| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
it is well-known that some kinases which are involved in the induction of synaptic plasticity probably modulate tau phosphorylation. |
2019-02-19 |
2023-08-13 |
rat |
| Qing-Hua Ma, Liu-Fang Jiang, Jian-Liang Mao, Wen-Xin Xu, Min Huan. Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Molecular medicine reports. vol 17. issue 3. 2018-08-15. PMID:29257340. |
these results indicate that vildagliptin administration exerts a protective effect against cognitive deficits by reducing tau phosphorylation and increasing the expression of proteins associated with synaptic plasticity in the hippocampus. |
2018-08-15 |
2023-08-13 |
rat |
| Lidia Bakota, Abdala Ussif, Gunnar Jeserich, Roland Brand. Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies. Molecular and cellular neurosciences. vol 84. 2018-07-24. PMID:28318914. |
this review article weighs the evidence that tau has subtle but important systemic effects on neuronal network function by maintaining physiological neuronal transmission and synaptic plasticity, which are possibly independent from tau's microtubule modulating activities. |
2018-07-24 |
2023-08-13 |
human |
| Tetsuya Kimura, Mamiko Suzuki, Takumi Akag. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28874186. |
age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. |
2018-05-07 |
2023-08-13 |
mouse |
| Manon Domise, Sébastien Didier, Claudia Marinangeli, Haitian Zhao, Pallavi Chandakkar, Luc Buée, Benoit Viollet, Peter Davies, Philippe Marambaud, Valérie Vingtdeu. AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Scientific reports. vol 6. 2018-04-30. PMID:27230293. |
as a consequence, any changes in tau phosphorylation can have major impacts on synaptic plasticity and memory. |
2018-04-30 |
2023-08-13 |
mouse |
| Mark J Milla. Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review. Progress in neurobiology. vol 156. 2018-04-30. PMID:28322921. |
using extensive graphical support, this article discusses how a diverse panoply of mirnas convergently and divergently impact (and are impacted by) core pathophysiological processes underlying ad: neuroinflammation and oxidative stress; aberrant generation of β-amyloid-42 (aβ42); anomalies in the production, cleavage and post-translational marking of tau; impaired clearance of aβ42 and tau; perturbation of axonal organisation; disruption of synaptic plasticity; endoplasmic reticulum stress and the unfolded protein response; mitochondrial dysfunction; aberrant induction of cell cycle re-entry; and apoptotic loss of neurons. |
2018-04-30 |
2023-08-13 |
human |
| Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Renu Sharma, Abhishek Shrivastava, Rashmi K Ambasta, Pravir Kuma. Stress-Induced Synaptic Dysfunction and Neurotransmitter Release in Alzheimer's Disease: Can Neurotransmitters and Neuromodulators be Potential Therapeutic Targets? Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:27662312. |
compelling evidence suggests that soluble amyloid-β (aβ) and hyperphosphorylated tau serve as toxins in the dysfunction of synaptic plasticity and aberrant neurotransmitter (nt) release at synapses consequently causing a cognitive decline in alzheimer's disease (ad). |
2018-02-23 |
2023-08-13 |
Not clear |
| Nady Braidy, Musthafa Mohamed Essa, Anne Poljak, Subash Selvaraju, Samir Al-Adawi, Thamilarasan Manivasagm, Arokiasamy Justin Thenmozhi, Lezanne Ooi, Perminder Sachdev, Gilles J Guillemi. Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease. Oncotarget. vol 7. issue 40. 2018-02-22. PMID:27486879. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by extracellular plaques containing abnormal amyloid beta (aβ) aggregates, intracellular neurofibrillary tangles containing hyperphosphorylated tau protein, microglia-dominated neuroinflammation, and impairments in synaptic plasticity underlying cognitive deficits. |
2018-02-22 |
2023-08-13 |
mouse |
| Yuxue Chen, Lu Liu, Mengzhu Li, Ensheng Yao, Jiahuan Hao, Yuanji Dong, Xiaolong Zheng, Xinghua Li. Expression of human Tau40 in the medial entorhinal cortex impairs synaptic plasticity and associated cognitive functions in mice. Biochemical and biophysical research communications. vol 496. issue 3. 2018-02-22. PMID:28472625. |
whether overexpression of human tau (htau40) in ec disrupts cognitive function and synaptic plasticity in ad has not been fully elucidated. |
2018-02-22 |
2023-08-13 |
mouse |
| Tara E Tracy, Li Ga. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 39. issue 4. 2018-01-12. PMID:28083916. |
a novel mechanistic link between tau toxicity and synaptic plasticity involves the acetylation of two lysines on tau, k274, and k281, which are associated with dementia in alzheimer's disease (ad). |
2018-01-12 |
2023-08-13 |
Not clear |
| Yaling Yin, Di Gao, Yali Wang, Zhi-Hao Wang, Xin Wang, Jinwang Ye, Dongqin Wu, Lin Fang, Guilin Pi, Ying Yang, Xiao-Chuan Wang, Chengbiao Lu, Keqiang Ye, Jian-Zhi Wan. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 26. 2017-12-12. PMID:27298345. |
