| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alka Ashok Singh, Shweta Katiyar, Minseok Son. Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders. Brain sciences. vol 15. issue 3. 2025-03-28. PMID:40149774. |
bdnf is an important target for neurodegenerative disease (nd) treatment since it regulates neuronal survival, synaptic plasticity, neurogenesis, and neuroprotection. |
2025-03-28 |
2025-03-30 |
Not clear |
| Congyuan Xia, Guoyan Zuo, Manni Wang, Yuming Wang, Yuxuan Guo, Yan Han, Honglin Xiang, Yungchi Cheng, Jiekun Xu, Jun He, Weiku Zhan. Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy. Molecular psychiatry. 2025-03-26. PMID:40133424. |
mechanistically, hint1 hinders sigma-1 receptor (sigma-1r) binding to n-methyl-d-aspartate receptor (nmdar), promotes postsynaptic density protein (psd95) binding to nmdar, inhibits brain derived neurotrophic factor (bdnf) signaling, and impairs synaptic plasticity. |
2025-03-26 |
2025-03-28 |
Not clear |
| Roli Kushwaha, Shashikant Patel, K S Yuvaraj, Pooja Sharma, Arvind Kumar, Sumana Chakravart. Investigating Molecular Mechanisms in Ischemic Preconditioning-Induced Resiliency to Severe Acute Global Cerebral Ischemia Using a Mouse Model of Chronic Cerebral Hypoperfusion. Cellular and molecular neurobiology. vol 45. issue 1. 2025-03-26. PMID:40138004. |
preconditioning enhanced synaptic plasticity by upregulating psd-95, synaptophysin and bdnf levels. |
2025-03-26 |
2025-03-30 |
mouse |
| Min Heui Yoo, Tae-Youn Kim, Ho-Kyong Kim, Ji-Hyun Yoo, Byoung-Seok Lee, Jae-Young Ko. Assessing the health hazards of low-dose ethylmercury: Neurochemical and behavioral impacts in neonatal mice through matrix metalloproteinase activation and brain-derived neurotrophic factor release. Ecotoxicology and environmental safety. vol 293. 2025-03-13. PMID:40080937. |
given that neurite outgrowth, matrix metalloproteinase (mmp) activity, and brain-derived neurotrophic factor (bdnf) expression play critical roles in brain development and synaptic plasticity, we hypothesized that ethg exposure disrupts these processes, leading to behavioral abnormalities. |
2025-03-13 |
2025-03-16 |
mouse |
| Daniela Maria Tanase, Emilia Valasciuc, Evelina Maria Gosav, Mariana Floria, Oana Nicoleta Buliga-Finis, Anca Ouatu, Andrei Ionut Cucu, Tina Botoc, Claudia Florida Coste. Enhancing Retinal Resilience: The Neuroprotective Promise of BDNF in Diabetic Retinopathy. Life (Basel, Switzerland). vol 15. issue 2. 2025-02-26. PMID:40003672. |
this article explores the crucial role in neuronal survival, axonal growth, and synaptic plasticity and the neuroprotective potential of brain-derived neurotrophic factor (bdnf) as a therapeutic strategy for enhancing retinal resilience in dr. |
2025-02-26 |
2025-02-28 |
Not clear |
| Leilei Shi, Mingmei Wang, Ruixuan Yu, Yuyu An, Xin Wang, Yuhan Zhang, Yongheng Shi, Chaojun Han, Jiping Li. Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes. Behavioural brain research. 2025-02-22. PMID:39986614. |
given the fundamental role of intact hippocampal synaptic plasticity in maintaining cognitive function, we investigated the correlation between sig-1r and brain-derived neurotrophic factor (bdnf), a well-established neurotrophic factor. |
2025-02-22 |
2025-02-25 |
rat |
| b' Alba Irisarri, Ana Corral, N\\xc3\\xbaria Perez-Salvador, Aina Bellver-Sanchis, Marta Ribalta-Vilella, Roger Bentanachs, Marta Alegret, Juan Carlos Laguna, Emma Barroso, Xavier Palomer, Daniel Ortu\\xc3\\xb1o-Sahag\\xc3\\xban, Manuel V\\xc3\\xa1zquez-Carrera, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Laura Herrero, Christian Gri\\xc3\\xb1\\xc3\\xa1n-Ferr\\xc3\\xa. FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice. Molecular medicine (Cambridge, Mass.). vol 31. issue 1. 2025-02-22. PMID:39984825.' |
improved synaptic plasticity was evident, as shown by increased levels of neurotrophic factors (bdnf, ngf) and restored neurite length and spine density. |
2025-02-22 |
