| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shiou-Lan Chen, Sheng-Yu Lee, Yun-Hsuan Chang, Tzu-Yun Wang, Shih-Heng Chen, Chun-Hsien Chu, Po See Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band L. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients. Scientific reports. vol 5. 2015-11-20. PMID:25640280. |
bdnf and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. |
2015-11-20 |
2023-08-13 |
human |
| Filip Vanevski, Baoji X. HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. PloS one. vol 10. issue 2. 2015-11-16. PMID:25692578. |
we present evidence linking a number of important processes involved in regulating synaptic plasticity, suggesting a mechanistic pathway whereby activity-dependent signaling, likely through protein kinase c (pkc)-mediated phosphorylation of hud, can relieve basal repression of bdnf mrna translation in dendrites, allowing for increased trkb signaling and synaptic remodeling. |
2015-11-16 |
2023-08-13 |
Not clear |
| A J Skilleter, C S Weickert, A Vercammen, R Lenroot, T W Weicker. Peripheral BDNF: a candidate biomarker of healthy neural activity during learning is disrupted in schizophrenia. Psychological medicine. vol 45. issue 4. 2015-11-13. PMID:25162472. |
brain-derived neurotrophic factor (bdnf) is an important regulator of synaptogenesis and synaptic plasticity underlying learning. |
2015-11-13 |
2023-08-13 |
Not clear |
| Sandra Dieni, Sigrun Nestel, Mirjam Sibbe, Michael Frotscher, Sabine Hellwi. Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice. Frontiers in synaptic neuroscience. vol 7. 2015-11-11. PMID:26557085. |
to this end, we used a mutant mouse model harboring a mutated form of the presynaptic scaffolding protein bassoon (bsn), which is phenotypically characterized by: (i) spontaneous generalized epileptic seizure activity, representing a chronically-imbalanced neuronal network; and (ii) a dramatic increase in hippocampal brain-derived neurotrophic factor (bdnf) protein concentration, a key player in synaptic plasticity. |
2015-11-11 |
2023-08-13 |
mouse |
| Khampaseuth Rasakham, Heath D Schmidt, Kevin Kay, Megan N Huizenga, Narghes Calcagno, R Christopher Pierce, Tara L Spires-Jones, Ghazaleh Sadri-Vakil. Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administration. PloS one. vol 9. issue 7. 2015-11-09. PMID:25072653. |
as bdnf is known to affect neuronal survival and synaptic plasticity, we tested the hypothesis that abstinence from cocaine self-administration would lead to alterations in neuronal morphology and synaptic density in the pfc. |
2015-11-09 |
2023-08-13 |
human |
| Padmanabh Singh, Arpita Konar, Ashish Kumar, Sweta Srivas, Mahendra K Thaku. Hippocampal chromatin-modifying enzymes are pivotal for scopolamine-induced synaptic plasticity gene expression changes and memory impairment. Journal of neurochemistry. vol 134. issue 4. 2015-10-19. PMID:25982413. |
hdac inhibitor sodium butyrate and dnmt inhibitor aza-2'deoxycytidine recovered scopolamine-impaired hippocampal-dependent memory consolidation with concomitant increase in the expression of synaptic plasticity genes brain-derived neurotrophic factor (bdnf) and arc and level of histone h3k9 and h3k14 acetylation and decrease in dna methylation level. |
2015-10-19 |
2023-08-13 |
Not clear |
| Alberto Costa, Antonella Peppe, Giovanni Augusto Carlesimo, Silvia Zabberoni, Francesco Scalici, Carlo Caltagirone, Francesco Angelucc. Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment. Frontiers in behavioral neuroscience. vol 9. 2015-10-07. PMID:26441580. |
brain-derived neurotrophic factor (bdnf) is a trophic factor regulating cell survival and synaptic plasticity. |
2015-10-07 |
2023-08-13 |
Not clear |
| Alberto Costa, Antonella Peppe, Giovanni Augusto Carlesimo, Silvia Zabberoni, Francesco Scalici, Carlo Caltagirone, Francesco Angelucc. Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment. Frontiers in behavioral neuroscience. vol 9. 2015-10-07. PMID:26441580. |
given the role of bdnf in regulating synaptic plasticity, the present findings give further support to the hypothesis that this trophic factor may be a potential biomarker for evaluating cognitive changes in pd and other neurological syndromes associated with cognitive decline. |
2015-10-07 |
2023-08-13 |
Not clear |
| Caroline Ménard, Pierrette Gaudreau, Rémi Quirio. Signaling pathways relevant to cognition-enhancing drug targets. Handbook of experimental pharmacology. vol 228. 2015-09-28. PMID:25977080. |
first, we will discuss the role of the excitatory neurotransmitter glutamate and its receptors, downstream signaling effectors [e.g., calcium/calmodulin-dependent protein kinase ii (camkii), protein kinase c (pkc), extracellular signal-regulated kinases (erk), mammalian target of rapamycin (mtor), camp response element-binding protein (creb)], associated immediate early gene (e.g., homer 1a, arc and zif268), and growth factors [insulin-like growth factors (igfs) and brain-derived neurotrophic factor (bdnf)] in synaptic plasticity and memory formation. |
2015-09-28 |
2023-08-13 |
rat |
