| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Douglas P Dohrman And, Cindy K Reite. Chronic ethanol reduces nicotine-induced dopamine release in PC12 cells. Alcoholism, clinical and experimental research. vol 27. issue 11. 2004-06-29. PMID:14634503. |
the release of dopamine from these neurons is thought to mediate, at least in part, the reward of nicotine consumption. |
2004-06-29 |
2023-08-12 |
Not clear |
| Bonnie Spring, Sherry Pagoto, Dennis McChargue, Donald Hedeker, Jessica Wert. Altered reward value of carbohydrate snacks for female smokers withdrawn from nicotine. Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592688. |
altered reward value of carbohydrate snacks for female smokers withdrawn from nicotine. |
2004-06-18 |
2023-08-12 |
human |
| Bonnie Spring, Sherry Pagoto, Dennis McChargue, Donald Hedeker, Jessica Wert. Altered reward value of carbohydrate snacks for female smokers withdrawn from nicotine. Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592688. |
findings indicate that nicotine deprivation is associated with a heightened reward value of appealing snack foods for female smokers. |
2004-06-18 |
2023-08-12 |
human |
| Anne-Marie Salmon, Alexis Evrard, Imad Damaj, Jean-Pierre Changeu. Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out mice. Neuroscience letters. vol 360. issue 1-2. 2004-06-04. PMID:15082182. |
nicotine, the main substance responsible for the addictive behavior of smokers, binds to a variety of nicotinic acetylcholine receptors (nachrs) diversely distributed in the brain, notably in areas involved in motivation and reward mechanisms. |
2004-06-04 |
2023-08-12 |
mouse |
| Zara M Fagen, Huibert D Mansvelder, J Russel Keath, Daniel S McGehe. Short- and long-term modulation of synaptic inputs to brain reward areas by nicotine. Annals of the New York Academy of Sciences. vol 1003. 2004-02-13. PMID:14684446. |
short- and long-term modulation of synaptic inputs to brain reward areas by nicotine. |
2004-02-13 |
2023-08-12 |
human |
| P J Kenny, N E Paterson, B Boutrel, S Semenova, A A Harrison, F Gasparini, G F Koob, P D Skoubis, A Marko. Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Annals of the New York Academy of Sciences. vol 1003. 2004-02-13. PMID:14684476. |
metabotropic glutamate 5 receptor antagonist mpep decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. |
2004-02-13 |
2023-08-12 |
rat |
| John F Cryan, Adrie W Bruijnzeel, Karen L Skjei, Athina Marko. Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat. Psychopharmacology. vol 168. issue 3. 2004-02-10. PMID:12698231. |
bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat. |
2004-02-10 |
2023-08-12 |
rat |
| Yousef Tizabi, Mashael Al-Namaeh, Kebreten F Manaye, Robert E Taylo. Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells. Neurotoxicity research. vol 5. issue 5. 2004-01-28. PMID:14715450. |
in addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. |
2004-01-28 |
2023-08-12 |
rat |
| J Brek Eaton, Jian-Hong Peng, Katherine M Schroeder, Andrew A George, John D Fryer, Chandra Krishnan, Lori Buhlman, Yen-Ping Kuo, Ortrud Steinlein, Ronald J Luka. Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645658. |
naturally expressed nicotinic acetylcholine receptors composed of alpha4 and beta2 subunits (alpha4beta2-nachr) are the predominant form of high affinity nicotine binding site in the brain implicated in nicotine reward, mediation of nicotinic cholinergic transmission, modulation of signaling through other chemical messages, and a number of neuropsychiatric disorders. |
2004-01-16 |
2023-08-12 |
human |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
group ii metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. |
2003-10-03 |
2023-08-12 |
rat |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
this study investigated the role of ionotropic and metabotropic glutamate receptors in the deficits in brain reward function, as measured by elevations in intracranial self-stimulation (icss) reward thresholds, associated with nicotine withdrawal. |
2003-10-03 |
2023-08-12 |
rat |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
to investigate whether mgluii receptors contributed to nicotine withdrawal by decreasing glutamatergic transmission, we next examined whether direct blockade of postsynaptic glutamate receptors precipitated withdrawal-like reward deficits in nicotine-dependent rats. |
2003-10-03 |
2023-08-12 |
rat |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
overall, these data demonstrate that mgluii receptors play an important role in the reward deficits associated with nicotine withdrawal. |
2003-10-03 |
2023-08-12 |
rat |
| Peter Eichhammer, Monika Johann, Alexander Kharraz, Harald Binder, David Pittrow, Norbert Wodarz, Göran Haja. High-frequency repetitive transcranial magnetic stimulation decreases cigarette smoking. The Journal of clinical psychiatry. vol 64. issue 8. 2003-09-25. PMID:12927012. |
the mesolimbic dopaminergic reward system seems to play a crucial role in reinforcing effects of nicotine. |
2003-09-25 |
2023-08-12 |
Not clear |
| Michela Andreoli, Michela Tessari, Maria Pilla, Enzo Valerio, Jim J Hagan, Christian A Heidbrede. Selective antagonism at dopamine D3 receptors prevents nicotine-triggered relapse to nicotine-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12700694. |
drugs of abuse, including, nicotine have been shown to enhance brain reward functions in the mesocortico-limbic dopamine (da) system in general, and the nucleus accumbens in particular. |
2003-09-02 |
2023-08-12 |
rat |
| Jed E Rose, Lisa H Brauer, Frederique M Behm, Matthew Cramblett, Kevin Calkins, Dawn Lawho. Potentiation of nicotine reward by alcohol. Alcoholism, clinical and experimental research. vol 26. issue 12. 2003-06-05. PMID:12500124. |
potentiation of nicotine reward by alcohol. |
2003-06-05 |
2023-08-12 |
Not clear |
| Joyce Besheer, Rick A Bevin. Impact of nicotine withdrawal on novelty reward and related behaviors. Behavioral neuroscience. vol 117. issue 2. 2003-06-04. PMID:12708529. |
impact of nicotine withdrawal on novelty reward and related behaviors. |
2003-06-04 |
2023-08-12 |
rat |
| Joyce Besheer, Rick A Bevin. Impact of nicotine withdrawal on novelty reward and related behaviors. Behavioral neuroscience. vol 117. issue 2. 2003-06-04. PMID:12708529. |
the authors tested the decreased reward function hypothesis of nicotine withdrawal using a novel-object place conditioning task. |
2003-06-04 |
2023-08-12 |
rat |
| Paul Pentel, David Mali. A vaccine for nicotine dependence: targeting the drug rather than the brain. Respiration; international review of thoracic diseases. vol 69. issue 3. 2003-05-22. PMID:12097758. |
vaccination of rats against nicotine also reduces nicotine-induced dopamine release in the reward pathway of the brain and the reinstatement of nicotine responding, a model for relapse. |
2003-05-22 |
2023-08-12 |
rat |
| Ming D Li, Justin K Kane, Ozlen Kon. Nicotine, body weight and potential implications in the treatment of obesity. Current topics in medicinal chemistry. vol 3. issue 8. 2003-05-14. PMID:12678839. |
third is to present the current knowledge with respect to nicotine's effects on energy homeostatic and reward related pathways at the molecular level. |
2003-05-14 |
2023-08-12 |
Not clear |