| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alba Clara Fernández-Rilo, Nicola Forte, Letizia Palomba, Lea Tunisi, Fabiana Piscitelli, Roberta Imperatore, Alfonso Di Costanzo, Vincenzo Di Marzo, Luigia Cristin. Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity. Molecular metabolism. 2023-03-28. PMID:36977433. |
here, we investigated the hypothesis that, under acute (6h fasting in wt mice) or chronic (in ob/ob mice) hypothalamic leptin signaling reduction, ox-a-induced enhancement of 2-ag levels leads to the production of the 2-ag-derived 2-arachidonoyl-sn-glycerol-3-phosphate (2-agp), a bioactive lipid belonging to the class of lysophosphatidic acids (lpas), which then regulates hypothalamic synaptic plasticity by disassembling α-msh anorexigenic inputs via gsk-3β-mediated tau phosphorylation, ultimately affecting food intake. |
2023-03-28 |
2023-08-14 |
mouse |
| Irep Uras, Merve Karayel-Basar, Betul Sahin, Ahmet Tarik Bayka. Detection of early proteomic alterations in 5xFAD Alzheimer's disease neonatal mouse model via MALDI-MSI. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-03-19. PMID:36934297. |
ad is considered a multifactorial disorder where multiple processes like amyloid-beta and tau accumulation, axonal degeneration, synaptic plasticity, and autophagic processes plays an important role. |
2023-03-19 |
2023-08-14 |
mouse |
| Valentina Latina, Margherita De Introna, Chiara Caligiuri, Alessia Loviglio, Rita Florio, Federico La Regina, Annabella Pignataro, Martine Ammassari-Teule, Pietro Calissano, Giuseppina Amador. Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model. Pharmaceutics. vol 15. issue 2. 2023-02-25. PMID:36839831. |
we found out that non-invasive administration of 12 a12mab markedly reduced the pathological accumulation of both truncated tau and aβ in the v1 area, correlated to significant improvement in visual recognition memory performance along with local increase in two direct readouts of cortical synaptic plasticity, including the dendritic spine density and the expression level of activity-regulated cytoskeleton protein arc/arg3.1. |
2023-02-25 |
2023-08-14 |
mouse |
| Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao, Mei-Na W. Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism. Neurobiology of aging. vol 124. 2023-02-09. PMID:36758468. |
in the present study, the effects of oxa on cognitive functions, synaptic plasticity, aβ levels, tau hyperphosphorylation, bace1 and nep expression, and circadian locomotor rhythm were evaluated. |
2023-02-09 |
2023-08-14 |
mouse |
| Dilek Mercan, Michael Thomas Henek. The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer's Disease. Biology. vol 11. issue 12. 2022-12-23. PMID:36552331. |
since the lc is the main source of noradrenaline (na) in the brain, degeneration of the lc in ad leads to decreased na levels, causing increased neuroinflammation, enhanced amyloid and tau burden, decreased phagocytosis and impairment in cognition and long-term synaptic plasticity. |
2022-12-23 |
2023-08-14 |
Not clear |
| Itzhak Fische. Evolutionary perspective of Big tau structure: 4a exon variants of MAPT. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533137. |
tau plays important roles in modulating microtubule dynamics, axonal transport, synaptic plasticity, and dna repair, and has also been associated with neurodegenerative diseases (tauopathies) including alzheimer's disease and frontotemporal dementia. |
2022-12-19 |
2023-08-14 |
human |
| Desh Deepak Singh, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K Yada. Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development. Cells. vol 11. issue 23. 2022-12-11. PMID:36497027. |
brain cells becoming resistant to insulin leads to elevated blood glucose levels, impaired synaptic plasticity, microglial overactivation, mitochondrial dysfunction, neuronal apoptosis, nutrient deprivation, tau (tubulin-associated unit) phosphorylation, and cholinergic dysfunction. |
2022-12-11 |
2023-08-14 |
Not clear |
| Nastaran Karimi, Feyza Bayram Çatak, Ebru Arslan, Amene Saghazadeh, Nima Rezae. Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy. International immunopharmacology. vol 113. issue Pt B. 2022-11-21. PMID:36410182. |
tau contributes to the synaptic plasticity of axons; hyperphosphorylated and aggregated tau have been shown to increase the likelihood of cognitive impairments. |
2022-11-21 |
2023-08-14 |
Not clear |
| Narjes Baazaoui, Khalid Iqba. Alzheimer's Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291618. |
a deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofibrillary tau and amyloid β pathologies and neuroinflammation. |
2022-10-27 |
2023-08-14 |
Not clear |
| Namy George, Majed AbuKhader, Khalid Al Balushi, Bushra Al Sabahi, Shah Alam Kha. An insight into the neuroprotective effects and molecular targets of pomegranate ( Nutritional neuroscience. 2022-09-20. PMID:36125072. |
various studies showing the ability of pomegranate in inhibiting enzymes, reducing reactive oxygen species, inhibition of microglial activation, inhibition of tau protein hyperphosphorylation, maintenance of synaptic plasticity, anti-inflammatory activity and its ability to inhibit beta secretase-1 (bace-1) has been reviewed in this article. |
