| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael N Smolka, Henning Budde, Anne C Karow, Lutz G Schmid. Neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence. Psychopharmacology. vol 175. issue 3. 2005-02-02. PMID:15114432. |
there is multiple evidence that nicotine--as with ethanol and other drugs of abuse--stimulates dopamine release in the ventral striatum as a central part of the brain reward circuits. |
2005-02-02 |
2023-08-12 |
Not clear |
| Michael N Smolka, Henning Budde, Anne C Karow, Lutz G Schmid. Neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence. Psychopharmacology. vol 175. issue 3. 2005-02-02. PMID:15114432. |
chronic nicotine exposure leads to changes in these dopaminergic reward circuits. |
2005-02-02 |
2023-08-12 |
Not clear |
| Adrie W Bruijnzeel, Athina Marko. Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats. Neuropharmacology. vol 47. issue 4. 2005-01-18. PMID:15380374. |
chronic administration of nicotine induces adaptations in the brain reward circuit to counteract the acute drug effects; when nicotine administration ceases, these adaptations remain unopposed and lead to drug withdrawal. |
2005-01-18 |
2023-08-12 |
rat |
| Adrie W Bruijnzeel, Athina Marko. Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats. Neuropharmacology. vol 47. issue 4. 2005-01-18. PMID:15380374. |
we show here that injections of the nachr antagonist dihydro-beta-erythroidine (dhbetae; 0.6-20 microg total bilateral dose) into the vta, but not outside the vta, resulted in significant elevations in brain reward thresholds in nicotine dependent rats (9 mg/kg/day nicotine hydrogen tartrate) while having no effect in saline-treated controls. |
2005-01-18 |
2023-08-12 |
rat |
| Terry E Robinson, Bryan Kol. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464124. |
in this paper we summarize evidence that, indeed, exposure to amphetamine, cocaine, nicotine or morphine produces persistent changes in the structure of dendrites and dendritic spines on cells in brain regions involved in incentive motivation and reward (such as the nucleus accumbens), and judgment and the inhibitory control of behavior (such as the prefrontal cortex). |
2004-12-20 |
2023-08-12 |
Not clear |
| Gaetano Di Chiara, Valentina Bassareo, Sandro Fenu, Maria Antonietta De Luca, Liliana Spina, Cristina Cadoni, Elio Acquas, Ezio Carboni, Valentina Valentini, Daniele Lecc. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464140. |
consistently with a role of da in drug reward, d2 or combined d1/d2 receptor blockade abolishes cocaine, amphetamine and nicotine cta. |
2004-12-20 |
2023-08-12 |
Not clear |
| Jie Wu, Andrew A George, Katherine M Schroeder, Lin Xu, Syndia Marxer-Miller, Linda Lucero, Ronald J Luka. Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 311. issue 1. 2004-12-15. PMID:15178698. |
dopamine (da) neurons located in the mammalian midbrain have been generally implicated in reward and drug reinforcement and more specifically in nicotine dependence. |
2004-12-15 |
2023-08-12 |
human |
| S Singer, S Rossi, S Verzosa, A Hashim, R Lonow, T Cooper, H Sershen, A Lajth. Nicotine-induced changes in neurotransmitter levels in brain areas associated with cognitive function. Neurochemical research. vol 29. issue 9. 2004-12-07. PMID:15453274. |
nicotine, one of the most widespread drugs of abuse, has long been shown to impact areas of the brain involved in addiction and reward. |
2004-12-07 |
2023-08-12 |
rat |
| Brian M Kelley, James D Rowa. Long-term, low-level adolescent nicotine exposure produces dose-dependent changes in cocaine sensitivity and reward in adult mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380833. |
long-term, low-level adolescent nicotine exposure produces dose-dependent changes in cocaine sensitivity and reward in adult mice. |
2004-12-02 |
2023-08-12 |
mouse |
| Brian M Kelley, James D Rowa. Long-term, low-level adolescent nicotine exposure produces dose-dependent changes in cocaine sensitivity and reward in adult mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380833. |
