| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Trevor Sharp, Nicholas M Barne. Central 5-HT receptors and their function; present and future. Neuropharmacology. vol 177. 2021-08-12. PMID:32522572. |
such highlights include extensive mapping of 5-ht receptors in both animal and human brain, culminating in readily-accessible brain atlases of 5-ht receptor distribution, as well as emerging data on how 5-ht receptors are distributed within complex neural circuits. |
2021-08-12 |
2023-08-13 |
human |
| Trevor Sharp, Nicholas M Barne. Central 5-HT receptors and their function; present and future. Neuropharmacology. vol 177. 2021-08-12. PMID:32522572. |
much more needs to be discovered and understood by 5-ht neuropharmacologists, not least how the diverse signalling effects of so many 5-ht receptor types interact with complex neural circuits to generate neurophysiological changes which ultimately lead to altered cognitions and behaviour. |
2021-08-12 |
2023-08-13 |
human |
| Rose E Presby, Renee A Rotolo, Erin M Hurley, Sarah M Ferrigno, Cayla E Murphy, Haley P McMullen, Pranally A Desai, Emma M Zorda, Felicita B Kuperwasser, Carla Carratala-Ros, Merce Correa, John D Salamon. Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33493546. |
the serotonin receptor mediating the suppressive effects of fluoxetine is uncertain, because serotonin antagonists with different patterns of receptor selectivity failed to reverse the effects of fluoxetine. |
2021-08-10 |
2023-08-13 |
rat |
| Hao Chen, Feng Wang, Xuan Ni, Yi Rigui, Yuxia Bai, Liang Xu, Jingfeng Yang, Xuefu Zhang, Jiang Deng, Jiawei Li, Xiaoyu Yin, Wuliji Ao, Kevin W H Kwok, Wu Don. Aconitine disrupts serotonin neurotransmission via 5-hydroxytryptamine receptor in zebrafish embryo. Journal of applied toxicology : JAT. vol 41. issue 3. 2021-07-12. PMID:33085127. |
experimental results showed that aconitine exposure (1, 10, and 100 μm) increased frequency of coiling behavior in zebrafish embryos in a dose-dependent manner and this effect can be triggered by either exposure to 5-hydroxytryptamine 1a (5-ht1a) receptor agonist (±)-8-hydroxy-2-(dipropylamino)tetralin (8-oh-dpat) or overexpression of serotonin receptor 5-htr1ab. |
2021-07-12 |
2023-08-13 |
zebrafish |
| Simon Bennet Sonnenberg, Jonah Rauer, Christoph Göhr, Nataliya Gorinski, Sophie Kristin Schade, Dalia Abdel Galil, Vladimir Naumenko, André Zeug, Stephan C Bischoff, Evgeni Ponimaskin, Daria Gusev. The 5-HT Journal of cell science. vol 134. issue 4. 2021-07-12. PMID:33536244. |
here, we uncovered a signaling pathway involving the adhesion molecule l1cam (l1) and serotonin receptor 5-ht |
2021-07-12 |
2023-08-13 |
Not clear |
| Jieon Lee, Diana Avramets, Byungsun Jeon, Hyunah Cho. Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-07-12. PMID:34199418. |
from this point of view, we noticed the correlation between serotonin receptor subtype 7 (5-ht |
2021-07-12 |
2023-08-13 |
Not clear |
| Johana L Rivera-Fonseca, Nelly González-Rivas, M V Basavanag Unnamatla, Marco A García-Eleno, Horacio Reyes, L Germán López-Valdez, David Corona-Becerril, Erick Cuevas-Yañe. Synthesis and Development of Indole Based 5-HT3 Receptor Antagonists as Anti-Emetic Drugs in Oncology: An Update. Current medicinal chemistry. 2021-07-09. PMID:34238146. |
