| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Fumagalli, G Racagni, M A Riv. The expanding role of BDNF: a therapeutic target for Alzheimer's disease? The pharmacogenomics journal. vol 6. issue 1. 2006-02-13. PMID:16314887. |
this review will focus on different pharmacological interventions that are currently in use or drugs under development, narrowing the therapeutic agents to those that interfere with the expression of the trophic factor brain-derived neurotrophic factor (bdnf), a molecule playing a pivotal role in synaptic plasticity and cognition. |
2006-02-13 |
2023-08-12 |
Not clear |
| Mariana Alonso, Pedro Bekinschtein, Martín Cammarota, Monica R M Vianna, Iván Izquierdo, Jorge H Medin. Endogenous BDNF is required for long-term memory formation in the rat parietal cortex. Learning & memory (Cold Spring Harbor, N.Y.). vol 12. issue 5. 2006-01-23. PMID:16204202. |
brain-derived neurotrophic factor (bdnf) modulates both short-term synaptic function and activity-dependent synaptic plasticity in hippocampal and cortical neurons. |
2006-01-23 |
2023-08-12 |
human |
| Rebeca Martínez-Turrillas, Joaquín Del Río, Diana Frechill. Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment. Neuropharmacology. vol 49. issue 8. 2006-01-17. PMID:16143352. |
the results suggest that paroxetine, but not desipramine, enhances synaptic plasticity in the hippocampus by increasing bdnf mrna expression, which determines a later ampar subunit trafficking to synaptic membranes. |
2006-01-17 |
2023-08-12 |
rat |
| Clive R Bramham, Elhoucine Messaoud. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Progress in neurobiology. vol 76. issue 2. 2005-12-15. PMID:16099088. |
bdnf function in adult synaptic plasticity: the synaptic consolidation hypothesis. |
2005-12-15 |
2023-08-12 |
Not clear |
| Clive R Bramham, Elhoucine Messaoud. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Progress in neurobiology. vol 76. issue 2. 2005-12-15. PMID:16099088. |
despite individual breakthroughs, an integrated understanding of bdnf function in synaptic plasticity is lacking. |
2005-12-15 |
2023-08-12 |
Not clear |
| Shih-Jen Tsa. Possible involvement of brain-derived neurotrophic factor in the antinociceptive effect of antidepressants in neuropathic pain. Medical hypotheses. vol 65. issue 3. 2005-10-27. PMID:15905042. |
brain-derived neurotrophic factor (bdnf), a member of the neurotrophic factor family, can modulate synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. |
2005-10-27 |
2023-08-12 |
human |
| Lisa M Rattiner, Michael Davis, Kerry J Ressle. Brain-derived neurotrophic factor in amygdala-dependent learning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 11. issue 4. 2005-10-19. PMID:16061519. |
the neurotrophin brain-derived neurotrophic factor (bdnf) has recently emerged as a possible molecular mediator of activity-dependent synaptic plasticity underlying learning and memory. |
2005-10-19 |
2023-08-12 |
Not clear |
| Guhan Nagappan, Bai L. Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends in neurosciences. vol 28. issue 9. 2005-10-12. PMID:16040136. |
although brain-derived neurotrophic factor (bdnf) has emerged as a key regulator of activity-dependent synaptic plasticity, a conceptually challenging question is how this diffusible molecule achieves local and synapse-specific modulation. |
2005-10-12 |
2023-08-12 |
Not clear |
| Newton H Woo, Henry K Teng, Chia-Jen Siao, Cristina Chiaruttini, Petti T Pang, Teresa A Milner, Barbara L Hempstead, Bai L. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nature neuroscience. vol 8. issue 8. 2005-09-27. PMID:16025106. |
these results show a crucial role for probdnf-p75(ntr) signaling in ltd and its potential mechanism, and together with the finding that mature bdnf promotes synaptic potentiation, suggest a bidirectional regulation of synaptic plasticity by probdnf and mature bdnf. |
2005-09-27 |
2023-08-12 |
mouse |
| M Silhol, V Bonnichon, F Rage, L Tapia-Arancibi. Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837123. |
among neurotrophins (considered as genuine molecular mediators of synaptic plasticity), brain-derived neurotrophic factor (bdnf) exhibits in adult rats, the highest concentrations in the hippocampus and hypothalamus. |
2005-08-30 |
2023-08-12 |
