| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruth M Barrientos, Matthew G Frank, Nicole Y Crysdale, Timothy R Chapman, Jared T Ahrendsen, Heidi E W Day, Serge Campeau, Linda R Watkins, Susan L Patterson, Steven F Maie. Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 32. 2011-10-04. PMID:21832188. |
among the outcomes of this exaggerated neuroinflammatory response are impairments in synaptic plasticity and reductions of brain-derived neurotrophic factor (bdnf), both of which have been associated with cognitive impairments. |
2011-10-04 |
2023-08-12 |
rat |
| Anders B Klein, Rebecca Williamson, Martin A Santini, Christoffer Clemmensen, Anders Ettrup, Maribel Rios, Gitte M Knudsen, Susana Azna. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. The international journal of neuropsychopharmacology. vol 14. issue 3. 2011-09-19. PMID:20604989. |
brain-derived neurotrophic factor (bdnf) is involved in synaptic plasticity, neuronal differentiation and survival of neurons. |
2011-09-19 |
2023-08-12 |
mouse |
| Christoph Laske, Konstantinos Stellos, Nadine Hoffmann, Elke Stransky, Guido Straten, Gerhard W Eschweiler, Thomas Leyh. Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. The international journal of neuropsychopharmacology. vol 14. issue 3. 2011-09-19. PMID:20860877. |
the neurotrophin brain-derived neurotrophic factor (bdnf) plays a critical role in neuronal survival, synaptic plasticity, and memory. |
2011-09-19 |
2023-08-12 |
Not clear |
| Mona El-Sayed, Jacob Hofman-Bang, Jens D Mikkelse. Effect of brain-derived neurotrophic factor on activity-regulated cytoskeleton-associated protein gene expression in primary frontal cortical neurons. Comparison with NMDA and AMPA. European journal of pharmacology. vol 660. issue 2-3. 2011-09-06. PMID:21515256. |
these results demonstrate bdnf to be a highly potent and efficient inducer of arc gene expression in vitro, emphasizing the role of this growth factor in synaptic plasticity in the frontal cortex. |
2011-09-06 |
2023-08-12 |
rat |
| Grabiele Musumeci, Liliana Minichiell. BDNF-TrkB signalling in fear learning: from genetics to neural networks. Reviews in the neurosciences. vol 22. issue 3. 2011-08-23. PMID:21639804. |
among the molecular systems required for fear learning and amygdalar synaptic plasticity, brain derived neurtrophic factor (bdnf) and its high affinity receptor ntrk2/trkb have been shown to play essential roles. |
2011-08-23 |
2023-08-12 |
Not clear |
| Valerio Ricci, Giovanni Martinotti, Francesca Gelfo, Federico Tonioni, Carlo Caltagirone, Pietro Bria, Francesco Angelucc. Chronic ketamine use increases serum levels of brain-derived neurotrophic factor. Psychopharmacology. vol 215. issue 1. 2011-08-15. PMID:21161184. |
in addition, neurotrophins, particularly bdnf, may regulate ltp in the hippocampus and influence synaptic plasticity. |
2011-08-15 |
2023-08-12 |
Not clear |
| Tanja Richter-Schmidinger, Panagiotis Alexopoulos, Marco Horn, Sebastian Maus, Martin Reichel, Cosima Rhein, Piotr Lewczuk, Christos Sidiropoulos, Thomas Kneib, Robert Perneczky, Arnd Doerfler, Johannes Kornhube. Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 2. 2011-08-12. PMID:21190051. |
apolipoprotein e (apoe) and brain-derived neurotrophic factor (bdnf) play an important role in cell growth, regeneration, synaptic plasticity, learning and memory processes. |
2011-08-12 |
2023-08-12 |
Not clear |
| Homeira Hatami, Mohammad Ali Hossainpour-Faizi, Maryam Azarfarin, Parvin Azarfa. Chronic ecstasy use increases neurotrophin-4 gene expression and protein levels in the rat brain. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273656. |
the molecular basis of addiction remains poorly understood, but diverse lines of evidence suggest that neurotrophins (bdnf, nt-3 and nt-4) play a role in the regulation of synaptic plasticity. |
2011-08-10 |
2023-08-12 |
rat |
| Fernando Gomez-Pinilla, Zhe Ying, Teodora Agoncillo, Ron Frosti. The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use. Brain research. vol 1388. 2011-08-08. PMID:21385568. |
based on the role of bdnf on synaptic plasticity and neuronal growth, the focus of this study is on bdnf and its downstream effectors creb, synapsin i, and gap-43. |
2011-08-08 |
2023-08-12 |
rat |
| Joanna L Spencer-Segal, Elizabeth M Waters, Kevin G Bath, Moses V Chao, Bruce S McEwen, Teresa A Milne. Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543608. |
using electron microscopy, we localized trkb phosphorylated at tyrosine 816 (ptrkb) in the hippocampal formation of male and female mice under conditions of naturally low circulating estradiol and naturally high circulating estradiol, when bdnf expression, trkb signaling, and synaptic plasticity are enhanced. |
