| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Taylor Hays, Jon O Ebber. Bupropion for the treatment of tobacco dependence: guidelines for balancing risks and benefits. CNS drugs. vol 17. issue 2. 2003-03-31. PMID:12521356. |
this area of the brain is believed to mediate reward for nicotine use and for other drugs of dependence. |
2003-03-31 |
2023-08-12 |
Not clear |
| Jong Y Bahk, Shupeng Li, Moon S Park, Myeong O Ki. Dopamine D1 and D2 receptor mRNA up-regulation in the caudate-putamen and nucleus accumbens of rat brains by smoking. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 6. 2003-03-26. PMID:12452531. |
the neurotransmitter dopamine (da) is important in the reward and reinforcing properties of many addictive drugs: however, the effect of nicotine by cigarette smoking itself on the expression of da receptors in the caudate-putamen (cpu), nucleus accumbens (nac) and olfactory tubercle (otu) has not been elucidated completely. |
2003-03-26 |
2023-08-12 |
rat |
| Huibert D Mansvelder, Daniel S McGehe. Cellular and synaptic mechanisms of nicotine addiction. Journal of neurobiology. vol 53. issue 4. 2003-01-13. PMID:12436424. |
examination of the nachr subtypes expressed within the reward centers has identified potential roles for these receptors in normal physiology, as well as the effects of nicotine exposure. |
2003-01-13 |
2023-08-12 |
Not clear |
| Theodore A Slotki. Nicotine and the adolescent brain: insights from an animal model. Neurotoxicology and teratology. vol 24. issue 3. 2002-12-19. PMID:12009492. |
effects of nicotine on critical components of reward pathways and circuits involved in learning, memory and mood are likely to contribute to increased addictive properties and long-term behavioral problems seen in adolescent smokers. |
2002-12-19 |
2023-08-12 |
rat |
| Peter G Shield. Molecular epidemiology of smoking and lung cancer. Oncogene. vol 21. issue 45. 2002-11-05. PMID:12362269. |
they govern smoking behavior (affecting dopamine reward mechanisms due to nicotine and nicotine metabolism), carcinogen metabolism and detoxification, dna repair, cell cycle control and other cellular responses. |
2002-11-05 |
2023-08-12 |
Not clear |
| Steven R Laviolette, Tania O Alexson, Derek van der Koo. Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 19. 2002-10-24. PMID:12351739. |
using a conditioned place preference paradigm, bilateral tpp lesions blocked a nicotine reward signal and revealed the aversive motivational properties of intra-vta nicotine. |
2002-10-24 |
2023-08-12 |
Not clear |
| Steven R Laviolette, Tania O Alexson, Derek van der Koo. Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 19. 2002-10-24. PMID:12351739. |
our results suggest that the rewarding effects of nicotine in the vta are dependent on a nondopaminergic, descending reward pathway to the brainstem tpp. |
2002-10-24 |
2023-08-12 |
Not clear |
| Istvan Sziráki, Henry Sershen, Audrey Hashim, Abel Lajth. Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens. Neurochemical research. vol 27. issue 3. 2002-10-04. PMID:11958525. |
as part of our continuing studies of the mechanisms of nicotine effects in the brain, in particular, effects on reward and cognitive mechanisms, in the present study we examined the role of various receptors in the ventral tegmental area in nicotine and cocaine reward. |
2002-10-04 |
2023-08-12 |
Not clear |
| Istvan Sziráki, Henry Sershen, Audrey Hashim, Abel Lajth. Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens. Neurochemical research. vol 27. issue 3. 2002-10-04. PMID:11958525. |
the findings indicate that a number of receptors in the ventral tegmental area mediate nicotine-induced dopamine changes in the nucleus accumbens, a major component of the nicotine reward mechanism. |
2002-10-04 |
2023-08-12 |
Not clear |
| Laura Cardenas, Lescia K Tremblay, Claudio A Naranjo, Nathan Herrmann, Martin Zack, Usoa E Bust. Brain reward system activity in major depression and comorbid nicotine dependence. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183688. |
brain reward system activity in major depression and comorbid nicotine dependence. |
2002-09-18 |
