| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Onno N Groeneveld, L Jaap Kappelle, Geert Jan Biessel. Potentials of incretin-based therapies in dementia and stroke in type 2 diabetes mellitus. Journal of diabetes investigation. vol 7. issue 1. 2016-10-24. PMID:26816596. |
experimental studies on alzheimer's disease have found beneficial effects of incretin-based therapies on cognition, synaptic plasticity and metabolism of amyloid-β and microtubule-associated protein tau. |
2016-10-24 |
2023-08-13 |
Not clear |
| Jada Lewis, Dennis W Dickso. Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta neuropathologica. vol 131. issue 1. 2016-09-29. PMID:26576562. |
the basis for the selective vulnerability of specific populations of neurons to tau pathology and cell death is largely unknown, although there have been a number of hypotheses based upon shared properties of vulnerable neurons (e.g., degree of axonal myelination or synaptic plasticity). |
2016-09-29 |
2023-08-13 |
human |
| Helen Wong, Josien Levenga, Peter Cain, Beverly Rothermel, Eric Klann, Charles Hoeffe. RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease. Acta neuropathologica. vol 130. issue 6. 2016-08-24. PMID:26497675. |
we show that brain-specific overexpression of the human rcan1.1s isoform in mice promotes early age-dependent memory and synaptic plasticity deficits, tau pathology, and dysregulation of dynamin-related protein 1 (drp1) activity associated with mitochondrial dysfunction and oxidative stress, reproducing key ad features. |
2016-08-24 |
2023-08-13 |
mouse |
| Yajing Peng, Mi Jin Kim, Rikki Hullinger, Kenneth J O'Riordan, Corinna Burger, Mariana Pehar, Luigi Pugliell. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26787453. |
specifically, we observed reduced levels of soluble amyloid-β aggregates, reduced amyloid-β pathology, reduced phosphorylation of tau, improved synaptic plasticity, and increased lifespan of the animals. |
2016-07-18 |
2023-08-13 |
mouse |
| Carla Letizia Busceti, Paola Di Pietro, Barbara Riozzi, Anna Traficante, Francesca Biagioni, Robert Nisticò, Francesco Fornai, Giuseppe Battaglia, Ferdinando Nicoletti, Valeria Brun. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological research. vol 99. 2016-06-13. PMID:26145279. |
5-ht(2c) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. |
2016-06-13 |
2023-08-13 |
mouse |
| Antonella Caccamo, Caterina Branca, Joshua S Talboom, Darren M Shaw, Dharshaun Turner, Luyao Ma, Angela Messina, Zebing Huang, Jie Wu, Salvatore Odd. Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 41. 2016-01-19. PMID:26468204. |
using a mouse model of ad, we found that genetic reduction of s6k1 improved synaptic plasticity and spatial memory deficits, and reduced the accumulation of amyloid-β and tau, the two neuropathological hallmarks of ad. |
2016-01-19 |
2023-08-13 |
mouse |
| María José Pérez, Rodrigo A Quintanill. Therapeutic Actions of the Thiazolidinediones in Alzheimer's Disease. PPAR research. vol 2015. 2015-11-20. PMID:26587016. |
furthermore, studies on animal models have shown that tzds inhibit neuroinflammation, facilitate amyloid-β plaque clearance, enhance mitochondrial function, improve synaptic plasticity, and, more recently, attenuate tau hyperphosphorylation. |
2015-11-20 |
2023-08-13 |
mouse |
| Tariq Ahmed, Ann Van der Jeugd, David Blum, Marie-Christine Galas, Rudi D'Hooge, Luc Buee, Detlef Balschu. Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion. Neurobiology of aging. vol 35. issue 11. 2015-10-19. PMID:24913895. |
cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion. |
2015-10-19 |
2023-08-13 |
mouse |
| Liliana Letra, Isabel Santana, Raquel Seiç. Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24553879. |
interestingly, extensive research on the central effects of leptin in alzheimer's disease-transgenic mice has demonstrated its capacity to enhance synaptic plasticity and strength, as well as to prevent beta-amyloid deposition and tau phosphorylation. |
2015-10-16 |
2023-08-12 |
mouse |
| Rafael Andres Posada-Duque, Alejandro López-Tobón, Diego Piedrahita, Christian González-Billault, Gloria Patricia Cardona-Gome. p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing. Journal of neurochemistry. vol 134. issue 2. 2015-09-14. PMID:25864429. |