here we found that overexpression of human wild-type full-length tau (termed htau) induced memory deficits with impairments of synaptic plasticity. |
2017-12-12 |
2023-08-13 |
human |
| Xun-Hu Gu, Li-Jun Xu, Zhi-Qiang Liu, Bo Wei, Yuan-Jian Yang, Guo-Gang Xu, Xiao-Ping Yin, Wei Wan. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease. Behavioural brain research. vol 311. 2017-11-27. PMID:27233830. |
changes in hippocampal 12/15 lipoxygenase (12/15lo) and glycogen synthase kinase 3β (gsk3β) activity, aβ production, tau phosphorylation, synaptic plasticity, and dendritic spine density were evaluated. |
2017-11-27 |
2023-08-13 |
mouse |
| Elodie Marciniak, Antoine Leboucher, Emilie Caron, Tariq Ahmed, Anne Tailleux, Julie Dumont, Tarik Issad, Ellen Gerhardt, Patrick Pagesy, Margaux Vileno, Clément Bournonville, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Dominique Demeyer, Sabiha Eddarkaoui, Emmanuelle Vallez, Didier Vieau, Sandrine Humez, Emilie Faivre, Benjamin Grenier-Boley, Tiago F Outeiro, Bart Staels, Philippe Amouyel, Detlef Balschun, Luc Buee, David Blu. Tau deletion promotes brain insulin resistance. The Journal of experimental medicine. vol 214. issue 8. 2017-09-26. PMID:28652303. |
one prevalent hypothesis is that hyperphosphorylation, misfolding, and fibrillization of tau impair synaptic plasticity and cause degeneration. |
2017-09-26 |
2023-08-13 |
mouse |
| Thomas DiChiara, Nadia DiNunno, Jeffrey Clark, Riana Lo Bu, Erika N Cline, Madeline G Rollins, Yuesong Gong, David L Brody, Stephen G Sligar, Pauline T Velasco, Kirsten L Viola, William L Klei. Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station. The Yale journal of biology and medicine. vol 90. issue 1. 2017-09-15. PMID:28356893. |
when given to cns cultures or injected icv into non-human primates and other non-transgenic animals, aβos have been found to cause impaired synaptic plasticity, loss of memory function, tau hyperphosphorylation and tangle formation, synapse elimination, oxidative and er stress, inflammatory microglial activation, and selective nerve cell death. |
2017-09-15 |
2023-08-13 |
Not clear |
| Pu Wang, Zhan-You Wan. Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease. Ageing research reviews. vol 35. 2017-08-07. PMID:27829171. |
moreover, the mechanisms of oxidative stress, synaptic plasticity, neurotoxicity, autophagy and apoptosis mediate the effects of metal ions-induced the aggregation state of aβ and phosphorylated tau on ad development. |
2017-08-07 |
2023-08-13 |
Not clear |
| Ting Yang, Shaomin Li, Huixin Xu, Dominic M Walsh, Dennis J Selko. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053038. |
soluble oligomers of amyloid β-protein (oaβ) isolated from the brains of alzheimer's disease (ad) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, and impair memory in normal adult rodents. |
2017-07-24 |
2023-08-13 |
mouse |
| Tara E Tracy, Peter Dongmin Sohn, S Sakura Minami, Chao Wang, Sang-Won Min, Yaqiao Li, Yungui Zhou, David Le, Iris Lo, Ravikumar Ponnusamy, Xin Cong, Birgit Schilling, Lisa M Ellerby, Richard L Huganir, Li Ga. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. vol 90. issue 2. 2017-06-19. PMID:27041503. |
acetylated tau obstructs kibra-mediated signaling in synaptic plasticity and promotes tauopathy-related memory loss. |
2017-06-19 |
2023-08-13 |
mouse |
| Tara E Tracy, Peter Dongmin Sohn, S Sakura Minami, Chao Wang, Sang-Won Min, Yaqiao Li, Yungui Zhou, David Le, Iris Lo, Ravikumar Ponnusamy, Xin Cong, Birgit Schilling, Lisa M Ellerby, Richard L Huganir, Li Ga. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. vol 90. issue 2. 2017-06-19. PMID:27041503. |
here we report abnormal acetylation of k274 and k281 on tau, identified in ad brains, promotes memory loss and disrupts synaptic plasticity by reducing postsynaptic kidney/brain (kibra) protein, a memory-associated protein. |
2017-06-19 |
2023-08-13 |
mouse |
| Tong Guo, Wendy Noble, Diane P Hange. Roles of tau protein in health and disease. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28386764. |
recent advances in our understanding of the multiple functions and different locations of tau inside and outside neurons have revealed novel insights into its importance in a diverse range of molecular pathways including cell signalling, synaptic plasticity, and regulation of genomic stability. |
2017-04-20 |
2023-08-13 |
Not clear |
| Frederik Sündermann, Maria-Pilar Fernandez, Reginald O Morga. An evolutionary roadmap to the microtubule-associated protein MAP Tau. BMC genomics. vol 17. 2016-11-03. PMID:27030133. |
the microtubule associated protein tau (mapt) promotes assembly and interaction of microtubules with the cytoskeleton, impinging on axonal transport and synaptic plasticity. |
2016-11-03 |
2023-08-13 |
Not clear |