| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Normansell, J Panksep. Effects of quipazine and methysergide on play in juvenile rats. Pharmacology, biochemistry, and behavior. vol 22. issue 5. 1985-08-09. PMID:2989950. |
thus, the quipazine effect was probably mediated through a serotonin receptor; however, the role of serotonin in play appears to be a general modulatory one rather than a specific influence on play. |
1985-08-09 |
2023-08-11 |
rat |
| S Narumi, A Nagaoka, Y Nagaw. Effects of idebenone (CV-2619) on endogenous monoamine release and cyclic AMP formation in diencephalon slices from rats. Japanese journal of pharmacology. vol 37. issue 2. 1985-07-12. PMID:2987589. |
methysergide (10(-4) m), a 5-ht receptor blocker, almost completely blocked cv-2619 (10(-4) m)- and 5-ht (10(-4) m)-induced cyclic amp formation. |
1985-07-12 |
2023-08-11 |
rat |
| M J Rowan, R Anwy. The effect of prolonged treatment with tricyclic antidepressants on the actions of 5-hydroxytryptamine in the hippocampal slice of the rat. Neuropharmacology. vol 24. issue 2. 1985-06-19. PMID:3157877. |
acute application of the 5-ht receptor antagonists cyproheptadine (10(-5) m) and ketanserin (7.5 x 10(-6) m) completely prevented the appearance of the inhibitory effect of 10(-5) m 5-ht without affecting the excitatory effects. |
1985-06-19 |
2023-08-11 |
rat |
| E Schlicker, F Brandt, K Classen, M Göther. Serotonin release in human cerebral cortex and its modulation via serotonin receptors. Brain research. vol 331. issue 2. 1985-06-17. PMID:2580598. |
unlabelled serotonin decreased, and the serotonin receptor antagonist metitepin increased, the evoked overflow. |
1985-06-17 |
2023-08-11 |
human |
| J W Frie. Therapeutic implications of modifying endogenous serotonergic analgesic systems. Anesthesia progress. vol 32. issue 1. 1985-06-03. PMID:2986489. |
the evidence reviewed suggests that precursor loading to increase brain serotonin levels and administration of serotonin receptor inhibitors and serotonin receptor agonists may lead to novel methods of pain control and the development of useful analgesic drugs. |
1985-06-03 |
2023-08-11 |
Not clear |
| M L Cohen, L A Wittenaue. Relationship between serotonin and tryptamine receptors in the rat stomach fundus. The Journal of pharmacology and experimental therapeutics. vol 233. issue 1. 1985-05-23. PMID:3981465. |
the affinity of five 5-ht receptor antagonists, ketanserin, metergoline, 1-(1-naphthyl)piperazine, ly154930 and ly175041 was similar when 5-ht or tryptamine was the agonist, indicating that 5-ht and tryptamine are interacting with the same receptor in the fundus. |
1985-05-23 |
2023-08-11 |
rat |
| G I Drummond, S Wernham, K Lukowia. Stimulation of adenylate cyclase in the heart of Aplysia californica by biogenic amines. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 80. issue 1. 1985-05-17. PMID:2858332. |
the stimulatory action of 5-ht was antagonized by the 5-ht receptor blockers methergoline and metitepine and by the da receptor blocker chlorpromazine. |
1985-05-17 |
2023-08-11 |
aplysia |
| M D Tricklebank, C Forler, J R Fozar. The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. European journal of pharmacology. vol 106. issue 2. 1985-04-26. PMID:6241568. |
the centrally active 5-ht receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) has a high affinity for the 5-ht1a subtype of the 5-ht1 recognition site in cerebral membranes and, in the rat, induces most aspects of the '5-ht behavioural syndrome' including hyperlocomotion, head weaving, a flat body posture and reciprocal forepaw treading. |
1985-04-26 |
2023-08-12 |
rat |
| M L Cohen, K W Schenck, W Colbert, L Wittenaue. Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle. The Journal of pharmacology and experimental therapeutics. vol 232. issue 3. 1985-04-25. PMID:3973826. |
prazosin, but not the serotonin receptor antagonists, blocked serotonin-induced contractions in the rat vas deferens, indicating that alpha adrenergic and not 5-ht1 or 5-ht2 receptors mediate the contractile response to serotonin in this tissue. |
1985-04-25 |
2023-08-11 |
rat |
| R Lalonde, M I Bote. Chronic phenytoin and the stereotyped motor response induced by 5-methoxy-N,N-dimethyltryptamine in rats. Brain research. vol 326. issue 2. 1985-04-08. PMID:4038621. |
it is suggested that pht increases the functional availability of 5-ht before its receptors, and thereby causes 5-ht receptor subsensitivity. |
1985-04-08 |
2023-08-11 |
rat |
| F Kobayashi, T Kushiro, N Kajiwar. [The effects of the intracerebroventricular administration of 5-hydroxytryptamine on hemodynamics in conscious rats. Participation of the serotonin receptor and the sympathetic nervous system]. Nihon Naibunpi Gakkai zasshi. vol 60. issue 11. 1985-03-22. PMID:6526084. |
serotonin receptor antagonist, methysergide pretreatment on hemodynamic response to centrally administrated 5-ht was studied. |
1985-03-22 |
2023-08-12 |
rat |