cdk5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to tau hyperphosphorylation and cognitive impairment. |
2015-09-14 |
2023-08-13 |
mouse |
| Sophie Sokolow, Kristen M Henkins, Tina Bilousova, Bianca Gonzalez, Harry V Vinters, Carol A Miller, Lindsey Cornwell, Wayne W Poon, Karen H Gyly. Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25393609. |
the microtubule-associated protein tau has primarily been associated with axonal location and function; however, recent work shows tau release from neurons and suggests an important role for tau in synaptic plasticity. |
2015-06-22 |
2023-08-13 |
human |
| Sophie Sokolow, Kristen M Henkins, Tina Bilousova, Bianca Gonzalez, Harry V Vinters, Carol A Miller, Lindsey Cornwell, Wayne W Poon, Karen H Gyly. Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25393609. |
this study indicates that tau is normally highly localized to synaptic terminals in cortex where it is well-positioned to affect synaptic plasticity. |
2015-06-22 |
2023-08-13 |
human |
| Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson, Charles A Hoeffe. Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252661. |
tau pathology induces loss of gabaergic interneurons leading to altered synaptic plasticity and behavioral impairments. |
2015-03-31 |
2023-08-12 |
mouse |
| Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson, Charles A Hoeffe. Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252661. |
tauopathies are also associated with deficits in synaptic plasticity such as long-term potentiation (ltp), but the specific role of tau in the manifestation of these deficiencies is not well-understood. |
2015-03-31 |
2023-08-12 |
mouse |
| Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson, Charles A Hoeffe. Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252661. |
we examined long lasting forms of synaptic plasticity in jnpl3 (bl6) mice expressing mutant tau that is identified in some inherited ftds. |
2015-03-31 |
2023-08-12 |
mouse |
| Carolyn C Rudy, Holly C Hunsberger, Daniel S Weitzner, Miranda N Ree. The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease. Aging and disease. vol 6. issue 2. 2015-03-30. PMID:25821641. |
both aβ and tau alter synaptic plasticity, leading to synapse loss, neural network dysfunction, and eventually neuron loss. |
2015-03-30 |
2023-08-13 |
Not clear |
| Sudad Saman, Norman C Y Lee, Itoro Inoyo, Jun Jin, Zhihan Li, Thomas Doyle, Ann C McKee, Garth F Hal. Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24718102. |
by contrast, the involvement of synaptic plasticity and axonogenesis markers is highly specific to both tau and ad and may be relevant to the reactivation of developmental programs involving tau in ad and the recently demonstrated ability of secreted tau to establish tissue distribution gradients in cns neuropil. |
2015-01-16 |
2023-08-13 |
human |
| Ioannis Sotiropoulos, André T Lopes, Vitor Pinto, Sofia Lopes, Sara Carlos, Sara Duarte-Silva, Andreia Neves-Carvalho, Filipa Pinto-Ribeiro, Sara Pinheiro, Rui Fernandes, Armando Almeida, Nuno Sousa, Hugo Leite-Almeid. Selective impact of Tau loss on nociceptive primary afferents and pain sensation. Experimental neurology. vol 261. 2014-12-17. PMID:25079367. |
in physiological conditions, tau contributes to cytoskeletal dynamics and in this way, influences a number of cellular mechanisms including axonal trafficking, myelination and synaptic plasticity, processes that are also implicated in pain perception. |
2014-12-17 |
2023-08-13 |
mouse |
| Sungsu Lim, Md Mamunul Haque, Dohee Kim, Dong Jin Kim, Yun Kyung Ki. Cell-based Models To Investigate Tau Aggregation. Computational and structural biotechnology journal. vol 12. issue 20-21. 2014-12-16. PMID:25505502. |
tau is a neuron specific microtubule-associated protein that regulates microtubule stability, which is critical for axonal outgrowth and synaptic plasticity. |
2014-12-16 |
2023-08-13 |
Not clear |
| Yanxing Chen, Zhihou Liang, Zhu Tian, Julie Blanchard, Chun-Ling Dai, Sonia Chalbot, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23996345. |
we also observed an increase in tau hyperphosphorylation and neuroinflammation, a disturbance of brain insulin signaling, and a decrease in synaptic plasticity and amyloid β peptides in the brain after stz treatment. |
2014-10-27 |
2023-08-12 |
mouse |