| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Sharif Shajib, Usha Chauhan, Salman Adeeb, Yeshale Chetty, David Armstrong, Smita L S Halder, John K Marshall, Waliul I Kha. Characterization of Serotonin Signaling Components in Patients with Inflammatory Bowel Disease. Journal of the Canadian Association of Gastroenterology. vol 2. issue 3. 2020-09-30. PMID:31294376. |
secreted 5-ht regulates various gut functions through diverse 5-ht receptor (5-htr) families, and 5-ht transporter (5-htt) sequesters its activity via uptake into surrounding cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Motohiro Okada, Kouji Fukuyama, Ruri Okubo, Takashi Shiroyama, Yuto Ued. Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus. Pharmaceuticals (Basel, Switzerland). vol 12. issue 4. 2020-09-30. PMID:31590422. |
following systemic and local administrations of lurasidone, mk801 and 5-ht receptor modulators, we determined releases of 5-ht in dorsal raphe nucleus (drn), mediodorsal thalamic nucleus (mdtn) and medial prefrontal cortex (mpfc) and γ-aminobutyric acid (gaba) in drn using multiprobe microdialysis with ultra-high-performance liquid chromatography (uhplc). |
2020-09-30 |
2023-08-13 |
Not clear |
| Kei Odai, Tohru Sugimoto, Etsuro It. Biophysics and physicobiology. vol 16. 2020-09-30. PMID:31608202. |
these complicated functions of 5-ht are supported by several 5-ht receptor and 5-ht transporter subtypes. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yessenia Ballou, Alexandria Rivas, Andres Belmont, Luv Patel, Clarissa N Amaya, Shane Lipson, Thuraieh Khayou, Erin B Dickerson, Zeina Nahleh, Brad A Brya. 5-HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability. Molecular and clinical oncology. vol 9. issue 3. 2020-09-29. PMID:30155245. |
previous studies have provided evidence that elevated serotonin (5-ht) and serotonin receptor levels may contribute to oncogenic progression, yet little is known regarding the mechanism by which this occurs. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yessenia Ballou, Alexandria Rivas, Andres Belmont, Luv Patel, Clarissa N Amaya, Shane Lipson, Thuraieh Khayou, Erin B Dickerson, Zeina Nahleh, Brad A Brya. 5-HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability. Molecular and clinical oncology. vol 9. issue 3. 2020-09-29. PMID:30155245. |
the data demonstrated that serotonin receptor mrnas and proteins are expressed across diverse cancer types, and that serotonin stimulation of tumor cells activates oncogenic signaling mediators including components of the akt, creb, gsk3, and mapk pathways. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yann Develle, Hugues Leblon. Biphasic Effect of Buspirone on the H-Reflex in Acute Spinal Decerebrated Mice. Frontiers in cellular neuroscience. vol 13. 2020-09-28. PMID:32009904. |
buspirone, a partial serotonin receptor agonist (5-ht |
2020-09-28 |
2023-08-13 |
mouse |
| Jin-Young Lee, Changwon Yang, Whasun Lim, Gwonhwa Son. Methiothepin Suppresses Human Ovarian Cancer Cell Growth by Repressing Mitochondrion-Mediated Metabolism and Inhibiting Angiogenesis In Vivo. Pharmaceutics. vol 12. issue 7. 2020-09-28. PMID:32698407. |
serotonin has cell growth-promoting functions in a variety of carcinomas, but the effect of serotonin receptor antagonists on ovarian cancer cells is unknown. |
2020-09-28 |
2023-08-13 |
human |
| Jirasuda Nakeim, Napamanee Kornthong, Jirawat Saetan, Supawadee Duangprom, Prasert Sobhon, Prapee Sretarugs. Presence of serotonin and its receptor in the central nervous system and ovary and molecular cloning of the novel crab serotonin receptor of the blue swimming crab, Portunus pelagicus. Acta histochemica. vol 122. issue 1. 2020-09-24. PMID:31708231. |
presence of serotonin and its receptor in the central nervous system and ovary and molecular cloning of the novel crab serotonin receptor of the blue swimming crab, portunus pelagicus. |
2020-09-24 |
2023-08-13 |
Not clear |
| Jirasuda Nakeim, Napamanee Kornthong, Jirawat Saetan, Supawadee Duangprom, Prasert Sobhon, Prapee Sretarugs. Presence of serotonin and its receptor in the central nervous system and ovary and molecular cloning of the novel crab serotonin receptor of the blue swimming crab, Portunus pelagicus. Acta histochemica. vol 122. issue 1. 2020-09-24. PMID:31708231. |
due to the presence of 5-ht receptor we suggest that 5-ht acts primarily at the cns and ovary, thus implicating its role in reproduction especially in the development of oocytes though its exact function in this crab needed to be explored further. |
2020-09-24 |
2023-08-13 |
Not clear |
| Deblina Dey, Vipan K Parihar, Gergely G Szabo, Peter M Klein, Jenny Tran, Jonathan Moayyad, Faizy Ahmed, Quynh-Anh Nguyen, Alexandria Murry, David Merriott, Brandon Nguyen, Jodi Goldman, Maria C Angulo, Daniele Piomelli, Ivan Soltesz, Janet E Baulch, Charles L Limol. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiation research. vol 193. issue 5. 2020-09-14. PMID:32134362. |
