All Relations between synaptic plasticity and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Narjes Baazaoui, Khalid Iqba. Alzheimer's Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291618. a deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofibrillary tau and amyloid β pathologies and neuroinflammation. 2022-10-27 2023-08-14 Not clear
Namy George, Majed AbuKhader, Khalid Al Balushi, Bushra Al Sabahi, Shah Alam Kha. An insight into the neuroprotective effects and molecular targets of pomegranate ( Nutritional neuroscience. 2022-09-20. PMID:36125072. various studies showing the ability of pomegranate in inhibiting enzymes, reducing reactive oxygen species, inhibition of microglial activation, inhibition of tau protein hyperphosphorylation, maintenance of synaptic plasticity, anti-inflammatory activity and its ability to inhibit beta secretase-1 (bace-1) has been reviewed in this article. 2022-09-20 2023-08-14 Not clear
Yanan Wang, Nitin Khandelwal, Shuiqiao Liu, Mi Zhou, Lei Bao, Jennifer E Wang, Ashwani Kumar, Chao Xing, Jay R Gibson, Yingfei Wan. KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2. Molecular psychiatry. 2022-08-26. PMID:36028572. kdm6b cooperates with tau and regulates synaptic plasticity and cognition via inducing vglut1/2. 2022-08-26 2023-08-14 mouse
Jing Sun, Yuhe Zhang, Yu Kong, Tao Ye, Qingxia Yu, Senthil Kumaran Satyanarayanan, Kuan-Pin Su, Jiaming Li. Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice. Brain, behavior, and immunity. 2022-08-12. PMID:35961580. for example, microbiota-derived indoles via tryptophan metabolism prevented aβ accumulation and tau hyperphosphorylation, restored synaptic plasticity, and then promoted the cognitive and behavioral ability of app/ps1 mice. 2022-08-12 2023-08-14 mouse
Burak Tan, Ercan Babur, Nihal Toy, Buse Günaydın, Nurcan Dursun, Cem Süe. Tau Protein is Differentially Phosphorylated in Young- and Old- Aged Rats with Experimentally Induced Hyperthyroidism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-07-29. PMID:35904470. aging involves progressive physiological changes, including thyroid dysfunction; thus, changes in plasma ths level may affect neuronal function such as synaptic plasticity and tau phosphorylation. 2022-07-29 2023-08-14 rat
Xing Fan, Liye Xia, Zheng Zhou, Yanyan Qiu, Chenhao Zhao, Xiaomin Yin, Wei Qia. Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction. Frontiers in aging neuroscience. vol 14. 2022-06-17. PMID:35711910. in the present review, we discuss tau phosphorylation, which is critical for the dendritic localization of tau and synaptic plasticity. 2022-06-17 2023-08-14 Not clear
Xia Zhao, Li Xiong, Lingyu She, Liwei Li, Ping Huang, Guang Lian. The role and therapeutic implication of protein tyrosine phosphatases in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-06-09. PMID:35676788. studies have shown that protein phosphorylation signaling pathways mediates intracellular accumulation of aβ and tau during ad development and are involved in synaptic plasticity and other stress responses. 2022-06-09 2023-08-14 Not clear
Zhong-Hao Zhang, Xian-Chun Cao, Jia-Ying Peng, Shao-Ling Huang, Chen Chen, Shi-Zheng Jia, Jia-Zuan Ni, Guo-Li Son. Reversal of Lipid Metabolism Dysregulation by Selenium and Folic Acid Co-Supplementation to Mitigate Pathology in Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624693. in addition to a reduction in aβ generation and tau hyperphosphorylation, a restoration of synaptic plasticity and cognitive ability was observed in ad mice upon se-fa administration. 2022-05-28 2023-08-13 mouse
Anastasiia Ilina, Vladimir Khavinson, Natalia Linkova, Mikhael Petukho. Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457077. the pathogenetic links of this disease are the misfolding and aggregation of tau protein and amyloid peptides, mitochondrial dysfunction, oxidative stress, impaired energy metabolism, destruction of the blood-brain barrier, and neuroinflammation, all of which lead to impaired synaptic plasticity and memory loss. 2022-04-23 2023-08-13 Not clear
Mengqian Ge, Jinghui Zhang, Simiao Chen, Yanfen Huang, Weiyan Chen, Lan He, Yuyan Zhan. Role of Calcium Homeostasis in Alzheimer's Disease. Neuropsychiatric disease and treatment. vol 18. 2022-03-10. PMID:35264851. several studies have suggested that intracellular calcium homeostasis is dysregulated in ad, and this has been implicated in the deposition of amyloid β (aβ), hyperphosphorylation of tau protein, abnormal synaptic plasticity, and apoptosis, all of which are involved in the occurrence and development of ad. 2022-03-10 2023-08-13 Not clear
