| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher N Parkhurst, Guang Yang, Ipe Ninan, Jeffrey N Savas, John R Yates, Juan J Lafaille, Barbara L Hempstead, Dan R Littman, Wen-Biao Ga. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. vol 155. issue 7. 2014-02-26. PMID:24360280. |
microglial bdnf increases neuronal tropomyosin-related kinase receptor b phosphorylation, a key mediator of synaptic plasticity. |
2014-02-26 |
2023-08-12 |
mouse |
| Ditte Olsen, Mathias Kaas, Ole Schwartz, Anders Nykjaer, Simon Gleru. Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 9. 2014-02-17. PMID:23959707. |
mature bdnf signals through trkb, while its precursor probdnf employs p75(ntr), resulting in activation of signaling cascades with opposite effects on neuronal survival, growth cone decisions, and synaptic plasticity. |
2014-02-17 |
2023-08-12 |
mouse |
| Tempei Ikegame, Miki Bundo, Yui Murata, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamot. DNA methylation of the BDNF gene and its relevance to psychiatric disorders. Journal of human genetics. vol 58. issue 7. 2014-02-12. PMID:23739121. |
brain-derived neurotrophic factor (bdnf) is a neurotrophic factor, which is important for neuronal survival, development and synaptic plasticity. |
2014-02-12 |
2023-08-12 |
Not clear |
| Jean-Charles Lamy, Maxwell Boaky. BDNF Val66Met polymorphism alters spinal DC stimulation-induced plasticity in humans. Journal of neurophysiology. vol 110. issue 1. 2014-01-24. PMID:23576701. |
the brain-derived neurotrophic factor gene (bdnf) is one of many genes thought to influence neuronal survival, synaptic plasticity, and neurogenesis. |
2014-01-24 |
2023-08-12 |
human |
| Sandra Schildt, Thomas Endres, Volkmar Lessmann, Elke Edelman. Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus. Neuropharmacology. vol 71. 2014-01-10. PMID:23587649. |
brain-derived neurotrophic factor (bdnf) signaling via trkb crucially regulates synaptic plasticity in the brain. |
2014-01-10 |
2023-08-12 |
mouse |
| Sandra Schildt, Thomas Endres, Volkmar Lessmann, Elke Edelman. Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus. Neuropharmacology. vol 71. 2014-01-10. PMID:23587649. |
although bdnf is abundant at hippocampal mossy fiber (mf) synapses, which critically contribute to hippocampus dependent memory, its role in mf synaptic plasticity (long-term potentiation, ltp) remained largely unclear. |
2014-01-10 |
2023-08-12 |
mouse |
| Brigitte Schulz-Klaus, Volkmar Lessmann, Thomas Endre. BDNF-dependent consolidation of fear memories in the perirhinal cortex. Frontiers in behavioral neuroscience. vol 7. 2014-01-01. PMID:24381548. |
since the neurotrophin brain-derived neurotrophic factor (bdnf) is an important mediator of synaptic plasticity and also crucially involved in memory consolidation of several learning paradigms, we analyzed now whether fear conditioning influences the expression of bdnf protein in the prh. |
2014-01-01 |
2023-08-12 |
Not clear |
| Karlie A Intlekofer, Carl W Cotma. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiology of disease. vol 57. 2013-12-31. PMID:22750524. |
accumulating research shows that physical activity reinstates hippocampal function by enhancing the expression of brain-derived neurotrophic factor (bdnf) and other growth factors that promote neurogenesis, angiogenesis, and synaptic plasticity. |
2013-12-31 |
2023-08-12 |
human |
| Ying Huang, Jian-Jun Wang, Wing-Ho Yun. Coupling between GABA-A receptor and chloride transporter underlies ionic plasticity in cerebellar Purkinje neurons. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23341142. |
ionic plasticity, a form of synaptic plasticity unique to inhibitory neurotransmission, can be induced in cerebellar purkinje neurons by brain-derived neurotrophic factor (bdnf). |
2013-12-04 |
2023-08-12 |
Not clear |
| Mariah B Blegen, Bruce C Kennedy, Katie A Thibert, Jonathan C Gewirtz, Phu V Tran, Michael K Georgief. Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF signaling. Physiological reports. vol 1. issue 5. 2013-12-04. PMID:24303168. |
notably, expression of brain-derived neurotrophic factor (bdnf), a gene critical for neuronal maturation and synaptic plasticity, is lowered both acutely and in adulthood following early-life iron deficiency. |
