All Relations between synaptic plasticity and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Syed Faraz Kazim, Abhijeet Sharma, Sivaprakasam R Saroja, Joon Ho Seo, Chloe S Larson, Aarthi Ramakrishnan, Minghui Wang, Robert D Blitzer, Li Shen, Catherine J Peña, John F Crary, Larissa A Shimoda, Bin Zhang, Eric J Nestler, Ana C Pereir. Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures. Biological psychiatry. 2021-09-24. PMID:34130857. chronic intermittent hypoxia enhances pathological tau seeding, propagation, and accumulation and exacerbates alzheimer-like memory and synaptic plasticity deficits and molecular signatures. 2021-09-24 2023-08-13 mouse
Syed Faraz Kazim, Abhijeet Sharma, Sivaprakasam R Saroja, Joon Ho Seo, Chloe S Larson, Aarthi Ramakrishnan, Minghui Wang, Robert D Blitzer, Li Shen, Catherine J Peña, John F Crary, Larissa A Shimoda, Bin Zhang, Eric J Nestler, Ana C Pereir. Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures. Biological psychiatry. 2021-09-24. PMID:34130857. this study was undertaken to evaluate the effect of cih on pathological human tau seeding, propagation, and accumulation; cognition; synaptic plasticity; neuronal network excitability; and gene expression profiles in a p301s human mutant tau mouse model of ad and related tauopathies. 2021-09-24 2023-08-13 mouse
Miranda Robbins, Emma Clayton, Gabriele S Kaminski Schierl. Synaptic tau: A pathological or physiological phenomenon? Acta neuropathologica communications. vol 9. issue 1. 2021-09-22. PMID:34503576. thus, we have seen a shift in the research focus from tau as a microtubule-stabilising protein in axons, to tau as a synaptic protein with roles in accelerating spine formation, dendritic elongation, and in synaptic plasticity coordinating memory pathways. 2021-09-22 2023-08-13 Not clear
Bin Zhao, Yi Wang, Rui Liu, Xiao-Li Jia, Nan Hu, Xing-Wei An, Chen-Guang Zheng, Chong Chen, Hong-Tao Sun, Feng Chen, Jing-Jing Wang, Xiao-Hong L. Rutaecarpine Ameliorated High Sucrose-Induced Alzheimer's Disease Like Pathological and Cognitive Impairments in Mice. Rejuvenation research. vol 24. issue 3. 2021-09-09. PMID:32892706. our results showed that rutaecarpine significantly attenuated high sucrose diet-induced spatial memory impairment and enhanced synaptic plasticity; rutaecarpine prevented high sucrose diet-induced tau hyperphosphorylation by decreasing glycogen synthase kinase-3β (gsk-3β) activity; activation of gsk-3β reversed the protective effect of rutaecarpine on learning and memory deficits, synaptic plasticity, and tau hyperphosphorylation induced by high-glucose diet significantly, suggesting that gsk-3β activation is required for high glucose-induced tau hyperphosphorylation. 2021-09-09 2023-08-13 mouse
Anjanet Loon, Frank Zamudio, Awa Sanneh, Breanna Brown, Shayna Smeltzer, Milene L Brownlow, Zainuddin Quadri, Melinda Peters, Edwin Weeber, Kevin Nash, Daniel C Lee, Marcia N Gordon, Dave Morgan, Maj-Linda B Selenic. Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice. GeroScience. 2021-08-19. PMID:34410588. accumulation of c-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice. 2021-08-19 2023-08-13 mouse
Burak Tan, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. N-methyl-D-aspartate receptor blockade reduces plasticity-related tau expression and phosphorylation of tau at Ser416 residue but not Thr231 residue. Experimental brain research. vol 239. issue 5. 2021-07-28. PMID:33768378. the molecular mechanisms regulating n-methyl-d-aspartate (nmda) receptor-dependent synaptic plasticity are complex, and the contribution of tau protein in the physiological process is not fully understood. 2021-07-28 2023-08-13 Not clear
Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jone. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European journal of neuroscience. vol 53. issue 2. 2021-06-28. PMID:33169893. we hypothesized that these mice would also display memory and hippocampal synaptic plasticity deficits as has been reported for many plaque bearing mouse models which express endogenous mouse tau. 2021-06-28 2023-08-13 mouse
Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubaméa, Stéphanie Chasseigneaux, Véronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnès Dodacki, Salvatore Cisternino, Xavier Declèves, Fanchon Bourasse. Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration. Neuropharmacology. vol 191. 2021-06-23. PMID:33940010. the inducible p25 overexpression mouse model recapitulate many hallmark features of alzheimer's disase including progressive neuronal loss, elevated aβ, tau pathology, cognitive dysfunction, and impaired synaptic plasticity. 2021-06-23 2023-08-13 mouse
Marangelie Criado-Marrero, Niat T Gebru, Lauren A Gould, Danielle M Blazier, Yamile Vidal-Aguiar, Taylor M Smith, Salma S Abdelmaboud, Lindsey B Shelton, Xinming Wang, Jan Dahrendorff, David Beaulieu-Abdelahad, Chad A Dickey, Laura J Blai. FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model. NPJ aging and mechanisms of disease. vol 7. issue 1. 2021-05-07. PMID:33941782. we examined hippocampal-dependent memory, synaptic plasticity, tau phosphorylation status, and neuronal health. 2021-05-07 2023-08-13 mouse
