| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Endres, Volkmar Lessman. Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice. Learning & memory (Cold Spring Harbor, N.Y.). vol 19. issue 12. 2013-05-07. PMID:23154927. |
beyond its trophic function, the neurotrophin bdnf (brain-derived neurotrophic factor) is well known to crucially mediate synaptic plasticity and memory formation. |
2013-05-07 |
2023-08-12 |
mouse |
| Hae Jeong Park, Won Sub Kang, Jong Woo Paik, Jong Woo Ki. Effect of valproic acid through regulation of NMDA receptor-ERK signaling in sleep deprivation rats. Journal of molecular neuroscience : MN. vol 47. issue 3. 2013-04-11. PMID:22101740. |
we investigated the effect of vpa (200 mg/kg, every 12 h) in sleep deprivation (sd) rats (72 h), the manic-like animal model, focusing on the n-methyl-d: -aspartic acid (nmda) receptor and signaling mediators of synaptic plasticity such as extracellular signal-regulated protein kinase (erk), camp response element-binding protein (creb), b cell chronic lymphocytic leukemia/lymphoma 2 (bcl2), and brain-derived neurotrophic factor (bdnf). |
2013-04-11 |
2023-08-12 |
rat |
| E M Nikulina, M J Lacagnina, S Fanous, J Wang, R P Hamme. Intermittent social defeat stress enhances mesocorticolimbic ΔFosB/BDNF co-expression and persistently activates corticotegmental neurons: implication for vulnerability to psychostimulants. Neuroscience. vol 212. 2013-04-01. PMID:22521816. |
brain-derived neurotrophic factor (bdnf) mediates synaptic plasticity and cellular responses to stress and drugs of abuse. |
2013-04-01 |
2023-08-12 |
rat |
| Ege T Kavalali, Lisa M Monteggi. Synaptic mechanisms underlying rapid antidepressant action of ketamine. The American journal of psychiatry. vol 169. issue 11. 2013-03-27. PMID:23534055. |
they focus on their recent work demonstrating that ketamine-mediated blockade of nmda receptors at rest deactivates eukaryotic elongation factor 2 (eef2) kinase, resulting in reduced eef2 phosphorylation and desuppression of rapid dendritic protein translation, including bdnf (brain-derived neurotrophic factor), which then contributes to synaptic plasticity mechanisms that mediate longterm effects of the drug. |
2013-03-27 |
2023-08-12 |
Not clear |
| Filip Vanevski, Baoji X. Molecular and neural bases underlying roles of BDNF in the control of body weight. Frontiers in neuroscience. vol 7. 2013-03-25. PMID:23519010. |
brain-derived neurotrophic factor (bdnf) is a potent regulator of neuronal development and synaptic plasticity that is fundamental to neural circuit formation and cognition. |
2013-03-25 |
2023-08-12 |
mouse |
| Ruth M Barrientos, Matthew G Frank, Linda R Watkins, Steven F Maie. Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition. Hormones and behavior. vol 62. issue 3. 2013-03-14. PMID:22370243. |
among the outcomes of an exaggerated neuroinflammatory response are impairments in synaptic plasticity, and reductions in key downstream mediators such as arc and bdnf. |
2013-03-14 |
2023-08-12 |
Not clear |
| Atsuko Ikenouchi-Sugita, Reiji Yoshimura, Taro Kishi, Wakako Umene-Nakano, Hikaru Hori, Asuka Katsuki, Kazuyoshi Saito, Nakao Iwata, Yoshiya Tanaka, Jun Nakamur. No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients. Human psychopharmacology. vol 26. issue 4-5. 2013-03-12. PMID:21678493. |
brain-derived neurotrophic factor (bdnf) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. |
2013-03-12 |
2023-08-12 |
Not clear |
| Olga Geisel, Roman Banas, Rainer Hellweg, Christian A Mülle. Altered serum levels of brain-derived neurotrophic factor in patients with pathological gambling. European addiction research. vol 18. issue 6. 2013-03-12. PMID:22854676. |
brain-derived neurotrophic factor (bdnf) plays important roles in neurotransmitter release and synaptic plasticity and has been hypothesized to be involved in the development and maintenance of addictive disorders. |
2013-03-12 |
2023-08-12 |
Not clear |
| Iva Dincheva, Charles E Glatt, Francis S Le. Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 18. issue 5. 2013-03-05. PMID:22367929. |
brain-derived neurotrophic factor (bdnf) is a member of the neurotrophin growth factor family and is implicated as a modulator of neuronal survival and differentiation, synaptic plasticity, and higher order cognitive functions such as learning and memory. |
2013-03-05 |
2023-08-12 |
mouse |
| Nicholas A Castello, Kim N Green, Frank M LaFerl. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870188. |
brain-derived neurotrophic factor (bdnf) is a neurotrophin critically involved in cell survival, synaptic plasticity, and memory. |