relevant to the known roles of the serotonin axis in mood disorders, we found that 5ht1a serotonin receptor levels were decreased by ∼50% in the hippocampus at both early and late time points, and a 37% decrease in serotonin levels was observed at 15 weeks postirradiation. |
2020-09-14 |
2023-08-13 |
mouse |
| Sandra Sacre, Albert Jaxa-Chamiec, Caroline M R Low, Giselle Chamberlain, Cathy Tralau-Stewar. Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors. Frontiers in immunology. vol 10. 2020-08-24. PMID:31244825. |
to explore if engagement of 5-hydroxytryptamine (5-ht) receptors was required for the anti-inflammatory effect of the tetracyclic antidepressant mianserin, a series of structural derivatives were generated with the aim of reducing 5-ht receptor binding. |
2020-08-24 |
2023-08-13 |
human |
| Sandra Sacre, Albert Jaxa-Chamiec, Caroline M R Low, Giselle Chamberlain, Cathy Tralau-Stewar. Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors. Frontiers in immunology. vol 10. 2020-08-24. PMID:31244825. |
the lead compound demonstrated a significant loss in 5-ht receptor binding, as assessed by non-selective 5-ht binding of radiolabelled serotonin in rat cerebral cortex. |
2020-08-24 |
2023-08-13 |
human |
| Maria C Cartolano, Haley N Gancel, Joshua Lonthair, Chris M Wood, M Danielle McDonal. Pulsatile urea excretion in Gulf toadfish: the role of circulating serotonin and additional 5-HT receptor subtypes. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 189. issue 5. 2020-07-01. PMID:31317244. |
pulsatile urea excretion in gulf toadfish: the role of circulating serotonin and additional 5-ht receptor subtypes. |
2020-07-01 |
2023-08-13 |
Not clear |
| Elena Kondratskaya, Oleksandr Ievglevskyi, Mark Züchner, Athina Samara, Joel C Glover, Jean-Luc Boullan. Locomotor central pattern generator excitability states and serotonin sensitivity after spontaneous recovery from a neonatal lumbar spinal cord injury. Brain research. vol 1708. 2020-06-15. PMID:30521786. |
this increased serotonin sensitivity was correlated with post-injury changes in the expression of specific serotonin receptor transcripts, but not of dopamine receptor transcripts. |
2020-06-15 |
2023-08-13 |
mouse |
| Md Rajib Sharker, Zahid Parvez Sukhan, Soo Cheol Kim, Won Kyo Lee, Kang Hee Kh. Identification, characterization, and expression analysis of a serotonin receptor involved in the reproductive process of the Pacific abalone, Haliotis discus hannai. Molecular biology reports. vol 47. issue 1. 2020-06-12. PMID:31696430. |
serotonin receptor (5-ht) is a biogenic amine acting as a neurotransmitter and neuromodulator that mediates various aspects of reproduction and gametogenesis. |
2020-06-12 |
2023-08-13 |
Not clear |
| Haruka Mori, Keita Ashida, Hisashi Shidara, Tatsuya Nikai, Kohji Hotta, Kotaro Ok. Serotonin modulates behavior-related neural activity of RID interneuron in Caenorhabditis elegans. PloS one. vol 14. issue 12. 2020-04-06. PMID:31800640. |
we simultaneously measured the neural activity of the rid and behavior in worms with three conditions: mock animals, animals pre-exposed to 5-ht, and 5-ht receptor mod-1 mutants. |
2020-04-06 |
2023-08-13 |
caenorhabditis_elegans |
| Minako Ito, Kyoko Komai, Toshihiro Nakamura, Tanakorn Srirat, Akihiko Yoshimur. Tissue regulatory T cells and neural repair. International immunology. vol 31. issue 6. 2020-04-03. PMID:30893423. |
brain tregs resemble other tissue tregs in many ways but, unlike the other tissue tregs, brain tregs express neural-cell-specific genes such as the serotonin receptor (htr7) and respond to serotonin. |
2020-04-03 |
2023-08-13 |
mouse |
| Rong Xiong, Wei Zhao, Xi Chen, Tian Li, Haiyin Li, Yan Li, Wangshang Shen, Ping Che. Pharmacological characterization of the 5-HT1A receptor of Bombyx mori and its role in locomotion. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 231. 2020-04-02. PMID:30690153. |
the effects of serotonin are mediated through interactions of several 5-ht receptor types. |
2020-04-02 |
2023-08-13 |
Not clear |
| Ana M Lucas-Osma, Yaqing Li, Katie Murray, Shihao Lin, Sophie Black, Marilee J Stephens, Andrew H Ahn, C J Heckman, Keith K Fenrich, Karim Fouad, David J Bennet. 5-HT Journal of neurophysiology. vol 121. issue 5. 2020-02-26. PMID:30625007. |
in chronic spinal rats, numerous 5-ht receptor agonists, including zolmitriptan, methylergonovine, and 5-ht, inhibited the msr with a potency highly correlated to their binding affinity to 5-ht |
2020-02-26 |
2023-08-13 |
rat |
| Yuan-Qiang Wang, Wei-Wei Lin, Nan Wu, Si-Yi Wang, Mao-Zi Chen, Zhi-Hua Lin, Xiang-Qun Xie, Zhi-Wei Fen. Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis. Acta pharmacologica Sinica. vol 40. issue 9. 2020-02-05. PMID:30814658. |
however, due to a high sequence similarity/identity among 5-ht receptors and the unavailability of the 3d structure of the different 5-ht receptor, no report was available so far regarding the systematical comparison of the key and selective residues involved in the binding pocket, making it difficult to design subtype-selective serotonergic drugs. |
2020-02-05 |
2023-08-13 |
Not clear |