| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stepan Lerner, Tatiana Karelin. Quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109086. |
quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. |
2022-02-03 |
2023-08-13 |
Not clear |
| Stepan Lerner, Tatiana Karelin. Quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109086. |
quantitative systems pharmacology (qsp) model of synaptic plasticity was developed to investigate influence of tau hyperphosphorylation on impairment of ltp. |
2022-02-03 |
2023-08-13 |
Not clear |
| Nicole P Kasica, Xueyan Zhou, Qian Yang, Xin Wang, Wenzhong Yang, Helena R Zimmermann, Caroline E Holland, Elizabeth Koscielniak, Hanzhi Wu, Anderson O Cox, Jingyun Lee, Alexey G Ryazanov, Cristina M Furdui, Tao M. Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice. Journal of neurochemistry. 2021-12-21. PMID:34932218. |
our data revealed that treatment with eef2k inhibitors improved ad-associated synaptic plasticity impairments and cognitive dysfunction, without altering brain amyloid β (aβ) and tau pathology. |
2021-12-21 |
2023-08-13 |
mouse |
| Lei Xia, Yayan Pang, Junjie Li, Bin Wu, Yehong Du, Yuxin Chen, Man Luo, Yan Wang, Zhifang Don. Dihydroartemisinin Induces O-GlcNAcylation and Improves Cognitive Function in a Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. vol 84. issue 1. 2021-12-10. PMID:34511503. |
hyperphosphorylation modification promotes tau protein misfolding and aggregation into neurofibrillary tangles, leading to impairments of synaptic plasticity and learning and memory. |
2021-12-10 |
2023-08-13 |
mouse |
| Guiping Wang, Huan-Huan Zhou, Lan Luo, Li-Qiang Qin, Jieyun Yin, Zengli Yu, Lin Zhang, Zhongxiao Wa. Voluntary wheel running is capable of improving cognitive function only in the young but not the middle-aged male APPSwe/PS1De9 mice. Neurochemistry international. vol 145. 2021-11-18. PMID:33684544. |
this might be owing to that in young app/ps1 mice voluntary exercise reduced tau phosphorylation via inhibiting p-gsk3β activity, as well as reduced neuro-inflammation and elevated key proteins involved in synaptic plasticity. |
2021-11-18 |
2023-08-13 |
mouse |
| Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. |
importantly, p2x7 deletion ultimately rescued synaptic plasticity and memory impairments of tau mice. |
2021-11-11 |
2023-08-13 |
mouse |
| Mascia Amici, Yeseul Lee, Robert J P Pope, Clarrisa A Bradley, Adam Cole, Graham L Collingridg. GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα. The European journal of neuroscience. vol 54. issue 8. 2021-11-03. PMID:32463939. |
in this context, gsk-3β plays a role in the induction of nmda receptor-dependent long-term depression (ltd) and several substrates for gsk-3β have been identified in this form of synaptic plasticity, including klc-2, psd-95 and tau. |
2021-11-03 |
2023-08-13 |
rat |
| b' Elisabetta Lauretti, Konrad Dabrowski, Domenico Pratic\\xc3\\xb. The neurobiology of non-coding RNAs and Alzheimer\'s disease pathogenesis: Pathways, mechanisms and translational opportunities. Ageing research reviews. vol 71. 2021-10-11. PMID:34384901.' |
although the mechanisms are still not fully elucidated, studies have revealed that these highly conserved ncrnas are important modulators of gene expression, amyloid-β production, tau phosphorylation, inflammation, synaptic plasticity and neuronal survival, all features considered central to ad pathogenesis. |
2021-10-11 |
2023-08-13 |
mouse |
| Syed Faraz Kazim, Abhijeet Sharma, Sivaprakasam R Saroja, Joon Ho Seo, Chloe S Larson, Aarthi Ramakrishnan, Minghui Wang, Robert D Blitzer, Li Shen, Catherine J Peña, John F Crary, Larissa A Shimoda, Bin Zhang, Eric J Nestler, Ana C Pereir. Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures. Biological psychiatry. 2021-09-24. PMID:34130857. |
chronic intermittent hypoxia enhances pathological tau seeding, propagation, and accumulation and exacerbates alzheimer-like memory and synaptic plasticity deficits and molecular signatures. |
2021-09-24 |
2023-08-13 |
mouse |
| Syed Faraz Kazim, Abhijeet Sharma, Sivaprakasam R Saroja, Joon Ho Seo, Chloe S Larson, Aarthi Ramakrishnan, Minghui Wang, Robert D Blitzer, Li Shen, Catherine J Peña, John F Crary, Larissa A Shimoda, Bin Zhang, Eric J Nestler, Ana C Pereir. Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures. Biological psychiatry. 2021-09-24. PMID:34130857. |
this study was undertaken to evaluate the effect of cih on pathological human tau seeding, propagation, and accumulation; cognition; synaptic plasticity; neuronal network excitability; and gene expression profiles in a p301s human mutant tau mouse model of ad and related tauopathies. |
2021-09-24 |
2023-08-13 |
mouse |
| Miranda Robbins, Emma Clayton, Gabriele S Kaminski Schierl. Synaptic tau: A pathological or physiological phenomenon? Acta neuropathologica communications. vol 9. issue 1. 2021-09-22. PMID:34503576. |
thus, we have seen a shift in the research focus from tau as a microtubule-stabilising protein in axons, to tau as a synaptic protein with roles in accelerating spine formation, dendritic elongation, and in synaptic plasticity coordinating memory pathways. |
2021-09-22 |
2023-08-13 |
Not clear |
