the rate of 5-ht synthesis in whole brain but not spinal cord and methergoline decreased spinal cord 5-hiaa concentration. |
1981-09-25 |
2023-08-12 |
rat |
| A R Green, J E Hall, A R Ree. A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists. British journal of pharmacology. vol 73. issue 3. 1981-09-25. PMID:6166345. |
none of the other drugs had any significant effects on the concentration of 5-ht, 5-hiaa or 5-ht synthesis rate in brain or spinal cord.9 experiments with compounds structurally related to quipazine and with molecular models suggested that quipazine produces behavioural changes probably by stimulating the 5-ht receptor in a similar way to 5-ht but that it would bind weakly, in agreement with ligand-receptor binding studies.10 it is suggested, therefore, that cyproheptadine, cinanserin and mianserin fail to inhibit 5-ht and 5-meodmt-induced behaviours because they are weak antagonists whilst they are able to inhibit the same behaviours induced by quipazine because it is a weak agonist.11 these data indicate that extreme care should be taken in accepting or rejecting 5-ht as a mediator of behaviours or of other responses unless several antagonists or agonists have been examined. |
1981-09-25 |
2023-08-12 |
rat |
| H L Nash, D I Walli. Effects of divalent cations on responses of a sympathetic ganglion to 5-hydroxytryptamine and 1,1-dimethyl-4-phenyl piperazinium. British journal of pharmacology. vol 73. issue 3. 1981-09-25. PMID:6265020. |
in ca/mg-free solutions, 5-ht depolarizations were potentiated but no significant shift in the curve was observed.6 it is suggested that divalent cations modulate the coupling between 5-ht receptor and ion channel, an increase in [ca(2+)](o) reducing the coupling or stabilizing the ion channel in the closed conformation. |
1981-09-25 |
2023-08-12 |
Not clear |
| M Hamon, D L Nelson, A Herbet, J Bockaert, J Glowinsk. Characteristics of serotonin receptors in the rat brain. Monographs in neural sciences. vol 7. 1981-07-23. PMID:7231436. |
indeed, several observations strongly suggested that the high affinity binding site for 3h-5-ht did not correspond to the 5-ht receptor coupled to adenylate cyclase in synaptic membranes: 1) the apparent affinity of the 5-ht-sensitive adenylate cyclase for 5-ht was about 300 times lower (kd = 0.5 microm) than that of the specific 3h-5-ht binding site; 2)the ontogenic evolutions of 3h-5-ht binding and 5-ht-sensitive adenylate cyclase were not parallel, notably in the hippocampus; 3) they were differently affected by several drugs. |
1981-07-23 |
2023-08-12 |
rat |
| L B Wallnau, G D Bordash, P Cors. The effects of tryptophan and manipulations of serotonergic receptors on tonic immobility in chickens. Pharmacology, biochemistry, and behavior. vol 14. issue 4. 1981-07-20. PMID:7195035. |
this effect was reversed by quipazine, a 5-ht receptor agonist, and p-chloroamphetamine, a 5-ht releaser. |
1981-07-20 |
2023-08-12 |
Not clear |
| D Wallis, H Nas. Relative activities of substances related to 5-hydroxytryptamine as depolarizing agents of superior cervical ganglion cells. European journal of pharmacology. vol 70. issue 3. 1981-07-20. PMID:7227456. |
the results suggest that: (1) the optimal requirements for activating ganglionic 5-ht receptors are a hydroxyl group at position 5 on the indole nucleus and a side-chain bearing an ethylamine amino group; (2) methyl substituents around the terminal nitrogen atom are well tolerated and a quaternary nitrogen may increase activity at the 5-ht receptor; and (3) substitution of a methyl group at carbon atom 2 of the indole nucleus reduces activity. |
1981-07-20 |
2023-08-12 |
rabbit |
| E S Vizi, L G Hársing, G Zsill. Evidence of the modulatory role of serotonin in acetylcholine release from striatal interneurons. Brain research. vol 212. issue 1. 1981-07-09. PMID:7225867. |
l-(m-chlorophenyl)-piperazine, a pure serotonin receptor stimulant and d-fenfluramine, a serotonin releaser significantly reduced the release of acetylcholine evoked by ouabain. |
1981-07-09 |
2023-08-12 |
rat |
| S O Ogren, S B Ross, H Hall, A C Holm, A L Reny. The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6452789. |
in contrast to amitriptyline (ami) and mianserin (mian), zim only in extremely high doses displayed a 5-ht receptor blocking action in vitro and failed to block 5-ht mediated behaviour. |
1981-06-13 |
2023-08-12 |
mouse |
| G R Van Loon, A Shum, M J Sol. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Endocrinology. vol 108. issue 4. 1981-05-21. PMID:6258905. |
the adrenalectomy-induced decreases in brain 5ht turnover were also prevented by the administration of the serotonin receptor antagonist, pizotifen. |
1981-05-21 |
2023-08-12 |
rat |
| G R Van Loon, A Shum, M J Sol. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Endocrinology. vol 108. issue 4. 1981-05-21. PMID:6258905. |
in addition, serotonin receptor blockade with pizotifen inhibited the effect of corticosterone to normalize the adrenalectomy-induced changes in both the plasma acth concentration and brain 5ht turnover. |
1981-05-21 |
2023-08-12 |
rat |
| S R White, D Biege. Central serotonin receptor sensitivity in rats with experimental allergic encephalomyelitis. Research communications in chemical pathology and pharmacology. vol 30. issue 2. 1981-02-26. PMID:6969416. |
similarly, in urethane-anesthetized eae rats, serotonergically-evoked automatic swallowing activity was unchanged as judged by the effects of serotonin receptor agonists, and a serotonin precursor, a reuptake blocker and an antagonist. |
1981-02-26 |
2023-08-12 |
rat |
| A Pletscher, A Laubsche. Blood platelets as models for neurons: uses and limitations. Journal of neural transmission. Supplementum. issue 16. 1981-01-16. PMID:6933224. |
platelets show similarities with 5-hydroxytryptaminergic neurons with respect to (1) uptake kinetics of 5-hydroxytryptamine (5-ht) at the plasma membrane, (2) inhibitory effects of tricyclic antidepressants and neuroleptics on 5-ht uptake, (3) granular storage of 5-ht and possibly catecholamines, (4) action of drugs interfering with granular and possibly extragranular amine storage and (5) reaction of the 5-ht receptor at the plasma membrane to 5-ht agonists and antagonists. |
1981-01-16 |
2023-08-12 |
Not clear |
| E Müller-Schweinitze. The mechanism of ergometrine-induced coronary arterial spasm: in vitro studies on canine arteries. Journal of cardiovascular pharmacology. vol 2. issue 5. 1980-11-25. PMID:6157956. |
the use of the antagonists phentolamine, indoramine, pimozide, pizotifen, and methysergide provided evidence that ergometrine and 5-ht induce contraction of coronary arteries by stimulating the same type of 5-ht receptor, which, however, seems to be different from the 5-ht receptor present in basilar arteries. |
1980-11-25 |
2023-08-12 |
Not clear |
| R W Fuller, H D Snoddy, J A Clemen. Elevation of serum prolactin acutely after administration of p-chloroamphetamine in rats. Endocrine research communications. vol 7. issue 2. 1980-11-25. PMID:6447591. |
the effect was antagonized by pretreatment with p-chlorophenylalanine, an inhibitor of serotonin synethesis, or by metergoline, a serotonin receptor antagonist. |
1980-11-25 |
2023-08-12 |
rat |