| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryan T Lacy, Lauren L Hord, Amanda J Morgan, Steven B Harro. Intravenous gestational nicotine exposure results in increased motivation for sucrose reward in adult rat offspring. Drug and alcohol dependence. vol 124. issue 3. 2012-12-10. PMID:22377090. |
animal models show that gestational nicotine (gn) exposure mediates changes in responding for sucrose and drug reward. |
2012-12-10 |
2023-08-12 |
rat |
| Laura L Locklear, Craig G McDonald, Robert F Smith, Karl J Fryxel. Adult mice voluntarily progress to nicotine dependence in an oral self-selection assay. Neuropharmacology. vol 63. issue 4. 2012-11-30. PMID:22583831. |
however, high throughput models of nicotine reward have not been developed in mice. |
2012-11-30 |
2023-08-12 |
mouse |
| Die Zhang, Ming Gao, Dan Xu, Wei-Xing Shi, Boris S Gutkin, Scott C Steffensen, Ronald J Lukas, Jie W. Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956827. |
systemic administration of nicotine increases dopaminergic (da) neuron firing in the ventral tegmental area (vta), which is thought to underlie nicotine reward. |
2012-11-16 |
2023-08-12 |
rat |
| Leigh V Panlilio, Zuzana Justinova, Paola Mascia, Marco Pistis, Antonio Luchicchi, Salvatore Lecca, Chanel Barnes, Godfrey H Redhi, Jordan Adair, Stephen J Heishman, Sevil Yasar, Mano Aliczki, Jozsef Haller, Steven R Goldber. Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22453137. |
novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings. |
2012-11-13 |
2023-08-12 |
human |
| Leigh V Panlilio, Zuzana Justinova, Paola Mascia, Marco Pistis, Antonio Luchicchi, Salvatore Lecca, Chanel Barnes, Godfrey H Redhi, Jordan Adair, Stephen J Heishman, Sevil Yasar, Mano Aliczki, Jozsef Haller, Steven R Goldber. Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22453137. |
the fibrates are a class of pparα-activating medications that are widely prescribed to improve lipid profiles and prevent cardiovascular disease, but these drugs have not been tested in animal models of nicotine reward. |
2012-11-13 |
2023-08-12 |
human |
| Lee Hogarth, Henry W Chas. Evaluating psychological markers for human nicotine dependence: tobacco choice, extinction, and Pavlovian-to-instrumental transfer. Experimental and clinical psychopharmacology. vol 20. issue 3. 2012-10-29. PMID:22369668. |
to evaluate these three candidate markers for nicotine dependence, experiment 1 contrasted daily (n = 22) and nondaily smoker groups (n = 22) on a novel instrumental learning task, where one s+ was first trained as a predictor of tobacco reward before being extinguished. |
2012-10-29 |
2023-08-12 |
human |
| Steven B Harrod, Ryan T Lacy, Amanda J Morga. Offspring of Prenatal IV Nicotine Exposure Exhibit Increased Sensitivity to the Reinforcing Effects of Methamphetamine. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22719728. |
preclinical research shows that in utero exposure to nicotine, the primary psychoactive compound in tobacco smoke, influences the neurodevelopment of reward systems and alters motivated behavior in offspring. |
2012-10-02 |
2023-08-12 |
human |
| Hui Chen, Sonia Saad, Shaun L Sandow, Paul P Bertran. Cigarette smoking and brain regulation of energy homeostasis. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22848202. |
nicotine exposure from cigarette smoke can change brain feeding regulation to reduce appetite via both energy homeostatic and reward mechanisms, causing a negative energy state which is characterized by reduced energy intake and increased energy expenditure that are linked to low body weight. |
2012-10-02 |
2023-08-12 |
Not clear |
| Patricia Mesa-Gresa, Asunción Pérez-Martínez, Rosa Redolat-Iborr. [Nicotine and animal models: what does the environmental enrichment paradigm tell us?]. Adicciones. vol 24. issue 2. 2012-10-01. PMID:22648311. |
we discuss the major changes induced by ee at physical, neurobiological and behavioral levels and review the results of recent studies which indicate that ee promotes both neurochemical (potentiation of the increase in dopamine release induced by nicotine in the brain cortex) and behavioral changes (increased ability to discriminate the presence of reward and decreased impulsivity), thus supporting the hypothesis put forward. |
2012-10-01 |
2023-08-12 |
human |
| Patricia Mesa-Gresa, Asunción Pérez-Martínez, Rosa Redolat-Iborr. [Nicotine and animal models: what does the environmental enrichment paradigm tell us?]. Adicciones. vol 24. issue 2. 2012-10-01. PMID:22648311. |
in light of these results, ee can be proposed as a model for the study of vulnerability to addiction to different drugs of abuse, including cocaine and nicotine, though further studies are needed in order to establish the neurobiological implications of the effects of exposure to enriched environments and their possible relationship with changes in brain reward systems. |
2012-10-01 |
2023-08-12 |
human |