2022-09-20 |
2023-08-14 |
Not clear |
| Yanan Wang, Nitin Khandelwal, Shuiqiao Liu, Mi Zhou, Lei Bao, Jennifer E Wang, Ashwani Kumar, Chao Xing, Jay R Gibson, Yingfei Wan. KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2. Molecular psychiatry. 2022-08-26. PMID:36028572. |
kdm6b cooperates with tau and regulates synaptic plasticity and cognition via inducing vglut1/2. |
2022-08-26 |
2023-08-14 |
mouse |
| Jing Sun, Yuhe Zhang, Yu Kong, Tao Ye, Qingxia Yu, Senthil Kumaran Satyanarayanan, Kuan-Pin Su, Jiaming Li. Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice. Brain, behavior, and immunity. 2022-08-12. PMID:35961580. |
for example, microbiota-derived indoles via tryptophan metabolism prevented aβ accumulation and tau hyperphosphorylation, restored synaptic plasticity, and then promoted the cognitive and behavioral ability of app/ps1 mice. |
2022-08-12 |
2023-08-14 |
mouse |
| Burak Tan, Ercan Babur, Nihal Toy, Buse Günaydın, Nurcan Dursun, Cem Süe. Tau Protein is Differentially Phosphorylated in Young- and Old- Aged Rats with Experimentally Induced Hyperthyroidism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-07-29. PMID:35904470. |
aging involves progressive physiological changes, including thyroid dysfunction; thus, changes in plasma ths level may affect neuronal function such as synaptic plasticity and tau phosphorylation. |
2022-07-29 |
2023-08-14 |
rat |
| Xing Fan, Liye Xia, Zheng Zhou, Yanyan Qiu, Chenhao Zhao, Xiaomin Yin, Wei Qia. Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction. Frontiers in aging neuroscience. vol 14. 2022-06-17. PMID:35711910. |
in the present review, we discuss tau phosphorylation, which is critical for the dendritic localization of tau and synaptic plasticity. |
2022-06-17 |
2023-08-14 |
Not clear |
| Xia Zhao, Li Xiong, Lingyu She, Liwei Li, Ping Huang, Guang Lian. The role and therapeutic implication of protein tyrosine phosphatases in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-06-09. PMID:35676788. |
studies have shown that protein phosphorylation signaling pathways mediates intracellular accumulation of aβ and tau during ad development and are involved in synaptic plasticity and other stress responses. |
2022-06-09 |
2023-08-14 |
Not clear |
| Zhong-Hao Zhang, Xian-Chun Cao, Jia-Ying Peng, Shao-Ling Huang, Chen Chen, Shi-Zheng Jia, Jia-Zuan Ni, Guo-Li Son. Reversal of Lipid Metabolism Dysregulation by Selenium and Folic Acid Co-Supplementation to Mitigate Pathology in Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624693. |
in addition to a reduction in aβ generation and tau hyperphosphorylation, a restoration of synaptic plasticity and cognitive ability was observed in ad mice upon se-fa administration. |
2022-05-28 |
2023-08-13 |
mouse |
| Anastasiia Ilina, Vladimir Khavinson, Natalia Linkova, Mikhael Petukho. Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457077. |
the pathogenetic links of this disease are the misfolding and aggregation of tau protein and amyloid peptides, mitochondrial dysfunction, oxidative stress, impaired energy metabolism, destruction of the blood-brain barrier, and neuroinflammation, all of which lead to impaired synaptic plasticity and memory loss. |
2022-04-23 |
2023-08-13 |
Not clear |
| Mengqian Ge, Jinghui Zhang, Simiao Chen, Yanfen Huang, Weiyan Chen, Lan He, Yuyan Zhan. Role of Calcium Homeostasis in Alzheimer's Disease. Neuropsychiatric disease and treatment. vol 18. 2022-03-10. PMID:35264851. |
several studies have suggested that intracellular calcium homeostasis is dysregulated in ad, and this has been implicated in the deposition of amyloid β (aβ), hyperphosphorylation of tau protein, abnormal synaptic plasticity, and apoptosis, all of which are involved in the occurrence and development of ad. |
2022-03-10 |
2023-08-13 |
Not clear |
| Tapan Behl, Dapinder Kaur, Aayush Sehgal, Sukhbir Singh, Hafiz A Makeen, Mohammed Albratty, Ahmed A H Abdellatif, Sudharshan Reddy Dachani, Simona Bunga. Exploring the potential role of rab5 protein in endo-lysosomal impairment in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-03-04. PMID:35245734. |
as a result, variations in the autophagic and endo-lysosomal torrent, as a measure of degenerative function in these sections or pathways, may have a direct impact on disease-related processes, such as aß clearance from the brain and interneuronal deposition of aß and tau aggregates, thus disrupting synaptic plasticity. |
2022-03-04 |
2023-08-13 |
Not clear |
| Hannah Walgrave, Evgenia Salta, Sarah Snoeck, Renzo Mancuso, Sriram Balusu, Kristofer Davie, Francis Impens, Bart de Stroope. Systematic evaluation of the therapeutic potential of microRNA-132 in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108990. |
of particular interest is microrna-132 (mir-132), which is consistently and robustly downregulated in ad patient brain and has been shown to be involved in pivotal processes in the central nervous system that are also affected in ad, such as amyloid plaque deposition, tau phosphorylation, inflammation, synaptic plasticity and memory formation. |
2022-02-03 |
2023-08-13 |
Not clear |