| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura E O'Del. A psychobiological framework of the substrates that mediate nicotine use during adolescence. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18723034. |
thus, it is hypothesized that adolescents display enhanced nicotine reward and reduced withdrawal via enhanced excitation and reduced inhibition of vta cell bodies that release dopamine in the nacc. |
2009-04-15 |
2023-08-12 |
Not clear |
| Jennifer E Murray, Rick A Bevin. Acquired appetitive responding to intravenous nicotine reflects a Pavlovian conditioned association. Behavioral neuroscience. vol 123. issue 1. 2009-04-15. PMID:19170434. |
recent research examining pavlovian appetitive conditioning has extended the associative properties of nicotine from the unconditioned stimulus or reward to include the role of a conditional stimulus (cs), capable of acquiring the ability to evoke a conditioned response. |
2009-04-15 |
2023-08-12 |
rat |
| Raffaella Isola, Hailin Zhang, Gopi A Tejwani, Norton H Neff, Maria Hadjiconstantino. Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum. Psychopharmacology. vol 201. issue 4. 2009-04-01. PMID:18807250. |
nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. |
2009-04-01 |
2023-08-12 |
Not clear |
| Kechun Yang, Jun Hu, Linda Lucero, Qiang Liu, Chao Zheng, Xuechu Zhen, Guozhang Jin, Ronald J Lukas, Jie W. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. The Journal of physiology. vol 587. issue 2. 2009-03-09. PMID:19047205. |
dopaminergic (daergic) neuronal activity in the ventral tegmental area (vta) is thought to contribute generally to pleasure, reward, and drug reinforcement and has been implicated in nicotine dependence. |
2009-03-09 |
2023-08-12 |
rat |
| Paul J Kenny, Elena Chartoff, Marisa Roberto, William A Carlezon, Athina Marko. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18418357. |
nmda receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. |
2009-02-23 |
2023-08-12 |
rat |
| Paul J Kenny, Elena Chartoff, Marisa Roberto, William A Carlezon, Athina Marko. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18418357. |
nicotine increases glutamate-mediated transmission throughout brain reward circuitries. |
2009-02-23 |
2023-08-12 |
rat |
| Paul J Kenny, Elena Chartoff, Marisa Roberto, William A Carlezon, Athina Marko. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18418357. |
here we show that the competitive n-methyl-d-aspartate (nmda) receptor antagonist ly235959 (0.5-2.5 mg per kg) abolished nicotine-enhanced brain reward function, reflected in blockade of the lowering of intracranial self-stimulation (icss) thresholds usually observed after experimenter-administered (0.25 mg per kg) or intravenously self-administered (0.03 mg per kg per infusion) nicotine injections. |
2009-02-23 |
2023-08-12 |
rat |
| Paul J Kenny, Elena Chartoff, Marisa Roberto, William A Carlezon, Athina Marko. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18418357. |
taken together, these data suggest that nmda receptors, including those in the cea and vta, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug. |
2009-02-23 |
2023-08-12 |
rat |
| Hidenori Sagara, Yoshihisa Kitamura, Tetsuji Yae, Kazuhiko Shibata, Katsuya Suemaru, Toshiaki Sendo, Hiroaki Araki, Yutaka Gomit. Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method. Journal of pharmacological sciences. vol 108. issue 4. 2009-02-19. PMID:19057129. |
under these reward and priming stimulation conditions, nicotine (0.2 mg/kg) induced a significant increase in running speed. |
2009-02-19 |
2023-08-12 |
rat |
| Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamad. Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1. Journal of pharmacological sciences. vol 108. issue 4. 2009-02-19. PMID:19098386. |
basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tpa) - plasmin system via proteinase-activated receptor 1. |
2009-02-19 |
2023-08-12 |
mouse |