an important group of anti-emetic drugs used in the treatment of nausea and vomiting after chemotherapy contains an indole moiety in their structures, working as 5-hydroxytryptamine type 3 serotonin receptor antagonist (5-ht3). |
2021-07-09 |
2023-08-13 |
Not clear |
| Kazuhiro Mio, Shoko Fujimura, Masaki Ishihara, Masahiro Kuramochi, Hiroshi Sekiguchi, Tai Kubo, Yuji C Sasak. Living-Cell Diffracted X-ray Tracking Analysis Confirmed Internal Salt Bridge Is Critical for Ligand-Induced Twisting Motion of Serotonin Receptors. International journal of molecular sciences. vol 22. issue 10. 2021-07-02. PMID:34067933. |
the serotonin receptor subtype 2a (5-ht |
2021-07-02 |
2023-08-13 |
Not clear |
| Y V M Lages, A D Rossi, T E Krahe, J Landeira-Fernande. Effect of chronic unpredictable mild stress on the expression profile of serotonin receptors in rats and mice: a meta-analysis. Neuroscience and biobehavioral reviews. vol 124. 2021-06-25. PMID:33524415. |
evidence from animal studies has reported a variety of results regarding the effects of chronic unpredictable mild stress (cums) on serotonin signaling pathways and 5-ht receptor subtypes. |
2021-06-25 |
2023-08-13 |
mouse |
| Elina T L'Estrade, Maria Erlandsson, Fraser G Edgar, Tomas Ohlsson, Gitte M Knudsen, Matthias M Hert. Towards selective CNS PET imaging of the 5-HT Neuropharmacology. vol 172. 2021-06-21. PMID:31669129. |
towards selective cns pet imaging of the 5-ht since its discovery in 1993, the serotonin receptor subtype 7 (5-ht |
2021-06-21 |
2023-08-13 |
Not clear |
| Changwon Yang, Gwonhwa Song, Whasun Li. Methiothepin mesylate causes apoptosis of human prostate cancer cells by mediating oxidative stress and mitochondrial dysfunction. Free radical biology & medicine. vol 150. 2021-06-18. PMID:32035100. |
we verified apoptotic cell death in prostate cancer cell lines after treatment with methiothepin mesylate (met), an antagonist for serotonin receptor 5-ht |
2021-06-18 |
2023-08-13 |
human |
| Michael W Lewis, Russell T Jones, Margaret T Davi. Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32678079. |
the serotonin 1-a receptor (5-ht1a) is an inhibitory g protein-coupled serotonin receptor encoded by the htr1a gene that plays a role in regulating serotonin release, physiological stress responding, and emotional behavior. |
2021-06-18 |
2023-08-13 |
human |
| Wayne E Pratt, Rafaella Vaca-Tricerri, Alexa C Blanchard, Thomas R Hopkins, Adeolu O Ilesanmi, Zachary Pierce-Messick, Ian A Rosner, Rose Yin. Selective serotonin receptor stimulation of the ventral tegmentum differentially affects appetitive motivation for sugar on a progressive ratio schedule of reinforcement. Behavioural brain research. vol 403. 2021-06-18. PMID:33497748. |
there were no effects of stimulating ventral tegmental serotonin 1b, 2a, or 2b receptors on break point; neither did antagonism of any of the serotonin receptor subtypes significantly affect performance. |
2021-06-18 |
2023-08-13 |
rat |
| Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Noriaki Sakai, Seiji Nishino, Hiroyoshi Sé. Intracranial mast cells contribute to the control of social behavior in male mice. Behavioural brain research. vol 403. 2021-06-18. PMID:33516739. |
mas-treck male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. |
2021-06-18 |
2023-08-13 |
mouse |
