| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Manzardo, L Stein, J D Belluzz. Rats prefer cocaine over nicotine in a two-lever self-administration choice test. Brain research. vol 924. issue 1. 2002-02-27. PMID:11743990. |
using a two-lever "choice" self-administration procedure developed in our laboratory, we evaluated drug preferences as an index of relative reward strength for nicotine versus cocaine in nicotine-trained rats. |
2002-02-27 |
2023-08-12 |
rat |
| A M Manzardo, L Stein, J D Belluzz. Rats prefer cocaine over nicotine in a two-lever self-administration choice test. Brain research. vol 924. issue 1. 2002-02-27. PMID:11743990. |
these results indicate that cocaine has greater reward strength than nicotine and supports previous findings that self-administering rats seek to maximize reward magnitude regardless of the self-administered drug or training history. |
2002-02-27 |
2023-08-12 |
rat |
| A M Manzardo, L Stein, J D Belluzz. Rats prefer cocaine over nicotine in a two-lever self-administration choice test. Brain research. vol 924. issue 1. 2002-02-27. PMID:11743990. |
it is possible that dependence elevates nicotine's reward magnitude or nicotine addiction may rely more importantly upon negative rather than pure positive reinforcement. |
2002-02-27 |
2023-08-12 |
rat |
| C Martin-Sölch, S Magyar, G Künig, J Missimer, W Schultz, K L Leender. Changes in brain activation associated with reward processing in smokers and nonsmokers. A positron emission tomography study. Experimental brain research. vol 139. issue 3. 2002-01-29. PMID:11545466. |
in order to better understand the relationship between nicotine addiction and reward in humans, we investigated differences between smokers and nonsmokers in the activation of brain regions involved in processing reward information. |
2002-01-29 |
2023-08-12 |
Not clear |
| H Miyata, T Yanagit. Neurobiological mechanisms of nicotine craving. Alcohol (Fayetteville, N.Y.). vol 24. issue 2. 2001-12-04. PMID:11522428. |
affective symptoms experienced during withdrawal from nicotine are milder than those experienced in withdrawal from other drugs, probably because of its mode of action on the reward systems, which is similar to that of natural rewards. |
2001-12-04 |
2023-08-12 |
Not clear |
| B E Schroeder, J M Binzak, A E Kelle. A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cues. Neuroscience. vol 105. issue 3. 2001-11-01. PMID:11516821. |
using the detection of the immediate-early gene product, fos, we examined which regions of the brain are activated by environmental cues associated with nicotine administration, and compared this profile to the pattern induced by cues associated with a natural reward, chocolate. |
2001-11-01 |
2023-08-12 |
rat |
| W A Carlezon, M S Todtenkopf, D L McPhie, P Pimentel, A M Pliakas, J R Stellar, M Trzcinsk. Repeated exposure to rewarding brain stimulation downregulates GluR1 expression in the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 2. 2001-10-11. PMID:11425507. |
considering that elevated glur1 expression in the vta has been associated with increased sensitivity to drug reward, the finding that bsr and drugs of abuse have opposite effects on glur1 expression in this region may provide an explanation for why the reward-related effects of many drugs (cocaine, morphine, amphetamine, pcp, nicotine) do not sensitize with repeated testing in bsr procedures that quantify reward strength. |
2001-10-11 |
2023-08-12 |
Not clear |
| A Clark, S Lindgren, S P Brooks, W P Watson, H J Littl. Chronic infusion of nicotine can increase operant self-administration of alcohol. Neuropharmacology. vol 41. issue 1. 2001-09-20. PMID:11445191. |
doses of nicotine of 0.25, 1.25 and 7.5 mg/kg/24 h had no significant effects on the maintenance of responding for alcohol, but 5 mg/kg/24 h nicotine resulted in a significant increase in responding on the lever delivering the reward when water was substituted for the alcohol, indicating delayed extinction of responding. |
2001-09-20 |
2023-08-12 |
rat |
| A Clark, S Lindgren, S P Brooks, W P Watson, H J Littl. Chronic infusion of nicotine can increase operant self-administration of alcohol. Neuropharmacology. vol 41. issue 1. 2001-09-20. PMID:11445191. |