Magdalena Gąssowska-Dobrowolska, Agnieszka Kolasa-Wołosiuk, Magdalena Cieślik, Agnieszka Dominiak, Kristina Friedland, Agata Adamczy. Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33809910. the observed changes in tau protein together with an excessive decrease in α/β-tubulin level may suggest destabilization and thus dysfunction of the mt cytoskeleton network, which in consequence may lead to the disturbance in synaptic plasticity and the development of autistic-like behaviours. 2021-04-30 2023-08-13 rat
Anna Pensalfini, Seonil Kim, Shivakumar Subbanna, Cynthia Bleiwas, Chris N Goulbourne, Philip H Stavrides, Ying Jiang, Ju-Hyun Lee, Sandipkumar Darji, Monika Pawlik, Chunfeng Huo, James Peddy, Martin J Berg, John F Smiley, Balapal S Basavarajappa, Ralph A Nixo. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell reports. vol 33. issue 8. 2021-04-26. PMID:33238112. modest neuron-specific transgenic rab5 expression inducing hyperactivation of rab5 comparable to that in ad brain reproduces ad-related rab5-endosomal enlargement and mistrafficking, hippocampal synaptic plasticity deficits via accelerated ampar endocytosis and dendritic spine loss, and tau hyperphosphorylation via activated glycogen synthase kinase-3β. 2021-04-26 2023-08-13 mouse
Vidyasagar Naik Bukke, Moola Archana, Rosanna Villani, Antonino Davide Romano, Agata Wawrzyniak, Krzysztof Balawender, Stanislaw Orkisz, Sarah Beggiato, Gaetano Serviddio, Tommaso Cassan. The Dual Role of Glutamatergic Neurotransmission in Alzheimer's Disease: From Pathophysiology to Pharmacotherapy. International journal of molecular sciences. vol 21. issue 20. 2021-02-26. PMID:33050345. alzheimer's disease (ad) is an age-related dementia and neurodegenerative disorder, characterized by aβ and tau protein deposition impairing learning, memory and suppressing synaptic plasticity of neurons. 2021-02-26 2023-08-13 Not clear
Mohammad Saeedi, Ali Rashidy-Pou. Association between chronic stress and Alzheimer's disease: Therapeutic effects of Saffron. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-24. PMID:33232931. the inhibitory actions on acetylcholinesterase activity, aggregation of beta-amyloid protein into amyloid plaques and tau protein into neurofibrillary tangles, and also the antioxidant, anti-inflammatory, and the promotion of synaptic plasticity effects are among the possible mechanisms to explain the neuroprotective effects of saffron. 2021-02-24 2023-08-13 Not clear
Daniela Puzzo, Elentina K Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa', Domenica D Li Puma, Claudio Grassi, Luciano D'Adamio, Nicholas M Kanaan, Paul E Fraser, Ottavio Aranci. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544084. here, using a multidisciplinary approach combining molecular biological, biochemical, histopathological, electrophysiological, and behavioral methods, we demonstrated that tau suppression did not protect against aβ-induced damage of long-term synaptic plasticity and memory, or from amyloid deposition. 2021-02-08 2023-08-13 mouse
Daniela Puzzo, Elentina K Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa', Domenica D Li Puma, Claudio Grassi, Luciano D'Adamio, Nicholas M Kanaan, Paul E Fraser, Ottavio Aranci. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544084. similarly, tau suppression did not protect against exogenous oligomeric tau-induced impairment of long-term synaptic plasticity and memory. 2021-02-08 2023-08-13 mouse
Sara Momtazmanesh, George Perry, Nima Rezae. Toll-like receptors in Alzheimer's disease. Journal of neuroimmunology. vol 348. 2020-12-14. PMID:32858428. signaling of tlrs affects the core of ad changes, including synaptic plasticity, microglial activity, tau phosphorylation, and inflammatory responses. 2020-12-14 2023-08-13 Not clear
Yali Jia, Ning Cao, Jinglei Zhai, Quan Zeng, Pei Zheng, Ruyu Su, Tuling Liao, Jiajing Liu, Haiyun Pei, Zeng Fan, Junnian Zhou, Jiafei Xi, Lijuan He, Lin Chen, Xue Nan, Wen Yue, Xuetao Pe. HGF Mediates Clinical-Grade Human Umbilical Cord-Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence-Accelerated Mouse Model of Alzheimer's Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 7. issue 17. 2020-10-02. PMID:32995116. a functional assay identifies that the core functional factor hepatocyte growth factor (hgf) secreted from huc-mscs plays critical roles in huc-msc-modulated recovery of damaged neural cells by down-regulating hyperphosphorylated tau, reversing spine loss, and promoting synaptic plasticity in an ad cell model. 2020-10-02 2023-08-13 mouse
Jian Bao, Yacoubou A R Mahaman, Rong Liu, Jian-Zhi Wang, Zhiguo Zhang, Bin Zhang, Xiaochuan Wan. Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD. Frontiers in aging neuroscience. vol 9. 2020-09-29. PMID:29163130. we also found tau hyperphosphorylation, an increase of aβ40/42 as well as increase in both gsk-3β and bace1 activities, while a loss of dendritic and synaptic plasticity was observed in the male stz rats. 2020-09-29 2023-08-13 rat
Athanasia K Papazafiropoulou, Chris Koros, Andreas Melidonis, Stavros Antonopoulo. Diabetes and dementia - the two faces of Janus. Archives of medical sciences. Atherosclerotic diseases. vol 5. 2020-09-28. PMID:32832719. in addition, experimental studies on patients with diabetes and alzheimer's disease have shown beneficial effects on synaptic plasticity, metabolism of amyloid-β, and microtubule-associated protein tau. 2020-09-28 2023-08-13 Not clear
Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. in transgenic mice overexpressing human tau with n279 k mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. 2020-09-23 2023-08-13 mouse