| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tresa M McGranahan, Natalie E Patzlaff, Sharon R Grady, Stephen F Heinemann, T K Booke. α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795541. |
α4-nachrs specifically on dopaminergic neurons were demonstrated to be necessary for nicotine reward as measured by nicotine place preference, but not for another drug of addiction, cocaine. |
2011-10-07 |
2023-08-12 |
mouse |
| Riju Ray, Kosha Ruparel, Andrew Newberg, E Paul Wileyto, James W Loughead, Chaitanya Divgi, Julie A Blendy, Jean Logan, Jon-Kar Zubieta, Caryn Lerma. Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21576462. |
among g allele carriers, the extent of subjective reward difference (denicotinized versus nicotine cigarette) was associated significantly with mor bp(nd) difference in right amygdala, caudate, anterior cingulate cortex, and thalamus. |
2011-08-23 |
2023-08-12 |
human |
| Paola Mascia, Marco Pistis, Zuzana Justinova, Leigh V Panlilio, Antonio Luchicchi, Salvatore Lecca, Maria Scherma, Walter Fratta, Paola Fadda, Chanel Barnes, Godfrey H Redhi, Sevil Yasar, Bernard Le Foll, Gianluigi Tanda, Daniele Piomelli, Steven R Goldber. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biological psychiatry. vol 69. issue 7. 2011-07-01. PMID:20801430. |
blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. |
2011-07-01 |
2023-08-12 |
rat |
| Teresa Franklin, Ze Wang, Jesse J Suh, Rebecca Hazan, Jeffrey Cruz, Yin Li, Marina Goldman, John A Detre, Charles P O'Brien, Anna Rose Childres. Effects of varenicline on smoking cue–triggered neural and craving responses. Archives of general psychiatry. vol 68. issue 5. 2011-06-30. PMID:21199958. |
it indirectly affects the dopaminergic reward system by reducing withdrawal symptoms during abstinence and by decreasing the reinforcement received from nicotine while smoking. |
2011-06-30 |
2023-08-12 |
Not clear |
| Christie D Fowler, Qun Lu, Paul M Johnson, Michael J Marks, Paul J Kenn. Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature. vol 471. issue 7340. 2011-05-25. PMID:21278726. |
remarkably, α5 subunit knockdown in mhb did not alter the rewarding effects of nicotine but abolished the inhibitory effects of higher nicotine doses on brain reward systems. |
2011-05-25 |
2023-08-12 |
mouse |
| T Javelot, H Javelot, A Baratta, L Weiner, M Messaoudi, P Lemoin. [Acute psychotic disorders related to bupropion: review of the literature]. L'Encephale. vol 36. issue 6. 2011-05-16. PMID:21130229. |
it has recently been discovered that bupropion may act as a non-competitive cholinergic nicotinic receptor antagonist, and that it may inhibit the activation of reward systems triggered by nicotine. |
2011-05-16 |
2023-08-12 |
human |
| Nichole M Neugebauer, Robert M Henehan, Claire A Hales, Marina R Picciott. Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference. Pharmacology, biochemistry, and behavior. vol 98. issue 1. 2011-05-04. PMID:21172385. |
the aim of the current study was to examine the role of galanin signaling in nicotine reward by testing the effects of nicotine in mice lacking galanin peptide (gal-/-) as compared to wild-type (gal+/+) controls. |
2011-05-04 |
2023-08-12 |
mouse |
| Adrie W Bruijnzeel, Mahendra Bishnoi, Irma A van Tuijl, Kim F M Keijzers, Kate R Yavarovich, Tim M Pasek, Jenna Ford, Jon C Alexander, Hidetaka Yamad. Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats. Psychopharmacology. vol 212. issue 4. 2011-02-25. PMID:20697697. |
effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats. |
2011-02-25 |
2023-08-12 |
rat |
| Fernando Berrendero, Patricia Robledo, José Manuel Trigo, Elena Martín-García, Rafael Maldonad. Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. Neuroscience and biobehavioral reviews. vol 35. issue 2. 2011-02-17. PMID:20170672. |
neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. |
2011-02-17 |
2023-08-12 |
Not clear |
| M B Doura, T V Luu, N H Lee, D C Perr. Persistent gene expression changes in ventral tegmental area of adolescent but not adult rats in response to chronic nicotine. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20633606. |
these findings support a model whereby adolescent brains are uniquely vulnerable to long-term changes in gene expression in the brain's reward pathway caused by early exposure to nicotine. |
2011-01-20 |
2023-08-12 |
rat |
