| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Saeedi, Ali Rashidy-Pou. Association between chronic stress and Alzheimer's disease: Therapeutic effects of Saffron. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-24. PMID:33232931. |
the inhibitory actions on acetylcholinesterase activity, aggregation of beta-amyloid protein into amyloid plaques and tau protein into neurofibrillary tangles, and also the antioxidant, anti-inflammatory, and the promotion of synaptic plasticity effects are among the possible mechanisms to explain the neuroprotective effects of saffron. |
2021-02-24 |
2023-08-13 |
Not clear |
| Daniela Puzzo, Elentina K Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa', Domenica D Li Puma, Claudio Grassi, Luciano D'Adamio, Nicholas M Kanaan, Paul E Fraser, Ottavio Aranci. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544084. |
here, using a multidisciplinary approach combining molecular biological, biochemical, histopathological, electrophysiological, and behavioral methods, we demonstrated that tau suppression did not protect against aβ-induced damage of long-term synaptic plasticity and memory, or from amyloid deposition. |
2021-02-08 |
2023-08-13 |
mouse |
| Daniela Puzzo, Elentina K Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa', Domenica D Li Puma, Claudio Grassi, Luciano D'Adamio, Nicholas M Kanaan, Paul E Fraser, Ottavio Aranci. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544084. |
similarly, tau suppression did not protect against exogenous oligomeric tau-induced impairment of long-term synaptic plasticity and memory. |
2021-02-08 |
2023-08-13 |
mouse |
| Sara Momtazmanesh, George Perry, Nima Rezae. Toll-like receptors in Alzheimer's disease. Journal of neuroimmunology. vol 348. 2020-12-14. PMID:32858428. |
signaling of tlrs affects the core of ad changes, including synaptic plasticity, microglial activity, tau phosphorylation, and inflammatory responses. |
2020-12-14 |
2023-08-13 |
Not clear |
| Yali Jia, Ning Cao, Jinglei Zhai, Quan Zeng, Pei Zheng, Ruyu Su, Tuling Liao, Jiajing Liu, Haiyun Pei, Zeng Fan, Junnian Zhou, Jiafei Xi, Lijuan He, Lin Chen, Xue Nan, Wen Yue, Xuetao Pe. HGF Mediates Clinical-Grade Human Umbilical Cord-Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence-Accelerated Mouse Model of Alzheimer's Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 7. issue 17. 2020-10-02. PMID:32995116. |
a functional assay identifies that the core functional factor hepatocyte growth factor (hgf) secreted from huc-mscs plays critical roles in huc-msc-modulated recovery of damaged neural cells by down-regulating hyperphosphorylated tau, reversing spine loss, and promoting synaptic plasticity in an ad cell model. |
2020-10-02 |
2023-08-13 |
mouse |
| Jian Bao, Yacoubou A R Mahaman, Rong Liu, Jian-Zhi Wang, Zhiguo Zhang, Bin Zhang, Xiaochuan Wan. Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD. Frontiers in aging neuroscience. vol 9. 2020-09-29. PMID:29163130. |
we also found tau hyperphosphorylation, an increase of aβ40/42 as well as increase in both gsk-3β and bace1 activities, while a loss of dendritic and synaptic plasticity was observed in the male stz rats. |
2020-09-29 |
2023-08-13 |
rat |
| Athanasia K Papazafiropoulou, Chris Koros, Andreas Melidonis, Stavros Antonopoulo. Diabetes and dementia - the two faces of Janus. Archives of medical sciences. Atherosclerotic diseases. vol 5. 2020-09-28. PMID:32832719. |
in addition, experimental studies on patients with diabetes and alzheimer's disease have shown beneficial effects on synaptic plasticity, metabolism of amyloid-β, and microtubule-associated protein tau. |
2020-09-28 |
2023-08-13 |
Not clear |
| Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. |
in transgenic mice overexpressing human tau with n279 k mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. |
2020-09-23 |
2023-08-13 |
mouse |
| Alejandro R Roda, Laia Montoliu-Gaya, Sandra Villega. The Role of Apolipoprotein E Isoforms in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-14. PMID:30775980. |
the current review compiles the involvement of apoe isoforms in amyloid-β protein precursor transcription, aβ aggregation and clearance, synaptic plasticity, neuroinflammation, lipid metabolism, mitochondrial function, and tau hyperphosphorylation. |
2020-07-14 |
2023-08-13 |
Not clear |
| Erica Acquarone, Elentina K Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D'Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorit. Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31248451. |