rat |
| Tamao End. Glycans and glycan-binding proteins in brain: galectin-1-induced expression of neurotrophic factors in astrocytes. Current drug targets. vol 6. issue 4. 2005-08-25. PMID:16026261. |
bdnf is known to promote neuronal survival, guide axonal pathfinding, and participate in activity-dependent synaptic plasticity during development. |
2005-08-25 |
2023-08-12 |
Not clear |
| Sarah E Slack, John Grist, Qing Mac, Stephen B McMahon, Sophie Peze. TrkB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons. The Journal of comparative neurology. vol 489. issue 1. 2005-08-23. PMID:15977164. |
brain-derived neurotrophic factor (bdnf) is a neurotrophin implicated in the phenomena of synaptic plasticity in the adult. |
2005-08-23 |
2023-08-12 |
rat |
| Pierre Le Grevè. Pleiotrophin gene transcription in the rat nucleus accumbens is stimulated by an acute dose of amphetamine. Brain research bulletin. vol 65. issue 6. 2005-07-25. PMID:15862925. |
as the response to the two drugs resembles the one earlier reported on the gene expression of brain-derived neurotrophic factor (bdnf), the present results suggest that ptn may be an attractive protein to study further in the field of synaptic plasticity. |
2005-07-25 |
2023-08-12 |
rat |
| Syed I A Zaidi, Anjum Jafri, Toye Doggett, Musa A Haxhi. Airway-related vagal preganglionic neurons express brain-derived neurotrophic factor and TrkB receptors: implications for neuronal plasticity. Brain research. vol 1044. issue 2. 2005-07-18. PMID:15885212. |
recent evidence indicates that brain-derived neurotrophic factor (bdnf) is present in neurons and may affect neurotransmitter release, cell excitability, and synaptic plasticity via activation of tyrosine kinase b (trkb) receptors. |
2005-07-18 |
2023-08-12 |
Not clear |
| Zhe Ying, Roland R Roy, V Reggie Edgerton, Fernando Gómez-Pinill. Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury. Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869943. |
the levels of the downstream effectors for the action of bdnf on synaptic plasticity synapsin i and creb were lower in sed-hx than con rats at all time points. |
2005-07-15 |
2023-08-12 |
rat |
| Elena Butovsky, Ana Juknat, Igor Goncharov, Judith Elbaz, Raya Eilam, Abraham Zangen, Zvi Voge. In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol. Journal of neurochemistry. vol 93. issue 4. 2005-07-05. PMID:15857384. |
moreover, bdnf is known to modulate synaptic plasticity and adaptive processes underlying learning and memory, leading to long-term functional and structural modification of synaptic connections. |
2005-07-05 |
2023-08-12 |
rat |
| Holger Rosenbrock, Eliza Koros, Anita Bloching, Jana Podhorna, Franco Borsin. Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats. Brain research. vol 1040. issue 1-2. 2005-06-07. PMID:15804426. |
chronic restraint stress may change hippocampal mrna levels of markers for synaptic plasticity such as synaptophysin, growth-associated protein 43 (gap-43), and brain-derived neurotrophic factor (bdnf). |
2005-06-07 |
2023-08-12 |
rat |
| Helen E Scharfman, Neil J Maclusk. Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue? Trends in neurosciences. vol 28. issue 2. 2005-04-25. PMID:15667930. |
the possible role of bdnf as a signaling molecule downstream of estrogen in the hippocampus has implications for our understanding of several cellular and behavioral hippocampal functions, including dendritic and synaptic plasticity, learning and cognitive behavior. |
2005-04-25 |
2023-08-12 |
Not clear |
| Petti T Pang, Bai L. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing research reviews. vol 3. issue 4. 2005-04-12. PMID:15541709. |
further work will be required to address the relationship between bdnf and tpa in various forms of synaptic plasticity, and the mechanisms by which bdnf/tpa achieves synapse-specific modulation. |
2005-04-12 |
2023-08-12 |
Not clear |
| Ingrid Y C Liu, W Ernest Lyons, Laura A Mamounas, Richard F Thompso. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356210. |
because bdnf is involved in synaptic transmission and contextual learning is hippocampal dependent, we hypothesized that this deficit is attributable to abnormal bdnf-modulated synaptic plasticity in the hippocampus. |
2005-04-05 |
2023-08-12 |
mouse |