| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karlie A Intlekofer, Carl W Cotma. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiology of disease. vol 57. 2013-12-31. PMID:22750524. |
accumulating research shows that physical activity reinstates hippocampal function by enhancing the expression of brain-derived neurotrophic factor (bdnf) and other growth factors that promote neurogenesis, angiogenesis, and synaptic plasticity. |
2013-12-31 |
2023-08-12 |
human |
| Ying Huang, Jian-Jun Wang, Wing-Ho Yun. Coupling between GABA-A receptor and chloride transporter underlies ionic plasticity in cerebellar Purkinje neurons. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23341142. |
ionic plasticity, a form of synaptic plasticity unique to inhibitory neurotransmission, can be induced in cerebellar purkinje neurons by brain-derived neurotrophic factor (bdnf). |
2013-12-04 |
2023-08-12 |
Not clear |
| Mariah B Blegen, Bruce C Kennedy, Katie A Thibert, Jonathan C Gewirtz, Phu V Tran, Michael K Georgief. Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF signaling. Physiological reports. vol 1. issue 5. 2013-12-04. PMID:24303168. |
notably, expression of brain-derived neurotrophic factor (bdnf), a gene critical for neuronal maturation and synaptic plasticity, is lowered both acutely and in adulthood following early-life iron deficiency. |
2013-12-04 |
2023-08-12 |
rat |
| Carmen Vivar, Michelle C Potter, Henriette van Praa. All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:22847651. |
in this present chapter we will highlight the effects of physical activity on cognition in rodents, as well as on dentate gyrus (dg) neurogenesis, synaptic plasticity, spine density, neurotransmission and growth factors, in particular brain-derived nerve growth factor (bdnf). |
2013-11-19 |
2023-08-12 |
human |
| Andrea Gómez-Palacio-Schjetnan, Martha L Escoba. Neurotrophins and synaptic plasticity. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:23519767. |
in this chapter, we review the studies that have represented a significant step forward in understanding the role played by bdnf and nt-3 in long-term synaptic plasticity. |
2013-11-19 |
2023-08-12 |
Not clear |
| Andrea Gómez-Palacio-Schjetnan, Martha L Escoba. Neurotrophins and synaptic plasticity. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:23519767. |
the effects of bdnf and nt-3 on synaptic plasticity can be of a permissive nature, establishing the conditions under which plastic changes can take place, or it may be instructive, directly modifying the communication and morphology of synapses. |
2013-11-19 |
2023-08-12 |
Not clear |
| Andrea Gómez-Palacio-Schjetnan, Martha L Escoba. Neurotrophins and synaptic plasticity. Current topics in behavioral neurosciences. vol 15. 2013-11-19. PMID:23519767. |
one important finding that highlights the participation of these neurotrophins in synaptic plasticity is the observation that adding bdnf or nt-3 gives rise to drastic long-term increases in synaptic transmission, similar to the long-term potentiation in the hippocampus and neocortex of mammals. |
2013-11-19 |
2023-08-12 |
Not clear |
| J D Gray, T A Milner, B S McEwe. Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience. vol 239. 2013-10-17. PMID:22922121. |
however, recent evidence suggests that bdnf also plays a rapid and essential role in regulating synaptic plasticity, providing another mechanism through which bdnf can modulate learning and memory after a stressful event. |
2013-10-17 |
2023-08-12 |
Not clear |
| J D Gray, T A Milner, B S McEwe. Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience. vol 239. 2013-10-17. PMID:22922121. |
this review briefly summarizes the evidence supporting bdnf's role as a trophic factor modulating neuronal survival, and will primarily focus on the interactions between bdnf and other systems within the brain to facilitate synaptic plasticity. |
2013-10-17 |
2023-08-12 |
Not clear |
| F Jeanneteau, M V Cha. Are BDNF and glucocorticoid activities calibrated? Neuroscience. vol 239. 2013-10-17. PMID:23022538. |
in the present review, we will discuss the complementary roles shared by bdnf and glucocorticoids in synaptic plasticity, and delineate possible signaling mechanisms mediating these effects. |
2013-10-17 |
2023-08-12 |
Not clear |
| S M Rothman, M P Mattso. Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience. vol 239. 2013-10-17. PMID:23079624. |
a similar interplay between neurotransmitter and neurotrophic factor signaling pathways mediates adaptive responses of neural networks to environmental demands in adult mammals, with the excitatory neurotransmitter glutamate and brain-derived neurotrophic factor (bdnf) being particularly prominent regulators of synaptic plasticity throughout the central nervous system. |
