| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maurizio Popoli, Massimo Gennarelli, Giorgio Racagn. Modulation of synaptic plasticity by stress and antidepressants. Bipolar disorders. vol 4. issue 3. 2003-01-17. PMID:12180272. |
a central role in these synaptic changes is exerted by brain-derived neurotrophic factor (bdnf), which modulates both synaptic plasticity and its molecular mediators, as well as inducing morphological synaptic changes. |
2003-01-17 |
2023-08-12 |
Not clear |
| Fernando Gómez-Pinilla, Zhe Ying, Roland R Roy, Raffaella Molteni, V Reggie Edgerto. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. Journal of neurophysiology. vol 88. issue 5. 2003-01-14. PMID:12424260. |
rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (bdnf), its signal transduction receptor (trkb), and downstream effectors for the action of bdnf on synaptic plasticity. |
2003-01-14 |
2023-08-12 |
rat |
| Agnieszka Balkowiec, David M Kat. Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451139. |
to shed light on mechanisms underlying bdnf-dependent synaptic plasticity, the present study was undertaken to characterize release of native bdnf from newborn rat hippocampal neurons in response to physiologically relevant patterns of electrical field stimulation in culture, including tonic stimulation at 5 hz, bursting stimulation at 25 and 100 hz, and theta-burst stimulation (tbs). |
2002-12-23 |
2023-08-12 |
rat |
| R J Tolwani, P S Buckmaster, S Varma, J M Cosgaya, Y Wu, C Suri, E M Shoote. BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus. Neuroscience. vol 114. issue 3. 2002-12-20. PMID:12220579. |
this is the first study to evaluate the effects of bdnf overexpression on dendrite morphology in the intact hippocampus and extends previous in vitro observations that bdnf influences synaptic plasticity by increasing complexity of dendritic arbors. |
2002-12-20 |
2023-08-12 |
mouse |
| Xiao hui Zhang, Mu-ming Po. Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon. Neuron. vol 36. issue 4. 2002-12-19. PMID:12441056. |
brain-derived neurotrophic factor (bdnf) is known to promote neuronal survival, guide axonal pathfinding, and participate in activity-dependent synaptic plasticity. |
2002-12-19 |
2023-08-12 |
xenopus_laevis |
| Mary Eve McCutchen, Clive R Bramham, Lucas D Pozzo-Mille. Modulation of neuronal calcium signaling by neurotrophic factors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175855. |
because of the well-established role of post-synaptic elevations in concentrations of free ca(2+) ions ([ca(2+)](i)) in synaptic plasticity, we investigated the hypothesis that bdnf exerts its neuromodulatory effects on hippocampal pyramidal neurons by enhancing dendritic [ca(2+)](i) transients mediated by voltage-dependent ca(2+) channels (vdccs) during the firing of back-propagating action potentials. |
2002-12-17 |
2023-08-12 |
Not clear |
| Mary Eve McCutchen, Clive R Bramham, Lucas D Pozzo-Mille. Modulation of neuronal calcium signaling by neurotrophic factors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175855. |
these results suggest that, despite bdnf's profound effects on hippocampal synaptic plasticity, and of l-type ca(2+) channels on neuronal gene transcription, the role of bdnf in cellular models of hippocampus-dependent learning and memory does not involve modulation of voltage-gated dendritic ca(2+) signaling mediated by l-type channels in apical dendrites of ca1 pyramidal neurons. |
2002-12-17 |
2023-08-12 |
Not clear |
| William J Tyler, Mariana Alonso, Clive R Bramham, Lucas D Pozzo-Mille. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learning & memory (Cold Spring Harbor, N.Y.). vol 9. issue 5. 2002-11-15. PMID:12359832. |
brain-derived neurotrophic factor (bdnf) has recently emerged as one of the most potent molecular mediators of not only central synaptic plasticity, but also behavioral interactions between an organism and its environment. |
2002-11-15 |
2023-08-12 |
Not clear |
| Robert Blum, Karl W Kafitz, Arthur Konnert. Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Nature. vol 419. issue 6908. 2002-11-08. PMID:12384689. |
many types of neurons in the central nervous system are excited by bdnf or neurotrophin-4/5, an action that has recently been implicated in synaptic plasticity. |
2002-11-08 |
2023-08-12 |
Not clear |