2025-02-24 |
mouse |
| Gianna Carla Riccitelli, Riccardo Gironi, Giorgia Melli, Alain Kaelin-Lan. The Effect of Repetitive Transcranial Magnetic Stimulation Treatment on Plasma BDNF Concentration and Executive Functions in Parkinson's Disease: A Theoretical Translational Medicine Approach. International journal of molecular sciences. vol 26. issue 3. 2025-02-13. PMID:39940980. |
brain-derived neurotrophic factor (bdnf), a neurotrophin crucial for the survival of dopaminergic neurons, plays a pivotal role in neuronal and glial development, neuroprotection, and the modulation of synaptic plasticity. |
2025-02-13 |
2025-02-15 |
Not clear |
| Spandana Rajendra Kopalli, Tapan Behl, Ashishkumar Kyada, M M Rekha, Mayank Kundlas, Pooja Rani, Deepak Nathiya, K Satyam Naidu, Monica Gulati, Manish Bhise, Priyanka Gupta, Pranay Wal, Mohammad Fareed, Seema Ramniwas, Sushruta Koppula, Amin Gasm. Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression. Neuroscience. 2025-02-08. PMID:39922366. |
flavonoids modulate key signaling pathways such as mapk/erk and pi3k/akt/mtor to support neuroprotection, synaptic plasticity, and neuronal health, while also influencing neurotrophic factors (bdnf, ngf) and their receptors (trkb, trka). |
2025-02-08 |
2025-02-11 |
Not clear |
| Samira Khayat, Hamed Fanaei, Kiarash Anaraki Haji Bagher. Social isolation during pregnancy disrupts maternal behavior and hippocampal neurochemistry in rats: A role for BDNF, corticosterone, and GABAARα1. Comprehensive psychoneuroendocrinology. vol 21. 2025-02-06. PMID:39911146. |
the altered concentration of corticosterone and bdnf, and gabaarα1 mrna expression in the hippocampus of social isolation group suggests disruptions in stress response regulation and synaptic plasticity during pregnancy to form normal maternal behavior. |
2025-02-06 |
2025-02-08 |
rat |
| Tatiana Guncay, Jorge Concha, Pedro Lobos, Jamileth More, Barbara Bruna, Daniel Sansores, Pamela Contreras, Daniela P Ponce, Julian Brañez, Gabriel Quiroz, Genaro Barrientos, Cecilia Hidalgo, Felipe Salec. Nicotinamide Prevents The Plasticity Impairments And The Cognitive Dysfunction Caused By Bone Fracture In Older Mice. The journals of gerontology. Series A, Biological sciences and medical sciences. 2025-01-17. PMID:39823270. |
we found that surgery increased the oxidation of ryanodine receptor calcium channels (cellular redox sensors), and decreased bdnf protein levels; nam supplementation mitigated both effects and prevented the cognitive decline and synaptic plasticity deficits while reducing inflammation post-surgery by lowering il-1 beta and cd38 protein levels. |
2025-01-17 |
2025-01-20 |
mouse |
| Magdalena Kostka, Julia Morys, Andrzej Małecki, Marta Nowacka-Chmielewsk. Muscle-brain crosstalk mediated by exercise-induced myokines - insights from experimental studies. Frontiers in physiology. vol 15. 2024-12-17. PMID:39687518. |
it is speculated that, in particular, brain-derived neurotrophic factor (bdnf), irisin, cathepsin b (ctsb), interleukin 6 (il-6), and insulin-like growth factor-1 (igf-1) partake in this crosstalk by promoting neuronal proliferation and synaptic plasticity, also resulting in improved cognition and ameliorated behavioral alterations. |
2024-12-17 |
2024-12-21 |
Not clear |
| Bin Zhang, Su-Lan Chen, Xin Teng, Qi Han, Tong Wu, Zhen Yang, Yin Liu, Ke Xiang, Li Su. Function of Brain-Derived Neurotrophic Factor in the Vestibular-Cochlear System. Neurochemical research. vol 50. issue 1. 2024-12-14. PMID:39673652. |
bdnf promotes the growth, differentiation, and synaptic plasticity of vestibular neurons, ensuring their normal operation and maintenance. |
2024-12-14 |
2024-12-21 |
Not clear |
| Hayder M Al-Kuraishy, Ghassan M Sulaiman, Hamdoon A Mohammed, Salim Albukhaty, Ali K Albuhadily, Ali I Al-Gareeb, Daniel J Klionsky, Mosleh M Abomughai. The Compelling Role of Brain-Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators. CNS neuroscience & therapeutics. vol 30. issue 12. 2024-12-10. PMID:39654365. |