2023-08-12 |
human |
| Laura Cardenas, Lescia K Tremblay, Claudio A Naranjo, Nathan Herrmann, Martin Zack, Usoa E Bust. Brain reward system activity in major depression and comorbid nicotine dependence. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183688. |
we hypothesized that a dysfunctional dopaminergic brain reward system (brs) might be a neurobiological link between mdd and nicotine dependence and that smoking modulates the activity of the brs by enhancing dopaminergic activity and relieving some depressive symptoms. |
2002-09-18 |
2023-08-12 |
human |
| Sean P David, Elaine Johnstone, Siân-Elin Griffiths, Michael Murphy, Patricia Yudkin, David Mant, Robert Walto. No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation. Pharmacogenetics. vol 12. issue 3. 2002-09-03. PMID:11927842. |
nicotine stimulates dopamine release and activates dopaminergic reward neurones in central pathways giving rise to dependence. |
2002-09-03 |
2023-08-12 |
Not clear |
| Amanda A Harrison, Fabrizio Gasparini, Athina Marko. Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology. vol 160. issue 1. 2002-06-24. PMID:11862374. |
nicotine potentiation of brain stimulation reward reversed by dh beta e and sch 23390, but not by eticlopride, ly 314582 or mpep in rats. |
2002-06-24 |
2023-08-12 |
rat |
| R D Hur. New medications for nicotine dependence treatment. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 1 Suppl 2. 2002-05-22. PMID:11768177. |
nicotine and mecamylamine both occupy receptors that would otherwise be acted upon by nicotine from cigarettes, thus, when administered in combination, would be expected to occupy more receptors than either drug alone, thereby attenuating smoking reward and facilitating extinction of the smoking behavior. |
2002-05-22 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, J Russel Keath, Daniel S McGehe. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron. vol 33. issue 6. 2002-04-08. PMID:11906697. |
a single nicotine exposure increases dopamine levels in the mesolimbic reward system for hours, but nicotine concentrations experienced by smokers desensitize nachrs on dopamine neurons in seconds to minutes. |
2002-04-08 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, J Russel Keath, Daniel S McGehe. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron. vol 33. issue 6. 2002-04-08. PMID:11906697. |
these results suggest that spatial and temporal differences in nicotinic receptor activity on both excitatory and inhibitory neurons in reward areas coordinate to reinforce nicotine self-administration. |
2002-04-08 |
2023-08-12 |
Not clear |
| P J Kenny, A Marko. Neurobiology of the nicotine withdrawal syndrome. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796152. |
however, only central populations of nachrs are involved in mediating affective aspects of nicotine withdrawal, as measured by elevations in brain-stimulation reward thresholds and conditioned place aversion. |
2002-03-12 |
2023-08-12 |
human |
| A Markou, N E Paterso. The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 3. issue 4. 2002-03-06. PMID:11694204. |
nicotinic acetylcholine receptor (nachr) antagonists have been shown previously to decrease nicotine self-administration and precipitate elevations in brain reward thresholds and somatic signs of withdrawal in animals chronically exposed to nicotine. |
2002-03-06 |
2023-08-12 |
rat |
| A Markou, N E Paterso. The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 3. issue 4. 2002-03-06. PMID:11694204. |
mla was administered to animals allowed to self-administer nicotine intravenously, and also to animals that had been prepared with nicotine-containing osmotic mini-pumps and trained on a brain stimulation reward procedure. |
2002-03-06 |
2023-08-12 |
rat |
| A Markou, N E Paterso. The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 3. issue 4. 2002-03-06. PMID:11694204. |
nevertheless, mla administration, at all doses tested, had no effect on brain reward thresholds or the number of somatic signs of withdrawal observed in rats chronically exposed to either nicotine or saline. |
2002-03-06 |
2023-08-12 |
rat |