| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Burak Tan, Esra Tufan, Özlem Barutçu, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. Physiology international. 2024-03-04. PMID:38436684. |
the aim of this study is to show the relationship between the change in the strengthening of synaptic plasticity and tau phosphorylation and tau-kinases and phosphatase. |
2024-03-04 |
2024-03-06 |
Not clear |
| Burak Tan, Esra Tufan, Özlem Barutçu, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. Physiology international. 2024-03-04. PMID:38436684. |
if the increase in phosphorylation of tau cannot be prevented, together with inhibition of the subsequent ltp, this may indicate that the physiological role of hyperphosphorylated tau in synaptic plasticity may extend to pathological processes. |
2024-03-04 |
2024-03-06 |
Not clear |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. The Journal of clinical investigation. vol 134. issue 3. 2024-02-01. PMID:38299587. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2024-02-01 |
2024-02-03 |
mouse |
| Daniel P Chapman, Sarah D Power, Stefano Vicini, Tomás J Ryan, Mark P Burn. Amnesia after repeated head impact is caused by impaired synaptic plasticity in the memory engram. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-01-16. PMID:38228367. |
in sham mice the hippocampal engram neurons exhibited synaptic plasticity, evident in amplified ampa:nmda ratio, enhanced ampa-weighted tau, and increased dendritic spine volume compared to non-engram neurons. |
2024-01-16 |
2024-01-19 |
mouse |
| Hana Baek, Sanjay, Miey Park, Hae-Jeung Le. Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model. Journal of neuroinflammation. vol 20. issue 1. 2023-11-18. PMID:37978414. |
however, as the effects of c3g on the amyloidogenic pathway, autophagy, tau phosphorylation, neuronal cell death, and synaptic plasticity in alzheimer's disease models have not been reported, we attempted to investigate the same in the brains of appswe/ps1Δe9 mice were analyzed. |
2023-11-18 |
2023-11-20 |
mouse |
| Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Ca. High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy. Experimental neurology. 2023-10-28. PMID:37898395. |
hfd may reduce synaptic plasticity and cause tau hyperphosphorylation, but the mechanisms involved remain unclear. |
2023-10-28 |
2023-11-08 |
mouse |
| Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. |
furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. |
2023-09-18 |
2023-10-07 |
Not clear |
| Pinky, Neha, Mubashshir Ali, Prachi Tiwari, Mohammad Mumtaz Alam, Haroonrashid M Hattiwale, Azfar Jamal, Suhel Parve. Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer's Disease: Critical role of the restoration of neuronal circuits. Ageing research reviews. 2023-09-11. PMID:37696304. |
increasing evidence suggests that ros may affect many pathological aspects of ad, including aβ accumulation, tau hyperphosphorylation, synaptic plasticity, and mitochondrial dysfunction, which may collectively result in neurodegeneration in the brain. |
2023-09-11 |
2023-10-07 |
Not clear |
| Seong Sool Shim, Ken Berglund, Shan Ping Y. Lithium: An Old Drug for New Therapeutic Strategy for Alzheimer's Disease and Related Dementia. Neuro-degenerative diseases. 2023-09-04. PMID:37666228. |
the diverse lines of evidence have revealed that lithium reduces amyloid and tau pathology, attenuates neuronal loss, enhances synaptic plasticity and improves cognitive function. |
2023-09-04 |
2023-09-07 |
Not clear |
| Yaoyao Ren, Shengtao Q. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023-08-24. PMID:37619620. |
these isoflavones prevent aβ aggregation, inhibit tau hyperphosphorylation, increase cholinergic neurotransmitter levels, reduce neuroinflammation and oxidative stress, improve synaptic plasticity, promote nerve regeneration, and prevent apoptosis. |
2023-08-24 |
2023-09-07 |
Not clear |
