| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabel R Schlaepfer, Nicole R Hoft, Marissa A Ehringe. The genetic components of alcohol and nicotine co-addiction: from genes to behavior. Current drug abuse reviews. vol 1. issue 2. 2009-08-28. PMID:19492010. |
the nachrs are important components of the dopaminergic reward system because some of the receptors have been shown to activate the release of dopamine, and mice lacking genes for specific nachr gene subunits show altered behavioral responses to nicotine and alcohol. |
2009-08-28 |
2023-08-12 |
mouse |
| Helen C Fox, Rajita Sinh. Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women. Harvard review of psychiatry. vol 17. issue 2. 2009-08-14. PMID:19373619. |
this article therefore initially reviews studies that have examined gender differences in emotional and biophysiological changes to the stress and reward system following the acute administration of drugs, including cocaine, alcohol, and nicotine. |
2009-08-14 |
2023-08-12 |
Not clear |
| Catherine A Marcinkiewcz, Melissa M Prado, Shani K Isaac, Alex Marshall, Daria Rylkova, Adrie W Bruijnzee. Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19145226. |
previous research has shown that an increased central release of corticotropin-releasing factor (crf) at least partly mediates the deficit in brain reward function associated with nicotine withdrawal in rats. |
2009-08-03 |
2023-08-12 |
rat |
| Catherine A Marcinkiewcz, Melissa M Prado, Shani K Isaac, Alex Marshall, Daria Rylkova, Adrie W Bruijnzee. Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19145226. |
the aim of these studies was to investigate the role of crf in the central nucleus of the amygdala (cea), the lateral bed nucleus of the stria terminalis (bnst), and the nucleus accumbens shell (nacc shell) in the deficit in brain reward function associated with precipitated nicotine withdrawal. |
2009-08-03 |
2023-08-12 |
rat |
| Catherine A Marcinkiewcz, Melissa M Prado, Shani K Isaac, Alex Marshall, Daria Rylkova, Adrie W Bruijnzee. Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19145226. |
in all experiments, the nicotinic receptor antagonist mecamylamine (3 mg/kg) elevated the brain reward thresholds of the nicotine-dependent rats (9 mg/kg per day of nicotine salt) and did not affect the brain reward thresholds of the saline-treated control rats. |
2009-08-03 |
2023-08-12 |
rat |
| Zheng-xiong Xi, Krista Spiller, Eliot L Gardne. Mechanism-based medication development for the treatment of nicotine dependence. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19434058. |
in the present article, we first discuss the neural mechanisms underlying nicotine reward, and then review various mechanism-based pharmacological agents for the treatment of nicotine dependence. |
2009-07-31 |
2023-08-12 |
Not clear |
| Zheng-xiong Xi, Krista Spiller, Eliot L Gardne. Mechanism-based medication development for the treatment of nicotine dependence. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19434058. |
in addition, chronic nicotine treatment increases endocannabinoid levels in the mesolimbic da system, which indirectly modulates nac da release and nicotine reward. |
2009-07-31 |
2023-08-12 |
Not clear |
| Ke-chun Yang, Guo-zhang Jin, Jie W. Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19498417. |
by modulating da release in the nucleus accumbens (nac) and modulating gaba release onto daergic neurons in the ventral tegmental area (vta), alpha6*-nachrs may play important roles in the mediation of nicotine reward and addiction. |
2009-07-31 |
2023-08-12 |
mouse |
| Neil E Paterso. The neuropharmacological substrates of nicotine reward: reinforcing versus reinforcement-enhancing effects of nicotine. Behavioural pharmacology. vol 20. issue 3. 2009-07-23. PMID:19421028. |
the neuropharmacological substrates of nicotine reward: reinforcing versus reinforcement-enhancing effects of nicotine. |
2009-07-23 |
2023-08-12 |
Not clear |
| Neil E Paterso. The neuropharmacological substrates of nicotine reward: reinforcing versus reinforcement-enhancing effects of nicotine. Behavioural pharmacology. vol 20. issue 3. 2009-07-23. PMID:19421028. |
interestingly, however, a few pharmacological classes of compounds seem to exert selective effects on components of the dual nicotine reward mechanisms, indicating differences in the pharmacological substrates of the reinforcing and reinforcement-enhancing effects of nicotine. |
2009-07-23 |
2023-08-12 |
Not clear |
