| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naomi Lomeli, Diana C Pearre, Maureen Cruz, Kaijun Di, Joni L Ricks-Oddie, Daniela A Bot. Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity. Experimental neurology. 2024-02-09. PMID:38336286. |
in conclusion, we established the first middle-aged rat model of cisplatin-induced crci, assessing the contribution of medical stress and longitudinal changes in bdnf levels with cognitive function, although future studies are warranted to assess the efficacy of bdnf enhancement in vivo on synaptic plasticity. |
2024-02-09 |
2024-02-12 |
rat |
| Judit Català-Solsona, Stefano Lutzu, Pablo J Lituma, Cristina Fábregas-Ordoñez, Dolores Siedlecki, Lydia Giménez-Llort, Alfredo J Miñano-Molina, Carlos A Saura, Pablo E Castillo, José Rodriguez-Álvare. Nr4a2 blocks oAβ-mediated synaptic plasticity dysfunction and ameliorates spatial memory deficits in the APP bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328087. |
recently, it has been reported that nr4a2, a member of the nr4a family of orphan nuclear receptors, plays a role in hippocampal synaptic plasticity by regulating bdnf and synaptic ampa receptors. |
2024-02-08 |
2024-02-10 |
mouse |
| J Solich, M Kolasa, A Faron-Górecka, P Pabian, K Latocha, A Korlatowicz, M Dziedzicka-Wasylewsk. Modulating Stress Susceptibility and Resilience: Insights from miRNA Manipulation and Neural Mechanisms in Mice. Molecular neurobiology. 2024-01-27. PMID:38280111. |
the expression changes of genes such as dgkq, bdnf, ntrk2, and pde4b in the mouse cerebellum suggested a link between cerebellar function, synaptic plasticity, and the differential stress responses observed in susceptible and resilient mice. |
2024-01-27 |
2024-01-30 |
mouse |
| Fatemeh Nikpour, Amir Salimi, Amene Saghazadeh, Nima Rezae. Blood and CSF levels of brain-derived neurotrophic factor in patients with encephalopathy/encephalitis: a systematic review and meta-analysis. Acta neurologica Belgica. 2024-01-24. PMID:38267724. |
brain-derived neurotrophic factor (bdnf) is critical for enhancing the survival and growth of neurons and modulating the synaptic plasticity. |
2024-01-24 |
2024-01-27 |
Not clear |
| Hideo Takekoshi, Masaki Fujishima, Taiki Miyazawa, Ohki Higuchi, Takahiko Fujikawa, Teruo Miyazaw. Simultaneous Intake of Chlorella and Ascidian Ethanolamine Plasmalogen Accelerates Activation of BDNF-TrkB-CREB Signaling in Rats. Molecules (Basel, Switzerland). vol 29. issue 2. 2024-01-23. PMID:38257270. |
brain-derived neurotrophic factor (bdnf) plays an important role in neurogenesis, synaptic plasticity, and cognition. |
2024-01-23 |
2024-01-25 |
human |
| Zhenlong Li, Chau-Shoun Lee, Si Chen, Benyu He, Xinya Chen, Hsien-Yu Peng, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Dylan Cho. Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala. Neurobiology of stress. vol 28. 2024-01-08. PMID:38187456. |
collectively, these results suggest that blan results in stress-evoked heightened aggressive phenotypes, which may work by enhancing bla bdnf signaling and synaptic plasticity. |
2024-01-08 |
2024-01-10 |
rat |
| Md Anisuzzaman Chowdhury, Jessica M Collins, David A Gell, Sharn Perry, Michael C Breadmore, Sarah Shigdar, Anna E Kin. Isolation and Identification of the High-Affinity DNA Aptamer Target to the Brain-Derived Neurotrophic Factor (BDNF). ACS chemical neuroscience. 2023-12-27. PMID:38149631. |
bdnf is a potential biomarker of brain health and neurodegenerative diseases and has functions in the synaptic plasticity and survival of neurons. |
