| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oliver Gruber, Alkomiet Hasan, Harald Scherk, Thomas Wobrock, Thomas Schneider-Axmann, Savira Ekawardhani, Andrea Schmitt, Martin Backens, Wolfgang Reith, Jobst Meyer, Peter Falka. Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system. European archives of psychiatry and clinical neuroscience. vol 262. issue 1. 2012-05-31. PMID:21509595. |
the brain-derived neurotrophic factor (bdnf) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. |
2012-05-31 |
2023-08-12 |
human |
| P Li Voti, A Conte, A Suppa, E Iezzi, M Bologna, M S Aniello, G Defazio, J C Rothwell, Alfredo Berardell. Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects. Experimental brain research. vol 212. issue 1. 2012-05-11. PMID:21537966. |
we also examined whether any of these measures were influenced by the presence of a val66met polymorphism in the bdnf gene since this is another factor that has been suggested to be able to predict response to tests of synaptic plasticity. |
2012-05-11 |
2023-08-12 |
human |
| Hyun Yi, Jianfei Hu, Jiang Qian, Abigail S Hacka. Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway. Neuroreport. vol 23. issue 3. 2012-05-10. PMID:22198686. |
brain-derived neurotrophic factor (bdnf) is a well characterized neurotrophin that mediates a wide variety of activities in the central nervous system, including neuronal differentiation, neuroprotection, and synaptic plasticity. |
2012-05-10 |
2023-08-12 |
Not clear |
| Kristine L P Garcia, Guanhua Yu, Chiara Nicolini, Bernadeta Michalski, Diego J Garzon, Victor S Chiu, Enrico Tongiorgi, Peter Szatmari, Margaret Fahnestoc. Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism. Journal of neuropathology and experimental neurology. vol 71. issue 4. 2012-05-07. PMID:22437340. |
brain-derived neurotrophic factor (bdnf) plays a critical role in synaptogenesis and synaptic plasticity. |
2012-05-07 |
2023-08-12 |
Not clear |
| Kristine L P Garcia, Guanhua Yu, Chiara Nicolini, Bernadeta Michalski, Diego J Garzon, Victor S Chiu, Enrico Tongiorgi, Peter Szatmari, Margaret Fahnestoc. Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism. Journal of neuropathology and experimental neurology. vol 71. issue 4. 2012-05-07. PMID:22437340. |
distortion of the balance among the 3 bdnf isoforms, each of which may exhibit different biological activities, could lead to changes in connectivity and synaptic plasticity and, hence, behavior. |
2012-05-07 |
2023-08-12 |
Not clear |
| R Scott Bitne. Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22119240. |
while creb dimers are thought to be constitutively bound to response elements on dna under basal conditions, it is creb phosphorylation that is believed to be responsible for transcriptional activation leading to gene products such as bdnf that play a key role in synaptic plasticity and cognitive function. |
2012-04-13 |
2023-08-12 |
Not clear |
| Luis Constandil, Rodrigo Aguilera, Mariela Goich, Alejandro Hernández, Pedro Alvarez, Claudio Infante, Teresa Pelissie. Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats. Brain research bulletin. vol 86. issue 5-6. 2012-04-05. PMID:21864655. |
brain-derived neurotrophic factor (bdnf) is involved in neuronal survival and synaptic plasticity of the central and peripheral nervous system. |
2012-04-05 |
2023-08-12 |
rat |
| Chen-Jee Hong, Ying-Jay Liou, Shih-Jen Tsa. Effects of BDNF polymorphisms on brain function and behavior in health and disease. Brain research bulletin. vol 86. issue 5-6. 2012-04-05. PMID:21924328. |
brain-derived neurotrophic factor (bdnf), the most abundant neurotrophin in the brain, serves an important role during brain development and in synaptic plasticity. |
2012-04-05 |
2023-08-12 |
human |
| Breno Satler Diniz, Antonio Lucio Teixeir. Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond. Neuromolecular medicine. vol 13. issue 4. 2012-03-26. PMID:21898045. |
brain-derived neurotrophic factor (bdnf) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. |
2012-03-26 |
2023-08-12 |
human |
| Mireia Tondo, Pilar Poo, Montserrat Naudó, Teresa Ferrando, Jordi Genovés, Marta Molero, Loreto Martorel. Predisposition to epilepsy in fragile X syndrome: does the Val66Met polymorphism in the BDNF gene play a role? Epilepsy & behavior : E&B. vol 22. issue 3. 2012-03-12. PMID:21890420. |
the brain-derived neurotrophic factor (bdnf) gene is a specific regulator of synaptic plasticity, and disturbances in its function cause dendrite abnormalities similar to those observed in fxs. |
