| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin G Bath, Deqiang Q Jing, Iva Dincheva, Christine C Neeb, Siobhan S Pattwell, Moses V Chao, Francis S Lee, Ipe Nina. BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22218094. |
we assessed hippocampal bdnf protein levels, survival rates of adult born cells, and synaptic plasticity (long-term potentiation, ltp) in the dentate gyrus either with or without chronic (28-day) fluoxetine treatment. |
2012-07-20 |
2023-08-12 |
mouse |
| Kevin G Bath, Deqiang Q Jing, Iva Dincheva, Christine C Neeb, Siobhan S Pattwell, Moses V Chao, Francis S Lee, Ipe Nina. BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22218094. |
the observed effects of the bdnf val66met snp on hippocampal bdnf expression and synaptic plasticity provide a possible mechanistic basis by which this common bdnf snp may impair efficacy of ssri drug treatment. |
2012-07-20 |
2023-08-12 |
mouse |
| Kathleen M Salerno, Xiaotang Jing, Charlotte M Diges, Pamela K Cornuet, Joseph C Glorioso, Kathryn M Alber. Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner. Journal of neuroscience research. vol 90. issue 5. 2012-07-16. PMID:22331573. |
brain-derived neurotrophic factor (bdnf) is a pleiotropic growth factor that has effects on neuronal survival, differentiation, synaptic plasticity, and regeneration. |
2012-07-16 |
2023-08-12 |
mouse |
| S Meis, T Endres, V Lessman. Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents. The Journal of physiology. vol 590. issue 1. 2012-07-10. PMID:22083603. |
the neurotrophin brain-derived neurotrophic factor (bdnf) is known to regulate synaptic plasticity and memory formation in the hippocampus and the neocortex of the mammalian brain. |
2012-07-10 |
2023-08-12 |
mouse |
| S Meis, T Endres, V Lessman. Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents. The Journal of physiology. vol 590. issue 1. 2012-07-10. PMID:22083603. |
in contrast, a role of bdnf in mediating synaptic plasticity and fear learning in the amygdala is just beginning to evolve. |
2012-07-10 |
2023-08-12 |
mouse |
| Che-Ming Yeh, Chiung-Chun Huang, Kuei-Sen Hs. Prenatal stress alters hippocampal synaptic plasticity in young rat offspring through preventing the proteolytic conversion of pro-brain-derived neurotrophic factor (BDNF) to mature BDNF. The Journal of physiology. vol 590. issue 4. 2012-06-26. PMID:22155932. |
prenatal stress alters hippocampal synaptic plasticity in young rat offspring through preventing the proteolytic conversion of pro-brain-derived neurotrophic factor (bdnf) to mature bdnf. |
2012-06-26 |
2023-08-12 |
rat |
| Sivasankaran Balaratnasingam, Aleksandar Janc. Brain Derived Neurotrophic Factor: a novel neurotrophin involved in psychiatric and neurological disorders. Pharmacology & therapeutics. vol 134. issue 1. 2012-06-26. PMID:22281237. |
bdnf may be the "missing-link" that mediates the interaction between gene and environment, synaptic plasticity and apoptosis and transgenerational transmission of disease vulnerability. |
2012-06-26 |
2023-08-12 |
human |
| Enikö A Kramár, Lulu Y Chen, Julie C Lauterborn, Danielle A Simmons, Christine M Gall, Gary Lync. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:20674095. |
bdnf upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. |
2012-06-15 |
2023-08-12 |
human |
| Timothy R Chapman, Ruth M Barrientos, Jared T Ahrendsen, Jennifer M Hoover, Steven F Maier, Susan L Patterso. Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21907460. |
in these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of e. coli leads to specific deficits in long-term memory and long-lasting synaptic plasticity in hippocampal area ca1-processes strongly dependent on brain-derived neurotrophic factor (bdnf). |
2012-06-15 |
2023-08-12 |
rat |
| Monika Karczewska-Kupczewska, Irina Kowalska, Agnieszka Nikołajuk, Agnieszka Adamska, Magdalena Zielińska, Natalia Kamińska, Elżbieta Otziomek, Maria Górska, Marek Strączkowsk. Circulating brain-derived neurotrophic factor concentration is downregulated by intralipid/heparin infusion or high-fat meal in young healthy male subjects. Diabetes care. vol 35. issue 2. 2012-06-12. PMID:22210566. |
brain-derived neurotrophic factor (bdnf) regulates neuronal differentiation and synaptic plasticity, and its decreased levels are supposed to play a role in the pathogenesis of alzheimer's disease and other disorders. |
2012-06-12 |
2023-08-12 |
human |
