| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olivia A Shipton, Julie R Leitz, Jenny Dworzak, Christine E J Acton, Elizabeth M Tunbridge, Franziska Denk, Hana N Dawson, Michael P Vitek, Richard Wade-Martins, Ole Paulsen, Mariana Vargas-Caballer. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 5. 2011-04-01. PMID:21289177. |
together, these findings show that tau protein is required for aβ to impair synaptic plasticity in the hippocampus and suggest that the aβ-induced impairment of ltp is mediated by tau phosphorylation. |
2011-04-01 |
2023-08-12 |
mouse |
| Astrid Sydow, Ann Van der Jeugd, Fang Zheng, Tariq Ahmed, Detlef Balschun, Olga Petrova, Dagmar Drexler, Lepu Zhou, Gabriele Rune, Eckhard Mandelkow, Rudi D'Hooge, Christian Alzheimer, Eva-Maria Mandelko. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 7. 2011-04-01. PMID:21325519. |
tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic tau mutant. |
2011-04-01 |
2023-08-12 |
mouse |
| Astrid Sydow, Ann Van der Jeugd, Fang Zheng, Tariq Ahmed, Detlef Balschun, Olga Petrova, Dagmar Drexler, Lepu Zhou, Gabriele Rune, Eckhard Mandelkow, Rudi D'Hooge, Christian Alzheimer, Eva-Maria Mandelko. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 7. 2011-04-01. PMID:21325519. |
we now tested the mice with regard to neuromotor parameters, behavior, learning and memory, and synaptic plasticity and correlated this with histological and biochemical parameters in different stages of switching tau(rd) on or off. |
2011-04-01 |
2023-08-12 |
mouse |
| Miguel Medina, Jesús Avil. Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease. Current pharmaceutical design. vol 16. issue 25. 2011-02-08. PMID:20698823. |
besides having been identified as the major tau protein kinase, gsk-3 mediates aβ neurotoxicity, plays an essential role in synaptic plasticity and memory, might be involved in aβ formation, and it has an important role in inflammation and neuronal survival, all key features of ad neuropathology. |
2011-02-08 |
2023-08-12 |
Not clear |
| Niklas Mattsson, Karin Sävman, Gustaf Osterlundh, Kaj Blennow, Henrik Zetterber. Converging molecular pathways in human neural development and degeneration. Neuroscience research. vol 66. issue 3. 2010-06-07. PMID:19961883. |
animal studies suggest that phosphorylation of microtubule-associated protein tau is a physiological way of destabilizing axons in the developing brain, promoting synaptic plasticity, while in the adult human brain tau phosphorylation is a specific sign of alzheimer's disease. |
2010-06-07 |
2023-08-12 |
human |
| Lenka Munoz, Alaina J Ammi. Targeting p38 MAPK pathway for the treatment of Alzheimer's disease. Neuropharmacology. vol 58. issue 3. 2010-04-07. PMID:19951717. |
however, deepening insight into the underlying biology of alzheimer's disease reveals that p38 mapk operates in other events related to ad, such as excitotoxicity, synaptic plasticity and tau phosphorylation. |
2010-04-07 |
2023-08-12 |
Not clear |
| Jungsu Kim, Jacob M Basak, David M Holtzma. The role of apolipoprotein E in Alzheimer's disease. Neuron. vol 63. issue 3. 2009-08-28. PMID:19679070. |
other potential mechanisms, such as the differential modulation of neurotoxicity and tau phosphorylation by apoe isoforms as well as its role in synaptic plasticity and neuroinflammation, have not been ruled out. |
2009-08-28 |
2023-08-12 |
Not clear |
| Yue Wang, Nigel H Greig, Qian-sheng Yu, Mark P Mattso. Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices. Neurobiology of aging. vol 30. issue 7. 2009-08-21. PMID:18068871. |
similar alterations in acetylcholine and nmda receptor-mediated components of synaptic plasticity are evident in 3xtgad mice with ps1, amyloid precursor protein and tau mutations, suggesting that the adverse effects of mutant ps1 on synaptic plasticity can occur in the absence or presence of amyloid and tau pathologies. |
2009-08-21 |
2023-08-12 |
mouse |
| Gerald Schmid, Joanna B Strosznajder, Józefa Wesierska-Gade. Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors. Molecular neurobiology. vol 34. issue 1. 2009-02-12. PMID:17003520. |
the proper phosphorylation of the most important substrates, such as tau protein and neurofilament h, is essential for the correct regulation of the cytoskeletal organization, thereby regulating cell adhesion, motility, and synaptic plasticity. |