2013-10-17 |
2023-08-12 |
human |
| S M Rothman, M P Mattso. Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience. vol 239. 2013-10-17. PMID:23079624. |
glucocorticoids impair synaptic plasticity in the brain by negatively regulating spine density, neurogenesis and long-term potentiation, effects that are potentially linked to glucocorticoid regulation of bdnf. |
2013-10-17 |
2023-08-12 |
human |
| Y C Wu, R A Hill, A Gogos, M van den Buus. Sex differences and the role of estrogen in animal models of schizophrenia: interaction with BDNF. Neuroscience. vol 239. 2013-10-17. PMID:23085218. |
both estrogen and bdnf have trophic effects on the developing brain and promote synaptic plasticity and maintain neurons well into adulthood. |
2013-10-17 |
2023-08-12 |
Not clear |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
both brain-derived neurotrophic factor (bdnf) and its tyrosine kinase receptor trkb play a critical role in hippocampus-dependent synaptic plasticity and memory. |
2013-09-30 |
2023-08-12 |
mouse |
| Naoki Adachi, Tadahiro Numakawa, Emi Kumamaru, Chiaki Itami, Shuichi Chiba, Yoshimi Iijima, Misty Richards, Ritsuko Katoh-Semba, Hiroshi Kunug. Phencyclidine-induced decrease of synaptic connectivity via inhibition of BDNF secretion in cultured cortical neurons. Cerebral cortex (New York, N.Y. : 1991). vol 23. issue 4. 2013-09-23. PMID:22467667. |
considering that brain-derived neurotrophic factor (bdnf) plays an important role in synaptic plasticity, we examined whether exposure to pcp leads to impaired bdnf function in cultured cortical neurons. |
2013-09-23 |
2023-08-12 |
Not clear |
| Ritabrata Banerjee, Anup K Ghosh, Balaram Ghosh, Somnath Bhattacharyya, Amal C Monda. Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain. Clinical medicine insights. Pathology. vol 6. 2013-09-13. PMID:24031163. |
given the importance of bdnf and ngf and their cognate receptors in mediating physiological functions, including cell survival and synaptic plasticity, our findings of reduced expression of bdnf, trkb, ngf, and trka on both the protein and mrna levels of postmortem brains of suicide victims suggest that these molecules may play an important role in the pathophysiological aspects of suicidal behavior. |
2013-09-13 |
2023-08-12 |
human |
| Hussam Jourdi, Mohamed Kabba. Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression. PloS one. vol 8. issue 2. 2013-09-03. PMID:23460828. |
brain-derived neurotrophic factor (bdnf) plays several prominent roles in synaptic plasticity and in learning and memory formation. |
2013-09-03 |
2023-08-12 |
Not clear |
| Madhurima Benekareddy, Amrita R Nair, Brian G Dias, Deepika Suri, Anita E Autry, Lisa M Monteggia, Vidita A Vaidy. Induction of the plasticity-associated immediate early gene Arc by stress and hallucinogens: role of brain-derived neurotrophic factor. The international journal of neuropsychopharmacology. vol 16. issue 2. 2013-08-21. PMID:22404904. |
these findings suggest the possibility that the regulation of arc expression via bdnf provides a molecular substrate for the structural and synaptic plasticity observed following stimuli such as stress and hallucinogens. |
2013-08-21 |
2023-08-12 |
mouse |
| Wallace C Duncan, Simone Sarasso, Fabio Ferrarelli, Jessica Selter, Brady A Riedner, Nadia S Hejazi, Peixiong Yuan, Nancy Brutsche, Husseini K Manji, Giulio Tononi, Carlos A Zarat. Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder. The international journal of neuropsychopharmacology. vol 16. issue 2. 2013-08-21. PMID:22676966. |
this study investigated the acute effects of a single ketamine infusion on depressive symptoms, eeg swa, individual slow wave parameters (surrogate markers of central synaptic plasticity) and plasma bdnf (a peripheral marker of plasticity) in 30 patients with treatment-resistant mdd. |
2013-08-21 |
2023-08-12 |
rat |
| Wallace C Duncan, Simone Sarasso, Fabio Ferrarelli, Jessica Selter, Brady A Riedner, Nadia S Hejazi, Peixiong Yuan, Nancy Brutsche, Husseini K Manji, Giulio Tononi, Carlos A Zarat. Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder. The international journal of neuropsychopharmacology. vol 16. issue 2. 2013-08-21. PMID:22676966. |
intriguingly, this link was present only in patients who responded to ketamine treatment, suggesting that enhanced synaptic plasticity - as reflected by increased swa, individual slow wave parameters and plasma bdnf - is part of the physiological mechanism underlying the rapid antidepressant effects of nmda antagonists. |
2013-08-21 |
2023-08-12 |
rat |