| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pietro Scaduto, Michela Marcatti, Nemil Bhatt, Rakez Kayed, Giulio Taglialatel. Calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers. Brain communications. vol 6. issue 5. 2024-09-06. PMID:39239152. |
calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers. |
2024-09-06 |
2024-09-08 |
Not clear |
| Pietro Scaduto, Michela Marcatti, Nemil Bhatt, Rakez Kayed, Giulio Taglialatel. Calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers. Brain communications. vol 6. issue 5. 2024-09-06. PMID:39239152. |
alzheimer's brain-derived tau oligomers are potent inhibitors of synaptic plasticity; however, the involved mechanism is still not fully understood. |
2024-09-06 |
2024-09-08 |
Not clear |
| Pietro Scaduto, Michela Marcatti, Nemil Bhatt, Rakez Kayed, Giulio Taglialatel. Calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers. Brain communications. vol 6. issue 5. 2024-09-06. PMID:39239152. |
using a combination of electrophysiological and rna-sequencing techniques, we provide here evidence that fk506 has the potential to block the acute toxic effect of brain-derived tau oligomers on synaptic plasticity, as well as to restore the levels of some key synaptic mrnas. |
2024-09-06 |
2024-09-08 |
Not clear |
| Nahid Sarahian, Fariba Khodagholi, Neda Valian, Abolhassan Ahmadian. Interplay of MeCP2/ REST/ Synaptophysin-BDNF and intranasal oxytocin influence on Aβ-induced memory and cognitive impairments. Behavioural brain research. 2024-09-05. PMID:39236931. |
alzheimer's disease (ad) is linked to the accumulation of aβ, increased tau hyperphosphorylation, persistent neuroinflammation, and a decline in neurotrophic factors, neurogenesis, and synaptic plasticity. |
2024-09-05 |
2024-09-08 |
rat |
| Shuang Qi, Yuan Yuan, Wen Yang, Jing-Yang Su, Li-Ying Ha. [Calcium Dyshomeostasis and Alzheimer's Disease]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 46. issue 4. 2024-09-02. PMID:39223024. |
alzheimer's disease (ad) is a common neurodegenerative disease with the main manifestations of progressive cognitive dysfunction,behavioral disorders,and gradual decline of living ability.the etiology of ad is complex,and the pathogenesis of this disease remains controversial.calcium signaling plays an important role in regulating neuronal activities,including neurotransmitter release,synaptic plasticity,memory storage,and neuronal apoptosis.increasing studies have shown that neuronal calcium dyshomeostasis is a major pathological factor in the occurrence and development of ad.this article reviews the role and research progress in intracellular calcium dyshomeostasis in ad,including the relationship between calcium homeostasis and amyloid β,the role of calcium/calmodulin-dependent protein kinases in tau phosphorylation,calcium signaling pathways,the relationship between calcium homeostasis and mitochondrial function,autophagy,and neuroinflammation. |
2024-09-02 |
2024-09-05 |
Not clear |
| João Fonseca-Gomes, Tiago Costa-Coelho, Mafalda Ferreira-Manso, Sara Inteiro-Oliveira, Sandra H Vaz, Nuno Alemãn-Serrano, Henrique Atalaia-Barbacena, Leonor Ribeiro-Rodrigues, Rita M Ramalho, Rui Pinto, Hugo Vicente Miranda, Sara R Tanqueiro, Carolina de Almeida-Borlido, Maria João Ramalho, Catarina Miranda-Lourenço, Rita F Belo, Catarina B Ferreira, Vera Neves, Diogo M Rombo, Ricardo Viais, Ivo C Martins, André Jerónimo-Santos, António Caetano, Nuno Manso, Petra Mäkinen, Mikael Marttinen, Mari Takalo, Michael Bremang, Ian Pike, Annakaisa Haapasalo, Joana A Loureiro, Maria Carmo Pereira, Nuno C Santos, Tiago F Outeiro, Miguel A R B Castanho, Adelaide Fernandes, Mikko Hiltunen, Carlos B Duarte, Eero Castrén, Alexandre de Mendonça, Ana M Sebastião, Tiago M Rodrigues, Maria José Diógene. A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer's Disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-08-29. PMID:39205389. |
furthermore, this tat-trkb peptide improved the cognitive performance, ameliorated synaptic plasticity deficits and prevented tau pathology progression in vivo in the 5xfad mouse model of ad. |
2024-08-29 |
2024-09-04 |
mouse |
| Yucai Ye, Chaojing Fu, Yan Li, Junli Sun, Xinru Li, Shifan Chai, Shuo Li, Meng Hou, Hongyan Cai, Meina Wu, Zhaojun Wan. Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease. Experimental neurology. 2024-08-14. PMID:39142368. |
we found that adf increased circulating βohb concentrations in 3xtg mice, improved cognitive function, reduced anxiety-like behaviors, improved hippocampal synaptic plasticity, and reduced neuronal loss, aβ oligomers and tau hyperphosphorylation. |
2024-08-14 |
2024-08-17 |
mouse |
| Yanxin Shen, Meng Zhao, Panpan Zhao, Lingjie Meng, Yan Zhang, Guimei Zhang, Yezi Taishi, Li Su. Molecular mechanisms and therapeutic potential of lithium in Alzheimer's disease: repurposing an old class of drugs. Frontiers in pharmacology. vol 15. 2024-07-26. PMID:39055498. |
lithium's neuroprotective properties in ad by acting on multiple neuropathological targets, such as reducing amyloid deposition and tau phosphorylation, enhancing autophagy, neurogenesis, and synaptic plasticity, regulating cholinergic and glucose metabolism, inhibiting neuroinflammation, oxidative stress, and apoptosis, while preserving mitochondrial function. |
2024-07-26 |
2024-07-28 |
Not clear |