while this "gateway drug effect" is assumed to be related to psychosocial factors, data from our laboratory suggests that adolescent nicotine use may permanently disrupt reward systems through changes in dopamine receptor function. |
2004-12-02 |
2023-08-12 |
mouse |
| Brian M Kelley, James D Rowa. Long-term, low-level adolescent nicotine exposure produces dose-dependent changes in cocaine sensitivity and reward in adult mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380833. |
a dose-dependent relationship between adolescent nicotine exposure and cocaine reward was noted in the adult mice across both test conditions. |
2004-12-02 |
2023-08-12 |
mouse |
| Brian M Kelley, James D Rowa. Long-term, low-level adolescent nicotine exposure produces dose-dependent changes in cocaine sensitivity and reward in adult mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380833. |
in summary, this is the first study to demonstrate a dose-response relationship between adolescent nicotine exposure and changes in cocaine reward and sensitivity during adulthood. |
2004-12-02 |
2023-08-12 |
mouse |
| Andrew R Tapper, Sheri L McKinney, Raad Nashmi, Johannes Schwarz, Purnima Deshpande, Cesar Labarca, Paul Whiteaker, Michael J Marks, Allan C Collins, Henry A Leste. Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science (New York, N.Y.). vol 306. issue 5698. 2004-11-26. PMID:15528443. |
nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. |
2004-11-26 |
2023-08-12 |
mouse |
| Olivera Pluzarev, Subhash C Pande. Modulation of CREB expression and phosphorylation in the rat nucleus accumbens during nicotine exposure and withdrawal. Journal of neuroscience research. vol 77. issue 6. 2004-11-06. PMID:15334606. |
these results suggest the possibility that decreased creb activity in the shell of nac may be associated with abnormal reward mechanisms during nicotine withdrawal after chronic exposure. |
2004-11-06 |
2023-08-12 |
rat |
| Jed E Rose, Frederique M Beh. Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 6. issue 3. 2004-10-05. PMID:15203786. |
these findings demonstrate the importance of sensory cues in determining subjective reward and show that the reward value of these cues can be altered by removal of nicotine from tobacco or by pharmacological manipulations that interfere with the reinforcing effects of nicotine. |
2004-10-05 |
2023-08-12 |
human |
| Frances M Leslie, Sandra E Loughlin, Ruihua Wang, Lilyanna Perez, Shahrdad Lotfipour, James D Belluzzi. Adolescent development of forebrain stimulant responsiveness: insights from animal studies. Annals of the New York Academy of Sciences. vol 1021. 2004-08-23. PMID:15251884. |
here evidence, derived from studies in rodents, is presented that suggests that tobacco use initiation during early adolescence results from a higher reward value of nicotine. |
2004-08-23 |
2023-08-12 |
Not clear |
| Kenneth A Perkins, Lynette Jacobs, Melinda Ciccocioppo, Cynthia Conklin, Michael Sayette, Anthony Caggiul. The influence of instructions and nicotine dose on the subjective and reinforcing effects of smoking. Experimental and clinical psychopharmacology. vol 12. issue 2. 2004-08-17. PMID:15122953. |
most ratings of the nicotine content and reward value of cigarettes were higher for those told regular nicotine versus told low nicotine, and for those given regular nicotine versus given low nicotine. |
2004-08-17 |
2023-08-12 |
Not clear |
| Joyce Besheer, Matthew I Palmatier, Dawn M Metschke, Rick A Bevin. Nicotine as a signal for the presence or absence of sucrose reward: a Pavlovian drug appetitive conditioning preparation in rats. Psychopharmacology. vol 172. issue 1. 2004-08-03. PMID:14530902. |
nicotine as a signal for the presence or absence of sucrose reward: a pavlovian drug appetitive conditioning preparation in rats. |
2004-08-03 |
2023-08-12 |
rat |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. |
2004-07-22 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
nicotine reinforces smoking behaviour by activating nicotinic acetylcholine receptors in the midbrain dopaminergic reward centres. |
2004-07-22 |
2023-08-12 |
Not clear |