| Bin Zhao, Yi Wang, Rui Liu, Xiao-Li Jia, Nan Hu, Xing-Wei An, Chen-Guang Zheng, Chong Chen, Hong-Tao Sun, Feng Chen, Jing-Jing Wang, Xiao-Hong L. Rutaecarpine Ameliorated High Sucrose-Induced Alzheimer's Disease Like Pathological and Cognitive Impairments in Mice. Rejuvenation research. vol 24. issue 3. 2021-09-09. PMID:32892706. |
our results showed that rutaecarpine significantly attenuated high sucrose diet-induced spatial memory impairment and enhanced synaptic plasticity; rutaecarpine prevented high sucrose diet-induced tau hyperphosphorylation by decreasing glycogen synthase kinase-3β (gsk-3β) activity; activation of gsk-3β reversed the protective effect of rutaecarpine on learning and memory deficits, synaptic plasticity, and tau hyperphosphorylation induced by high-glucose diet significantly, suggesting that gsk-3β activation is required for high glucose-induced tau hyperphosphorylation. |
2021-09-09 |
2023-08-13 |
mouse |
| Anjanet Loon, Frank Zamudio, Awa Sanneh, Breanna Brown, Shayna Smeltzer, Milene L Brownlow, Zainuddin Quadri, Melinda Peters, Edwin Weeber, Kevin Nash, Daniel C Lee, Marcia N Gordon, Dave Morgan, Maj-Linda B Selenic. Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice. GeroScience. 2021-08-19. PMID:34410588. |
accumulation of c-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice. |
2021-08-19 |
2023-08-13 |
mouse |
| Burak Tan, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. N-methyl-D-aspartate receptor blockade reduces plasticity-related tau expression and phosphorylation of tau at Ser416 residue but not Thr231 residue. Experimental brain research. vol 239. issue 5. 2021-07-28. PMID:33768378. |
the molecular mechanisms regulating n-methyl-d-aspartate (nmda) receptor-dependent synaptic plasticity are complex, and the contribution of tau protein in the physiological process is not fully understood. |
2021-07-28 |
2023-08-13 |
Not clear |
| Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jone. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European journal of neuroscience. vol 53. issue 2. 2021-06-28. PMID:33169893. |
we hypothesized that these mice would also display memory and hippocampal synaptic plasticity deficits as has been reported for many plaque bearing mouse models which express endogenous mouse tau. |
2021-06-28 |
2023-08-13 |
mouse |
| Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubaméa, Stéphanie Chasseigneaux, Véronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnès Dodacki, Salvatore Cisternino, Xavier Declèves, Fanchon Bourasse. Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration. Neuropharmacology. vol 191. 2021-06-23. PMID:33940010. |
the inducible p25 overexpression mouse model recapitulate many hallmark features of alzheimer's disase including progressive neuronal loss, elevated aβ, tau pathology, cognitive dysfunction, and impaired synaptic plasticity. |
2021-06-23 |
2023-08-13 |
mouse |
| Marangelie Criado-Marrero, Niat T Gebru, Lauren A Gould, Danielle M Blazier, Yamile Vidal-Aguiar, Taylor M Smith, Salma S Abdelmaboud, Lindsey B Shelton, Xinming Wang, Jan Dahrendorff, David Beaulieu-Abdelahad, Chad A Dickey, Laura J Blai. FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model. NPJ aging and mechanisms of disease. vol 7. issue 1. 2021-05-07. PMID:33941782. |
we examined hippocampal-dependent memory, synaptic plasticity, tau phosphorylation status, and neuronal health. |
2021-05-07 |
2023-08-13 |
mouse |
| Magdalena Gąssowska-Dobrowolska, Agnieszka Kolasa-Wołosiuk, Magdalena Cieślik, Agnieszka Dominiak, Kristina Friedland, Agata Adamczy. Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33809910. |
the observed changes in tau protein together with an excessive decrease in α/β-tubulin level may suggest destabilization and thus dysfunction of the mt cytoskeleton network, which in consequence may lead to the disturbance in synaptic plasticity and the development of autistic-like behaviours. |
2021-04-30 |
2023-08-13 |
rat |
| Anna Pensalfini, Seonil Kim, Shivakumar Subbanna, Cynthia Bleiwas, Chris N Goulbourne, Philip H Stavrides, Ying Jiang, Ju-Hyun Lee, Sandipkumar Darji, Monika Pawlik, Chunfeng Huo, James Peddy, Martin J Berg, John F Smiley, Balapal S Basavarajappa, Ralph A Nixo. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell reports. vol 33. issue 8. 2021-04-26. PMID:33238112. |
modest neuron-specific transgenic rab5 expression inducing hyperactivation of rab5 comparable to that in ad brain reproduces ad-related rab5-endosomal enlargement and mistrafficking, hippocampal synaptic plasticity deficits via accelerated ampar endocytosis and dendritic spine loss, and tau hyperphosphorylation via activated glycogen synthase kinase-3β. |
2021-04-26 |
2023-08-13 |
mouse |
| Vidyasagar Naik Bukke, Moola Archana, Rosanna Villani, Antonino Davide Romano, Agata Wawrzyniak, Krzysztof Balawender, Stanislaw Orkisz, Sarah Beggiato, Gaetano Serviddio, Tommaso Cassan. The Dual Role of Glutamatergic Neurotransmission in Alzheimer's Disease: From Pathophysiology to Pharmacotherapy. International journal of molecular sciences. vol 21. issue 20. 2021-02-26. PMID:33050345. |
alzheimer's disease (ad) is an age-related dementia and neurodegenerative disorder, characterized by aβ and tau protein deposition impairing learning, memory and suppressing synaptic plasticity of neurons. |
2021-02-26 |
2023-08-13 |
Not clear |