| Liliana Minichiello, Anna Maria Calella, Diego L Medina, Tobias Bonhoeffer, Rüdiger Klein, Martin Kort. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. vol 36. issue 1. 2002-11-04. PMID:12367511. |
the trkb receptor tyrosine kinase and its ligand, bdnf, have an essential role in certain forms of synaptic plasticity. |
2002-11-04 |
2023-08-12 |
mouse |
| Yuji Ikegaya, Yoko Ishizaka, Norio Matsuk. BDNF attenuates hippocampal LTD via activation of phospholipase C: implications for a vertical shift in the frequency-response curve of synaptic plasticity. The European journal of neuroscience. vol 16. issue 1. 2002-10-09. PMID:12153539. |
bdnf attenuates hippocampal ltd via activation of phospholipase c: implications for a vertical shift in the frequency-response curve of synaptic plasticity. |
2002-10-09 |
2023-08-12 |
rat |
| R Molteni, R J Barnard, Z Ying, C K Roberts, F Gómez-Pinill. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088740. |
consequent to the action of bdnf on synaptic function, downstream effectors for the action of bdnf on synaptic plasticity were reduced proportionally to bdnf levels, in the hippocampus of rats maintained on the hfs diet between 2 and 24 months. |
2002-09-03 |
2023-08-12 |
rat |
| Nicole C Berchtold, J Patrick Kesslak, Carl W Cotma. Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. Journal of neuroscience research. vol 68. issue 5. 2002-08-12. PMID:12111841. |
brain-derived neurotrophic factor (bdnf) enhances synaptic plasticity and neuron function. |
2002-08-12 |
2023-08-12 |
Not clear |
| Kobi Rosenblum, Marie Futter, Karen Voss, Muriel Erent, Paul A Skehel, Pim French, Louis Obosi, Matt W Jones, Tim V P Blis. The role of extracellular regulated kinases I/II in late-phase long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 13. 2002-07-29. PMID:12097495. |
to test whether the induction of persistent synaptic plasticity by stimuli such as bdnf is associated with nuclear translocation of erki/ii, we expressed enhanced green fluorescent protein (egfp)-erkii in pc12 cell lines and primary cortical cultures. |
2002-07-29 |
2023-08-12 |
Not clear |
| Susan G Dorsey, Linda L Bambrick, Rita J Balice-Gordon, Bruce K Kruege. Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923422. |
the neurotrophin, brain derived neurotrophic factor (bdnf), exerts multiple effects on the development and maintenance of the nervous system, including regulating synaptic plasticity and promoting neuron survival. |
2002-04-08 |
2023-08-12 |
mouse |
| Shui-Wang Ying, Marie Futter, Kobi Rosenblum, Mark J Webber, Stephen P Hunt, Timothy V P Bliss, Clive R Bramha. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880483. |
brain-derived neurotrophic factor (bdnf) is implicated in long-term synaptic plasticity in the adult hippocampus, but the cellular mechanisms are little understood. |
2002-03-22 |
2023-08-12 |
Not clear |
| Alexandre R Carter, Chinfei Chen, Phillip M Schwartz, Rosalind A Sega. Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 4. 2002-02-26. PMID:11850459. |
these data suggest that bdnf regulates both the mechanisms that underlie short-term synaptic plasticity and the steady-state relationship between different vesicle pools within the terminal. |
2002-02-26 |
2023-08-12 |
mouse |
| Kiyofumi Yamada, Makoto Mizuno, Toshitaka Nabeshim. Role for brain-derived neurotrophic factor in learning and memory. Life sciences. vol 70. issue 7. 2002-02-22. PMID:11833737. |
long-term potentiation, a form of synaptic plasticity, is markedly impaired in bdnf mutant mice, but the changes were restored by the re-expression of bdnf. |
2002-02-22 |
2023-08-12 |
mouse |
| A H Kossel, S B Cambridge, U Wagner, T Bonhoeffe. A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 25. 2002-01-10. PMID:11724927. |
our experiments therefore strengthen the view that endogenous bdnf has fast effects during induction of synaptic plasticity. |
2002-01-10 |
2023-08-12 |
Not clear |
| M Hartmann, R Heumann, V Lessman. Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. The EMBO journal. vol 20. issue 21. 2001-12-07. PMID:11689429. |
the protein brain-derived neurotrophic factor (bdnf) has been postulated to be a retrograde or paracrine synaptic messenger in long-term potentiation and other forms of activity-dependent synaptic plasticity. |
2001-12-07 |
2023-08-12 |
Not clear |