| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles Métais, Kathryn Brennan, Alex J Mably, Michael Scott, Dominic M Walsh, Caroline E Herro. Simvastatin treatment preserves synaptic plasticity in AβPPswe/PS1dE9 mice. Journal of Alzheimer's disease : JAD. vol 39. issue 2. 2014-10-21. PMID:24164738. |
importantly, a diet supplemented with 0.04% simvastatin for one month (at 7 months) positively affected synaptic plasticity in aβppswe/ps1de9 mice and did not significantly alter levels of water-soluble, detergent-soluble, or fa-soluble aβ, but did increase phosphorylation of both akt and gsk-3, while tau and tau phosphorylation were unaltered. |
2014-10-21 |
2023-08-12 |
mouse |
| Manuela Polydoro, Volodymyr I Dzhala, Amy M Pooler, Samantha B Nicholls, A Patrick McKinney, Laura Sanchez, Rose Pitstick, George A Carlson, Kevin J Staley, Tara L Spires-Jones, Bradley T Hyma. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta neuropathologica. vol 127. issue 2. 2014-09-30. PMID:24271788. |
we show that the early tau lesions are associated with nearly normal performance in contextual fear conditioning, a hippocampal-related behavior task, but more robust changes in neuronal system activation as marked by arc induction and clear electrophysiological defects in perforant pathway synaptic plasticity. |
2014-09-30 |
2023-08-12 |
mouse |
| Tetsuya Kimura, Daniel J Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L Collingridge, Akihiko Takashima, Kwangwook Ch. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298146. |
to investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (ltd) in tau knockout mice in vivo and in vitro, an effect that was replicated by rnai knockdown of tau in vitro. |
2014-08-11 |
2023-08-12 |
mouse |
| Andrew B Wolf, Jon Valla, Guojun Bu, Jungsu Kim, Mary Jo LaDu, Eric M Reiman, Richard J Casell. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimer's research & therapy. vol 5. issue 5. 2014-06-24. PMID:23998393. |
particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. |
2014-06-24 |
2023-08-12 |
Not clear |
| Marie Lise Frandemiche, Sandrine De Seranno, Travis Rush, Eve Borel, Auréliane Elie, Isabelle Arnal, Fabien Lanté, Alain Buisso. Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 17. 2014-06-09. PMID:24760868. |
here, we report the implication of tau in the profound functional synaptic modification associated with synaptic plasticity. |
2014-06-09 |
2023-08-13 |
human |
| Adrian C Lo, Emilia Iscru, David Blum, Ina Tesseur, Zsuzsanna Callaerts-Vegh, Luc Buée, Bart De Strooper, Detlef Balschun, Rudi D'Hoog. Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 37. issue 1. 2014-04-08. PMID:23788007. |
amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of alzheimer's disease. |
2014-04-08 |
2023-08-12 |
mouse |
| Yaomin Chen, Bin Wang, Dan Liu, Jing Jing Li, Yueqiang Xue, Kazuko Sakata, Ling-qiang Zhu, Scott A Heldt, Huaxi Xu, Francesca-Fang Lia. Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 7. 2014-04-02. PMID:24523537. |
together, our findings identify a novel function of hsp90 inhibition in regulating synaptic plasticity, in addition to the known neuroprotective effects of the chaperones against aβ and tau toxicity, thus further supporting the potential of hsp90 inhibitors in treating neurodegenerative diseases. |
2014-04-02 |
2023-08-12 |
mouse |
| Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Paula I Moreira, Mariana C Acevedo-Aquino, Sylvain William. Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-02-19. PMID:23936615. |
here, we propose that phosphorylated tau protein could be playing the role of potential connector and, therefore, that a combined therapy involving antioxidants and check points for synaptic plasticity during early stages of the disease could become a viable therapeutic option for ad treatment. |
2014-02-19 |
2023-08-12 |
Not clear |
| Jose Abisambra, Umesh K Jinwal, Yoshinari Miyata, Justin Rogers, Laura Blair, Xiaokai Li, Sandlin P Seguin, Li Wang, Ying Jin, Justin Bacon, Sarah Brady, Matthew Cockman, Chantal Guidi, Juan Zhang, John Koren, Zapporah T Young, Christopher A Atkins, Bo Zhang, Lisa Y Lawson, Edwin J Weeber, Jeffrey L Brodsky, Jason E Gestwicki, Chad A Dicke. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. vol 74. issue 5. 2014-02-18. PMID:23607970. |
allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. |
2014-02-18 |
2023-08-12 |
Not clear |
| Jose Abisambra, Umesh K Jinwal, Yoshinari Miyata, Justin Rogers, Laura Blair, Xiaokai Li, Sandlin P Seguin, Li Wang, Ying Jin, Justin Bacon, Sarah Brady, Matthew Cockman, Chantal Guidi, Juan Zhang, John Koren, Zapporah T Young, Christopher A Atkins, Bo Zhang, Lisa Y Lawson, Edwin J Weeber, Jeffrey L Brodsky, Jason E Gestwicki, Chad A Dicke. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. vol 74. issue 5. 2014-02-18. PMID:23607970. |
