| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adrie W Bruijnzeel, George Zislis, Carrie Wilson, Mark S Gol. Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 4. 2007-05-01. PMID:16943772. |
in the third experiment, the effect of d-phe crf((12-41)) on the elevations in brain reward thresholds associated with spontaneous nicotine withdrawal was investigated. |
2007-05-01 |
2023-08-12 |
rat |
| Adrie W Bruijnzeel, George Zislis, Carrie Wilson, Mark S Gol. Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 4. 2007-05-01. PMID:16943772. |
administration of d-phe crf((12-41)) 6 h after the explantation of the nicotine pumps, did not result in a lowering of the brain reward thresholds. |
2007-05-01 |
2023-08-12 |
rat |
| Theodore A Slotkin, Frederic J Seidle. A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration. Neurotoxicology and teratology. vol 29. issue 1. 2007-04-17. PMID:16919421. |
animal models of nicotine withdrawal indicate involvement of striatal serotonin (5-ht) systems in nicotine reward, withdrawal and craving. |
2007-04-17 |
2023-08-12 |
rat |
| Eric P Nolley, Brian M Kelle. Adolescent reward system perseveration due to nicotine: studies with methylphenidate. Neurotoxicology and teratology. vol 29. issue 1. 2007-04-17. PMID:17129706. |
adolescent reward system perseveration due to nicotine: studies with methylphenidate. |
2007-04-17 |
2023-08-12 |
mouse |
| Eric P Nolley, Brian M Kelle. Adolescent reward system perseveration due to nicotine: studies with methylphenidate. Neurotoxicology and teratology. vol 29. issue 1. 2007-04-17. PMID:17129706. |
previous data suggests adolescent nicotine exposure permanently disrupts reward systems. |
2007-04-17 |
2023-08-12 |
mouse |
| Eric P Nolley, Brian M Kelle. Adolescent reward system perseveration due to nicotine: studies with methylphenidate. Neurotoxicology and teratology. vol 29. issue 1. 2007-04-17. PMID:17129706. |
behavioral pharmacological methods were used to assess the effects of adolescent nicotine exposure on methylphenidate (mpd) sensitivity and reward from adolescence to adulthood. |
2007-04-17 |
2023-08-12 |
mouse |
| Eric P Nolley, Brian M Kelle. Adolescent reward system perseveration due to nicotine: studies with methylphenidate. Neurotoxicology and teratology. vol 29. issue 1. 2007-04-17. PMID:17129706. |
taken together it appears that adolescent nicotine exposure retards the development of reward systems, thus, maintaining an adolescent state indefinitely, which could result in increased vulnerability to substance abuse problems throughout adulthood. |
2007-04-17 |
2023-08-12 |
mouse |
| Susan C McQuown, James D Belluzzi, Frances M Lesli. Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Neurotoxicology and teratology. vol 29. issue 1. 2007-04-17. PMID:17174067. |
low dose nicotine treatment during early adolescence increases subsequent cocaine reward. |
2007-04-17 |
2023-08-12 |
rat |
| Susan C McQuown, James D Belluzzi, Frances M Lesli. Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Neurotoxicology and teratology. vol 29. issue 1. 2007-04-17. PMID:17174067. |
these findings provide evidence that the adolescent brain is uniquely vulnerable to the effects of nicotine on subsequent drug reward. |
2007-04-17 |
2023-08-12 |
rat |
| Nestor D Kapusta, Paul L Plener, Rainer Schmid, Kenneth Thau, Henriette Walter, Otto M Lesc. Multiple substance use among young males. Pharmacology, biochemistry, and behavior. vol 86. issue 2. 2007-04-16. PMID:17126388. |
nicotine has been shown to sensitize the reward pathway, thereby causing increased drug-seeking behavior. |
2007-04-16 |
2023-08-12 |
human |
| Song Guo, Da Fang Chen, Dong Feng Zhou, Hong Qiang Sun, Gui Ying Wu, Colin N Haile, Therese A Kosten, Thomas R Kosten, Xiang Yang Zhan. Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. Psychopharmacology. vol 190. issue 4. 2007-04-06. PMID:17206495. |
catechol-o-methyltransferase (comt) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. |
2007-04-06 |
2023-08-12 |
Not clear |
| Matthias E Liechti, Athina Marko. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17113075. |
interactive effects of the mglu5 receptor antagonist mpep and the mglu2/3 receptor antagonist ly341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. |
2007-03-06 |
2023-08-12 |
rat |
| Matthias E Liechti, Athina Marko. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17113075. |
because both presynaptic inhibitory mglu2/3 and postsynaptic excitatory mglu5 receptors provide potential targets for treatment of aspects of nicotine dependence, we examined interacting effects of mglu5 (2-methyl-6-(phenylethynyl)-pyridine, mpep) and mglu2/3 (ly341495) receptor antagonists on nicotine self-administration and brain reward threshold elevations associated with spontaneous nicotine withdrawal in rats. |
2007-03-06 |
2023-08-12 |
rat |
| Matthias E Liechti, Athina Marko. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17113075. |
we also hypothesized that blocking postsynaptic actions of glutamate on mglu5 receptors would exacerbate nicotine withdrawal-induced reward deficits, and that this effect would be attenuated by co-administration of the mglu2/3 receptor antagonist ly341495. |
2007-03-06 |
2023-08-12 |
rat |
| Matthias E Liechti, Athina Marko. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17113075. |
spontaneous nicotine withdrawal induced somatic signs of withdrawal and reward threshold elevations indicating reward deficits. |
2007-03-06 |
2023-08-12 |
rat |
| Matthias E Liechti, Athina Marko. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17113075. |
thus, increasing glutamate transmission via mglu2/3 autoreceptor blockade reduces the effects of mglu5 receptor blockade on nicotine self-administration and mpep-induced exacerbation of brain reward deficits associated with nicotine withdrawal. |
2007-03-06 |
2023-08-12 |
rat |
| Aracy Pereira Silveira Balbani, Jair Cortez Montovan. Methods for smoking cessation and treatment of nicotine dependence. Brazilian journal of otorhinolaryngology. vol 71. issue 6. 2007-02-08. PMID:16878254. |
nicotine induces tolerance and addiction by acting on the central dopaminergic pathways, thus leading to pleasure and reward sensations within the limbic system. |
2007-02-08 |
2023-08-12 |
Not clear |
| K Michael Cummings, Martin Mahone. Current and emerging treatment approaches for tobacco dependence. Current oncology reports. vol 8. issue 6. 2007-02-06. PMID:17040625. |
nicotine creates dependence by activating the dopaminergic reward system in the brain. |
2007-02-06 |
2023-08-12 |
Not clear |
| Stewart L MacLeod, Parimal Chowdhur. The genetics of nicotine dependence: relationship to pancreatic cancer. World journal of gastroenterology. vol 12. issue 46. 2007-01-31. PMID:17167830. |
recent evidence suggests that individuals have genetically based differences in their ability to metabolize nicotine, as well as genetic differences in the psychological reward pathways that may influence individual response to smoking initiation, dependence, addiction and cessation. |
2007-01-31 |
2023-08-12 |
Not clear |
| Soh Agatsuma, Moonsook Lee, Hongwen Zhu, Kevin Chen, Jean C Shih, Isabelle Seif, Noboru Hiro. Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli. Human molecular genetics. vol 15. issue 18. 2006-11-08. PMID:16893910. |
we examined the impact of constitutive monoamine oxidase a (maoa) deficiency in mice on nicotine reward and responses to novel stimuli. |
2006-11-08 |
2023-08-12 |
mouse |