| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Martin, Danuta Marona-Lewicka, David E Nichols, Charles D Nichol. Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia. Neuropharmacology. vol 83. 2015-01-29. PMID:24704148. |
functional clustering analysis indicates differentially expressed genes are enriched in pathways involving neurotransmission (drd2, gabrb1), synaptic plasticity (nr2a, krox20), energy metabolism (atp5d, ndufa1) and neuropeptide signaling (npy, bdnf), among others. |
2015-01-29 |
2023-08-13 |
rat |
| Yuan-Jian Yang, Yan-Kun Li, Wei Wang, Jian-Guo Wan, Bin Yu, Mei-Zhen Wang, Bin H. Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24662915. |
we found that mk-801-treated rats showed significant deficits in working learning ability and hippocampal synaptic plasticity, as well as reduction of bdnf, trkb, and phosphorylated trkb in the hippocampus. |
2015-01-26 |
2023-08-12 |
rat |
| Yixuan Song, Koichi Miyaki, Tomoko Suzuki, Yasuharu Sasaki, Akizumi Tsutsumi, Norito Kawakami, Akihito Shimazu, Masaya Takahashi, Akiomi Inoue, Chiemi Kan, Sumiko Kurioka, Takuro Shimb. Altered DNA methylation status of human brain derived neurotrophis factor gene could be useful as biomarker of depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 165B. issue 4. 2015-01-21. PMID:24801253. |
brain-derived neurotrophic factor (bdnf) is involved in the survival, development, and synaptic plasticity of neurons. |
2015-01-21 |
2023-08-13 |
human |
| Aron K Barbey, Roberto Colom, Erick Paul, Chad Forbes, Frank Krueger, David Goldman, Jordan Grafma. Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor. PloS one. vol 9. issue 2. 2015-01-09. PMID:24586380. |
brain-derived neurotrophic factor (bdnf) promotes survival and synaptic plasticity in the human brain. |
2015-01-09 |
2023-08-12 |
human |
| Jianmin Yang, Lauren C Harte-Hargrove, Chia-Jen Siao, Tina Marinic, Roshelle Clarke, Qian Ma, Deqiang Jing, John J Lafrancois, Kevin G Bath, Willie Mark, Douglas Ballon, Francis S Lee, Helen E Scharfman, Barbara L Hempstea. proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell reports. vol 7. issue 3. 2015-01-05. PMID:24746813. |
mature brain-derived neurotrophic factor (bdnf) modulates neuronal morphology and synaptic plasticity, including long-term potentiation (ltp) via trkb activation. |
2015-01-05 |
2023-08-13 |
mouse |
| Anand Gururajan, Rachel Hill, Maarten van den Buus. Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used. Neuroscience letters. vol 576. 2015-01-05. PMID:24907687. |
brain-derived neurotrophic factor (bdnf) has key roles in neurodevelopment and synaptic plasticity and is implicated in affective disorders such as anxiety and depression. |
2015-01-05 |
2023-08-13 |
rat |
| Natalie Kaplan, Aya Vituri, Amos D Korczyn, Oren S Cohen, Rivka Inzelberg, Gilad Yahalom, Evgenia Kozlova, Roni Milgrom, Yael Laitman, Eitan Friedman, Saharon Rosset, Sharon Hassin-Bae. Sequence variants in SLC6A3, DRD2, and BDNF genes and time to levodopa-induced dyskinesias in Parkinson's disease. Journal of molecular neuroscience : MN. vol 53. issue 2. 2015-01-02. PMID:24633632. |
in order to identify genetic factors associated with lid, 352 (213 males) levodopa-treated israeli pd patients were genotyped for 34 polymorphisms within three candidate genes affecting dopaminergic activity and synaptic plasticity: dopamine transporter gene (dat1 or slc6a3) [14 single nucleotide polymorphisms (snps) and 40-bp variable number tandem repeat (vntr)], drd2 [11 snps and dinucleotide ca short tandem repeat (str)], and bdnf (7 snps). |
2015-01-02 |
2023-08-12 |
human |
| Lizbeth Cárdenas-Morales, Georg Grön, Eun-Jin Sim, Julia C Stingl, Thomas Kamme. Neural activation in humans during a simple motor task differs between BDNF polymorphisms. PloS one. vol 9. issue 5. 2014-12-30. PMID:24828051. |
the bdnf val66met polymorphism has been linked to decreased synaptic plasticity involved in motor learning tasks. |
2014-12-30 |
2023-08-13 |
human |
| Jan Pláteník, Zdeněk Fišar, Richard Buchal, Roman Jirák, Eva Kitzlerová, Martina Zvěřová, Jiří Raboc. GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 50. 2014-12-11. PMID:24334212. |
glycogen synthase kinase-3β (gsk3β), camp-response element-binding protein (creb) and brain-derived neurotrophic factor (bdnf) play critical roles in neuronal survival, synaptic plasticity and memory and participate in the pathophysiology of both depressive disorder and alzheimer's disease (ad). |
2014-12-11 |
2023-08-12 |
Not clear |
| Nikhil J Kasarpalkar, Sweta T Kothari, Usha P Dav. Brain-Derived Neurotrophic Factor in children with Autism Spectrum Disorder. Annals of neurosciences. vol 21. issue 4. 2014-12-02. PMID:25452672. |
brain-derived neurotrophic factor (bdnf) has emerged as a key neurotrophin regulating synaptic plasticity, neuronal differentiation and survival. |