2023-12-27 |
2023-12-29 |
Not clear |
| Cristina Lao-Peregrin, Guoqing Xiang, Jihye Kim, Ipsit Srivastava, Alexandra B Fall, Danielle M Gerhard, Piia Kohtala, Daegeon Kim, Minseok Song, Mikel Garcia-Marcos, Joshua Levitz, Francis S Le. Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk. Cell reports. vol 43. issue 1. 2023-12-20. PMID:38117654. |
we find that the receptor tyrosine kinase (rtk) trkb and the g-protein-coupled receptor (gpcr) metabotropic glutamate receptor 5 (mglur5) together mediate hippocampal synaptic plasticity in response to brain-derived neurotrophic factor (bdnf). |
2023-12-20 |
2023-12-23 |
Not clear |
| Marta Ditmer, Agata Gabryelska, Szymon Turkiewicz, Marcin Socha. Investigating the Role of BDNF in Insomnia: Current Insights. Nature and science of sleep. vol 15. 2023-12-13. PMID:38090631. |
bdnf is a neurotrophin primarily responsible for synaptic plasticity and proper functioning of neurons. |
2023-12-13 |
2023-12-17 |
Not clear |
| Pranglada Jearjaroen, Phakkawat Thangwong, Chainarong Tocharus, Anusorn Lungkaphin, Waraluck Chaichompoo, Jaranwit Srijun, Apichart Suksamrarn, Jiraporn Tocharu. Hexahydrocurcumin Attenuates Neuronal Injury and Modulates Synaptic Plasticity in Chronic Cerebral Hypoperfusion in Rats. Molecular neurobiology. 2023-12-12. PMID:38087168. |
moreover, hhc or piracetam also improved synaptic plasticity via the brain-derived neurotrophic factor (bdnf)/tyrosine receptor kinase b (trkb)/camp responsive element binding protein (creb) signaling pathway. |
2023-12-12 |
2023-12-17 |
rat |
| Ruyu Wang, Yiwei Chen, Zhiying Wang, Baorui Cao, Jinxin Du, Tingting Deng, Meina Yang, Jinxiang Ha. Antidepressant effect of licorice total flavonoids and liquiritin: A review. Heliyon. vol 9. issue 11. 2023-12-11. PMID:38074876. |
studies have shown that lf and liquiritin can exert their antidepressant effects by improving depressive behavior, regulating endocrine and hypothalamic-pituitary-adrenal (hpa) axis function, affecting the brain-derived neurotrophic factor (bdnf)/tyrosine kinase b (trkb) signaling pathway, enhancing synaptic plasticity, increasing monoamine neurotransmitter levels, protecting nerve cells, reducing inflammation, preventing apoptosis, reducing oxidation and other ways. |
2023-12-11 |
2023-12-17 |
Not clear |
| Robert Shen, Christian Ardianto, Celia Celia, Veronika Maria Sidharta, Poppy Kristina Sasmita, Irawan Satriotomo, Yuda Turan. Brain-derived neurotrophic factor interplay with oxidative stress: neuropathology approach in potential biomarker of Alzheimer's disease. Dementia & neuropsychologia. vol 17. 2023-12-06. PMID:38053647. |
oxidative stress, as a molecular hallmark that causes susceptibility in ad, interplays to other ad-related neuropathology cascades and decreases the expression of central and circulation brain-derived neurotrophic factor (bdnf), an essential neurotrophin that serves as nerve development and survival, and synaptic plasticity in ad. |
2023-12-06 |
2023-12-10 |
Not clear |
| Udaykanth Suryavanshi, Kiran Kumar Angadi, V Sudhakar Reddy, G Bhanuprakash Reddy. Neuroprotective role of vitamin B12 in streptozotocin-induced type 1 diabetic rats. Chemico-biological interactions. 2023-12-04. PMID:38049026. |
further, b12 supplementation restored the markers of neurotrophic support (bdnf, ngf, and gdnf), and synaptic plasticity (syp, and psd-95) in diabetic rats. |
2023-12-04 |
2023-12-10 |
rat |