| Toshiyuki Mizui, Yasuyuki Ishikawa, Haruko Kumanogoh, Maria Lume, Tomoya Matsumoto, Tomoko Hara, Shigeto Yamawaki, Masami Takahashi, Sadao Shiosaka, Chiaki Itami, Koichi Uegaki, Mart Saarma, Masami Kojim. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 23. 2015-09-25. PMID:26015580. |
thus, the bdnf pro-peptide is involved in synaptic plasticity that regulates a mechanism responsible for promoting ltd. |
2015-09-25 |
2023-08-13 |
human |
| Ulrika Beitnere, Zane Dzirkale, Sergejs Isajevs, Juris Rumaks, Simons Svirskis, Vija Klus. Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats. European journal of pharmacology. vol 745. 2015-08-24. PMID:25446926. |
the present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic plasticity, such as brain-derived neurotrophic factor (bdnf), acetylcholine esterase and glutamate decarboxylase 67 (gad67). |
2015-08-24 |
2023-08-13 |
rat |
| Jinwook Kim, Miyoung Yang, Juhwan Kim, Lina Song, Sueun Lee, Yeonghoon Son, Sohi Kang, Chun-Sik Bae, Jong-Choon Kim, Sung-Ho Kim, Taekyun Shin, Hongbing Wang, Changjong Moo. Developmental and degenerative modulation of brain-derived neurotrophic factor transcript variants in the mouse hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 38. 2015-08-21. PMID:25124374. |
brain-derived neurotrophic factor (bdnf) is regarded as an important factor for neurogenesis, synaptic plasticity, and neuronal network organization in brain circuits. |
2015-08-21 |
2023-08-13 |
mouse |
| Jinwook Kim, Miyoung Yang, Juhwan Kim, Lina Song, Sueun Lee, Yeonghoon Son, Sohi Kang, Chun-Sik Bae, Jong-Choon Kim, Sung-Ho Kim, Taekyun Shin, Hongbing Wang, Changjong Moo. Developmental and degenerative modulation of brain-derived neurotrophic factor transcript variants in the mouse hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 38. 2015-08-21. PMID:25124374. |
these observations suggest that the differential regulation of bdnf exon transcripts may be associated with neuronal and synaptic maturation during postnatal development, and neuronal survival and synaptic plasticity in chemically induced neurodegeneration. |
2015-08-21 |
2023-08-13 |
mouse |
| Xuan Li, Marina E Wol. Multiple faces of BDNF in cocaine addiction. Behavioural brain research. vol 279. 2015-08-20. PMID:25449839. |
last, we will review the role of bdnf in synaptic plasticity, particularly as it relates to plasticity of ampa receptor transmission after cocaine exposure. |
2015-08-20 |
2023-08-13 |
Not clear |
| Tanja Novkovic, Thomas Mittmann, Denise Manahan-Vaugha. BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment. Hippocampus. vol 25. issue 1. 2015-08-11. PMID:25112659. |
bdnf contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment. |
2015-08-11 |
2023-08-13 |
mouse |
| Tanja Novkovic, Thomas Mittmann, Denise Manahan-Vaugha. BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment. Hippocampus. vol 25. issue 1. 2015-08-11. PMID:25112659. |
as brain-derived neurotrophic factor (bdnf) supports hippocampal long-term potentiation (ltp), we explored whether it participates in the facilitation of synaptic plasticity and hippocampus-dependent learning that occurs following ee. |
2015-08-11 |
2023-08-13 |
mouse |
| Tanja Novkovic, Thomas Mittmann, Denise Manahan-Vaugha. BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment. Hippocampus. vol 25. issue 1. 2015-08-11. PMID:25112659. |
these data support that bdnf plays an intrinsic role in improvements of synaptic plasticity and cognition that occur in ee. |
2015-08-11 |
2023-08-13 |
mouse |
| Luis M Rodríguez-Serrano, Betsabee Ramírez-León, Luis F Rodríguez-Durán, Martha L Escoba. Acute infusion of brain-derived neurotrophic factor in the insular cortex promotes conditioned taste aversion extinction. Neurobiology of learning and memory. vol 116. 2015-08-07. PMID:25451308. |
brain-derived neurotrophic factor (bdnf) has emerged as one of the most potent molecular mediators not only for synaptic plasticity, but also for the behavioral organism-environment interactions. |
2015-08-07 |
2023-08-13 |
rat |
| Jun Ma, Zhanchi Zhang, Lin Kang, Dandan Geng, Yanyong Wang, Mingwei Wang, Huixian Cu. Repetitive transcranial magnetic stimulation (rTMS) influences spatial cognition and modulates hippocampal structural synaptic plasticity in aging mice. Experimental gerontology. vol 58. 2015-08-06. PMID:25172625. |
in conclusion, we infer that aging-induced cognitive deficits are closely associated with hippocampal structural synaptic plasticity, and low-frequency magnetic stimulation plays an important role in regulating cognitive behavior via changing structural synaptic plasticity, and bdnf signaling might participate in this event. |
2015-08-06 |
2023-08-13 |
mouse |
| Debabrata Panja, Justin W Kenney, Laura D'Andrea, Francesca Zalfa, Anni Vedeler, Karin Wibrand, Rikiro Fukunaga, Claudia Bagni, Christopher G Proud, Clive R Bramha. Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell reports. vol 9. issue 4. 2015-07-21. PMID:25453757. |
bdnf signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of trkb signaling and mechanisms of translation have not been defined. |
2015-07-21 |
2023-08-13 |
Not clear |