| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Redenšek Trampuž, Sander van Riet, Åsa Nordling, Magnus Ingelman-Sundber. Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model. Scientific reports. vol 14. issue 1. 2024-01-16. PMID:38228622. |
treatment of the spheroids with 5-ht or free fatty acids (ffa) induced fibrosis, whereas treatment of the spheroids with the 5-ht receptor antagonists ketanserin, pimavanserin, sarpogrelate, and sb269970 inhibited ffa-induced fibrosis via a reduction in stellate cell activation as determined by the expression of vimentin, tgf-β1 and col1a1 production. |
2024-01-16 |
2024-01-19 |
human |
| Patryk Pyka, Wawrzyniec Haberek, Małgorzata Więcek, Ewa Szymanska, Wesam Ali, Agnieszka Cios, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Sabina Podlewska, Silvia Di Giacomo, Antonella Di Sotto, Sabrina Garbo, Tadeusz Karcz, Chiara Lambona, Francesco Marocco, Gniewomir Latacz, Sylwia Sudoł-Tałaj, Barbara Mordyl, Monika Głuch-Lutwin, Agata Siwek, Kinga Czarnota-Łydka, Dawid Gogola, Agnieszka Olejarz-Maciej, Natalia Wilczyńska-Zawal, Ewelina Honkisz-Orzechowska, Małgorzata Starek, Monika Dąbrowska, Katarzyna Kucwaj-Brysz, Rossella Fioravanti, Muhammad Jawad Nasim, Marius Hittinger, Anna Partyka, Anna Wesołowska, Cecilia Battistelli, Clemens Zwergel, Jadwiga Handzli. First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT Journal of medicinal chemistry. 2024-01-08. PMID:38190615. |
first-in-class selenium-containing potent serotonin receptor 5-ht alzheimer's disease (ad) has a complex and not-fully-understood etiology. |
2024-01-08 |
2024-01-10 |
Not clear |
| Patryk Pyka, Wawrzyniec Haberek, Małgorzata Więcek, Ewa Szymanska, Wesam Ali, Agnieszka Cios, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Sabina Podlewska, Silvia Di Giacomo, Antonella Di Sotto, Sabrina Garbo, Tadeusz Karcz, Chiara Lambona, Francesco Marocco, Gniewomir Latacz, Sylwia Sudoł-Tałaj, Barbara Mordyl, Monika Głuch-Lutwin, Agata Siwek, Kinga Czarnota-Łydka, Dawid Gogola, Agnieszka Olejarz-Maciej, Natalia Wilczyńska-Zawal, Ewelina Honkisz-Orzechowska, Małgorzata Starek, Monika Dąbrowska, Katarzyna Kucwaj-Brysz, Rossella Fioravanti, Muhammad Jawad Nasim, Marius Hittinger, Anna Partyka, Anna Wesołowska, Cecilia Battistelli, Clemens Zwergel, Jadwiga Handzli. First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT Journal of medicinal chemistry. 2024-01-08. PMID:38190615. |
recently, the serotonin receptor 5-ht |
2024-01-08 |
2024-01-10 |
Not clear |
| Ivona Bečeheli, Marina Horvatiček, Maja Perić, Barbara Nikolić, Cyrielle Holuka, Marija Klasić, Marina Ivanišević, Mirta Starčević, Gernot Desoye, Dubravka Hranilović, Jonathan D Turner, Jasminka Šteful. Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence. Clinical epigenetics. vol 16. issue 1. 2024-01-03. PMID:38172913. |
dna methylation plays a significant role in modulating the expression of genes responsible for maintaining 5-ht balance, such as 5-ht transporter (slc6a4), monoamine oxidase a (maoa), and 5-ht receptor type 2a (htr2a). |
2024-01-03 |
2024-01-06 |
human |
| Jieling Cai, Jamie Cheung, Samson W M Cheung, Karie T C Chin, Ricky W K Leung, Ronald S T Lam, Rakesh Sharma, Jensen H C Yiu, Connie W Wo. Butyrate acts as a positive allosteric modulator of serotonin transporter to decrease ileal serotonin availability. British journal of pharmacology. 2023-12-22. PMID:38129963. |