2013-02-19 |
2023-08-12 |
mouse |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
the results suggest that the beneficial effects of acute stress on cognitive improvement may be mediated by bdnf-enhanced synaptic plasticity that is hippocampal cell proliferation-independent, whereas chronic stress may impair cognition by decreasing hippocampal cell proliferation and bdnf levels. |
2013-01-24 |
2023-08-12 |
rat |
| Bo Xing, Juan Guo, Xia Meng, Shu-guang Wei, Sheng-bin L. The dopamine D1 but not D3 receptor plays a fundamental role in spatial working memory and BDNF expression in prefrontal cortex of mice. Behavioural brain research. vol 235. issue 1. 2013-01-23. PMID:22776159. |
previous studies have suggest the importance of dopamine receptors signaling in regulating the brain-derived neurotrophic factor (bdnf) function that is associated with synaptic plasticity underlying normal memory formation. |
2013-01-23 |
2023-08-12 |
mouse |
| Gaston Calfa, Christopher A Chapleau, Susan Campbell, Takafumi Inoue, Sarah J Morse, Farah D Lubin, Lucas Pozzo-Mille. HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. Hippocampus. vol 22. issue 7. 2013-01-15. PMID:22161912. |
considering that brain-derived neurotrophic factor (bdnf) plays an important role in synaptic plasticity and behavioral adaptations, it is not surprising that regulation of this gene is subject to histone acetylation changes during synaptic plasticity and hippocampal-dependent memory formation. |
2013-01-15 |
2023-08-12 |
human |
| Paulina Carriba, Luis Pardo, Arnaldo Parra-Damas, Mathieu P Lichtenstein, Carlos A Saura, Aurora Pujol, Roser Masgrau, Elena Gale. ATP and noradrenaline activate CREB in astrocytes via noncanonical Ca(2+) and cyclic AMP independent pathways. Glia. vol 60. issue 9. 2013-01-14. PMID:22593004. |
both transmitters induced creb phosphorylation (western blots), creb-dependent transcription (cre-luciferase reporter assays), and the transcription of bdnf, a canonical regulator of synaptic plasticity (quantitative rt-pcr). |
2013-01-14 |
2023-08-12 |
rat |
| Kwok-On Lai, Alan S L Wong, Man-Chun Cheung, Pei Xu, Zhuoyi Liang, Ka-Chun Lok, Hui Xie, Mary E Palko, Wing-Ho Yung, Lino Tessarollo, Zelda H Cheung, Nancy Y I. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nature neuroscience. vol 15. issue 11. 2013-01-03. PMID:23064382. |
the neurotrophin brain-derived neurotrophic factor (bdnf) and its receptor trkb participate in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial for learning and memory. |
2013-01-03 |
2023-08-12 |
mouse |
| Fabien Boulle, Gunter Kenis, Maxime Cazorla, Michel Hamon, Harry W M Steinbusch, Laurence Lanfumey, Daniel L A van den Hov. TrkB inhibition as a therapeutic target for CNS-related disorders. Progress in neurobiology. vol 98. issue 2. 2012-11-23. PMID:22705453. |
the interaction of brain-derived neurotrophic factor (bdnf) with its tropomyosin-related kinase receptor b (trkb) is involved in fundamental cellular processes including neuronal proliferation, differentiation and survival as well as neurotransmitter release and synaptic plasticity. |
2012-11-23 |
2023-08-12 |
human |
| Zonggang Hou, Wei Luo, Xuejun Sun, Shuyu Hao, Ying Zhang, Feifan Xu, Zhongcheng Wang, Baiyun Li. Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain research bulletin. vol 88. issue 6. 2012-11-23. PMID:22742936. |
in addition, treatment with hydrogen-rich saline, which elevated the levels of molecules associated with brain-derived neurotropic factor (bdnf)-mediated synaptic plasticity, improved cognitive performance in the morris water maze after mild tbi. |
2012-11-23 |
2023-08-12 |
rat |
| R Andero, K J Ressle. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22530815. |
brain-derived neurotrophic factor (bdnf) is the most studied neurotrophin involved in synaptic plasticity processes that are required for long-term learning and memory. |
2012-11-20 |
2023-08-12 |
Not clear |
| R Andero, K J Ressle. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22530815. |
the aim of this review is to provide a translational point of view that stems from findings in the bdnf regulation of synaptic plasticity and fear extinction. |
2012-11-20 |
2023-08-12 |
Not clear |
| Michelle D Amaral, Lucas Pozzo-Mille. Intracellular Ca2+ stores and Ca2+ influx are both required for BDNF to rapidly increase quantal vesicular transmitter release. Neural plasticity. vol 2012. 2012-11-20. PMID:22811938. |
brain-derived neurotrophic factor (bdnf) is well known as a survival factor during brain development as well as a regulator of adult synaptic plasticity. |
2012-11-20 |
2023-08-12 |
Not clear |