2011-08-05 |
2023-08-12 |
mouse |
| E Bałkowiec-Iskra, A Vermehren-Schmaedick, A Balkowie. Tumor necrosis factor-α increases brain-derived neurotrophic factor expression in trigeminal ganglion neurons in an activity-dependent manner. Neuroscience. vol 180. 2011-08-04. PMID:21335064. |
in the present study, we examined the effects of tnfα on neuronal expression of brain-derived neurotrophic factor (bdnf), whose role in synaptic plasticity and sensitization of nociceptive pathways is well documented. |
2011-08-04 |
2023-08-12 |
rat |
| Carla Cunha, Riccardo Brambilla, Kerrie L Thoma. A simple role for BDNF in learning and memory? Frontiers in molecular neuroscience. vol 3. 2011-07-14. PMID:20162032. |
more recently, bdnf has also emerged as an important regulator of synaptogenesis and synaptic plasticity mechanisms underlying learning and memory in the adult cns. |
2011-07-14 |
2023-08-12 |
human |
| Carla Cunha, Riccardo Brambilla, Kerrie L Thoma. A simple role for BDNF in learning and memory? Frontiers in molecular neuroscience. vol 3. 2011-07-14. PMID:20162032. |
in this review we will discuss our knowledge about the multiple intracellular signalling pathways activated by bdnf, and the role of this neurotrophin in long-term synaptic plasticity and memory formation as well as in synaptogenesis. |
2011-07-14 |
2023-08-12 |
human |
| Carla Cunha, Riccardo Brambilla, Kerrie L Thoma. A simple role for BDNF in learning and memory? Frontiers in molecular neuroscience. vol 3. 2011-07-14. PMID:20162032. |
we will show that maturation of bdnf, its cellular localization and its ability to regulate both excitatory and inhibitory synapses in the cns may result in conflicting alterations in synaptic plasticity and memory formation. |
2011-07-14 |
2023-08-12 |
human |
| Tadahiro Numakawa, Daisaku Yokomaku, Misty Richards, Hiroaki Hori, Naoki Adachi, Hiroshi Kunug. Functional interactions between steroid hormones and neurotrophin BDNF. World journal of biological chemistry. vol 1. issue 5. 2011-07-14. PMID:21540998. |
brain-derived neurotrophic factor (bdnf), a critical neurotrophin, regulates many neuronal aspects including cell differentiation, cell survival, neurotransmission, and synaptic plasticity in the central nervous system (cns). |
2011-07-14 |
2023-08-12 |
Not clear |
| H A Boger, P Mannangatti, D J Samuvel, A J Saylor, T S Bender, J F McGinty, A M Fortress, V Zaman, P Huang, L D Middaugh, P K Randall, L D Jayanthi, B Rohrer, K L Helke, A-C Granholm, S Ramamoorth. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, brain, and behavior. vol 10. issue 2. 2011-06-15. PMID:20860702. |
brain-derived neurotrophic factor (bdnf) is critical in synaptic plasticity and in the survival and function of midbrain dopamine neurons. |
2011-06-15 |
2023-08-12 |
mouse |
| Giuseppe P Cortese, Ruth M Barrientos, Steven F Maier, Susan L Patterso. Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 11. 2011-06-15. PMID:21411668. |
interestingly, these deficits occur in forms of long-term memory and synaptic plasticity known to be strongly dependent on brain-derived neurotrophic factor (bdnf). |
2011-06-15 |
2023-08-12 |
rat |
| Giuseppe P Cortese, Ruth M Barrientos, Steven F Maier, Susan L Patterso. Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 11. 2011-06-15. PMID:21411668. |
these data suggest that inflammation-evoked reductions in bdnf at synapses might contribute to inflammation-evoked disruptions in long-term memory and synaptic plasticity in aging. |
2011-06-15 |
2023-08-12 |
rat |
| Chiara Cazzin, Silvia Mion, Fabrizio Caldara, Joseph M Rimland, Enrico Domenic. Microarray analysis of cultured rat hippocampal neurons treated with brain derived neurotrophic factor. Molecular biology reports. vol 38. issue 2. 2011-05-26. PMID:20535563. |
more studies are needed to investigate and confirm the role of these genes in synaptic plasticity, but the results reported in this paper show that microarray analysis of hippocampal cultures can be used to expand our current knowledge of the molecular events triggered by bdnf in the hippocampus. |
2011-05-26 |
2023-08-12 |
rat |
| Hui-li Liu, Gang Zhao, Kui Cai, Hai-hua Zhao, Li-de Sh. Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation. Behavioural brain research. vol 218. issue 2. 2011-05-06. PMID:21192984. |
however, bdnf has emerged as a crucial regulator of synaptic plasticity mechanisms underlying learning and memory in wild-type mice, but not in app/ps1 mice. |
2011-05-06 |
2023-08-12 |
mouse |