| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Liu, Zhen Li, Jian-Hua Ding, Su-Yi Liu, Jie Wu, Gang H. Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats. Brain research. vol 1085. issue 1. 2006-08-10. PMID:16647046. |
therefore, ipt may serve as a novel compound to block nicotine-induced dopamine and glutamate release in the brain reward center, in turn decreasing nicotine reinforcement and dependence. |
2006-08-10 |
2023-08-12 |
rat |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. |
2006-08-07 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
nevertheless, remarkably little is known concerning the acute or long-lasting actions of nicotine on brain reward systems in vivo. |
2006-08-07 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
here, we investigated the effects of intravenously self-administered nicotine (0.03 mg/kg/infusion, free base) on the sensitivity of brain reward systems, reflected in alterations of intracranial self-stimulation (icss) thresholds in rats. |
2006-08-07 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
rats self-administered nicotine during 1 or 12 h daily sessions, with reward thresholds assessed 1 h before and 15 min after each self-administration session. |
2006-08-07 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
nicotine self-administration increased the sensitivity of brain reward systems, detected by post-nicotine lowering of reward thresholds in 1 and 12 h rats. |
2006-08-07 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
surprisingly, nicotine-induced excitation of reward systems persisted for at least 36 days after nicotine self-administration had ceased. |
2006-08-07 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
overall, these data demonstrate that rats can voluntarily consume quantities of nicotine sufficient to increase the sensitivity of brain reward systems, an action likely crucial in establishing and maintaining the nicotine habit. |
2006-08-07 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16192981. |
moreover, self-administered nicotine resets the sensitivity of reward systems to a new increased level, thereby imprinting an indelible 'memory' of its effects in reward systems, an action that so far appears unique to nicotine among drugs of abuse. |
2006-08-07 |
2023-08-12 |
human |
| Nina Lindblom, Sabina H L de Villiers, Svetlana Semenova, Genadiy Kalayanov, Sandra Gordon, Björn Schilström, Anette M Johansson, Athina Markou, Torgny H Svensso. Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. Naunyn-Schmiedeberg's archives of pharmacology. vol 372. issue 3. 2006-07-20. PMID:16292514. |
active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. |
2006-07-20 |
2023-08-12 |
rat |
| Nina Lindblom, Sabina H L de Villiers, Svetlana Semenova, Genadiy Kalayanov, Sandra Gordon, Björn Schilström, Anette M Johansson, Athina Markou, Torgny H Svensso. Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. Naunyn-Schmiedeberg's archives of pharmacology. vol 372. issue 3. 2006-07-20. PMID:16292514. |
measuring brain reward thresholds and somatic signs of nicotine withdrawal, the effects of immunisation were also tested during chronic nicotine treatment and after its withdrawal. |
2006-07-20 |
2023-08-12 |
rat |
| Nina Lindblom, Sabina H L de Villiers, Svetlana Semenova, Genadiy Kalayanov, Sandra Gordon, Björn Schilström, Anette M Johansson, Athina Markou, Torgny H Svensso. Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. Naunyn-Schmiedeberg's archives of pharmacology. vol 372. issue 3. 2006-07-20. PMID:16292514. |
finally, we examined the effect of immunisation on challenge injections of nicotine on brain reward thresholds after the increases in somatic signs and reward thresholds associated with nicotine withdrawal had dissipated. |
2006-07-20 |
2023-08-12 |
rat |
| Nina Lindblom, Sabina H L de Villiers, Svetlana Semenova, Genadiy Kalayanov, Sandra Gordon, Björn Schilström, Anette M Johansson, Athina Markou, Torgny H Svensso. Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. Naunyn-Schmiedeberg's archives of pharmacology. vol 372. issue 3. 2006-07-20. PMID:16292514. |
moreover, immunisation against nicotine did not precipitate a withdrawal syndrome, as measured by brain reward thresholds and somatic signs, in rats chronically exposed to nicotine. |
2006-07-20 |
2023-08-12 |
rat |
| Nina Lindblom, Sabina H L de Villiers, Svetlana Semenova, Genadiy Kalayanov, Sandra Gordon, Björn Schilström, Anette M Johansson, Athina Markou, Torgny H Svensso. Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. Naunyn-Schmiedeberg's archives of pharmacology. vol 372. issue 3. 2006-07-20. PMID:16292514. |
finally, the lowering in reward thresholds after nicotine challenge injections was attenuated in both naïve and previously nicotine-exposed immunised rats. |
2006-07-20 |
2023-08-12 |
rat |
| Helen L Alderson, Mary P Latimer, Philip Win. Intravenous self-administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus. The European journal of neuroscience. vol 23. issue 8. 2006-07-13. PMID:16630063. |
the resulting change in nicotine self-administration behaviour was hypothesized to reflect either a reduction in intrinsic nicotine reward value, or enhancement of associative incentive salience. |
2006-07-13 |
2023-08-12 |
rat |
| A D Lê, Z Li, D Funk, M Shram, T K Li, Y Shaha. Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 6. 2006-04-26. PMID:16467536. |
thus, alcohol-naive offspring of rats genetically selected for high alcohol intake are highly susceptible to nicotine self-administration and relapse, and this susceptibility is not likely caused by general reward deficits in np rats. |
2006-04-26 |
2023-08-12 |
human |
| Paul J Kenny, Athina Marko. Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987950. |
conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. |
2006-02-14 |
2023-08-12 |
rat |
| Paul J Kenny, Athina Marko. Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987950. |
withdrawal from nicotine decreases the activity of brain reward systems, measured in rats by elevations of intracranial self-stimulation (icss) thresholds. |
2006-02-14 |
2023-08-12 |
rat |
| Paul J Kenny, Athina Marko. Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987950. |
here we investigated whether hedonically neutral stimuli repeatedly paired with nicotine withdrawal gained "affective valence" such that withdrawal-associated conditioned stimuli alone decreased brain reward function. |
2006-02-14 |
2023-08-12 |
rat |
| Paul J Kenny, Athina Marko. Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987950. |
moreover, these data demonstrate that withdrawal-paired conditioned stimuli attain negative affective valence and can decrease the activity of brain reward systems, mimicking the reward deficit observed during withdrawal from nicotine and other addictive drugs. |
2006-02-14 |
2023-08-12 |
rat |