| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georg A Petroian. Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine". International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328784. |
based on the theoretical model presented the "ideal" antidote against serotonin syndrome hyperthermia appears to be an antagonist at the 5-ht receptor subtypes 2, 4 and 6 and an agonist at the receptor subtypes 1, 3 and 7. |
2022-03-25 |
2023-08-13 |
Not clear |
| Nadeem, Shumaila Usman, Rehan Imad, Uzair Nisar, Irfan Khan, Ghulam Abba. Pre-weaning fluoxetine exposure caused anti-depressant like behavior at adulthood via perturbing tryptophan metabolism in rats. Metabolic brain disease. 2022-03-18. PMID:35303245. |
additionally, the brain tryptophan, 5-ht (5-hydroxytryptamine) and its metabolite 5-hiaa (5-hydroxyindoleacetic acid) levels were quantified using enzyme linked immunosorbent assay (elisa), while expression of sert (serotonin receptor), 5-ht |
2022-03-18 |
2023-08-13 |
rat |
| Nikita Deo, Gregory Redpat. Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. Frontiers in cellular neuroscience. vol 15. 2022-03-14. PMID:35280519. |
ssris predominantly inhibit sert, preventing serotonin uptake to enhance 5-ht receptor signaling, while hallucinogenic compounds directly activate specific 5-ht receptors, altering their interaction with endocytic adaptor proteins to induce alternate signaling outcomes. |
2022-03-14 |
2023-08-13 |
Not clear |
| Robert W Garvey, Enza Lacivita, Mauro Niso, Beata Duszyńska, Paul E Harris, Marcello Leopold. Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor. ChemMedChem. 2022-03-14. PMID:35286016. |
among the 5-ht receptor subtype found in pancreatic islets, serotonin receptor 1a (5-ht 1a ) demonstrates a unique ability to inhibit beta-cell insulin secretion. |
2022-03-14 |
2023-08-13 |
human |
| Xiao Cui Yuan, Yu-Ying Wang, Li-Xia Tian, Xiang-Ji Yan, Yi-Xiao Guo, Yu-Long Zhao, Sani Sa'idu Baba, Hong Jia, Hui-Sheng Wang, Man Li, Fu-Quan Hu. Spinal 5-HT2A Receptor is Involved in Electroacupuncture Inhibition of Chronic Pain. Molecular pain. 2022-03-04. PMID:35240891. |
however, it is still unclear which among the 5-ht receptor subtype is involved in ea evoked 5-ht mediated inhibition of chronic pain in the dorsal spinal cord. |
2022-03-04 |
2023-08-13 |
mouse |
| Avital Fischer, Hedy S Rennert, Gad Renner. Selective serotonin reuptake inhibitors associated with increased mortality risk in breast cancer patients in Northern Israel. International journal of epidemiology. 2022-02-08. PMID:35134960. |
recent investigation demonstrated serotonin receptor (5-htr2b) expression in the breast and serotonin production as an indicator of poor breast cancer prognosis. |
2022-02-08 |
2023-08-13 |
Not clear |
| Lingna Guo, Wenxuan Dai, Zhengrong Xu, Qiaoyi Liang, Eliot T Miller, Shengju Li, Xia Gao, Maude W Baldwin, Renjie Chai, Qian L. Evolution of brain-expressed biogenic amine receptors into olfactory trace amine-associated receptors. Molecular biology and evolution. 2022-01-12. PMID:35021231. |
we further identify ligands for 61 orphan tarls and taars from sea lamprey, shark, ray-finned fishes, and mammals, as well as novel ligands for two 5-hydroxytryptamine receptor 4 (htr4) orthologs, a serotonin receptor subtype closely related to taars. |
2022-01-12 |
2023-08-13 |
Not clear |
| Emma Aaldijk, Yannick Vermeire. The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease: a narrative review. Ageing research reviews. 2022-01-06. PMID:34990844. |
of interest, preclinical studies point to serotonergic alterations, either induced via selective serotonin reuptake inhibitors or serotonin receptor (ant)agonists, in mitigating ad brain neuropathology next to its clinical symptoms, the latter being supported by a handful of human intervention trials. |
2022-01-06 |
2023-08-13 |
mouse |
| Faranak Vahid-Ansari, Paul R Alber. Rewiring of the Serotonin System in Major Depression. Frontiers in psychiatry. vol 12. 2022-01-03. PMID:34975594. |
in this review, we survey the possible 5-ht receptor mechanisms that could mediate 5-ht rewiring and assess the evidence that 5-ht-mediated brain rewiring is impacting recovery from mental illness. |
2022-01-03 |
2023-08-13 |
Not clear |
| Eline Pottie, Christophe P Stov. In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5-HT Journal of neurochemistry. 2022-01-03. PMID:34978711. |
in vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5-ht serotonergic psychedelics are substances that induce alterations in mood, perception and thought, and have the activation of serotonin (5-ht) 2a receptors (5-ht |
2022-01-03 |
2023-08-13 |
