| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eija Koponen, Merja Lakso, Eero Castré. Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519679. |
significant body of evidence indicates an important role for brain-derived neurotrophic factor (bdnf) in the hippocampal synaptic plasticity; however, the exact mechanisms how the bdnf signal is converted to plastic changes during memory processes are under an intense investigation. |
2005-03-30 |
2023-08-12 |
mouse |
| Kuo Wu, Guo-Wei Len, Geoff McAuliffe, Chia Ma, Jessica P Tai, Fei Xu, Ira B Blac. Brain-derived neurotrophic factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519688. |
our previous studies revealed that bdnf rapidly increases phosphorylation of nmda receptor subunits nr1 and nr2b in the postsynaptic density (psd), potentially linking receptor phosphorylation to synaptic plasticity. |
2005-03-30 |
2023-08-12 |
Not clear |
| Hong Lou, Soo-Kyung Kim, Eugene Zaitsev, Chris R Snell, Bai Lu, Y Peng Lo. Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e. Neuron. vol 45. issue 2. 2005-03-09. PMID:15664176. |
sorting and activity-dependent secretion of bdnf require interaction of a specific motif with the sorting receptor carboxypeptidase e. activity-dependent secretion of bdnf is important in mediating synaptic plasticity, but how it is achieved is unclear. |
2005-03-09 |
2023-08-12 |
mouse |
| Shoshanna Vaynman, Zhe Ying, Fernando Gomez-Pinill. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. The European journal of neuroscience. vol 20. issue 10. 2005-03-01. PMID:15548201. |
hippocampal bdnf mediates the efficacy of exercise on synaptic plasticity and cognition. |
2005-03-01 |
2023-08-12 |
Not clear |
| Shoshanna Vaynman, Zhe Ying, Fernando Gomez-Pinill. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. The European journal of neuroscience. vol 20. issue 10. 2005-03-01. PMID:15548201. |
the finding that exercise increased brain-derived neurotrophic factor (bdnf), a molecule important for synaptic plasticity and learning and memory, impelled us to examine whether a bdnf-mediated mechanism subserves the capacity of exercise to improve hippocampal-dependent learning. |
2005-03-01 |
2023-08-12 |
Not clear |
| Shoshanna Vaynman, Zhe Ying, Fernando Gomez-Pinill. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. The European journal of neuroscience. vol 20. issue 10. 2005-03-01. PMID:15548201. |
inhibiting bdnf action also blocked the effect of exercise on downstream systems regulated by bdnf and important for synaptic plasticity, camp response-element-binding protein (creb) and synapsin i. |
2005-03-01 |
2023-08-12 |
Not clear |
| Devin K Binder, Helen E Scharfma. Brain-derived neurotrophic factor. Growth factors (Chur, Switzerland). vol 22. issue 3. 2005-02-25. PMID:15518235. |
aside from its importance in neural development and cell survival, bdnf appears essential to molecular mechanisms of synaptic plasticity. |
2005-02-25 |
2023-08-12 |
Not clear |
| Devin K Binder, Helen E Scharfma. Brain-derived neurotrophic factor. Growth factors (Chur, Switzerland). vol 22. issue 3. 2005-02-25. PMID:15518235. |
pathologic levels of bdnf-dependent synaptic plasticity may contribute to conditions such as epilepsy and chronic pain sensitization, whereas application of the trophic properties of bdnf may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders. |
2005-02-25 |
2023-08-12 |
Not clear |
| John E Kolb, Joseph Trettel, Eric S Levin. BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol. Synapse (New York, N.Y.). vol 55. issue 1. 2005-02-17. PMID:15515007. |
these results provide a potential mechanism for the proposed role for bdnf in activity-dependent synaptic plasticity and, potentially, learning and memory processes. |
2005-02-17 |
2023-08-12 |
Not clear |
| Shingo Suzuki, Tadahiro Numakawa, Kazuhiro Shimazu, Hisatsugu Koshimizu, Tomoko Hara, Hiroshi Hatanaka, Lin Mei, Bai Lu, Masami Kojim. BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. The Journal of cell biology. vol 167. issue 6. 2005-02-08. PMID:15596541. |
brain-derived neurotrophic factor (bdnf) plays an important role in synaptic plasticity but the underlying signaling mechanisms remain unknown. |
2005-02-08 |
2023-08-12 |
Not clear |
| Fernando Gómez-Pinilla, Zhe Ying, Roland R Roy, John Hodgson, V Reggie Edgerto. Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15548637. |