during infusion of 2.5 mg/kg/24 h nicotine, responding was significantly greater over the "sucrose-fading" training sessions, during acquisition of responding, when mixtures of alcohol and sucrose were provided as reward. |
2001-09-20 |
2023-08-12 |
rat |
| A A Harrison, Y T Liem, A Marko. Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377919. |
fluoxetine combined with a serotonin-1a receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. |
2001-08-02 |
2023-08-12 |
rat |
| A A Harrison, Y T Liem, A Marko. Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377919. |
we report here that acute co-administration of fluoxetine, a selective serotonin reuptake inhibitor, and p-mppi, a serotonin-1a receptor antagonist, alleviated the diminished interest in brain stimulation reward observed during withdrawal from nicotine or amphetamine in rats (i.e., increased reward). |
2001-08-02 |
2023-08-12 |
rat |
| A A Harrison, Y T Liem, A Marko. Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377919. |
the reversal of the affective aspects of drug withdrawal by a treatment that enhances serotonin neurotransmission indicates that decreased serotonergic function may mediate the reward decrements characterizing nicotine and amphetamine withdrawal, and that these symptoms may be homologous to a core symptom of non-drug-induced depressions. |
2001-08-02 |
2023-08-12 |
rat |
| J R Hughe. Why does smoking so often produce dependence? A somewhat different view. Tobacco control. vol 10. issue 1. 2001-07-12. PMID:11226363. |
this review offers four somewhat different explanations: (1) nicotine can offer several psychopharmacological benefits at the age when such benefits are especially needed; (2) cigarettes provide for a rapid, frequent, reliable and easy-to-obtain reward; (3) nicotine is not intoxicating, allowing chronic intake; and (4) the long duration of the nicotine withdrawal syndrome effectively undermines cessation. |
2001-07-12 |
2023-08-12 |
Not clear |
| J E Rose, F M Behm, E C Westma. Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking. Pharmacology, biochemistry, and behavior. vol 68. issue 2. 2001-06-07. PMID:11267622. |
acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking. |
2001-06-07 |
2023-08-12 |
human |
| K Miyasat. [Recent advances in research on nicotine dependence and reward mechanism]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 117. issue 1. 2001-05-10. PMID:11233293. |
[recent advances in research on nicotine dependence and reward mechanism]. |
2001-05-10 |
2023-08-12 |
Not clear |
| Y Fu, S G Matta, W Gao, B M Shar. Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo. Neuroscience. vol 101. issue 2. 2001-02-01. PMID:11074160. |
this fine tuning of the dopamine reward pathway through alpha7 nicotinic cholinergic receptors in the nucleus accumbens may amplify the secretion of dopamine, allowing a subthreshold brain concentration of nicotine to become an effective stimulus for dopamine secretion. |
2001-02-01 |
2023-08-12 |
Not clear |
| E F McKinney, R T Walton, P Yudkin, A Fuller, N A Haldar, D Mant, M Murphy, K I Welsh, S E Marshal. Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers. Pharmacogenetics. vol 10. issue 6. 2001-01-25. PMID:10975602. |
central dopaminergic reward pathways give rise to dependence and are activated by nicotine. |
2001-01-25 |
2023-08-12 |
Not clear |
| J E Rose, F M Behm, E C Westman, M Johnso. Dissociating nicotine and nonnicotine components of cigarette smoking. Pharmacology, biochemistry, and behavior. vol 67. issue 1. 2001-01-04. PMID:11113486. |
however, no significant satisfaction or reward was reported after iv nicotine. |
2001-01-04 |
2023-08-12 |
human |
| G Panagis, A Kastellakis, C Spyraki, G Nomiko. Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward. Psychopharmacology. vol 149. issue 4. 2000-10-03. PMID:10867966. |
it has been shown that nicotine facilitates intracranial self-stimulation (icss) reward and that nicotinic acetylcholine receptors (nachrs) in the ventral tegmental area (vta) are of primary importance for its reinforcing and dependence-producing actions. |
2000-10-03 |
2023-08-12 |
Not clear |
| H D Mansvelder, D S McGehe. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. vol 27. issue 2. 2000-09-26. PMID:10985354. |
long-term potentiation of excitatory inputs to brain reward areas by nicotine. |
2000-09-26 |
2023-08-12 |
Not clear |