2013-12-04 |
2023-08-12 |
rat |
| Carmen Vivar, Michelle C Potter, Henriette van Praa. All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:22847651. |
in this present chapter we will highlight the effects of physical activity on cognition in rodents, as well as on dentate gyrus (dg) neurogenesis, synaptic plasticity, spine density, neurotransmission and growth factors, in particular brain-derived nerve growth factor (bdnf). |
2013-11-19 |
2023-08-12 |
human |
| Andrea Gómez-Palacio-Schjetnan, Martha L Escoba. Neurotrophins and synaptic plasticity. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:23519767. |
in this chapter, we review the studies that have represented a significant step forward in understanding the role played by bdnf and nt-3 in long-term synaptic plasticity. |
2013-11-19 |
2023-08-12 |
Not clear |
| Andrea Gómez-Palacio-Schjetnan, Martha L Escoba. Neurotrophins and synaptic plasticity. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:23519767. |
the effects of bdnf and nt-3 on synaptic plasticity can be of a permissive nature, establishing the conditions under which plastic changes can take place, or it may be instructive, directly modifying the communication and morphology of synapses. |
2013-11-19 |
2023-08-12 |
Not clear |
| Andrea Gómez-Palacio-Schjetnan, Martha L Escoba. Neurotrophins and synaptic plasticity. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:23519767. |
one important finding that highlights the participation of these neurotrophins in synaptic plasticity is the observation that adding bdnf or nt-3 gives rise to drastic long-term increases in synaptic transmission, similar to the long-term potentiation in the hippocampus and neocortex of mammals. |
2013-11-19 |
2023-08-12 |
Not clear |
| J D Gray, T A Milner, B S McEwe. Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience. vol 239. 2013-10-17. PMID:22922121. |
however, recent evidence suggests that bdnf also plays a rapid and essential role in regulating synaptic plasticity, providing another mechanism through which bdnf can modulate learning and memory after a stressful event. |
2013-10-17 |
2023-08-12 |
Not clear |
| J D Gray, T A Milner, B S McEwe. Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience. vol 239. 2013-10-17. PMID:22922121. |
this review briefly summarizes the evidence supporting bdnf's role as a trophic factor modulating neuronal survival, and will primarily focus on the interactions between bdnf and other systems within the brain to facilitate synaptic plasticity. |
2013-10-17 |
2023-08-12 |
Not clear |
| F Jeanneteau, M V Cha. Are BDNF and glucocorticoid activities calibrated? Neuroscience. vol 239. 2013-10-17. PMID:23022538. |
in the present review, we will discuss the complementary roles shared by bdnf and glucocorticoids in synaptic plasticity, and delineate possible signaling mechanisms mediating these effects. |
2013-10-17 |
2023-08-12 |
Not clear |
| S M Rothman, M P Mattso. Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience. vol 239. 2013-10-17. PMID:23079624. |
a similar interplay between neurotransmitter and neurotrophic factor signaling pathways mediates adaptive responses of neural networks to environmental demands in adult mammals, with the excitatory neurotransmitter glutamate and brain-derived neurotrophic factor (bdnf) being particularly prominent regulators of synaptic plasticity throughout the central nervous system. |
2013-10-17 |
2023-08-12 |
human |
| S M Rothman, M P Mattso. Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience. vol 239. 2013-10-17. PMID:23079624. |
glucocorticoids impair synaptic plasticity in the brain by negatively regulating spine density, neurogenesis and long-term potentiation, effects that are potentially linked to glucocorticoid regulation of bdnf. |
2013-10-17 |
2023-08-12 |
human |
| Y C Wu, R A Hill, A Gogos, M van den Buus. Sex differences and the role of estrogen in animal models of schizophrenia: interaction with BDNF. Neuroscience. vol 239. 2013-10-17. PMID:23085218. |
both estrogen and bdnf have trophic effects on the developing brain and promote synaptic plasticity and maintain neurons well into adulthood. |
2013-10-17 |
2023-08-12 |
Not clear |