synapsin i, an important mediator for the effects of bdnf on synaptic plasticity, also was lower in the lumbar region of si rats. |
2004-12-30 |
2023-08-12 |
rat |
| Christine R Rose, Robert Blum, Karl W Kafitz, Yury Kovalchuk, Arthur Konnert. From modulator to mediator: rapid effects of BDNF on ion channels. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 26. issue 11. 2004-12-17. PMID:15499580. |
thus, bdnf, in addition its role as a potent neuromodulator, emerges as an excitatory transmitter-like substance which acutely controls resting membrane potential, neuronal excitability, synaptic transmission and participates in the induction of synaptic plasticity. |
2004-12-17 |
2023-08-12 |
Not clear |
| Martina Gooney, Elhoucine Messaoudi, Frank O Maher, Clive R Bramham, Marina A Lync. BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events. Neurobiology of aging. vol 25. issue 10. 2004-12-15. PMID:15465630. |
brain-derived neurotrophic factor (bdnf) has emerged as a major regulator of synaptic plasticity in the adult brain and acute bdnf infusion has been shown to trigger long-term potentiation (bdnf-ltp) in adult rats. |
2004-12-15 |
2023-08-12 |
rat |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends in neurosciences. vol 27. issue 10. 2004-11-30. PMID:15374669. |
brain-derived neurotrophic factor (bdnf) and serotonin (5-hydroxytryptamine, 5-ht) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. |
2004-11-30 |
2023-08-12 |
Not clear |
| Fabio Fumagalli, Francesco Bedogni, Jorge Perez, Giorgio Racagni, Marco Andrea Riv. Corticostriatal brain-derived neurotrophic factor dysregulation in adult rats following prenatal stress. The European journal of neuroscience. vol 20. issue 5. 2004-11-09. PMID:15341606. |
in order to evaluate molecular changes that could participate in long-lasting effects on brain function, we analysed the effects of prenatal stress on the expression of brain-derived neurotrophic factor (bdnf), an important molecular determinant of synaptic plasticity and cellular homeostasis, in adult male rats under basal conditions as well as in response to a chronic stress. |
2004-11-09 |
2023-08-12 |
rat |
| Shigeyoshi Fujisawa, Maki K Yamada, Nobuyoshi Nishiyama, Norio Matsuki, Yuji Ikegay. BDNF boosts spike fidelity in chaotic neural oscillations. Biophysical journal. vol 86. issue 3. 2004-10-15. PMID:14990508. |
bdnf diminishes the ambiguity of spike time jitter and thereby might assure neural encoding, such as spike timing-dependent synaptic plasticity. |
2004-10-15 |
2023-08-12 |
Not clear |
| Shih-Jen Tsa. Is mania caused by overactivity of central brain-derived neurotrophic factor? Medical hypotheses. vol 62. issue 1. 2004-09-21. PMID:14728999. |
brain-derived neurotrophic factor (bdnf), a member of the neurotrophic factor family, can modulate synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems, as well as the intracellular signal-transduction pathway. |
2004-09-21 |
2023-08-12 |
Not clear |
| B Xu, B Michalski, R J Racine, M Fahnestoc. The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes. Neuroscience. vol 126. issue 3. 2004-09-14. PMID:15183502. |
brain-derived neurotrophic factor (bdnf) is a member of the neurotrophin family that mediates synaptic plasticity and excitability in the cns. |
2004-09-14 |
2023-08-12 |
mouse |
| Lisa M Rattiner, Michael Davis, Christopher T French, Kerry J Ressle. Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 20. 2004-09-10. PMID:15152040. |
brain-derived neurotrophic factor (bdnf) and its receptor, tyrosine kinase receptor b (trkb), play a critical role in activity-dependent synaptic plasticity and have been implicated as mediators of hippocampal-dependent learning and memory. |
2004-09-10 |
2023-08-12 |
Not clear |
| Ann M Marini, Xueying Jiang, Xuan Wu, Feng Tian, Daming Zhu, Peter Okagaki, Robert H Lipsk. Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype. Restorative neurology and neuroscience. vol 22. issue 2. 2004-09-09. PMID:15272146. |
brain-derived neurotrophic factor (bdnf) is a member of the family of neurotrophins and promotes diverse effects in neurons including development, maintenance of function, synaptic plasticity, and survival in different animal models. |
2004-09-09 |
2023-08-12 |
Not clear |