| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H D Mansvelder, D S McGehe. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. vol 27. issue 2. 2000-09-26. PMID:10985354. |
nicotine reinforces smoking behavior by activating nicotinic acetylcholine receptors (nachrs) in the midbrain dopaminergic (da) reward centers, including the ventral tegmental area (vta). |
2000-09-26 |
2023-08-12 |
Not clear |
| H D Mansvelder, D S McGehe. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. vol 27. issue 2. 2000-09-26. PMID:10985354. |
these results can explain the long-term excitation of brain reward areas induced by a brief nicotine exposure. |
2000-09-26 |
2023-08-12 |
Not clear |
| B Bunnemann, A Terron, V Zantedeschi, E Merlo Pich, C Chiamuler. Chronic nicotine treatment decreases neurofilament immunoreactivity in the rat ventral tegmental area. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771021. |
these preliminary results suggest that nicotine shares the same properties with cocaine and morphine to reduce neurofilament proteins in the ventral tegmental area, a key brain structure of the reward system. |
2000-08-11 |
2023-08-12 |
rat |
| G Di Chiar. Role of dopamine in the behavioural actions of nicotine related to addiction. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771025. |
these effects of nicotine resemble those of a reward like food except that nicotine-induced release of dopamine does not undergo single-trial, long-lasting habituation. |
2000-08-11 |
2023-08-12 |
Not clear |
| G Di Chiar. Role of dopamine in the behavioural actions of nicotine related to addiction. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771025. |
it is speculated that these adaptive changes are the substrate of a switch from abnormal incentive responding controlled by consequences (action-outcome responding) into abnormal habit responding, triggered by conditional stimuli and automatically driven by action schemata relatively independent from nicotine reward. |
2000-08-11 |
2023-08-12 |
Not clear |
| E Merlo Pich, C Chiamulera, L Carbon. Molecular mechanisms of the positive reinforcing effect of nicotine. Behavioural pharmacology. vol 10. issue 6-7. 2000-05-23. PMID:10780500. |
nicotine self-administration produces changes in the mesocorticolimbic da system, a key component of the reward system, as do other addictive drugs. |
2000-05-23 |
2023-08-12 |
mouse |
| S S Watkins, L Stinus, G F Koob, A Marko. Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. The Journal of pharmacology and experimental therapeutics. vol 292. issue 3. 2000-03-17. PMID:10688623. |
reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. |
2000-03-17 |
2023-08-12 |
human |
| S S Watkins, L Stinus, G F Koob, A Marko. Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. The Journal of pharmacology and experimental therapeutics. vol 292. issue 3. 2000-03-17. PMID:10688623. |
in the present studies in rats, brain stimulation reward thresholds, conditioned place aversions, and somatic signs of withdrawal were used to investigate the role of central and peripheral nicotinic acetylcholine and opioid receptors in nicotine withdrawal. |
2000-03-17 |
2023-08-12 |
human |
| B M Kelley, L D Middaug. Periadolescent nicotine exposure reduces cocaine reward in adult mice. Journal of addictive diseases. vol 18. issue 3. 1999-11-09. PMID:10507580. |
periadolescent nicotine exposure reduces cocaine reward in adult mice. |
1999-11-09 |
2023-08-12 |
mouse |
| B M Kelley, L D Middaug. Periadolescent nicotine exposure reduces cocaine reward in adult mice. Journal of addictive diseases. vol 18. issue 3. 1999-11-09. PMID:10507580. |
these changes were noted long after exposure, suggesting that nicotine may have altered neural systems mediating drug reward. |
1999-11-09 |
2023-08-12 |
mouse |
| G F Koo. The role of the striatopallidal and extended amygdala systems in drug addiction. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415664. |
chronic administration of drugs of abuse, including cocaine, amphetamines, nicotine, alcohol, and tetrahydrocannabinol leads to an increasing dysregulation of brain reward systems that is characterized by decreases in reward function. |
1999-08-10 |
2023-08-12 |
Not clear |
| G F Koo. The role of the striatopallidal and extended amygdala systems in drug addiction. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415664. |
withdrawal from chronic administration of cocaine, amphetamine, nicotine, alcohol, and tetrahydrocannabinol raises thresholds for brain stimulation reward. |
1999-08-10 |
2023-08-12 |
Not clear |
| H Miyata, T Yanagit. [Mechanism of nicotine dependence]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 33. issue 5. 1999-02-16. PMID:9844376. |
5) as for the neurobiology of nicotine dependence, the reward system is focused as a putative responsible region involved not only in the reinforcing effects of nicotine but also in the psychic withdrawal symptoms. |
1999-02-16 |
2023-08-12 |
Not clear |
| M A Bozarth, C M Pudiak, R KuoLe. Effect of chronic nicotine on brain stimulation reward. I. Effect of daily injections. Behavioural brain research. vol 96. issue 1-2. 1999-02-05. PMID:9821554. |
effect of chronic nicotine on brain stimulation reward. |
1999-02-05 |
2023-08-12 |
rat |
| M A Bozarth, C M Pudiak, R KuoLe. Effect of chronic nicotine on brain stimulation reward. I. Effect of daily injections. Behavioural brain research. vol 96. issue 1-2. 1999-02-05. PMID:9821554. |
previous work has shown that nicotine facilitates brain stimulation reward (bsr) but that the maximum effect obtainable with nicotine is similar to that seen with nonaddictive compounds. |
1999-02-05 |
2023-08-12 |
rat |
| M A Bozarth, C M Pudiak, R KuoLe. Effect of chronic nicotine on brain stimulation reward. II. An escalating dose regimen. Behavioural brain research. vol 96. issue 1-2. 1999-02-05. PMID:9821555. |
effect of chronic nicotine on brain stimulation reward. |
1999-02-05 |
2023-08-12 |
rat |
| M A Bozarth, C M Pudiak, R KuoLe. Effect of chronic nicotine on brain stimulation reward. II. An escalating dose regimen. Behavioural brain research. vol 96. issue 1-2. 1999-02-05. PMID:9821555. |
this study examined whether repeated nicotine injections, using an escalating dose regimen, would produce brain stimulation reward facilitation indicative of a strong rewarding action. |
1999-02-05 |
2023-08-12 |
rat |
| N L Benowitz, S Zevin, P Jaco. Suppression of nicotine intake during ad libitum cigarette smoking by high-dose transdermal nicotine. The Journal of pharmacology and experimental therapeutics. vol 287. issue 3. 1999-01-27. PMID:9864279. |
nicotine replacement therapy is believed to facilitate smoking cessation both by relieving withdrawal symptoms and by reducing the psychological reward from smoking. |
1999-01-27 |
2023-08-12 |
human |
| C Léna, J P Changeu. Allosteric nicotinic receptors, human pathologies. Journal of physiology, Paris. vol 92. issue 2. 1998-12-14. PMID:9782446. |
accumulating evidence, including experiments with knock-out animals, indicates that addiction to nicotine is linked to the activation of beta 2-subunit containing nicotinic receptors in the dopaminergic mesolimbic neurons which are part of the reward systems in the brain. |
1998-12-14 |
2023-08-12 |
human |
| M A Rossin. Genetic influences on smoking: candidate genes. Environmental health perspectives. vol 106. issue 5. 1998-09-02. PMID:9647893. |
habit-forming actions of nicotine appear to be triggered primarily at nicotinic receptors on the cell bodies of dopaminergic neurons in the mesolimbic "reward" system of the brain, a region implicated in addiction to other substances including cocaine, opiates, and alcohol. |
1998-09-02 |
2023-08-12 |
Not clear |