the effectiveness of serotonin receptor blocker to treat radiation therapy-induced emesis suggests the pathophysiological role of serotonin. |
2023-12-22 |
2023-12-24 |
Not clear |
| Marta Monteiro, Nuno C Pinheiro, Vikesh Samj. Serotonin Syndrome: An Emerging Reality in the Emergency Department. Cureus. vol 15. issue 10. 2023-12-01. PMID:38021488. |
serotonin syndrome (ss) is an entity caused by interference with the serotonin metabolism and/or by medications that act as serotonin receptor agonists. |
2023-12-01 |
2023-12-07 |
Not clear |
| Pareena Sharma, Reid W Collis, Julien Thoma. Serotonin Syndrome Triggered by an Interaction Between Opioid Analgesics and Cobicistat: A Challenging Diagnostic Case Report. Cureus. vol 15. issue 10. 2023-12-01. PMID:38022058. |
serotonin syndrome is a clinically diagnosed disorder that may occur secondary to medications that increase the release of endogenous serotonin, impair the reuptake of serotonin from the synaptic cleft, are direct serotonin receptor agonists, or increase the sensitivity of the postsynaptic serotonin receptor. |
2023-12-01 |
2023-12-07 |
Not clear |
| Marta Monteiro, Nuno C Pinheiro, Vikesh Samj. Serotonin Syndrome: An Emerging Reality in the Emergency Department. Cureus. vol 15. issue 10. 2023-12-01. PMID:38021488. |
serotonin syndrome (ss) is an entity caused by interference with the serotonin metabolism and/or by medications that act as serotonin receptor agonists. |
2023-11-29 |
2023-12-07 |
Not clear |
| Pareena Sharma, Reid W Collis, Julien Thoma. Serotonin Syndrome Triggered by an Interaction Between Opioid Analgesics and Cobicistat: A Challenging Diagnostic Case Report. Cureus. vol 15. issue 10. 2023-12-01. PMID:38022058. |
serotonin syndrome is a clinically diagnosed disorder that may occur secondary to medications that increase the release of endogenous serotonin, impair the reuptake of serotonin from the synaptic cleft, are direct serotonin receptor agonists, or increase the sensitivity of the postsynaptic serotonin receptor. |
2023-11-29 |
2023-12-07 |
Not clear |
| Elena V Mitroshina, Ekaterina A Marasanova, Maria V Vedunov. Functional Dimerization of Serotonin Receptors: Role in Health and Depressive Disorders. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003611. |
the objective of this review is to consolidate the current understanding of interactions within the 5-ht receptor family and between 5-ht receptors and members of other receptor families. |
2023-11-25 |
2023-11-28 |
Not clear |
| Philip J Cowe. SSRIs in the Treatment of Depression: A Pharmacological CUL-DE-SAC? Current topics in behavioral neurosciences. 2023-11-03. PMID:37922101. |
attempts to supplement serotonin reuptake activity with actions at serotonin receptor sub-types have not yet yielded substantial benefits; however, vortioxetine may provide more utility in the management of cognitive impairment. |
2023-11-03 |
2023-11-08 |
Not clear |
| Qiyi You, Qijun Li, Liyuan Lv, Zhihua Lin, Yinghui Dong, Hanhan Ya. Genome-Wide Identification of 5-HT Receptor Gene Family in Razor Clam Animals : an open access journal from MDPI. vol 13. issue 20. 2023-10-30. PMID:37893932. |
genome-wide identification of 5-ht receptor gene family in razor clam serotonin (5-ht) is primarily distributed in the gastrointestinal and central nervous systems, where it plays a crucial role in regulating various physiological functions such as digestion, reproduction and establishing animal emotions. |
