All Relations between synaptic plasticity and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Gerald Schmid, Joanna B Strosznajder, Józefa Wesierska-Gade. Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors. Molecular neurobiology. vol 34. issue 1. 2009-02-12. PMID:17003520. the proper phosphorylation of the most important substrates, such as tau protein and neurofilament h, is essential for the correct regulation of the cytoskeletal organization, thereby regulating cell adhesion, motility, and synaptic plasticity. 2009-02-12 2023-08-12 Not clear
Stephen M Fitzjohn, Andrew J Doherty, Graham L Collingridg. The use of the hippocampal slice preparation in the study of Alzheimer's disease. European journal of pharmacology. vol 585. issue 1. 2008-10-31. PMID:18423442. (v) the discovery of a role of glycogen synthase kinase-3beta (tau kinase) in synaptic plasticity. 2008-10-31 2023-08-12 Not clear
I Dewachter, L Ris, S Croes, P Borghgraef, H Devijver, T Voets, B Nilius, E Godaux, F Van Leuve. Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1. Neurobiology of aging. vol 29. issue 5. 2008-04-28. PMID:17222948. modulation of synaptic plasticity and tau phosphorylation by wild-type and mutant presenilin1. 2008-04-28 2023-08-12 mouse
Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. the formation of hyperphosphorylated tau protein may impair learning and the synaptic plasticity of neurons. 2007-02-20 2023-08-12 Not clear
Jürgen Götz, Lars M Ittner, Stefan Kin. Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease? Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16787410. the overall picture is that key players in ad, such as tau, app and ps, perturb axonal transport early on in ad, causing impaired synaptic plasticity and reducing survival rates. 2006-09-21 2023-08-12 mouse
W Härtig, M Oklejewicz, A M Strijkstra, A S Boerema, J Stieler, T Arend. Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging. Brain research. vol 1056. issue 1. 2005-11-21. PMID:16095576. the hippocampal ca3 region, a brain region with a high degree of synaptic plasticity, is known to be strongly involved in tau hyperphosphorylation in several neurodegenerative diseases. 2005-11-21 2023-08-12 Not clear
W Härtig, M Oklejewicz, A M Strijkstra, A S Boerema, J Stieler, T Arend. Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging. Brain research. vol 1056. issue 1. 2005-11-21. PMID:16095576. these findings implicate an additional link between aging, tau phosphorylation and synaptic plasticity. 2005-11-21 2023-08-12 Not clear
Thomas Arend. Neurodegeneration and plasticity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465280. failures of synaptic plasticity are, thus, assumed to represent early events in the course of ad that eventually lead to alteration of tau phosphorylation. 2004-12-15 2023-08-12 Not clear
Thomas Arend. Neurodegeneration and plasticity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465280. recently, we have used the hibernation cycle, a physiological model of adaptation associated with an extraordinary high degree of structural neuronal plasticity, to analyze the potential link between synaptic plasticity, synaptic detachment and the regulation of tau phosphorylation. 2004-12-15 2023-08-12 Not clear
Alexei R Koudinov, Natalia V Koudinov. Cholesterol, synaptic function and Alzheimer's disease. Pharmacopsychiatry. vol 36 Suppl 2. 2003-12-10. PMID:14574623. moreover, changes in the neurochemistry of amyloid beta, tau, neuronal cytoskeleton, and oxidative stress reactions due to alzheimer's likely represent physiological transitory mechanisms that aim to compensate impaired brain cholesterol dynamics and/or associated neurotransmission and synaptic plasticity failure. 2003-12-10 2023-08-12 rat
Makoto Michikaw. The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid beta-protein and cholesterol. Molecular neurobiology. vol 27. issue 1. 2003-05-30. PMID:12668899. all these findings suggest that the involvement of cholesterol in the pathogenesis of ad is dualistic-it is involved in abeta generation and in the amyloid cascade, leading to disruption of synaptic plasticity, promotion of tau phosphorylation, and eventual neurodegeneration. 2003-05-30 2023-08-12 Not clear
Qing Tian, Jianzhi Wan. Role of serine/threonine protein phosphatase in Alzheimer's disease. Neuro-Signals. vol 11. issue 5. 2003-03-27. PMID:12566927. the general characteristics and pathologic changes of pp1, pp2a and pp2b in ad, and their relations with microtubule-associated proteins, focusing mainly on tau protein, neurofilament (nf), amyloid precursor protein (app) processing and synaptic plasticity are discussed. 2003-03-27 2023-08-12 Not clear