| Daniel J Müller, Olga Likhodi, Andreas Hein. Neural markers of genetic vulnerability to drug addiction. Current topics in behavioral neurosciences. vol 3. 2011-01-20. PMID:21161757. |
ad and nd are among the most prevalent addictive disorders worldwide, are among the best studied, and are also associated globally with the largest socioeconomic impact.we describe different mechanisms through which genes can have an impact on the addictive behaviors, distinguishing between the genes that inscribe the proteins affecting the metabolism of the addictive substance (e.g., adh/aldh for alcohol or cyp2a6 for nicotine) and genes that code for the brain transmitter systems, such as genes involved in cerebral neurotransmission thought to be involved in addiction (e.g., brain reward system, mood regulation, opioid system). |
2011-01-20 |
2023-08-12 |
Not clear |
| Jie W. Double target concept for smoking cessation. Acta pharmacologica Sinica. vol 31. issue 9. 2011-01-04. PMID:20711220. |
through the nachrs in brain reward circuits, nicotine alters dopaminergic (da) neuronal function in the ventral tegmental area (vta) and increases dopamine release from vta to nuclear accumbens (na), which leads to nicotine reward, tolerance and dependence. |
2011-01-04 |
2023-08-12 |
Not clear |
| Jie W. Double target concept for smoking cessation. Acta pharmacologica Sinica. vol 31. issue 9. 2011-01-04. PMID:20711220. |
recently, evidence has been accumulated to reveal the molecular and cellular mechanisms of nicotine reward, tolerance and dependence. |
2011-01-04 |
2023-08-12 |
Not clear |
| Jie W. Double target concept for smoking cessation. Acta pharmacologica Sinica. vol 31. issue 9. 2011-01-04. PMID:20711220. |
here, i briefly summarize recent advancements of our understanding of nicotine reward, tolerance and dependence. |
2011-01-04 |
2023-08-12 |
Not clear |
| Svetlana Semenova, Athina Marko. The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20627663. |
the alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2a receptor antagonist m100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats. |
2010-12-22 |
2023-08-12 |
rat |
| Svetlana Semenova, Athina Marko. The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20627663. |
idazoxan treatment facilitated recovery from spontaneous nicotine, but not amphetamine, withdrawal by attenuating reward deficits and increase the number of somatic signs. |
2010-12-22 |
2023-08-12 |
rat |
| Andre Der-Avakian, Athina Marko. Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats. Behavioural pharmacology. vol 21. issue 4. 2010-11-04. PMID:20571366. |
we determined the effects of withdrawal from chronic exposure to nicotine (9 mg/kg/day salt, 28 days) or amphetamine (10 mg/kg/day salt, 7 days) on the motivated response for a sucrose reward and on social interaction in rats. |
2010-11-04 |
2023-08-12 |
rat |
| Ming Gao, Yu Jin, Kechun Yang, Die Zhang, Ronald J Lukas, Jie W. Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 41. 2010-11-04. PMID:20943922. |
collectively, these findings demonstrate that systemic nicotine acting via either α7- or β2*-nachrs increases presynaptic and postsynaptic glutamatergic function, and consequently initiates glutamatergic synaptic plasticity, which may be an important, early neuronal adaptation in nicotine reward and reinforcement. |
2010-11-04 |
2023-08-12 |
mouse |
| Antonio Luchicchi, Salvatore Lecca, Stefano Carta, Giuliano Pillolla, Anna L Muntoni, Sevil Yasar, Steven R Goldberg, Marco Pisti. Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors. Addiction biology. vol 15. issue 3. 2010-11-02. PMID:20477753. |
these results show that the blockade of nicotine-induced excitation of vta da neurons, which we previously described, is selective for nicotine and indicate novel mechanisms recruited to regulate the effects of addicting drugs within the shnac of the brain reward system. |
2010-11-02 |
2023-08-12 |
rat |
| David M Cole, Christian F Beckmann, Christopher J Long, Paul M Matthews, Michael J Durcan, John D Beave. Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics. NeuroImage. vol 52. issue 2. 2010-10-15. PMID:20441798. |
we specifically highlight the role of midline and prefrontal network regions in the neurocognitive response to nicotine pharmacotherapy and suggest that altered functional connectivity patterns of these networks reflect their engagement in reward and salience processing during smoking withdrawal. |
2010-10-15 |
2023-08-12 |
Not clear |