| Jonathan A Hollander, Qun Lu, Michael D Cameron, Theodore M Kamenecka, Paul J Kenn. Insular hypocretin transmission regulates nicotine reward. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 49. 2009-01-30. PMID:19033203. |
insular hypocretin transmission regulates nicotine reward. |
2009-01-30 |
2023-08-12 |
human |
| Jonathan A Hollander, Qun Lu, Michael D Cameron, Theodore M Kamenecka, Paul J Kenn. Insular hypocretin transmission regulates nicotine reward. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 49. 2009-01-30. PMID:19033203. |
blockade of hcrt-1 receptors also abolished the stimulatory effects of nicotine on brain reward circuitries, as measured by reversal of nicotine-induced lowering of intracranial self-stimulation thresholds. |
2009-01-30 |
2023-08-12 |
human |
| Adrie W Bruijnzeel, Athina Marko. Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16126181. |
decreased sensitivity to the effects of dopamine d1-like, but not d2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats. |
2009-01-26 |
2023-08-12 |
rat |
| Adrie W Bruijnzeel, Athina Marko. Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16126181. |
we show here that injections of the d1-like receptor antagonist sch 23390 (1-4 microg total bilateral dose) into the posterior hypothalamus/anterior vta differentially elevated brain reward thresholds in rats chronically treated with nicotine (9 mg/kg/day, salt) versus saline-treated rats. |
2009-01-26 |
2023-08-12 |
rat |
| Ilana Roth-Deri, Tamar Green-Sadan, Gal Yadi. Beta-endorphin and drug-induced reward and reinforcement. Progress in neurobiology. vol 86. issue 1. 2009-01-15. PMID:18602444. |
the existing information indicating the importance of beta-endorphin neurotransmission in mediating the reward pathways of nicotine and thc, is thus far circumstantial. |
2009-01-15 |
2023-08-12 |
mouse |
| Kenneth A Perkins, Caryn Lerman, Sarah Coddington, Joshua L Karelit. Association of retrospective early smoking experiences with prospective sensitivity to nicotine via nasal spray in nonsmokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 10. issue 8. 2009-01-14. PMID:18686181. |
ese responses were also compared with subjective spray ratings of nicotine reward (e.g., "liking") and perception (e.g., "feel the effects"), cardiovascular activity, and nicotine reinforcement via a nicotine spray choice procedure. |
2009-01-14 |
2023-08-12 |
Not clear |
| Kenneth A Perkins, Caryn Lerman, Sarah Coddington, Joshua L Karelit. Association of retrospective early smoking experiences with prospective sensitivity to nicotine via nasal spray in nonsmokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 10. issue 8. 2009-01-14. PMID:18686181. |
responses to some ese items were also related to prospective nicotine spray reward and perception, but no ese item was related to the cardiovascular or reinforcing effects of nicotine spray. |
2009-01-14 |
2023-08-12 |
Not clear |
| Kenneth A Perkin. Sex differences in nicotine reinforcement and reward: influences on the persistence of tobacco smoking. Nebraska Symposium on Motivation. Nebraska Symposium on Motivation. vol 55. 2009-01-14. PMID:19013943. |
sex differences in nicotine reinforcement and reward: influences on the persistence of tobacco smoking. |
2009-01-14 |
2023-08-12 |
Not clear |
| Matthew I Palmatier, Rick A Bevin. Occasion setting by drug states: Functional equivalence following similar training history. Behavioural brain research. vol 195. issue 2. 2009-01-12. PMID:18845189. |
to do so, a cs was paired with a sucrose reward in the nicotine (0.4 mg/kg), amphetamine (amp, 1mg/kg), or chlordiazepoxide (cdp, 5mg/kg) drug state; in separate saline sessions the cs was presented but was not followed by any reward. |
2009-01-12 |
2023-08-12 |
Not clear |
| Christie D Fowler, Michael A Arends, Paul J Kenn. Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. Behavioural pharmacology. vol 19. issue 5-6. 2008-12-31. PMID:18690103. |
subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. |
2008-12-31 |
2023-08-12 |
mouse |