Not clear |
| Shingo Nakamura, Takahiro Nonaka, Shuji Komatsu, Toshihiko Yamada, Tatsuo Yamamot. Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 146. 2021-12-27. PMID:34959121. |
in this study, we examined whether acetaminophen and am404 induce spinal 5-ht release and the mechanism through which spinal 5-ht receptor activation exerts analgesic effects in a rat formalin test in an inflammatory pain model. |
2021-12-27 |
2023-08-13 |
rat |
| Jiun-Rung Chen, Ming-Shyan Huang, Yi-Chen Lee, Min-His Lin, Yi-Fang Yan. Potential Clinical Value of 5-Hydroxytryptamine Receptor 3C as a Prognostic Biomarker for Lung Cancer. Journal of oncology. vol 2021. 2021-12-07. PMID:34868311. |
serotonin (5-hydroxytryptamine (5-ht)) promotes the proliferation of various cancer cell types mediated through the activation of the 5-ht receptor (htr). |
2021-12-07 |
2023-08-13 |
Not clear |
| Flavia Lo Castro, Simona Guerzoni, Lanfranco Pelles. Safety and Risk of Medication Overuse Headache in Lasmiditan and Second-Generation Gepants: A Rapid Review. Drug, healthcare and patient safety. vol 13. 2021-12-03. PMID:34849034. |
lasmiditan is a highly selective serotonin receptor agonist that binds to the 5-ht |
2021-12-03 |
2023-08-13 |
Not clear |
| Srdjan S Nedeljkovic, Inkyung Song, Xiaodong Bao, Jose L Zeballos, Darin J Correll, Yi Zhang, Johanna S Ledley, Ashish Bhandari, Xiang Bai, Sang Rim Lee, Sunyoung Ch. Exploratory study of VVZ-149, a novel analgesic molecule, in the affective component of acute postoperative pain after laparoscopic colorectal surgery. Journal of clinical anesthesia. vol 76. 2021-11-30. PMID:34794108. |
vvz-149 is a small molecule that inhibits the glycine transporter type 2 and the serotonin receptor 5-hydroxytryptamine 2a. |
2021-11-30 |
2023-08-13 |
Not clear |
| Guillaume Becker, Sylvia Da Silva, Amelia-Naomi Sabo, Maria Cristina Antal, Véronique Kemmel, Laurent Monassie. Blood-Brain Barrier Permeability: Is 5-Hydroxytryptamine Receptor Type 4 a Game Changer? Pharmaceutics. vol 13. issue 11. 2021-11-30. PMID:34834271. |
the aim of this work was to characterize the serotonin receptor 5-ht |
2021-11-30 |
2023-08-13 |
Not clear |
| Austen B Casey, Munmun Mukherjee, Ryan P McGlynn, Meng Cui, Stephen J Kohut, Raymond G Boot. A new class of serotonin 5-HT British journal of pharmacology. 2021-11-27. PMID:34837227. |
a new class of serotonin 5-ht the 5-ht receptor (5-htr) subtypes 5-ht |
2021-11-27 |
2023-08-13 |
Not clear |
| Marie-Belle El Mdawar, Blandine Maître, Stéphanie Magnenat, Florian Tupin, Friederike Jönsson, Christian Gachet, Henri de la Salle, Beatrice Hechle. Platelet FcγRIIA-induced serotonin release exacerbates the severity of transfusion-related acute lung injury in mice. Blood advances. vol 5. issue 23. 2021-11-25. PMID:34521102. |
furthermore, inhibition of 5-hydroxytryptamine 2a serotonin receptor with sarpogrelate, before or after the induction of trali, abolished the aggravation of lung edema in cd32a+ mice. |
2021-11-25 |
2023-08-13 |
mouse |
| Feras Altwal, Fernando E Padovan-Neto, Alexandra Ritger, Heinz Steiner, Anthony R Wes. Role of 5-HT1A Receptor in Vilazodone-Mediated Suppression of L-DOPA-Induced Dyskinesia and Increased Responsiveness to Cortical Input in Striatal Medium Spiny Neurons in an Animal Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 26. issue 19. 2021-11-16. PMID:34641332. |
selective serotonin reuptake inhibitors (ssris) or 5-ht receptor (5-htr) agonists can regulate 5-ht activity and attenuate dyskinesia, but they often also produce a loss of the antiparkinsonian efficacy of l-dopa. |
2021-11-16 |
2023-08-13 |
Not clear |
| Jacob Sama, Dhananjay Vaidya, Monica Mukherjee, Marlene William. Effects of clinical depression on left ventricular dysfunction in patients with acute coronary syndrome. Journal of thrombosis and thrombolysis. vol 51. issue 3. 2021-11-11. PMID:32876809. |
platelet serotonin response was measured by serotonin augmented platelet aggregation and platelet serotonin receptor density. |
2021-11-11 |
2023-08-13 |
human |
| Luoyang Ding, Shane K Maloney, Mengzhi Wang, Jennifer Rodger, Lianmin Chen, Dominique Blach. Association between temperament related traits and single nucleotide polymorphisms in the serotonin and oxytocin systems in Merino sheep. Genes, brain, and behavior. vol 20. issue 3. 2021-11-09. PMID:33161622. |
variations like single nucleotide polymorphisms (snps) in the genes for tryptophan 5-hydroxylase (tph2), the serotonin transporter (slc6a4), the serotonin receptor (htr2a), and the oxytocin receptor (oxtr) are associated with behavioral phenotype in humans. |
2021-11-09 |
2023-08-13 |
Not clear |