| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
the aim of the present study was to evaluate the effect of rosiglitazone (rsg) or pioglitazone (pog) on the synaptic plasticity, neuronal apoptosis, brain-derived neurotrophic factor (bdnf), and nitric oxide (no) metabolites in the hippocampus of juvenile hypothyroid rats. |
2024-08-01 |
2024-08-03 |
rat |
| Smijin K Soman, Maryann Swain, Ruben K Dagd. BDNF-TrkB Signaling in Mitochondria: Implications for Neurodegenerative Diseases. Molecular neurobiology. 2024-07-19. PMID:39030441. |
brain-derived neurotrophic factor (bdnf) plays a pivotal role in neuronal development, synaptic plasticity, and overall neuronal health by binding to its receptor, tyrosine receptor kinase b (trkb). |
2024-07-19 |
2024-07-22 |
Not clear |
| Morgan K Foret, Chiara Orciani, Lindsay A Welikovitch, Chunwei Huang, A Claudio Cuello, Sonia Do Carm. Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer's-like transgenic rat model. Communications biology. vol 7. issue 1. 2024-07-14. PMID:39004677. |
we also found increased expression of synaptic plasticity genes (grin2b (nr2b), camkiiα, bdnf, c-fos, and homer1a) and increased protein levels of top2β. |
2024-07-14 |
2024-07-18 |
rat |
| Anastasia Bougea, Efthalia Angelopoulou, Efthimios Vasilopoulos, Philippos Gourzis, Sokratis Papageorgio. Emerging Therapeutic Potential of Fluoxetine on Cognitive Decline in Alzheimer's Disease: Systematic Review. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928248. |
fluoxetine promoted neurogenesis and enhanced synaptic plasticity in preclinical models of ad, through a decrease in aβ pathology and increase in bdnf, by activating diverse pathways (such as the daf-16-mediated, tgf-beta1, ilk-akt-gsk3beta, and creb/p-creb/bdnf). |
2024-06-27 |
2024-06-29 |
human |
| Emily Z Huie, Xin Yang, Mengia S Rioult-Pedotti, Mandar Naik, Yu-Wen Alvin Huang, Jill L Silverman, John Marshal. Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895218. |
brain-derived neurotrophic factor (bdnf), and its receptor trkb, have a well-established role as regulators of synaptic plasticity, dendritic outgrowth, dendritic spine formation and maintenance. |
2024-06-19 |
2024-06-21 |
mouse |
| Sasa Wang, Xinlei Zhang, Yuru Zhao, Haoxuan Lv, Pengyu Li, Zhihao Zhang, Xiaomeng Qia. BCI Improves Alcohol-Induced Cognitive and Emotional Impairments by Restoring pERK-BDNF. Journal of molecular neuroscience : MN. vol 74. issue 3. 2024-06-18. PMID:38890235. |
extracellular regulated protein kinases (erk) maintain neuronal survival, growth, and regulation of synaptic plasticity by phosphorylating specific transcription factors to regulate expression of brain-derived neurotrophic factor (bdnf). |
2024-06-18 |
2024-06-21 |
mouse |
| Sri-Arun Iamjan, Siriluk Veerasakul, Gavin P Reynolds, Samur Thanoi, Sutisa Nudmamud-Thano. Regional-specific changes in rat brain BDNF in a model of methamphetamine abuse. Neuroscience letters. 2024-06-17. PMID:38885757. |
brain-derived neurotrophic factor (bdnf), a member of the neurotrophin family, plays key roles in neuronal protection and synaptic plasticity. |
2024-06-17 |
2024-06-21 |
rat |
| Gayathri Rajamanickam, Andy Thiam Huat Lee, Ping Lia. Role of Brain Derived Neurotrophic Factor and Related Therapeutic Strategies in Central Post-Stroke Pain. Neurochemical research. 2024-06-10. PMID:38856889. |
brain-derived neurotrophic factor (bdnf) is vital for synaptic plasticity, cell persistence, and neuronal development in peripheral and central nervous systems (cns). |
2024-06-10 |
2024-06-14 |
Not clear |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Juhyun Son. BDNF Signaling in Vascular Dementia and Its Effects on Cerebrovascular Dysfunction, Synaptic Plasticity, and Cholinergic System Abnormality. Journal of lipid and atherosclerosis. vol 13. issue 2. 2024-06-03. PMID:38826183. |
bdnf signaling in vascular dementia and its effects on cerebrovascular dysfunction, synaptic plasticity, and cholinergic system abnormality. |
2024-06-03 |
2024-06-05 |
human |
| Danbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Son. Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity. Clinical nutrition research. vol 13. issue 2. 2024-05-24. PMID:38784850. |
recently, adiponectin, brain-derived neurotrophic factor (bdnf), and glucose-like peptide-1 (glp-1) have been investigated to find therapeutic solutions for metabolic syndrome, with findings suggesting that they are involved in insulin sensitivity, enhanced lipid profiles, increased neuronal survival, and improved synaptic plasticity. |