| Y S Mineur, D H Brunzell, S R Grady, J M Lindstrom, J M McIntosh, M J Marks, S L King, M R Picciott. Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning. Genes, brain, and behavior. vol 8. issue 3. 2009-07-14. PMID:19077117. |
nicotine-induced locomotor activation, but not place preference, was rescued in mice with low-level vta expression, suggesting that low-level expression of beta2* nachrs in da neurons is not sufficient to support nicotine reward. |
2009-07-14 |
2023-08-12 |
mouse |
| Nibedita Naha, Hae Young Lee, Jin Su Hwang, Jong Yoon Bahk, Moon Seok Park, Sang Yeol Lee, Sung Hoon Kim, Myeong Ok Ki. Nicotine tolerance to PC12 cell line: acute and chronic exposures modulate dopamine D2 receptor and tyrosine hydroxylase expression. Neurological research. vol 31. issue 3. 2009-07-07. PMID:19406037. |
pc12 is a clonal cell line from chromaffin tumor of rat adrenal pheochromocytoma that releases catecholamine including dopamine, which via interaction with its receptor (d(1) and d(2) receptor), is known to be involved in reward and reinforcement properties of many addictive drugs like nicotine. |
2009-07-07 |
2023-08-12 |
rat |
| Sergio D Iñiguez, Brandon L Warren, Eric M Parise, Lyonna F Alcantara, Brittney Schuh, Melissa L Maffeo, Zarko Manojlovic, Carlos A Bolaños-Guzmá. Nicotine exposure during adolescence induces a depression-like state in adulthood. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 6. 2009-06-17. PMID:19092782. |
we report that nicotine exposure during adolescence-but not adulthood-leads to a depression-like state manifested in decreased sensitivity to natural reward (sucrose), and enhanced sensitivity to stress- (fst) and anxiety-eliciting situations (epm) later in life. |
2009-06-17 |
2023-08-12 |
rat |
| Xun Tang, Song Guo, Hongqiang Sun, Xuemei Song, Zuonin Jiang, Lixiang Sheng, Dongfeng Zhou, Yonghua Hu, Dafang Che. Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. Pharmacogenetics and genomics. vol 19. issue 5. 2009-06-17. PMID:19415821. |
nicotine is the major psychoactive ingredient in tobacco, and is responsible for dependence through the nicotine-stimulated reward pathway mediated by the central dopaminergic system. |
2009-06-17 |
2023-08-12 |
Not clear |
| Kenneth A Perkins, Sarah B Coddington, Joshua L Karelitz, Christopher Jetton, John A Scott, Annette S Wilson, Caryn Lerma. Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking. Drug and alcohol dependence. vol 99. issue 1-3. 2009-05-21. PMID:18775605. |
men had greater initial sensitivity than women to some self-reported effects of nicotine related to reward and incentive salience and to impairment in sensory processing, but men and women did not differ on most other effects. |
2009-05-21 |
2023-08-12 |
human |
| Kenneth A Perkins, Sarah B Coddington, Joshua L Karelitz, Christopher Jetton, John A Scott, Annette S Wilson, Caryn Lerma. Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking. Drug and alcohol dependence. vol 99. issue 1-3. 2009-05-21. PMID:18775605. |
prior marijuana use was associated with greater nicotine reward, nicotine reinforcement was greater in men versus women among those with prior marijuana use, and having parents who smoked was related to increased incentive salience. |
2009-05-21 |
2023-08-12 |
human |
| Kenneth A Perkins, Sarah B Coddington, Joshua L Karelitz, Christopher Jetton, John A Scott, Annette S Wilson, Caryn Lerma. Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking. Drug and alcohol dependence. vol 99. issue 1-3. 2009-05-21. PMID:18775605. |
yet, they suggest that sex differences in initial sensitivity to nicotine reward occur before the onset of dependence. |
2009-05-21 |
2023-08-12 |
human |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
based on the extensive coabuse of nicotine and alcohol, the aim of the present study was to explore whether interactions among varenicline, nicotine, and ethanol in the brain reward system could indicate the use of varenicline also for alcohol dependence. |
2009-04-28 |
2023-08-12 |
rat |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
the antismoking agent varenicline exhibits properties with respect to its interaction with ethanol and nicotine in the brain reward system that may be beneficial for treating patients with alcohol dependence with (and possibly also without) concomitant nicotine dependence. |
2009-04-28 |
2023-08-12 |
rat |
| Laura E O'Dell, Taline V Khroya. Rodent models of nicotine reward: what do they tell us about tobacco abuse in humans? Pharmacology, biochemistry, and behavior. vol 91. issue 4. 2009-04-23. PMID:19121334. |
rodent models of nicotine reward: what do they tell us about tobacco abuse in humans? |
2009-04-23 |
2023-08-12 |
human |