| Faisal Holil AlAnazi, Hayder M Al-Kuraishy, Athanasios Alexiou, Marios Papadakis, Mohamed H Mazhar Ashour, Saud A Alnaaim, Omnya Elhussieny, Hebatallah M Saad, Gaber El-Saber Batih. Primary Hypothyroidism and Alzheimer's Disease: A Tale of Two. Cellular and molecular neurobiology. 2023-08-04. PMID:37540395. |
hpt promotes the progression of ad by inducing the production of amyloid beta (aβ) and tau protein phosphorylation with the development of synaptic plasticity and memory dysfunction. |
2023-08-04 |
2023-08-14 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andrew Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowa. Tau and Aß in patient-derived aqueous brain extracts act concomitantly to disrupt LTP The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-25. PMID:37491315. |
here, we explore how intracerebral injection of aß and tau present in such aqueous extracts of patient brain contribute to disruption of synaptic plasticity in the ca1 area of the male rat hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andrew Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowa. Tau and Aß in patient-derived aqueous brain extracts act concomitantly to disrupt LTP The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-25. PMID:37491315. |
these findings support a critical role for diffusible tau in causing rapid onset, persistent synaptic plasticity deficits and in promoting aß-mediated synaptic dysfunction. |
2023-07-25 |
2023-08-14 |
rat |
| Junkai Xie, Shichen Wu, Hailey Szadowski, Sehong Min, Yang Yang, Aaron B Bowman, Jean-Christophe Rochet, Jennifer L Freeman, Chongli Yua. Developmental Pb exposure increases AD risk via altered intracellular Ca The Journal of biological chemistry. 2023-07-09. PMID:37423307. |
differentiated neurons exhibit altered calcium homeostasis, synaptic plasticity, epigenetic landscape along with elevated ad-like pathogenesis markers, including phosphorylated tau, tau aggregates and aβ42/40. |
2023-07-09 |
2023-08-14 |
human |
| Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim, YoungSoo Ki. Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407605. |
however, the drug seems to alleviate the key alzheimer-like phenotypes induced by aβ aggregation as we found attenuated neuroinflammation, improved post-synaptic density expression, associated with synaptic plasticity, and decreased phosphorylated tau levels. |
2023-07-05 |
2023-08-14 |
mouse |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398236. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2023-07-03 |
2023-08-14 |
mouse |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398236. |
instead, we find that ct-kibra binds to and stabilizes protein kinase mζ (pkmζ) to maintain synaptic plasticity and memory despite tau mediated pathogenesis. |
2023-07-03 |
2023-08-14 |
mouse |
| Bakhtiarzadeh Fatemeh, Shahpasand Koorosh, Shojaei Amir, Fathollahi Yaghoub, Mirnajafi-Zadeh Java. Intra-hippocampal cis-P tau microinjection induces long-term changes in behavior and synaptic plasticity in mice. Behavioral and brain functions : BBF. vol 19. issue 1. 2023-05-25. PMID:37231523. |
intra-hippocampal cis-p tau microinjection induces long-term changes in behavior and synaptic plasticity in mice. |
2023-05-25 |
2023-08-14 |
mouse |
| Maya Jammoul, Dareen Jammoul, Kevin K Wang, Firas Kobeissy, Ralph G Depalm. Traumatic Brain Injury and Opioids: Twin Plagues of the Twenty-First Century. Biological psychiatry. 2023-05-22. PMID:37217015. |
we examine the hypothesis that a tbi "first hit" induces a neuroinflammatory process involving microglial priming, which upon a "second hit"-related to opioid exposure-, exacerbates neuroinflammation, modifies synaptic plasticity, and spreads tau aggregates to promote neurodegeneration. |
2023-05-22 |
2023-08-14 |
Not clear |
| Carola Tapia-Monsalves, Margrethe A Olesen, Francisca Villavicencio-Tejo, Rodrigo A Quintanill. Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3. Molecular and cellular neurosciences. 2023-05-14. PMID:37182572. |
these tau forms affect synaptic plasticity contributing to the cognitive decline observed in the early stages of ad. |
2023-05-14 |
2023-08-14 |
mouse |