| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga Geisel, Roman Banas, Rainer Hellweg, Christian A Mülle. Altered serum levels of brain-derived neurotrophic factor in patients with pathological gambling. European addiction research. vol 18. issue 6. 2013-03-12. PMID:22854676. |
brain-derived neurotrophic factor (bdnf) plays important roles in neurotransmitter release and synaptic plasticity and has been hypothesized to be involved in the development and maintenance of addictive disorders. |
2013-03-12 |
2023-08-12 |
Not clear |
| Iva Dincheva, Charles E Glatt, Francis S Le. Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 18. issue 5. 2013-03-05. PMID:22367929. |
brain-derived neurotrophic factor (bdnf) is a member of the neurotrophin growth factor family and is implicated as a modulator of neuronal survival and differentiation, synaptic plasticity, and higher order cognitive functions such as learning and memory. |
2013-03-05 |
2023-08-12 |
mouse |
| Nicholas A Castello, Kim N Green, Frank M LaFerl. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870188. |
brain-derived neurotrophic factor (bdnf) is a neurotrophin critically involved in cell survival, synaptic plasticity, and memory. |
2013-02-19 |
2023-08-12 |
mouse |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
the results suggest that the beneficial effects of acute stress on cognitive improvement may be mediated by bdnf-enhanced synaptic plasticity that is hippocampal cell proliferation-independent, whereas chronic stress may impair cognition by decreasing hippocampal cell proliferation and bdnf levels. |
2013-01-24 |
2023-08-12 |
rat |
| Bo Xing, Juan Guo, Xia Meng, Shu-guang Wei, Sheng-bin L. The dopamine D1 but not D3 receptor plays a fundamental role in spatial working memory and BDNF expression in prefrontal cortex of mice. Behavioural brain research. vol 235. issue 1. 2013-01-23. PMID:22776159. |
previous studies have suggest the importance of dopamine receptors signaling in regulating the brain-derived neurotrophic factor (bdnf) function that is associated with synaptic plasticity underlying normal memory formation. |
2013-01-23 |
2023-08-12 |
mouse |
| Gaston Calfa, Christopher A Chapleau, Susan Campbell, Takafumi Inoue, Sarah J Morse, Farah D Lubin, Lucas Pozzo-Mille. HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. Hippocampus. vol 22. issue 7. 2013-01-15. PMID:22161912. |
considering that brain-derived neurotrophic factor (bdnf) plays an important role in synaptic plasticity and behavioral adaptations, it is not surprising that regulation of this gene is subject to histone acetylation changes during synaptic plasticity and hippocampal-dependent memory formation. |
2013-01-15 |
2023-08-12 |
human |
| Paulina Carriba, Luis Pardo, Arnaldo Parra-Damas, Mathieu P Lichtenstein, Carlos A Saura, Aurora Pujol, Roser Masgrau, Elena Gale. ATP and noradrenaline activate CREB in astrocytes via noncanonical Ca(2+) and cyclic AMP independent pathways. Glia. vol 60. issue 9. 2013-01-14. PMID:22593004. |
both transmitters induced creb phosphorylation (western blots), creb-dependent transcription (cre-luciferase reporter assays), and the transcription of bdnf, a canonical regulator of synaptic plasticity (quantitative rt-pcr). |
2013-01-14 |
2023-08-12 |
rat |
| Kwok-On Lai, Alan S L Wong, Man-Chun Cheung, Pei Xu, Zhuoyi Liang, Ka-Chun Lok, Hui Xie, Mary E Palko, Wing-Ho Yung, Lino Tessarollo, Zelda H Cheung, Nancy Y I. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nature neuroscience. vol 15. issue 11. 2013-01-03. PMID:23064382. |
the neurotrophin brain-derived neurotrophic factor (bdnf) and its receptor trkb participate in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial for learning and memory. |
2013-01-03 |
2023-08-12 |
mouse |
| Fabien Boulle, Gunter Kenis, Maxime Cazorla, Michel Hamon, Harry W M Steinbusch, Laurence Lanfumey, Daniel L A van den Hov. TrkB inhibition as a therapeutic target for CNS-related disorders. Progress in neurobiology. vol 98. issue 2. 2012-11-23. PMID:22705453. |
the interaction of brain-derived neurotrophic factor (bdnf) with its tropomyosin-related kinase receptor b (trkb) is involved in fundamental cellular processes including neuronal proliferation, differentiation and survival as well as neurotransmitter release and synaptic plasticity. |
2012-11-23 |
2023-08-12 |
human |
| Zonggang Hou, Wei Luo, Xuejun Sun, Shuyu Hao, Ying Zhang, Feifan Xu, Zhongcheng Wang, Baiyun Li. Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain research bulletin. vol 88. issue 6. 2012-11-23. PMID:22742936. |
