| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K M Huber, N B Sawtell, M F Bea. Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex. Neuropharmacology. vol 37. issue 4-5. 1999-05-26. PMID:9704998. |
the effects of brain-derived neurotrophic factor (bdnf) were investigated on synaptic transmission and two forms of activity-dependent synaptic plasticity, long-term potentiation (ltp) and long-term depression (ltd), in visual cortex slices prepared from young (p21 -28) rats. |
1999-05-26 |
2023-08-12 |
rat |
| K M Huber, N B Sawtell, M F Bea. Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex. Neuropharmacology. vol 37. issue 4-5. 1999-05-26. PMID:9704998. |
thus, bdnf treatment alters the relationship between stimulation frequency and synaptic plasticity in the visual cortex, shifting the modification threshold to the left. |
1999-05-26 |
2023-08-12 |
rat |
| K M Huber, N B Sawtell, M F Bea. Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex. Neuropharmacology. vol 37. issue 4-5. 1999-05-26. PMID:9704998. |
these data suggest that one role of bdnf during development of the visual cortex may be to modulate the properties of synaptic plasticity, enhancing synaptic strengthening and reducing synaptic weakening processes which contribute to the formation of specific synaptic connections. |
1999-05-26 |
2023-08-12 |
rat |
| H Fiumelli, D Jabaudon, P J Magistretti, J L Marti. BDNF stimulates expression, activity and release of tissue-type plasminogen activator in mouse cortical neurons. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215917. |
brain-derived neurotrophic factor (bdnf) is a neurotrophic factor involved in neuronal development and synaptic plasticity. |
1999-05-26 |
2023-08-12 |
mouse |
| H Fiumelli, D Jabaudon, P J Magistretti, J L Marti. BDNF stimulates expression, activity and release of tissue-type plasminogen activator in mouse cortical neurons. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215917. |
together these results suggest that activation of tpa by bdnf may contribute to structural changes associated with neuronal development or synaptic plasticity. |
1999-05-26 |
2023-08-12 |
mouse |
| S J Mowla, S Pareek, H F Farhadi, K Petrecca, J P Fawcett, N G Seidah, S J Morris, W S Sossin, R A Murph. Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 6. 1999-04-13. PMID:10066260. |
in contrast, brain-derived neurotrophic factor (bdnf) appears to be processed in the regulated secretory pathway of brain neurons and secreted in an activity-dependent manner to play a role in synaptic plasticity. |
1999-04-13 |
2023-08-12 |
Not clear |
| S Kinoshita, H Yasuda, N Taniguchi, R Katoh-Semba, H Hatanaka, T Tsumot. Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 6. 1999-04-13. PMID:10066265. |
if so, a shortage or blockade of bdnf might lead to another form of synaptic plasticity, long-term depression (ltd). |
1999-04-13 |
2023-08-12 |
rat |
| J Bradley, O Sporn. BDNF-dependent enhancement of exocytosis in cultured cortical neurons requires translation but not transcription. Brain research. vol 815. issue 1. 1999-03-30. PMID:9974134. |
neurotrophic factors, such as brain-derived neurotrophic factor (bdnf), are involved in acute modulation of synaptic plasticity. |
1999-03-30 |
2023-08-12 |
Not clear |
| J Bradley, O Sporn. BDNF-dependent enhancement of exocytosis in cultured cortical neurons requires translation but not transcription. Brain research. vol 815. issue 1. 1999-03-30. PMID:9974134. |
different modes of action of bdnf have been described with time courses ranging from seconds to hours, but the sequence of cellular processes responsible for bdnf-dependent modulation of synaptic plasticity is unknown. |
1999-03-30 |
2023-08-12 |
Not clear |
| T Hayashi, H Umemori, M Mishina, T Yamamot. The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature. vol 397. issue 6714. 1999-02-01. PMID:9892356. |
thus, ampa receptors generate intracellular signals from the cell surface to the nucleus through the lyn-mapk pathway, which may contribute to synaptic plasticity by regulating the expression of bdnf. |
1999-02-01 |
2023-08-12 |
Not clear |
| G Pellegri, P J Magistretti, J L Marti. VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones. The European journal of neuroscience. vol 10. issue 1. 1998-10-08. PMID:9753136. |
in addition to its neurotrophic effects, bdnf has been shown to be involved in neuronal plasticity and results reported here suggest that by stimulating bdnf expression, vip and pacap could modulate synaptic plasticity in the cerebral cortex. |
1998-10-08 |
2023-08-12 |
mouse |
| W Gottschalk, L D Pozzo-Miller, A Figurov, B L. Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 17. 1998-09-09. PMID:9712654. |
the preferential potentiation of highly active synapses by bdnf may have implications in the hebbian mechanism of synaptic plasticity. |
1998-09-09 |
2023-08-12 |
Not clear |
| W Haubensak, F Narz, R Heumann, V Lessman. BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons. Journal of cell science. vol 111 ( Pt 11). 1998-07-28. PMID:9580557. |
these data suggest that bdnf-gfp will be a useful tool to investigate synaptic release of bdnf during physiological synaptic stimulation, and will thereby allow us to elucidate the participation of neurotrophin release in activity dependent synaptic plasticity. |
1998-07-28 |
2023-08-12 |
rat |
| S L Patterson, T Abel, T A Deuel, K C Martin, J C Rose, E R Kande. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron. vol 16. issue 6. 1996-08-02. PMID:8663990. |
knockout mice can be used to study the roles of molecules like bdnf in synaptic plasticity with more molecular specificity than is possible using pharmacological approaches. |
1996-08-02 |
2023-08-12 |
mouse |
| M Knipper, M da Penha Berzaghi, A Blöchl, H Breer, H Thoenen, D Lindhol. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus. The European journal of neuroscience. vol 6. issue 4. 1994-08-11. PMID:8025717. |
the reciprocal regulation of ach, ngf and bdnf in the hippocampus suggests a novel molecular framework by which the neurotrophins might influence synaptic plasticity. |
1994-08-11 |
2023-08-12 |
rat |
| C Wetmore, L Olson, A J Bea. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 2. 1994-04-08. PMID:8126563. |
the synthesis and putative release of bdnf from somatic and/or dendritic sites within the hippocampus provide evidence of a potential autocrine or paracrine role for bdnf, and establish a local source of trophic support for the maintenance of synaptic plasticity and anatomic reorganization in the mature nervous system. |
1994-04-08 |
2023-08-12 |
Not clear |
| P A Lapchak, D M Araujo, K D Beck, C E Finch, S A Johnson, F Heft. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiology of aging. vol 14. issue 2. 1993-06-10. PMID:8487914. |
these findings indicate that altered hippocampal synaptic plasticity which occurs in the aged rat brain is not a reflection of changes in the expression of bdnf or trkb receptor mrna. |
1993-06-10 |
2023-08-12 |
rat |
| F Zafra, E Castrén, H Thoenen, D Lindhol. Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 22. 1991-12-26. PMID:1658793. |
the refined and rapid regulation of bdnf and ngf synthesis by the glutamate and gaba transmitter systems suggests that bdnf and ngf might be involved in activity-dependent synaptic plasticity. |
1991-12-26 |
2023-08-11 |
Not clear |