| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Huston-Lyons, C Kornetsk. Effects of nicotine on the threshold for rewarding brain stimulation in rats. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1594644. |
if nicotine acts as other drugs of abuse, it would be expected to lower the reward threshold, that is, increase an animal's sensitivity to rewarding brain stimulation, and naloxone would be expected to block this effect, as it does other stimulants in this paradigm. |
1992-06-30 |
2023-08-11 |
rat |
| D Huston-Lyons, C Kornetsk. Effects of nicotine on the threshold for rewarding brain stimulation in rats. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1594644. |
nicotine was found to significantly lower the reward threshold and mecamylamine blocked this effect. |
1992-06-30 |
2023-08-11 |
rat |
| D Huston-Lyons, C Kornetsk. Effects of nicotine on the threshold for rewarding brain stimulation in rats. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1594644. |
however, although naloxone increased the variability of nicotine's effect on the reward threshold, it failed to dose dependently block nicotine's threshold-lowering effect. |
1992-06-30 |
2023-08-11 |
rat |
| P Vezina, G Blanc, J Glowinski, J P Tassi. Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1578364. |
these findings suggest that nicotine differs from morphine in the way it elicits locomotion following repeated injection and possibly in its relation to da as a mediator of reward. |
1992-06-05 |
2023-08-11 |
Not clear |
| R A Wis. The role of reward pathways in the development of drug dependence. Pharmacology & therapeutics. vol 35. issue 1-2. 1988-02-20. PMID:3321101. |
ethanol, nicotine, caffeine and phencyclidine stimulate both locomotor activity and dopamine turnover, but their sites of interaction with reward pathways have not yet been identified. |
1988-02-20 |
2023-08-11 |
Not clear |
| N Gra. Low-tar cigarettes: bane or benefit. Cancer detection and prevention. vol 10. issue 3-4. 1987-05-28. PMID:3568015. |
there is, however, argument as to whether an optimal dose of nicotine reward is needed in order to prevent the development of compensatory smoking habits. |
1987-05-28 |
2023-08-11 |
Not clear |
| M A Russell, M J Jarvi. Theoretical background and clinical use of nicotine chewing gum. NIDA research monograph. vol 53. 1986-01-22. PMID:3934541. |
until the advent of nicotine gum it has required either a research interest, financial reward, or a degree of masochism to remain for long at the sharp end of the business of helping people to give up smoking. |
1986-01-22 |
2023-08-11 |
Not clear |
| P J Fudala, K W Teoh, E T Iwamot. Pharmacologic characterization of nicotine-induced conditioned place preference. Pharmacology, biochemistry, and behavior. vol 22. issue 2. 1985-05-09. PMID:2858867. |
nicotine's rewarding and aversive effects were linearly correlated with respect to dosage within the range of 0.1-0.8 mg/kg (reward increased and aversion decreased). |
1985-05-09 |
2023-08-11 |
rat |
| P B Clarke, R Kuma. Nicotine does not improve discrimination of brain stimulation reward by rats. Psychopharmacology. vol 79. issue 2-3. 1983-06-17. PMID:6405438. |
nicotine does not improve discrimination of brain stimulation reward by rats. |
1983-06-17 |
2023-08-12 |
human |