| Yvonne Schill, Monika Bijata, Olga Kopach, Volodymyr Cherkas, Dalia Abdel-Galil, Katrin Böhm, Markus H Schwab, Michiyuki Matsuda, Valerie Compan, Subhadip Basu, Krystian Bijata, Jakub Wlodarczyk, Lucie Bard, Nicholas Cole, Alexander Dityatev, Andre Zeug, Dmitri A Rusakov, Evgeni Ponimaski. Serotonin 5-HT Communications biology. vol 3. issue 1. 2021-06-17. PMID:32060357. |
here, we employ high-resolution time-lapse fret imaging in neuroblastoma cells and neuronal dendrites to establish that activation of serotonin receptor 5-ht |
2021-06-17 |
2023-08-13 |
Not clear |
| Chia-Chen Chang, Heidi Connahs, Estella Cai Yu Tan, Y Norma-Rashid, Mrinalini, Daiqin Li, Fook Tim Che. Female spider aggression is associated with genetic underpinnings of the nervous system and immune response to pathogens. Molecular ecology. vol 29. issue 14. 2021-06-04. PMID:32510793. |
individuals that have been treated with serotonin become less aggressive, but individuals treated with a nonselective serotonin receptor antagonist (methiothepin) also reduce aggression. |
2021-06-04 |
2023-08-13 |
spider |
| Ling Shen, Hai-Bo Qiu, Hui-Hong Xu, Kai Wei, Liang Zhao, Cheng-Cheng Zhu, Cheng-Jian Li, Zhi-Jie L. Nicotine withdrawal induces hyperalgesia via downregulation of descending serotonergic pathway in the nucleus raphe magnus. Neuropharmacology. vol 189. 2021-06-04. PMID:33722649. |
intrathecal injection of 5-ht or nrm microinjection of tph-overexpression adeno-associated virus alleviated nicotine withdrawal-induced hyperalgesia, whereas 5-ht receptor pharmacological blockade by methysergide (a 5-ht receptor antagonist) exacerbated hypersensitivity and diminished the difference between the two groups. |
2021-06-04 |
2023-08-13 |
rat |
| Nelly Durand, Méliné Simsir, Laurie Signetti, Fabien Labbal, Robert Ballotti, Isabelle Mus-Vetea. Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-24. PMID:33810240. |
we previously reported that methiothepin, a small molecule known as a nonselective serotonin 5-ht receptor antagonist, inhibited the doxorubicin efflux activity of the hedgehog receptor ptch1 and enhanced the cytotoxic, pro-apoptotic, anti-proliferative, and anti-clonogenic effects of doxorubicin on adrenocortical carcinoma cells. |
2021-05-24 |
2023-08-13 |
Not clear |
| Simli Dey, Dayana Surendran, Oskar Engberg, Ankur Gupta, Sashaina E Fanibunda, Anirban Das, Barun Kumar Maity, Arpan Dey, Vicky Visvakarma, Mamata Kallianpur, Holger A Scheidt, Gilbert Walker, Vidita A Vaidya, Daniel Huster, Sudipta Mait. Altered Membrane Mechanics Provides a Receptor-Independent Pathway for Serotonin Action. Chemistry (Weinheim an der Bergstrasse, Germany). vol 27. issue 27. 2021-05-19. PMID:33502812. |
in the rn46a immortalized serotonergic neuronal cell line, extracellular serotonin enhances transferrin receptor endocytosis, even in the presence of broad-spectrum serotonin receptor and transporter inhibitors. |
2021-05-19 |
2023-08-13 |
Not clear |
| Vasko Kramer, Agnete Dyssegaard, Jonathan Flores, Cristian Soza-Ried, Frank Rösch, Gitte Moos Knudsen, Horacio Amaral, Matthias M Hert. Characterization of the serotonin 2A receptor selective PET tracer (R)-[ European journal of nuclear medicine and molecular imaging. vol 47. issue 2. 2021-05-14. PMID:31606832. |
characterization of the serotonin 2a receptor selective pet tracer (r)-[ the serotonin receptor subtype 2a antagonist (5-ht |
2021-05-14 |
2023-08-13 |
Not clear |