in addition, treatment with hydrogen-rich saline, which elevated the levels of molecules associated with brain-derived neurotropic factor (bdnf)-mediated synaptic plasticity, improved cognitive performance in the morris water maze after mild tbi. |
2012-11-23 |
2023-08-12 |
rat |
| R Andero, K J Ressle. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22530815. |
brain-derived neurotrophic factor (bdnf) is the most studied neurotrophin involved in synaptic plasticity processes that are required for long-term learning and memory. |
2012-11-20 |
2023-08-12 |
Not clear |
| R Andero, K J Ressle. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22530815. |
the aim of this review is to provide a translational point of view that stems from findings in the bdnf regulation of synaptic plasticity and fear extinction. |
2012-11-20 |
2023-08-12 |
Not clear |
| Michelle D Amaral, Lucas Pozzo-Mille. Intracellular Ca2+ stores and Ca2+ influx are both required for BDNF to rapidly increase quantal vesicular transmitter release. Neural plasticity. vol 2012. 2012-11-20. PMID:22811938. |
brain-derived neurotrophic factor (bdnf) is well known as a survival factor during brain development as well as a regulator of adult synaptic plasticity. |
2012-11-20 |
2023-08-12 |
Not clear |
| Clarissa M Comim, Patrícia A Reis, Valber S Frutuoso, Gabriel R Fries, Daiane B Fraga, Flávio Kapczinski, Alexandra I Zugno, Tatiana Barichello, João Quevedo, Hugo C Castro-Faria-Net. Effects of experimental cerebral malaria in memory, brain-derived neurotrophic factor and acetylcholinesterase activity [correction for acitivity] in the hippocampus of survivor mice. Neuroscience letters. vol 523. issue 2. 2012-11-13. PMID:22750161. |
the brain-derived neurotrophic factor (bdnf) appears to be involved with activity-dependent synaptic plasticity. |
2012-11-13 |
2023-08-12 |
mouse |
| Soon-Tae Lee, Kon Chu, Keun-Hwa Jung, Jin Hee Kim, Ji-Young Huh, Hyejin Yoon, Dong-Kyu Park, Ji-Yeon Lim, Jeong-Min Kim, Daejong Jeon, Hoon Ryu, Sang Kun Lee, Manho Kim, Jae-Kyu Ro. miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Annals of neurology. vol 72. issue 2. 2012-11-01. PMID:22926857. |
alzheimer disease (ad) brains are deficient in brain-derived neurotrophic factor (bdnf), which regulates synaptic plasticity and memory. |
2012-11-01 |
2023-08-12 |
mouse |
| Sarah M Rothman, Kathleen J Griffioen, Ruiqian Wan, Mark P Mattso. Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health. Annals of the New York Academy of Sciences. vol 1264. 2012-10-25. PMID:22548651. |
by promoting synaptic plasticity and neurogenesis in the hippocampus, bdnf mediates exercise- and der-induced improvements in cognitive function and neuroprotection. |
2012-10-25 |
2023-08-12 |
Not clear |
| Haytham M Hashim, Nagy Fawzy, Mohab M Fawzi, Rehab A Kara. Brain-derived neurotrophic factor Val66Met polymorphism and obsessive-compulsive symptoms in Egyptian schizophrenia patients. Journal of psychiatric research. vol 46. issue 6. 2012-10-17. PMID:22521161. |
bdnf promote the function and growth of 5-ht neurons in the brain and modulate the synaptic plasticity of drd3-secreting neurons in the striatum, suggesting involvement of bdnf in the mediation of obsessive-compulsive disorder. |
2012-10-17 |
2023-08-12 |
Not clear |
| Li Sui, Yan Wang, Li-Hua Ju, Meng Che. Epigenetic regulation of reelin and brain-derived neurotrophic factor genes in long-term potentiation in rat medial prefrontal cortex. Neurobiology of learning and memory. vol 97. issue 4. 2012-09-17. PMID:22469747. |
these findings suggest that epigenetic regulation of dna demethylation and histone acetylation of target genes, such as reelin and bdnf, might underlie the mechanisms of synaptic plasticity and memory retention in the mpfc. |
2012-09-17 |
2023-08-12 |
rat |
| Sylvie Burnouf, Karim Belarbi, Laetitia Troquier, Maxime Derisbourg, Dominique Demeyer, Antoine Leboucher, Cyril Laurent, Malika Hamdane, Luc Buee, David Blu. Hippocampal BDNF expression in a tau transgenic mouse model. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272617. |
brain-derived neurotrophic factor (bdnf) is a neurotrophic factor playing a critical role in hippocampal synaptic plasticity and memory and whose levels have been shown reduced in ad brains. |
2012-09-07 |
2023-08-12 |
mouse |
| Andrea Gómez-Palacio Schjetnan, Martha L Escoba. In vivo BDNF modulation of hippocampal mossy fiber plasticity induced by high frequency stimulation. Hippocampus. vol 22. issue 1. 2012-09-06. PMID:20848610. |
here we used intrahippocampal microinfusion of bdnf to analyze its effects on functional and structural synaptic plasticity induced by subsequent mossy fiber hfs sufficient to induce ltp in adult rats, in vivo. |
2012-09-06 |
2023-08-12 |
human |