soluble aggregates of oligomeric forms of tau protein (otau) have been associated with impairment of synaptic plasticity and memory in alzheimer's disease. |
2020-06-23 |
2023-08-13 |
Not clear |
| R Loera-Valencia, A Cedazo-Minguez, P A Kenigsberg, G Page, A I Duarte, P Giusti, M Zusso, P Robert, G B Frisoni, A Cattaneo, M Zille, J Boltze, N Cartier, L Buee, G Johansson, B Winbla. Current and emerging avenues for Alzheimer's disease drug targets. Journal of internal medicine. vol 286. issue 4. 2020-05-25. PMID:31286586. |
we propose that ad could be tackled not only using combination therapies including aβ and tau, but also considering insulin and cholesterol metabolism, vascular function, synaptic plasticity, epigenetics, neurovascular junction and blood-brain barrier targets that have been studied recently. |
2020-05-25 |
2023-08-13 |
Not clear |
| Xiaolu Liu, Zhitao Feng, Lipeng Du, Yaguang Huang, Jinwen Ge, Yihui Deng, Zhigang Me. The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury. International journal of molecular sciences. vol 21. issue 1. 2020-05-07. PMID:31878035. |
paradoxically, mir-124 exerts beneficial effects in the age-related ie via regulating autophagy, neuroinflammation, oxidative stress, neuronal excitability, neurodifferentiation, aβ deposition, and hyperphosphorylation of tau protein, while it may play a dual role via regulating apoptosis and exerts detrimental effects on synaptic plasticity and axonal growth. |
2020-05-07 |
2023-08-13 |
Not clear |
| Jing Sun, Jingxuan Xu, Yi Ling, Fangyan Wang, Tianyu Gong, Changwei Yang, Shiqing Ye, Keyue Ye, Dianhui Wei, Ziqing Song, Danna Chen, Jiaming Li. Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice. Translational psychiatry. vol 9. issue 1. 2020-02-28. PMID:31383855. |
cognitive deficits, brain deposits of amyloid-β (aβ) and phosphorylation of tau, synaptic plasticity as well as neuroinflammation were assessed. |
2020-02-28 |
2023-08-13 |
mouse |
| Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T Corbett, Graham Fraser, Michael S Perkinton, Dominic M Walsh, Andrew Billinton, Michael J Rowa. Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo. Neurobiology of disease. vol 127. 2020-01-09. PMID:30910746. |
overall, these findings support the importance of cellular prion protein in mediating a range of, sometimes opposing, actions of soluble aß and tau aggregates with different effector mechanisms on synaptic plasticity. |
2020-01-09 |
2023-08-13 |
human |
| Neng-Wei Hu, Grant T Corbett, Steven Moore, Igor Klyubin, Tiernan T O'Malley, Dominic M Walsh, Frederick J Livesey, Michael J Rowa. Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity. Cell reports. vol 23. issue 7. 2019-12-02. PMID:29768194. |
extracellular forms of aβ and tau from ipsc models of alzheimer's disease disrupt synaptic plasticity. |
2019-12-02 |
2023-08-13 |
human |
| Stavros J Baloyanni. Brain capillaries in Alzheimer's disease. Hellenic journal of nuclear medicine. vol 18 Suppl 1. 2019-11-20. PMID:26665235. |
the neurotoxic properties of the oligomerics of the aβ-peptide and tau mediated neurodegeneration are among the main causative factors of impaired synaptic plasticity, neuronal loss, dendritic alterations and tremendous synaptic loss. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355631. |
cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau intracellular neurofibrillary tangles (nfts) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is alzheimer's disease (ad). |
2019-10-09 |
2023-08-13 |
rat |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355631. |
here we investigated the effect of different tau species on synaptic plasticity in the male rat hippocampus |
2019-10-09 |
2023-08-13 |
rat |
| Fabrizio Biundo, Dolores Del Prete, Hong Zhang, Ottavio Arancio, Luciano D'Adami. A role for tau in learning, memory and synaptic plasticity. Scientific reports. vol 8. issue 1. 2019-09-09. PMID:29453339. |
a role for tau in learning, memory and synaptic plasticity. |
2019-09-09 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabir, Abdullah Al Mamun, Mohamed M Abdel-Daim, George E Barreto, Ghulam Md Ashra. APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis. Molecular neurobiology. vol 56. issue 4. 2019-08-02. PMID:30032423. |
apoe has great influence in tau pathogenesis, tau-mediated neurodegeneration, and neuroinflammation, as well as α-synucleinopathy, lipid metabolism, and synaptic plasticity despite the presence of aβ pathology. |
2019-08-02 |
2023-08-13 |
Not clear |