| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P R Blanquet, J Mariani, P Dere. A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699783. |
brain-derived neurotrophic factor (bdnf) plays fundamental roles in synaptic plasticity in rat hippocampus. |
2003-06-16 |
2023-08-12 |
rat |
| P R Blanquet, J Mariani, P Dere. A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699783. |
recently, using rat hippocampal slices, we found that bdnf induces activation of calcium/calmodulin-dependent protein kinase 2 (camkii), a critical mediator of synaptic plasticity. |
2003-06-16 |
2023-08-12 |
rat |
| Julian Goggi, Ian A Pullar, Stephen L Carney, Henry F Bradfor. Signalling pathways involved in the short-term potentiation of dopamine release by BDNF. Brain research. vol 968. issue 1. 2003-06-04. PMID:12644273. |
brain-derived neurotrophic factor (bdnf) has been shown to modulate synaptic plasticity in the corpus striatum in vitro by activation of the tyrosine kinase linked receptor, trkb. |
2003-06-04 |
2023-08-12 |
rat |
| Marzia Malcangio, Volkmar Lessman. A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors. Trends in pharmacological sciences. vol 24. issue 3. 2003-04-08. PMID:12628355. |
in the schaffer collateral pathway of the hippocampus, binding of bdnf to high-affinity trkb receptors is essential for the induction of long-term potentiation, a specific type of synaptic plasticity. |
2003-04-08 |
2023-08-12 |
Not clear |
| Matylda Macias, Susanne Fehr, Anna Dwornik, Dorota Sulejczak, Maciej Wiater, Julita Czarkowska-Bauch, Malgorzata Skup, Melitta Schachne. Exercise increases mRNA levels for adhesion molecules N-CAM and L1 correlating with BDNF response. Neuroreport. vol 13. issue 18. 2003-04-04. PMID:12499861. |
these results suggest that exercise-induced rearrangements of the spinal network involve n-cam, l1 and bdnf, crucial in different aspects of synaptic plasticity and synapse formation. |
2003-04-04 |
2023-08-12 |
rat |
| Sophie Pezet, Marzia Malcangio, Stephen B McMaho. BDNF: a neuromodulator in nociceptive pathways? Brain research. Brain research reviews. vol 40. issue 1-3. 2003-04-01. PMID:12589922. |
in adulthood, bdnf has been suggested to act as an important modulator of synaptic plasticity. |
2003-04-01 |
2023-08-12 |
Not clear |
| Rachel Groth, Lin Aanonse. Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia. Pain. vol 100. issue 1-2. 2003-03-12. PMID:12435470. |
finally, with the accumulating evidence linking bdnf to synaptic plasticity, we investigated whether bdnf-induced hyperalgesia in normal mice involves the n-methyl-d-aspartate (nmda) receptor. |
2003-03-12 |
2023-08-12 |
mouse |
| Mariana Alonso, Monica R M Vianna, Amaicha M Depino, Tadeu Mello e Souza, Patricia Pereira, German Szapiro, Haydee Viola, Fernando Pitossi, Ivan Izquierdo, Jorge H Medin. BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation. Hippocampus. vol 12. issue 4. 2003-03-05. PMID:12201640. |
because brain-derived neutrophic factor (bdnf) modulates both short-term synaptic function and activity-dependent synaptic plasticity in the adult hippocampus, we examined the role of bdnf in stm and ltm formation of a hippocampal-dependent one-trial fear-motivated learning task in rats. |
2003-03-05 |
2023-08-12 |
human |
| Jeffrey W Grimm, Lin Lu, Teruo Hayashi, Bruce T Hope, Tsung-Ping Su, Yavin Shaha. Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 3. 2003-02-21. PMID:12574402. |
bdnf is involved in synaptic plasticity and was found to enhance responding for cues associated with natural rewards. |
2003-02-21 |
2023-08-12 |
rat |
| Sarah E Slack, Stephen W N Thompso. Brain-derived neurotrophic factor induces NMDA receptor 1 phosphorylation in rat spinal cord. Neuroreport. vol 13. issue 15. 2003-02-07. PMID:12395101. |
the nmda receptor and the neurotrophin brain-derived neurotrophic factor, bdnf, are involved in central sensitisation and synaptic plasticity in the spinal cord. |
2003-02-07 |
2023-08-12 |
rat |
| Masashi Yamada, Tadahiro Numakawa, Hisatsugu Koshimizu, Keiko Tanabe, Kazuyo Wada, Shinichi Koizumi, Hiroshi Hatanak. Distinct usages of phospholipase C gamma and Shc in intracellular signaling stimulated by neurotrophins. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419535. |
nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3), members of the neurotrophin family, bind to and activate trka, trkb and trkc, respectively, members of the trk receptor tyrosine kinase family, to exert various effects including promotion of differentiation and survival, and regulation of synaptic plasticity in neuronal cells. |
2003-01-31 |
2023-08-12 |
Not clear |
| Paula C Ashe, Jennifer Chlan-Fourney, Augusto V Juorio, Xin-Min L. Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426055. |
the role of brain-derived neurotrophic factor (bdnf) in neurodevelopment, cell viability and synaptic plasticity led to the investigation of bdnf as a potential candidate molecule in the pathophysiology of schizophrenia. |
2003-01-29 |
2023-08-12 |
rat |
| Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castré. BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus. Neurobiology of disease. vol 11. issue 1. 2003-01-23. PMID:12460560. |
our data provide evidence that bdnf via trkb signaling decreases fmrp expression and suggest a role for fmrp in bdnf-induced synaptic plasticity. |
2003-01-23 |
2023-08-12 |
mouse |
| Maurizio Popoli, Massimo Gennarelli, Giorgio Racagn. Modulation of synaptic plasticity by stress and antidepressants. Bipolar disorders. vol 4. issue 3. 2003-01-17. PMID:12180272. |
a central role in these synaptic changes is exerted by brain-derived neurotrophic factor (bdnf), which modulates both synaptic plasticity and its molecular mediators, as well as inducing morphological synaptic changes. |
2003-01-17 |
2023-08-12 |
Not clear |
| Fernando Gómez-Pinilla, Zhe Ying, Roland R Roy, Raffaella Molteni, V Reggie Edgerto. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. Journal of neurophysiology. vol 88. issue 5. 2003-01-14. PMID:12424260. |
rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (bdnf), its signal transduction receptor (trkb), and downstream effectors for the action of bdnf on synaptic plasticity. |
2003-01-14 |
2023-08-12 |
rat |
| Agnieszka Balkowiec, David M Kat. Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451139. |
to shed light on mechanisms underlying bdnf-dependent synaptic plasticity, the present study was undertaken to characterize release of native bdnf from newborn rat hippocampal neurons in response to physiologically relevant patterns of electrical field stimulation in culture, including tonic stimulation at 5 hz, bursting stimulation at 25 and 100 hz, and theta-burst stimulation (tbs). |
2002-12-23 |
2023-08-12 |
rat |
| R J Tolwani, P S Buckmaster, S Varma, J M Cosgaya, Y Wu, C Suri, E M Shoote. BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus. Neuroscience. vol 114. issue 3. 2002-12-20. PMID:12220579. |
this is the first study to evaluate the effects of bdnf overexpression on dendrite morphology in the intact hippocampus and extends previous in vitro observations that bdnf influences synaptic plasticity by increasing complexity of dendritic arbors. |
2002-12-20 |
2023-08-12 |
mouse |
| Xiao hui Zhang, Mu-ming Po. Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon. Neuron. vol 36. issue 4. 2002-12-19. PMID:12441056. |
brain-derived neurotrophic factor (bdnf) is known to promote neuronal survival, guide axonal pathfinding, and participate in activity-dependent synaptic plasticity. |
2002-12-19 |
2023-08-12 |
xenopus_laevis |
| Mary Eve McCutchen, Clive R Bramham, Lucas D Pozzo-Mille. Modulation of neuronal calcium signaling by neurotrophic factors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175855. |
because of the well-established role of post-synaptic elevations in concentrations of free ca(2+) ions ([ca(2+)](i)) in synaptic plasticity, we investigated the hypothesis that bdnf exerts its neuromodulatory effects on hippocampal pyramidal neurons by enhancing dendritic [ca(2+)](i) transients mediated by voltage-dependent ca(2+) channels (vdccs) during the firing of back-propagating action potentials. |
2002-12-17 |
2023-08-12 |
Not clear |
| Mary Eve McCutchen, Clive R Bramham, Lucas D Pozzo-Mille. Modulation of neuronal calcium signaling by neurotrophic factors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175855. |
these results suggest that, despite bdnf's profound effects on hippocampal synaptic plasticity, and of l-type ca(2+) channels on neuronal gene transcription, the role of bdnf in cellular models of hippocampus-dependent learning and memory does not involve modulation of voltage-gated dendritic ca(2+) signaling mediated by l-type channels in apical dendrites of ca1 pyramidal neurons. |
2002-12-17 |
2023-08-12 |
Not clear |