2012-03-12 |
2023-08-12 |
Not clear |
| Michael A Balamotis, Nele Tamberg, Young Jae Woo, Jingchuan Li, Brian Davy, Terumi Kohwi-Shigematsu, Yoshinori Kohw. Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development. Molecular and cellular biology. vol 32. issue 2. 2012-02-21. PMID:22064485. |
further, we found that in the cerebral cortex, satb1 binds to genomic loci of multiple immediate early genes (iegs) (fos, fosb, egr1, egr2, arc, and bdnf) and other key neuronal genes, many of which have been implicated in synaptic plasticity. |
2012-02-21 |
2023-08-12 |
mouse |
| Xiuping Fu, Yanrui Yang, Chenchang Xu, Yang Niu, Tielin Chen, Qin Zhou, Jia-Jia Li. Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. Molecular biology of the cell. vol 22. issue 19. 2012-02-06. PMID:21849472. |
brain-derived neurotrophic factor (bdnf) binds to its cell surface receptor trkb to regulate differentiation, development, synaptic plasticity, and functional maintenance of neuronal cells. |
2012-02-06 |
2023-08-12 |
Not clear |
| Yan Zeng, Miao Tan, Jun Kohyama, Marissa Sneddon, Joseph B Watson, Yi E Sun, Cui-Wei Xi. Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159096. |
epigenetic enhancement of bdnf signaling rescues synaptic plasticity in aging. |
2012-02-02 |
2023-08-12 |
rat |
| Emi Satomura, Hajime Baba, Yoshiyuki Nakano, Hitoshi Maeshima, Toshihito Suzuki, Heii Ara. Correlations between brain-derived neurotrophic factor and clinical symptoms in medicated patients with major depression. Journal of affective disorders. vol 135. issue 1-3. 2012-01-25. PMID:21774990. |
brain-derived neurotrophic factor (bdnf) is a member of the nerve growth factor family and plays a critical role in growth, differentiation, maintenance and synaptic plasticity of neuronal systems. |
2012-01-25 |
2023-08-12 |
Not clear |
| C Robinet, L Pelleri. Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2. Neuroscience. vol 192. 2012-01-18. PMID:21736920. |
brain-derived neurotrophic factor (bdnf) promotes synaptic plasticity via an enhancement in expression of specific synaptic proteins. |
2012-01-18 |
2023-08-12 |
mouse |
| C Robinet, L Pelleri. Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2. Neuroscience. vol 192. 2012-01-18. PMID:21736920. |
to investigate in vivo whether bdnf can modulate the expression of mct2 as well as other proteins involved in synaptic plasticity, acute injection of bdnf was performed in mouse dorsal hippocampal ca1 area. |
2012-01-18 |
2023-08-12 |
mouse |
| Kurt Gottmann, Thomas Mittmann, Volkmar Lessman. BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Experimental brain research. vol 199. issue 3-4. 2012-01-17. PMID:19777221. |
in addition, bdnf appears to be also an instructive factor for activity-dependent long-term synaptic plasticity. |
2012-01-17 |
2023-08-12 |
Not clear |
| Kurt Gottmann, Thomas Mittmann, Volkmar Lessman. BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Experimental brain research. vol 199. issue 3-4. 2012-01-17. PMID:19777221. |
this review attempts to summarize the current knowledge in synaptic secretion and synaptic action of bdnf, including both permissive and instructive effects of bdnf in synaptic plasticity. |
2012-01-17 |
2023-08-12 |
Not clear |
| Tadahiro Numakawa, Misty Richards, Naoki Adachi, Soichiro Kishi, Hiroshi Kunugi, Kazuo Hashid. MicroRNA function and neurotrophin BDNF. Neurochemistry international. vol 59. issue 5. 2012-01-12. PMID:21723895. |
on the other hand, numerous studies indicate that bdnf (brain-derived neurotrophic factor), one of the neurotrophins, is essential for a variety of neuronal aspects such as cell differentiation, survival, and synaptic plasticity in the central nervous system (cns). |
2012-01-12 |
2023-08-12 |
Not clear |
| Nader Perrou. Suicidal ideation during antidepressant treatment: do genetic predictors exist? CNS drugs. vol 25. issue 6. 2011-12-30. PMID:21649447. |
in this perspective, several genetic predictors have been highlighted, the majority of which relate to common mechanisms of antidepressant action: genes involved in the neurotrophic and synaptic plasticity systems (creb1, and bdnf and its receptor ntrk2), noradrenergic system (adra2a), glutamatergic system (gria3, grik2 and gda), inflammatory and hypothalamic-pituitary-adrenal (hpa) axis systems (il28ra and fkbp5) and in other brain functions (papln, apoo, kcnip4 and elp3). |
2011-12-30 |
2023-08-12 |
Not clear |