one way to treat these disorders may be to reduce abnormal tau levels through chaperone manipulation, thus subverting synaptic plasticity defects caused by tau's toxic accretion. |
2014-02-18 |
2023-08-12 |
Not clear |
| Shaowu Cheng, Dongfeng Cao, David A Hottman, LiLian Yuan, Martin O Bergo, Ling L. Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. The Journal of biological chemistry. vol 288. issue 50. 2014-02-13. PMID:24136196. |
isoprenoids and prenylated proteins have been implicated in the pathophysiology of alzheimer disease (ad), including amyloid-β precursor protein metabolism, tau phosphorylation, synaptic plasticity, and neuroinflammation. |
2014-02-13 |
2023-08-12 |
mouse |
| Katja Hochgräfe, Astrid Sydow, Eva-Maria Mandelko. Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23517246. |
to link tau pathology to cognitive impairments and defects in synaptic plasticity, we created four inducible tau transgenic mouse models with expression of pro- and anti-aggregant variants of either full-length human tau (htau40/Δk280 and htau40/Δk280/pp) or the truncated tau repeat domain (tau(rd)/Δk280 and tau(rd)/Δk280/pp). |
2013-10-25 |
2023-08-12 |
mouse |
| Nibaldo C Inestrosa, Carla Montecinos-Oliva, Marco Fuenzalid. Wnt signaling: role in Alzheimer disease and schizophrenia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 4. 2013-05-24. PMID:23160851. |
in fact, disrupted wnt signaling may be a direct link between aβ-toxicity and tau hyperphosphorylation, ultimately leading to impaired synaptic plasticity and/or neuronal degeneration, indicating that a single pathway can account for both neuro-pathological lesions and altered synaptic function. |
2013-05-24 |
2023-08-12 |
Not clear |
| Alvaro O Ardiles, Cheril C Tapia-Rojas, Madhuchhanda Mandal, Frédéric Alexandre, Alfredo Kirkwood, Nibaldo C Inestrosa, Adrian G Palacio. Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 34. 2012-10-31. PMID:22869717. |
moreover, age-related changes in aβ oligomers and tau phosphorylation levels are correlated with decreases in spatial and object recognition memory, postsynaptic function, and synaptic plasticity. |
2012-10-31 |
2023-08-12 |
mouse |
| Ann Van der Jeugd, Katja Hochgräfe, Tariq Ahmed, Jochen M Decker, Astrid Sydow, Anne Hofmann, Dan Wu, Lars Messing, Detlef Balschun, Rudi D'Hooge, Eva-Maria Mandelko. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22532069. |
we correlated hippocampal tau pathology with learning/memory performance and synaptic plasticity. |
2012-09-24 |
2023-08-12 |
mouse |
| Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Jannic Boeh. Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22482074. |
with this in mind we will focus on the relationship of synaptic plasticity with aβ and tau protein and their role as potential targets for the development of therapeutic drugs. |
2012-08-23 |
2023-08-12 |
Not clear |
| Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Paula I Moreira, Sylvain William. Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target? International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22779025. |
with this in mind we will discuss the relationship of synaptic plasticity with gsk3 and tau protein and their role as potential targets for the development of therapeutic strategies. |
2012-08-23 |
2023-08-12 |
Not clear |
| Qian Chen, Zhou Zhou, Lei Zhang, Yuan Wang, Yan-wen Zhang, Min Zhong, Shang-cheng Xu, Chun-hai Chen, Li Li, Zheng-ping Y. Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22226842. |
however, the signaling pathways that couple tau protein to neuronal physiology such as synaptic plasticity have not yet been elucidated. |
2012-06-25 |
2023-08-12 |
rat |
| Qian Chen, Zhou Zhou, Lei Zhang, Yuan Wang, Yan-wen Zhang, Min Zhong, Shang-cheng Xu, Chun-hai Chen, Li Li, Zheng-ping Y. Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22226842. |
these results highlight a possible role for tau protein in the dynamic rearrangement of cytoskeletal fibers vital for bdnf-induced synaptic plasticity. |
2012-06-25 |
2023-08-12 |
rat |
| Ann Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Belarbi, Malika Hamdame, Marie-Eve Grosjean, Sandrine Humez, Detlef Balschun, David Blum, Luc Buée, Rudi D'Hoog. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of learning and memory. vol 95. issue 3. 2011-08-03. PMID:21167950. |
we evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in thy-tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. |
2011-08-03 |
2023-08-12 |
mouse |