2023-10-30 |
2023-11-08 |
Not clear |
| Dhamyaa Abed Najm Al-Halboosi, Olena Savchenko, Lora K Heisler, Sergiy Sylantye. Modulation of GABA release by 5-HT Neuropharmacology. 2023-10-12. PMID:37827445. |
agonists of the 1b subtype of metabotropic serotonin receptor (5-ht |
2023-10-12 |
2023-10-15 |
Not clear |
| Apeksha Parajulee, Kuglae Ki. Structural studies of serotonin receptor family. BMB reports. 2023-10-11. PMID:37817438. |
understanding the structure, functions and pharmacology of the serotonin receptor family is essential for unraveling the complexities of serotonin signaling and developing targeted therapeutics for neuropsychiatric disorders. |
2023-10-11 |
2023-10-15 |
Not clear |
| Michael Hrabak, Connor Moon, Carlos A Bolaños-Guzmán, Heinz Steine. Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor. Molecular neurobiology. 2023-10-08. PMID:37807008. |
vilazodone differs from prototypical ssris in that, in addition to blocking serotonin reuptake, it acts as a partial agonist at the 5-ht1a serotonin receptor subtype. |
2023-10-08 |
2023-10-15 |
rat |
| Daisuke Kondo, Ruriko Suzuki, Ayako Matsumura, Hitomi Meguri, Masahiko Tanaka, Makoto Itakura, Naohide Hirashim. Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells. European journal of immunology. 2023-09-22. PMID:37736882. |
although antigen stimulation induces release of histamine and serotonin (5-ht) by exocytosis and mast cells express several types of 5-ht receptor, the detailed role of these receptors remains unclear. |
2023-09-22 |
2023-10-07 |
mouse |
| Min-Kyung Joo, Yoon-Jung Shin, Dong-Hyun Ki. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Scientific reports. vol 13. issue 1. 2023-09-19. PMID:37726354. |
alterations in central serotonin and 5-ht receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with gastrointestinal disorders. |
2023-09-19 |
2023-10-07 |
mouse |
| Min-Kyung Joo, Yoon-Jung Shin, Dong-Hyun Ki. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Scientific reports. vol 13. issue 1. 2023-09-19. PMID:37726354. |
cefaclor reduced serotonin levels and fluctuated 5-ht receptor mrna expressions such as htr1a, htr1b, and htr6 in the hippocampus. |
2023-09-19 |
2023-10-07 |
mouse |
| Yu Miyahara, Hideki Funahashi, Ayaka Haruta-Tsukamoto, Yoichiro Kogoh, Anna Kanemaru-Kawazoe, Yoji Hirano, Toshikazu Nishimori, Yasushi Ishid. Differential contribution of 5-HT Biological & pharmaceutical bulletin. 2023-09-18. PMID:37722878. |
differential contribution of 5-ht the involvement of serotonin (5-ht) and/or noradrenaline in acute pruriceptive processing in the central nervous system (cns) has been reported using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant; however, the roles of 5-ht receptor family in acute pruriceptive processing have not been fully elucidated in the cns. |
2023-09-18 |
2023-10-07 |
Not clear |
| Doaa Ghorab, Ejlal M Abu-El-Rub, Mohamed Hamdi Gharaibeh, Alaa Yehya, Ramada R Khasawneh, Laila M Matalqah, Ahmed Mohamed Helal. Neurological Effects of Combining Low Toxic Dose of Tramadol and Nicotine: An Animal Model Evidence of Endoplasmic Reticulum Stress. BioMed research international. vol 2023. 2023-08-18. PMID:37593523. |
serotonin receptor blockers such as olanzapine may increase systemic serotonin levels and need further investigation to utterly pinpoint their roles in managing mood disorders. |
2023-08-18 |
2023-09-07 |
rat |