| Jennifer Brielmaier, Craig G McDonald, Robert F Smit. Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors. Psychopharmacology. vol 219. issue 1. 2012-09-20. PMID:21720754. |
they may also mediate stress-induced potentiation of activity in multiple neural substrates implicated in nicotine reward. |
2012-09-20 |
2023-08-12 |
rat |
| Astrid K Stoker, Berend Olivier, Athina Marko. Role of α7- and β4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice. Behavior genetics. vol 42. issue 3. 2012-09-12. PMID:22009521. |
to assess which nicotinic acetylcholine receptors (nachrs) are involved in the aversive aspects of nicotine withdrawal, brain reward function and the somatic signs of nicotine withdrawal were assessed in mice that lack α7 and β4 nachr subunits. |
2012-09-12 |
2023-08-12 |
mouse |
| Francesca Ducci, David Goldma. The genetic basis of addictive disorders. The Psychiatric clinics of North America. vol 35. issue 2. 2012-09-06. PMID:22640768. |
it is not surprising that the genes discovered so far act in a variety of ways: via altered metabolism of drug (the alcohol and nicotine metabolic gene variants), via altered function of a drug receptor (the nicotinic receptor, which may alter affinity for nicotine but as discussed may also alter circuitry of reward), and via general mechanisms of addiction (genes such as monoamine oxidase a and the serotonin transporter that modulate stress response, emotion, and behavioral control). |
2012-09-06 |
2023-08-12 |
Not clear |
| Nathasha R Moallem, Lara A Ra. Dimensions of impulsivity among heavy drinkers, smokers, and heavy drinking smokers: singular and combined effects. Addictive behaviors. vol 37. issue 7. 2012-09-05. PMID:22445419. |
analyses supported an additive effect of alcohol and nicotine use in delay reward discounting. |
2012-09-05 |
2023-08-12 |
human |
| Astrid K Stoker, Berend Olivier, Athina Marko. Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. Psychopharmacology. vol 221. issue 2. 2012-08-15. PMID:22147259. |
involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. |
2012-08-15 |
2023-08-12 |
Not clear |
| Mehmet Sofuoglu, Aryeh I Herman, Haleh Nadim, Peter Jatlo. Rapid nicotine clearance is associated with greater reward and heart rate increases from intravenous nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22334123. |
rapid nicotine clearance is associated with greater reward and heart rate increases from intravenous nicotine. |
2012-08-14 |
2023-08-12 |
Not clear |
| Mehmet Sofuoglu, Aryeh I Herman, Haleh Nadim, Peter Jatlo. Rapid nicotine clearance is associated with greater reward and heart rate increases from intravenous nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22334123. |
these results suggest that enhanced nicotine reward and cigarette craving may contribute to the poor treatment response in smokers with high nmr. |
2012-08-14 |
2023-08-12 |
Not clear |
| Elizabeth E Van Voorhees, John T Mitchell, F Joseph McClernon, Jean C Beckham, Scott H Kollin. Sex, ADHD symptoms, and smoking outcomes: an integrative model. Medical hypotheses. vol 78. issue 5. 2012-08-09. PMID:22341778. |
on a neurobiological level, the dopamine reward processing system may be implicated in the potentially unique interaction of nicotine with sex and with adhd status. |
2012-08-09 |
2023-08-12 |
Not clear |
| Elizabeth E Van Voorhees, John T Mitchell, F Joseph McClernon, Jean C Beckham, Scott H Kollin. Sex, ADHD symptoms, and smoking outcomes: an integrative model. Medical hypotheses. vol 78. issue 5. 2012-08-09. PMID:22341778. |
specifically, nicotine appears to mitigate core adhd symptoms through interaction with the dopamine reward processing system, and ovarian hormones have been found to interact with nicotine within the dopamine reward processing system to affect neurotransmitter release and functioning. |
2012-08-09 |
2023-08-12 |
Not clear |
| Elizabeth E Van Voorhees, John T Mitchell, F Joseph McClernon, Jean C Beckham, Scott H Kollin. Sex, ADHD symptoms, and smoking outcomes: an integrative model. Medical hypotheses. vol 78. issue 5. 2012-08-09. PMID:22341778. |
based upon this model, the following hypotheses are proposed at the intersection of each of the three variables of sex, adhd, and smoking: (1) individuals with adhd have altered functioning of the dopamine reward system, which diminishes their ability to efficiently form conditioned associations based on environmental contingencies; these deficits are partially ameliorated by nicotine; (2) nicotine interacts with estrogen and the dopamine reward system to increase the positive and negative reinforcement value of smoking in female smokers; (3) in adult females with adhd, ovarian hormones interact with the dopamine reward system to exacerbate adhd-related deficits in the capacity to form conditioned associations; and (4) during different phases of the menstrual cycle, nicotine and ovarian hormones may interact differentially with the dopamine reward processing system to affect the type and value of reinforcement smoking provides for women with adhd. |
2012-08-09 |
2023-08-12 |
Not clear |