| S Yoshikawa, R Ishitan. Implication of acidic lipids in 5-hydroxytryptamine receptor mechanisms. Life sciences. vol 36. issue 5. 1985-03-18. PMID:3918224. |
to establish the possible involvement of acidic lipids in 5-ht receptor mechanisms, we subjected whole rat brain synaptic plasma membranes to treatment with several kinds of lipid-modifying reagents and examined the [3h]5-ht and [3h]spiperone binding properties of the membranes. |
1985-03-18 |
2023-08-11 |
rat |
| T Branchek, M Kates, M D Gersho. Enteric receptors for 5-hydroxytryptamine. Brain research. vol 324. issue 1. 1985-03-18. PMID:6518379. |
the inability of antagonists to displace [3h]5-ht indicated that the binding sites were not muscarinic or nicotinic receptors, alpha- or beta-adrenoceptors, h1 or h2 histamine receptors, dopamine receptors or either the s1 or s2 types of 5-ht receptor that have been found in the brain. |
1985-03-18 |
2023-08-12 |
rabbit |
| b' H H Hennies, W A G\\xc3\\xbcnzler, L Floh\\xc3\\xa. Influence of supidimide on brain neurotransmitter systems of rats and mice. Arzneimittel-Forschung. vol 34. issue 11. 1985-03-14. PMID:6084511.' |
with the above restrictions, the following parameters can be rated as not influenced by supidimide: levels of tryptophan in rat brain and serum (free and total); 5-ht biosynthesis in vivo (rat brain; 5-ht accumulation after monoamine oxidase (mao) blockade); activity of mao-a and mao-b (rat brain mitochondria); uptake of 5-ht, ne and da (rat synaptosomes); 5-ht receptor binding ( [3h]-lsd binding assay in rat cortical membranes); tyrosine hydroxylase activity (rat adrenal glands); catechol-o-methyl transferase (comt) (rat liver); ne binding to central alpha 1- and alpha 2-receptors (rat brain; radioligand assay with [3h]-dihydroergocryptine, [3h]-prazosin and [3h]-wb 4101 (2',6'-dimethoxy-(g-3h]-phenoxy]-ethylaminomethylbenzo-1,4-dioxane ); da levels (whole rat brain and striata); dihydroxyphenylacetic acid (dopac) levels (whole rat brain without cerebellum and striata); elevated dopac levels after pretreatment with haloperidol; da-dependent adenylate cyclase in vitro (rat striatum); d2 receptor binding ( [3h]-spiperone binding assay, rat striatum); gaba levels (mouse brain); gaba transaminase activity (mouse brain stem); sodium-independent [3h]-gaba receptor binding (rat brain) and benzodiazepine binding (rat cortical membranes, [3h]-diazepam binding assay). |
1985-03-14 |
2023-08-12 |
mouse |
| M C Bundman, R A Brownin. In vivo increase in hypothalamic cyclic AMP following 5-hydroxytryptophan administration in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 327. issue 3. 1984-12-19. PMID:6092975. |
consistently increased hypothalamic cyclic amp levels in rats treated 10 days earlier with the serotonin neurotoxin, 5,7-dihydroxytryptamine (5,7-dht), to produce 5-ht receptor supersensitivity. |
1984-12-19 |
2023-08-12 |
rat |
| M C Bundman, R A Brownin. In vivo increase in hypothalamic cyclic AMP following 5-hydroxytryptophan administration in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 327. issue 3. 1984-12-19. PMID:6092975. |
the 5-ht antagonist, methysergide, blocked the serotonin receptor mediated behavioral syndrome, but failed to prevent the increase in hypothalamic cyclic amp. |
1984-12-19 |
2023-08-12 |
rat |
| T Nabeshima, K Yamaguchi, M Hiramatsu, M Amano, H Furukawa, T Kameyam. Serotonergic involvement in phencyclidine-induced behaviors. Pharmacology, biochemistry, and behavior. vol 21. issue 3. 1984-12-11. PMID:6208563. |
the pcp-induced stereotyped behaviors (backpedalling, head weaving and turning) were attenuated by serotonin (5-ht) depleters [reserpine, p-chlorophenylalanine, p-chloroamphetamine (pca)] and 5-ht receptor antagonist (cyproheptadine). |
1984-12-11 |
2023-08-12 |
rat |
| G C Kirby, D S McQuee. Effects of the antagonists MDL 72222 and ketanserin on responses of cat carotid body chemoreceptors to 5-hydroxytryptamine. British journal of pharmacology. vol 83. issue 1. 1984-11-28. PMID:6487893. |
at least two types of 5-ht receptor appeared to be involved in the response of carotid body chemoreceptors to 5-ht. |
1984-11-28 |
2023-08-12 |
cat |
| A Suyama, H Kuriyam. Mechanisms of the ergonovine-induced vasoconstriction in the rabbit main coronary artery. Naunyn-Schmiedeberg's archives of pharmacology. vol 326. issue 4. 1984-11-13. PMID:6482985. |
ergonovine or 5-hydroxytryptamine (5-ht) slightly depolarized the membrane and methysergide, a relatively selective antagonist for the 5-ht receptor, had a slight inhibitory action on these depolarizations. |
1984-11-13 |
2023-08-12 |
rabbit |
| J F McElroy, R S Feldma. Discriminative stimulus properties of fenfluramine: evidence for serotonergic involvement. Psychopharmacology. vol 83. issue 2. 1984-09-20. PMID:6431469. |
the putative 5-ht receptor antagonists methysergide and cinanserin antagonized the fen discriminative stimulus, while chlordiazepoxide, an indirect inhibitor of 5-ht turnover, did not. |
1984-09-20 |
2023-08-12 |
rat |