Tapan Behl, Dapinder Kaur, Aayush Sehgal, Sukhbir Singh, Hafiz A Makeen, Mohammed Albratty, Ahmed A H Abdellatif, Sudharshan Reddy Dachani, Simona Bunga. Exploring the potential role of rab5 protein in endo-lysosomal impairment in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-03-04. PMID:35245734. as a result, variations in the autophagic and endo-lysosomal torrent, as a measure of degenerative function in these sections or pathways, may have a direct impact on disease-related processes, such as aß clearance from the brain and interneuronal deposition of aß and tau aggregates, thus disrupting synaptic plasticity. 2022-03-04 2023-08-13 Not clear
Hannah Walgrave, Evgenia Salta, Sarah Snoeck, Renzo Mancuso, Sriram Balusu, Kristofer Davie, Francis Impens, Bart de Stroope. Systematic evaluation of the therapeutic potential of microRNA-132 in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108990. of particular interest is microrna-132 (mir-132), which is consistently and robustly downregulated in ad patient brain and has been shown to be involved in pivotal processes in the central nervous system that are also affected in ad, such as amyloid plaque deposition, tau phosphorylation, inflammation, synaptic plasticity and memory formation. 2022-02-03 2023-08-13 Not clear
Stepan Lerner, Tatiana Karelin. Quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109086. quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. 2022-02-03 2023-08-13 Not clear
Stepan Lerner, Tatiana Karelin. Quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109086. quantitative systems pharmacology (qsp) model of synaptic plasticity was developed to investigate influence of tau hyperphosphorylation on impairment of ltp. 2022-02-03 2023-08-13 Not clear
Nicole P Kasica, Xueyan Zhou, Qian Yang, Xin Wang, Wenzhong Yang, Helena R Zimmermann, Caroline E Holland, Elizabeth Koscielniak, Hanzhi Wu, Anderson O Cox, Jingyun Lee, Alexey G Ryazanov, Cristina M Furdui, Tao M. Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice. Journal of neurochemistry. 2021-12-21. PMID:34932218. our data revealed that treatment with eef2k inhibitors improved ad-associated synaptic plasticity impairments and cognitive dysfunction, without altering brain amyloid β (aβ) and tau pathology. 2021-12-21 2023-08-13 mouse
Lei Xia, Yayan Pang, Junjie Li, Bin Wu, Yehong Du, Yuxin Chen, Man Luo, Yan Wang, Zhifang Don. Dihydroartemisinin Induces O-GlcNAcylation and Improves Cognitive Function in a Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. vol 84. issue 1. 2021-12-10. PMID:34511503. hyperphosphorylation modification promotes tau protein misfolding and aggregation into neurofibrillary tangles, leading to impairments of synaptic plasticity and learning and memory. 2021-12-10 2023-08-13 mouse
Guiping Wang, Huan-Huan Zhou, Lan Luo, Li-Qiang Qin, Jieyun Yin, Zengli Yu, Lin Zhang, Zhongxiao Wa. Voluntary wheel running is capable of improving cognitive function only in the young but not the middle-aged male APPSwe/PS1De9 mice. Neurochemistry international. vol 145. 2021-11-18. PMID:33684544. this might be owing to that in young app/ps1 mice voluntary exercise reduced tau phosphorylation via inhibiting p-gsk3β activity, as well as reduced neuro-inflammation and elevated key proteins involved in synaptic plasticity. 2021-11-18 2023-08-13 mouse
Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. importantly, p2x7 deletion ultimately rescued synaptic plasticity and memory impairments of tau mice. 2021-11-11 2023-08-13 mouse
Mascia Amici, Yeseul Lee, Robert J P Pope, Clarrisa A Bradley, Adam Cole, Graham L Collingridg. GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα. The European journal of neuroscience. vol 54. issue 8. 2021-11-03. PMID:32463939. in this context, gsk-3β plays a role in the induction of nmda receptor-dependent long-term depression (ltd) and several substrates for gsk-3β have been identified in this form of synaptic plasticity, including klc-2, psd-95 and tau. 2021-11-03 2023-08-13 rat
b' Elisabetta Lauretti, Konrad Dabrowski, Domenico Pratic\\xc3\\xb. The neurobiology of non-coding RNAs and Alzheimer\'s disease pathogenesis: Pathways, mechanisms and translational opportunities. Ageing research reviews. vol 71. 2021-10-11. PMID:34384901.' although the mechanisms are still not fully elucidated, studies have revealed that these highly conserved ncrnas are important modulators of gene expression, amyloid-β production, tau phosphorylation, inflammation, synaptic plasticity and neuronal survival, all features considered central to ad pathogenesis. 2021-10-11 2023-08-13 mouse