| Hui Xie, Wing-ho Yun. Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor. Acta pharmacologica Sinica. vol 33. issue 1. 2012-06-04. PMID:22212429. |
here, focusing on results derived from animal studies, we highlight a possible role of reduced expression of brain-derived neurotrophic factor (bdnf) in causing impairment in long-term synaptic plasticity and neurocognitive functions during chronic ih. |
2012-06-04 |
2023-08-12 |
human |
| Oliver Gruber, Alkomiet Hasan, Harald Scherk, Thomas Wobrock, Thomas Schneider-Axmann, Savira Ekawardhani, Andrea Schmitt, Martin Backens, Wolfgang Reith, Jobst Meyer, Peter Falka. Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system. European archives of psychiatry and clinical neuroscience. vol 262. issue 1. 2012-05-31. PMID:21509595. |
the brain-derived neurotrophic factor (bdnf) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. |
2012-05-31 |
2023-08-12 |
human |
| P Li Voti, A Conte, A Suppa, E Iezzi, M Bologna, M S Aniello, G Defazio, J C Rothwell, Alfredo Berardell. Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects. Experimental brain research. vol 212. issue 1. 2012-05-11. PMID:21537966. |
we also examined whether any of these measures were influenced by the presence of a val66met polymorphism in the bdnf gene since this is another factor that has been suggested to be able to predict response to tests of synaptic plasticity. |
2012-05-11 |
2023-08-12 |
human |
| Hyun Yi, Jianfei Hu, Jiang Qian, Abigail S Hacka. Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway. Neuroreport. vol 23. issue 3. 2012-05-10. PMID:22198686. |
brain-derived neurotrophic factor (bdnf) is a well characterized neurotrophin that mediates a wide variety of activities in the central nervous system, including neuronal differentiation, neuroprotection, and synaptic plasticity. |
2012-05-10 |
2023-08-12 |
Not clear |
| Kristine L P Garcia, Guanhua Yu, Chiara Nicolini, Bernadeta Michalski, Diego J Garzon, Victor S Chiu, Enrico Tongiorgi, Peter Szatmari, Margaret Fahnestoc. Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism. Journal of neuropathology and experimental neurology. vol 71. issue 4. 2012-05-07. PMID:22437340. |
brain-derived neurotrophic factor (bdnf) plays a critical role in synaptogenesis and synaptic plasticity. |
2012-05-07 |
2023-08-12 |
Not clear |
| Kristine L P Garcia, Guanhua Yu, Chiara Nicolini, Bernadeta Michalski, Diego J Garzon, Victor S Chiu, Enrico Tongiorgi, Peter Szatmari, Margaret Fahnestoc. Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism. Journal of neuropathology and experimental neurology. vol 71. issue 4. 2012-05-07. PMID:22437340. |
distortion of the balance among the 3 bdnf isoforms, each of which may exhibit different biological activities, could lead to changes in connectivity and synaptic plasticity and, hence, behavior. |
2012-05-07 |
2023-08-12 |
Not clear |
| R Scott Bitne. Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22119240. |
while creb dimers are thought to be constitutively bound to response elements on dna under basal conditions, it is creb phosphorylation that is believed to be responsible for transcriptional activation leading to gene products such as bdnf that play a key role in synaptic plasticity and cognitive function. |
2012-04-13 |
2023-08-12 |
Not clear |
| Luis Constandil, Rodrigo Aguilera, Mariela Goich, Alejandro Hernández, Pedro Alvarez, Claudio Infante, Teresa Pelissie. Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats. Brain research bulletin. vol 86. issue 5-6. 2012-04-05. PMID:21864655. |
brain-derived neurotrophic factor (bdnf) is involved in neuronal survival and synaptic plasticity of the central and peripheral nervous system. |
2012-04-05 |
2023-08-12 |
rat |
| Chen-Jee Hong, Ying-Jay Liou, Shih-Jen Tsa. Effects of BDNF polymorphisms on brain function and behavior in health and disease. Brain research bulletin. vol 86. issue 5-6. 2012-04-05. PMID:21924328. |
brain-derived neurotrophic factor (bdnf), the most abundant neurotrophin in the brain, serves an important role during brain development and in synaptic plasticity. |
2012-04-05 |
2023-08-12 |
human |
| Breno Satler Diniz, Antonio Lucio Teixeir. Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond. Neuromolecular medicine. vol 13. issue 4. 2012-03-26. PMID:21898045. |
brain-derived neurotrophic factor (bdnf) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. |
2012-03-26 |
2023-08-12 |
human |