2014-12-02 |
2023-08-13 |
Not clear |
| Andreas Mühlberger, Marta Andreatta, Heike Ewald, Evelyn Glotzbach-Schoon, Christian Tröger, Christian Baumann, Andreas Reif, Jürgen Deckert, Paul Paul. The BDNF Val66Met polymorphism modulates the generalization of cued fear responses to a novel context. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24247044. |
brain-derived neurotrophic factor (bdnf) has a crucial role in activity-dependent synaptic plasticity and learning and memory. |
2014-12-01 |
2023-08-12 |
human |
| James T H Teo, Graham Bentley, Philip Lawrence, Fruzsina Soltesz, Sam Miller, David Willé, Simon McHugh, Chris Dodds, Bai Lu, Rodney J Croft, Edward T Bullmore, Pradeep J Natha. Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24405657. |
the brain-derived neurotropic factor (bdnf) val66met polymorphism has been associated with abnormalities of synaptic plasticity in animal models, and abnormalities in motor cortical plasticity have also been described in humans using transcranial direct current stimulation. |
2014-12-01 |
2023-08-12 |
human |
| Sorabh Sharma, Rajeev Taliya. Neuroprotective role of Indirubin-3'-monoxime, a GSKβ inhibitor in high fat diet induced cognitive impairment in mice. Biochemical and biophysical research communications. vol 452. issue 4. 2014-12-01. PMID:25234596. |
based upon these findings it could be suggested that gsk3 β inhibition could prove to be beneficial in insulin resistance induced cognitive deficit and this neuroprotection could be the result of enhanced bdnf based synaptic plasticity. |
2014-12-01 |
2023-08-13 |
mouse |
| Shiou-Lan Chen, Sheng-Yu Lee, Yun-Hsuan Chang, Shih-Heng Chen, Chun-Hsien Chu, Tzu-Yun Wang, Po-See Chen, I-Hui Lee, Yen-Kuang Yang, Jau-Shyong Hong, Ru-Band L. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 51. 2014-11-25. PMID:24468644. |
bdnf and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. |
2014-11-25 |
2023-08-12 |
Not clear |
| Gabriela K Ferreira, Giselli Scaini, Isabela C Jeremias, Milena Carvalho-Silva, Cinara L Gonçalves, Talita C B Pereira, Giovanna M T Oliveira, Luiza W Kist, Maurício R Bogo, Patrícia F Schuck, Gustavo C Ferreira, Emilio L Strec. An evaluation of the effects of acute and chronic L-tyrosine administration on BDNF levels and BDNF mRNA expression in the rat brain. Molecular neurobiology. vol 49. issue 2. 2014-11-21. PMID:24091827. |
we hypothesize that oxidative stress can interact with the bdnf system to modulate synaptic plasticity and cognitive function. |
2014-11-21 |
2023-08-12 |
rat |
| Wenyu Cao, Juan Duan, Xueqin Wang, Xiaolin Zhong, Zhaolan Hu, Fulian Huang, Hongtao Wang, Juan Zhang, Fang Li, Jianyi Zhang, Xuegang Luo, Chang-Qi L. Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus. Behavioural brain research. vol 265. 2014-11-13. PMID:24569010. |
bdnf, which is synthesized as a precursor molecule (probdnf) that undergoes proteolytic cleavage, plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behavior. |
2014-11-13 |
2023-08-12 |
rat |
| Wenyu Cao, Juan Duan, Xueqin Wang, Xiaolin Zhong, Zhaolan Hu, Fulian Huang, Hongtao Wang, Juan Zhang, Fang Li, Jianyi Zhang, Xuegang Luo, Chang-Qi L. Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus. Behavioural brain research. vol 265. 2014-11-13. PMID:24569010. |
these results suggested that the ee up-regulated mmp-9 levels within the hippocampus, which might facilitate the conversion of probdnf to bdnf, thereby contributing to the long lasting alterations of synaptic plasticity and behavior. |
2014-11-13 |
2023-08-12 |
rat |
| Adam Czyzyk, Elena Casarosa, Michele Luisi, Agnieszka Podfigurna-Stopa, Blazej Meczekalski, Andrea Riccardo Genazzan. Brain-derived neurotrophic factor plasma levels in patients with Turner syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 30. issue 3. 2014-11-10. PMID:24397357. |
brain-derived neurotrophic factor (bdnf) plays a key role in neural development and synaptic plasticity. |
2014-11-10 |
2023-08-12 |
Not clear |
| Jenq-Lin Yang, Yu-Ting Lin, Pei-Chin Chuang, Vilhelm A Bohr, Mark P Mattso. BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1. Neuromolecular medicine. vol 16. issue 1. 2014-10-28. PMID:24114393. |
brain-derived neurotrophic factor (bdnf) promotes the survival and growth of neurons during brain development and mediates activity-dependent synaptic plasticity and associated learning and memory in the adult. |
2014-10-28 |
2023-08-12 |
mouse |
| Nobuyuki Takei, Kazuo Furukawa, Osamu Hanyu, Hirohito Sone, Hiroyuki Naw. A possible link between BDNF and mTOR in control of food intake. Frontiers in psychology. vol 5. 2014-10-13. PMID:25309497. |
brain-derived neurotrophic factor (bdnf), the most prominent neurotrophic factor in the brain, regulates differentiation, maturation, and synaptic plasticity throughout life. |
2014-10-13 |
2023-08-13 |
Not clear |