through activation of ntrk2/trkb (neurotrophic receptor tyrosine kinase 2), bdnf promotes neuronal survival, synaptic plasticity, and neuronal growth, whereas it inhibits microglial activation and the release of pro-inflammatory cytokines. |
2024-12-10 |
2024-12-12 |
Not clear |
| Xiaoping Zhu, Shengnan Han, Yulu Geng, Wenzhi Ren, Fushi Qua. Brain-Derived Neurotrophic Factor-TrkB Pathway on Synaptic Plasticity in Ischemic Stroke Rats. International heart journal. vol 65. issue 6. 2024-12-01. PMID:39617500. |
in this study, a rat cerebral ischemiareperfusion (middle cerebral artery occlusion) model was established, and the reliability of this model was determined.the expression changes of key proteins of the bdnf trkb pathway and synaptic plasticity markers (syp, psd-95, and map-2) were detected at different time points.the results showed that bdnf expression increased rapidly in the acute phase, and the expression of synaptic plasticity markers decreased, and blocking the bdnf-trkb pathway with the specific blocker k252a also had a significant effect.this suggests that changes in the bdnf-trkb signaling pathway can affect the synaptic plasticity in nerve cells of stroke patients. |
2024-12-01 |
2024-12-06 |
human |
| Nicola Mottolese, Manuela Loi, Stefania Trazzi, Marianna Tassinari, Beatrice Uguagliati, Giulia Candini, Khalid Iqbal, Giorgio Medici, Elisabetta Cian. Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder. Journal of neurodevelopmental disorders. vol 16. issue 1. 2024-11-27. PMID:39592934. |
p021, a tetra-peptide derived from the biologically active region of the human ciliary neurotrophic factor (cntf), was found to enhance neurogenesis and synaptic plasticity by promoting an increase in bdnf expression in preclinical models of brain disorders, such as alzheimer's disease and down syndrome, resulting in a beneficial therapeutic effect. |
2024-11-27 |
2024-11-29 |
mouse |
| Soomin Jeong, Charles K Davis, Raghu Vemugant. Mechanisms of time-restricted feeding-induced neuroprotection and neuronal plasticity in ischemic stroke as a function of circadian rhythm. Experimental neurology. vol 383. 2024-11-10. PMID:39510297. |
animal studies show that trf enhances brain-derived neurotrophic factor (bdnf) signaling and regulates autophagy and neuroinflammation, supporting synaptic plasticity, neurogenesis and neuroprotection. |
2024-11-10 |
2024-11-16 |
Not clear |
| In-Ae Choi, Ji Hee Yun, Jongmin Lee, Dong-Hee Cho. Neuropeptide FF Promotes Neuronal Survival and Enhances Synaptic Protein Expression Following Ischemic Injury. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519132. |
post-injury rnpff treatment led to a significant upregulation of pro-brain-derived neurotrophic factor (bdnf) and mature bdnf, which play critical roles in neuronal survival, growth, and synaptic plasticity. |
2024-11-09 |
2024-11-17 |
Not clear |
| Annabell Jäger, Anima Pieper, Kathlen Priebe, Rainer Hellweg, Kristina Meyer, Sarah Herrmann, Bernd Wolfarth, Maximilian Grummt, Andreas Ströhle, Nikola Schoof. Effects of high intensity interval training on serum brain-derived neurotrophic factor in individuals with PTSD. Journal of psychiatric research. vol 180. 2024-11-09. PMID:39520767. |
brain-derived neurotrophic factor (bdnf) is a protein important for synaptic plasticity and formation of memory. |
2024-11-09 |
2024-11-17 |
Not clear |
| Emily Z Huie, Xin Yang, Mengia S Rioult-Pedotti, Kyle Tran, Emma R Monsen, Kim Hansen, Michelle A Erickson, Mandar Naik, Anna Y Yotova, William A Banks, Yu-Wen Alvin Huang, Jill L Silverman, John Marshal. Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-11-08. PMID:39511336. |
brain-derived neurotrophic factor (bdnf), and its receptor tropomyosin receptor kinase b (trkb), have a well-established role as regulators of synaptic plasticity, dendritic outgrowth and spine formation. |
2024-11-08 |
2024-11-16 |
mouse |