2009-02-12 |
2023-08-12 |
Not clear |
| Stephen M Fitzjohn, Andrew J Doherty, Graham L Collingridg. The use of the hippocampal slice preparation in the study of Alzheimer's disease. European journal of pharmacology. vol 585. issue 1. 2008-10-31. PMID:18423442. |
(v) the discovery of a role of glycogen synthase kinase-3beta (tau kinase) in synaptic plasticity. |
2008-10-31 |
2023-08-12 |
Not clear |
| I Dewachter, L Ris, S Croes, P Borghgraef, H Devijver, T Voets, B Nilius, E Godaux, F Van Leuve. Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1. Neurobiology of aging. vol 29. issue 5. 2008-04-28. PMID:17222948. |
modulation of synaptic plasticity and tau phosphorylation by wild-type and mutant presenilin1. |
2008-04-28 |
2023-08-12 |
mouse |
| Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. |
the formation of hyperphosphorylated tau protein may impair learning and the synaptic plasticity of neurons. |
2007-02-20 |
2023-08-12 |
Not clear |
| Jürgen Götz, Lars M Ittner, Stefan Kin. Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease? Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16787410. |
the overall picture is that key players in ad, such as tau, app and ps, perturb axonal transport early on in ad, causing impaired synaptic plasticity and reducing survival rates. |
2006-09-21 |
2023-08-12 |
mouse |
| W Härtig, M Oklejewicz, A M Strijkstra, A S Boerema, J Stieler, T Arend. Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging. Brain research. vol 1056. issue 1. 2005-11-21. PMID:16095576. |
the hippocampal ca3 region, a brain region with a high degree of synaptic plasticity, is known to be strongly involved in tau hyperphosphorylation in several neurodegenerative diseases. |
2005-11-21 |
2023-08-12 |
Not clear |
| W Härtig, M Oklejewicz, A M Strijkstra, A S Boerema, J Stieler, T Arend. Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging. Brain research. vol 1056. issue 1. 2005-11-21. PMID:16095576. |
these findings implicate an additional link between aging, tau phosphorylation and synaptic plasticity. |
2005-11-21 |
2023-08-12 |
Not clear |
| Thomas Arend. Neurodegeneration and plasticity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465280. |
failures of synaptic plasticity are, thus, assumed to represent early events in the course of ad that eventually lead to alteration of tau phosphorylation. |
2004-12-15 |
2023-08-12 |
Not clear |
| Thomas Arend. Neurodegeneration and plasticity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465280. |
recently, we have used the hibernation cycle, a physiological model of adaptation associated with an extraordinary high degree of structural neuronal plasticity, to analyze the potential link between synaptic plasticity, synaptic detachment and the regulation of tau phosphorylation. |
2004-12-15 |
2023-08-12 |
Not clear |
| Alexei R Koudinov, Natalia V Koudinov. Cholesterol, synaptic function and Alzheimer's disease. Pharmacopsychiatry. vol 36 Suppl 2. 2003-12-10. PMID:14574623. |
moreover, changes in the neurochemistry of amyloid beta, tau, neuronal cytoskeleton, and oxidative stress reactions due to alzheimer's likely represent physiological transitory mechanisms that aim to compensate impaired brain cholesterol dynamics and/or associated neurotransmission and synaptic plasticity failure. |
2003-12-10 |
2023-08-12 |
rat |
| Makoto Michikaw. The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid beta-protein and cholesterol. Molecular neurobiology. vol 27. issue 1. 2003-05-30. PMID:12668899. |
all these findings suggest that the involvement of cholesterol in the pathogenesis of ad is dualistic-it is involved in abeta generation and in the amyloid cascade, leading to disruption of synaptic plasticity, promotion of tau phosphorylation, and eventual neurodegeneration. |
2003-05-30 |
2023-08-12 |
Not clear |
| Qing Tian, Jianzhi Wan. Role of serine/threonine protein phosphatase in Alzheimer's disease. Neuro-Signals. vol 11. issue 5. 2003-03-27. PMID:12566927. |
the general characteristics and pathologic changes of pp1, pp2a and pp2b in ad, and their relations with microtubule-associated proteins, focusing mainly on tau protein, neurofilament (nf), amyloid precursor protein (app) processing and synaptic plasticity are discussed. |
2003-03-27 |
2023-08-12 |
Not clear |