| Mizhu Sun, Qingmeng Zheng, Lulu Wang, Runzhi Wang, Hengzhen Cui, Xinlei Zhang, Chen Xu, Fangyuan Yin, Hongtao Yan, Xiaomeng Qia. Alcohol Consumption During Adolescence Alters the Cognitive Function in Adult Male Mice by Persistently Increasing Levels of DUSP6. Molecular neurobiology. 2023-11-17. PMID:37978157. |
extracellular signal-regulated kinase (erk) is involved in the synaptic plasticity and pathological brain injury by regulating the expression of cyclic adenosine monophosphate response element binding protein (creb) and brain-derived neurotrophic factor (bdnf). |
2023-11-17 |
2023-11-20 |
mouse |
| Nitasha Rana, Lakshay Kapil, Charan Singh, Arti Sing. Modeling Huntington's disease: An insight on in-vitro and in-vivo models. Behavioural brain research. 2023-11-12. PMID:37952684. |
several other molecular mechanisms have also been implicated in hd pathology, including brain-derived neurotrophic factor (bdnf), mitochondrial dysfunction, and altered synaptic plasticity in central spiny neurons. |
2023-11-12 |
2023-11-20 |
Not clear |
| Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. |
the potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 2 (tph2) is well characterized to facilitate rapid and long-lasting antidepressant actions. |
2023-11-02 |
2023-11-08 |
mouse |
| Anton Shkundin, Angelos Halari. Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder. Journal of personalized medicine. vol 13. issue 9. 2023-09-28. PMID:37763162. |
brain-derived neurotrophic factor (bdnf) is crucial for various aspects of neuronal development and function, including synaptic plasticity, neurotransmitter release, and supporting neuronal differentiation, growth, and survival. |
2023-09-28 |
2023-10-07 |
Not clear |
| Jie Yuan, Jing Gao, Kai-Qi Su, Xiao-Dong Fen. [Electroacupuncture improves learning and memory impairment and enhances hippocampal synaptic plasticity through BDNF/TRKB/CREB signaling pathway in cerebral ischemia-reperfusion injury rats]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 9. 2023-09-20. PMID:37730254. |
to observe the effect of electroacupuncture on brain-derived neurotrophin factor (bdnf) / tyrosine kinase receptor b (trkb) / cyclic adenosine monophosphate response element binding protein (creb) pathway, synaptic plasticity marker protein and synaptic ultrastructure in the hippocampus of rats with learning and memory impairment induced by cerebral ischemia reperfusion (ir), so as to explore its mechanisms underlying improvement of cognitive impairment after stroke. |
2023-09-20 |
2023-10-07 |
rat |
| Xiqi Hu, Jun Peng, Wei Tang, Ying Xia, Peipei Son. A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan. Bioscience trends. 2023-09-18. PMID:37722875. |
in addition, a diet restricted to the circadian rhythm induces increased expression of brain-derived neurotrophic factor (bdnf) in the forebrain region, regulating autophagy and increasing synaptic plasticity, thus enhancing cognitive function. |
2023-09-18 |
2023-10-07 |
Not clear |
| Cristina Lao-Peregrin, Guoqing Xiang, Jihye Kim, Ipsit Srivastava, Alexandra B Fall, Danielle M Gerhard, Piia Kohtala, Daegeon Kim, Minseok Song, Mikel Garcia-Marcos, Joshua Levitz, Francis S Le. Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693535. |
we find that the receptor tyrosine kinase (rtk), trkb, and the g protein-coupled receptor (gpcr), metabotropic glutamate receptor 5 (mglur5), together mediate a novel form of hippocampal synaptic plasticity in response to brain-derived neurotrophic factor (bdnf). |
2023-09-11 |
2023-10-07 |
Not clear |