2024-05-24 |
2024-05-27 |
Not clear |
| Danbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Son. Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity. Clinical nutrition research. vol 13. issue 2. 2024-05-24. PMID:38784850. |
our findings demonstrate the therapeutic potential of adiponectin, bdnf, and glp-1 in enhancing synaptic plasticity within brains affected by metabolic imbalance. |
2024-05-24 |
2024-05-27 |
Not clear |
| Zhenhuan Wang, Qi Hu, Chao Tian, Ruipeng Wang, Qingyan Jiao, Feng Chen, Tongrui Wu, Jialiang Wang, Yuxuan Zhu, Aili Liu, Wei Zhang, Jie Li, Hui She. Prophylactic Effects of n-Acethylcysteine on Inflammation-induced Depression-like Behaviors in Mice. Neuroscience. 2024-05-16. PMID:38729599. |
this study sought to determine whether nac use could mitigate inflammatory depressive behavior through the enhancement of synaptic transmission, synaptic plasticity, and increasing levels of brain-derived neurotrophic factor (bdnf). |
2024-05-16 |
2024-05-27 |
mouse |
| Carmen Almodóvar-Payá, Maria Guardiola-Ripoll, Maria Giralt-López, Maitane Oscoz-Irurozqui, Erick Jorge Canales-Rodríguez, Mercè Madre, Joan Soler-Vidal, Núria Ramiro, Luis F Callado, Bárbara Arias, Carme Gallego, Edith Pomarol-Clotet, Mar Fatjó-Vila. NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia. Brain structure & function. 2024-05-08. PMID:38720004. |
the expression of neuritin-1 (nrn1), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the brain derived neurotrophic factor (bdnf). |
2024-05-08 |
2024-05-27 |
human |
| Tareq I Jibril, Karem H Alzoubi, Nizar M Mhaidat, Omar F Khabour, Mohammad A Y Alqudah, Abeer M Rababa'h, Nasr Alrabadi, Doaa Al-Udat. Sildenafil prevents chronic psychosocial stress-induced working memory impairment: Role of brain-derived neurotrophic factor. Current research in pharmacology and drug discovery. vol 6. 2024-05-06. PMID:38706525. |
reduced brain-derived neurotrophic factor (bdnf) levels, increased oxidative stress, and alteration of synaptic plasticity biomarkers are also possible contributors to the negative impact of stress on learning and memory. |
2024-05-06 |
2024-05-08 |
rat |
| Jiena Hong, Jiemei Chen, Chao Li, Fei Zhao, Jiantao Zhang, Yilong Shan, Hongmei We. High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia. Behavioural brain research. vol 467. 2024-04-28. PMID:38678971. |
the underlying mechanism might be modulating the synaptic plasticity and up-regulating the expression psd95, syn, and bdnf in the hippocampus. |
2024-04-28 |
2024-05-01 |
rat |
| Theresa Harvey, Maribel Rio. The Role of BDNF and TrkB in the Central Control of Energy and Glucose Balance: An Update. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672441. |
bdnf is a highly conserved neurotrophin that signals via the tropomyosin-related kinase b (trkb) receptor to facilitate neuronal survival, differentiation, and synaptic plasticity and function. |
2024-04-27 |
2024-04-29 |
Not clear |
| Guillermo Moya-Alvarado, Xavier Valero-Peña, Alejandro Aguirre-Soto, Fernando J Bustos, Oscar M Lazo, Francisca C Bronfma. PLC-γ-Ca Frontiers in molecular neuroscience. vol 17. 2024-04-26. PMID:38660384. |
the binding of bdnf to trkb triggers the activation of different signaling pathways, including the erk, plc-γ and pi3k-mtor pathways, to induce dendritic growth and synaptic plasticity. |
2024-04-26 |
2024-04-28 |
Not clear |
| Alexandros Tsimpolis, Konstantinos Kalafatakis, Ioannis Charalampopoulo. Recent advances in the crosstalk between the brain-derived neurotrophic factor and glucocorticoids. Frontiers in endocrinology. vol 15. 2024-04-22. PMID:38645426. |
brain-derived neurotrophic factor (bdnf), a key neurotrophin within the brain, by selectively activating the trkb receptor, exerts multimodal effects on neurodevelopment, synaptic plasticity, cellular integrity and neural network dynamics. |
2024-04-22 |
2024-04-24 |
Not clear |
| Rafael Penadés, Carmen Almodóvar-Payá, Clemente García-Rizo, Victoria Ruíz, Rosa Catalán, Sergi Valero, Til Wykes, Mar Fatjó-Vilas, Bárbara Aria. Changes in BDNF methylation patterns after cognitive remediation therapy in schizophrenia: A randomized and controlled trial. Journal of psychiatric research. vol 173. 2024-03-27. PMID:38537483. |
a gene central to synaptic plasticity, the bdnf, has been proposed as one potential route. |
2024-03-27 |
2024-03-30 |
human |