| Anatoly V Skalny, Michael Aschner, Abel Santamaria, Tommaso Filippini, Viktor A Gritsenko, Yousef Tizabi, Feng Zhang, Xiong Guo, Joao B T Rocha, Alexey A Tinko. The Role of Gut Microbiota in the Neuroprotective Effects of Selenium in Alzheimer's Disease. Molecular neurobiology. 2024-07-16. PMID:39012446. |
correspondingly, supplementation with various forms of se in cellular and animal models of ad was shown to reduce aβ formation, tau phosphorylation, reverse the decline in brain antioxidant levels, inhibit neuronal oxidative stress and proinflammatory cytokine production, improve synaptic plasticity and neurogenesis, altogether resulting in improved cognitive functions. |
2024-07-16 |
2024-07-18 |
Not clear |
| Li Lu, Anna M Kotowska, Stefanie Kern, Min Fang, Timothy R Rudd, Morgan R Alexander, David J Scurr, Zheying Zh. Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer's Disease Using OrbiSIMS and LC-MS/MS. Analytical chemistry. 2024-07-11. PMID:38989551. |
apolipoprotein e4 (apoe4) is one of the most significant genetic risk factors for alzheimer's disease (ad), which is not only associated with the ad pathological features such as amyloid-β deposition, phosphorylation of tau proteins, and neuroinflammation but is also involved in metabolism, neuron growth, and synaptic plasticity. |
2024-07-11 |
2024-07-13 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Najah R Hadi, Abdullah A Assiri, Mohammed Alrouji, Nermeen N Welson, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon. Cellular and molecular neurobiology. vol 44. issue 1. 2024-07-08. PMID:38977507. |
glucagon/glp-1 has been shown to promote synaptogenesis, hippocampal synaptic plasticity, and learning and memory, while attenuating amyloid and tau pathologies. |
2024-07-08 |
2024-07-12 |
Not clear |
| Jana Hroudová, Zdeněk Fiša. Alzheimer's disease approaches - Focusing on pathology, biomarkers and clinical trial candidates. Progress in neuro-psychopharmacology & biological psychiatry. 2024-06-25. PMID:38917881. |
the main targets of new drugs for ad are processes related to amyloid beta and tau neurotoxicity, neurotransmission, inflammation, metabolism and bioenergetics, synaptic plasticity, and oxidative stress. |
2024-06-25 |
2024-06-29 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Yin Yang, Qiancheng Zhang, Brian J Rodriguez, Michael J Rowa. Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 379. issue 1906. 2024-06-10. PMID:38853565. |
remarkably, the persistent disruption of synaptic plasticity by patient-derived brain tau was rapidly reversed by a single intracerebral injection of different anti-tau monoclonal antibodies, including one directed to a specific human tau amino acid sequence. |
2024-06-10 |
2024-06-14 |
human |
| Magham Sai Varshini, Ramakkamma Aishwarya Reddy, Praveen Thaggikuppe Krishnamurth. Unlocking Hope: GSK-3 Inhibitors and Wnt Pathway Activation in Alzheimer's Therapy. Journal of drug targeting. 2024-06-05. PMID:38838023. |
the modulation of wnt signaling appears to have multifaceted benefits including the reduction of amyloid-β production, tau hyperphosphorylation, enhancement of synaptic plasticity, and inhibition of neuroinflammation. |
2024-06-05 |
2024-06-08 |
Not clear |
| Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioe. Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science (New York, N.Y.). vol 384. issue 6699. 2024-05-30. PMID:38815015. |
in amyloid-β and tau-driven mouse models of disease, res19-t agents restored synaptic plasticity, normalized brain network activity, and attenuated the development of both amyloid-β and tau pathology. |
2024-05-30 |
2024-06-14 |
mouse |
| Xiao-Hong Hu, Kai-Yue Yu, Xin-Xin Li, Jin-Nan Zhang, Juan-Juan Jiao, Zhao-Jun Wang, Hong-Yan Cai, Lei Wang, Ye-Xin He, Mei-Na W. Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer's disease in 3xTg-AD mice. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-04-29. PMID:38682858. |
then, immunohistochemistry, western blotting and elisa were used to detect aβ deposition, tau phosphorylation and neuroinflammation, and electrophysiological and wheel-running activity recording were recorded to observe hippocampal synaptic plasticity and circadian rhythm. |
2024-04-29 |
2024-05-02 |
mouse |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
besides its role in stabilizing microtubules, tau is localized at postsynaptic sites and can regulate synaptic plasticity. |
2024-03-29 |
2024-04-01 |
mouse |
| Margrethe A Olesen, Eugenia Pradenas, Francisca Villavicencio-Tejo, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging. Free radical biology & medicine. 2024-03-29. PMID:38552927. |
we previously showed that caspase-3 cleaved tau, a relevant tau form in alzheimer's disease (ad), affects mitochondrial bioenergetics, dynamics and synaptic plasticity by the opening of mitochondrial permeability transition pore (mptp). |
2024-03-29 |
2024-04-01 |
mouse |
| Chun Yuen Jerry Wong, Alberto Baldelli, Camilla M Hoyos, Ole Tietz, Hui Xin Ong, Daniela Train. Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy. Drug delivery and translational research. 2024-03-05. PMID:38441832. |
notably, intranasal insulin has shown neuroprotective effects, impacting aβ clearance, tau phosphorylation, and synaptic plasticity. |
2024-03-05 |
2024-03-07 |
Not clear |
| Burak Tan, Esra Tufan, Özlem Barutçu, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. Physiology international. 2024-03-04. PMID:38436684. |
phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. |
2024-03-04 |
2024-03-06 |
Not clear |